Downloads: 1
414 lines (413 with data), 13.7 kB
T1 Age 17 28 59-year-old T2 Sex 29 32 man T3 Date 58 73 age of 49 years E1 Date:T3 T4 Disease_disorder 48 50 PD E2 Disease_disorder:T4 #1 AnnotatorNotes E2 Parkinson's disease T5 Date 3988 4000 7 days later E3 Date:T5 T6 Diagnostic_procedure 180 195 quality of life E4 Diagnostic_procedure:T6 T7 Lab_value 155 165 diminished E5 Lab_value:T7 R1 MODIFY Arg1:E5 Arg2:E4 T8 Therapeutic_procedure 264 267 DBS E6 Therapeutic_procedure:T8 #2 AnnotatorNotes E6 Deep Brain Stimulation T9 Detailed_description 252 263 subthalamic T10 Detailed_description 242 251 bilateral R2 MODIFY Arg1:T9 Arg2:E6 R3 MODIFY Arg1:T10 Arg2:E6 T11 Diagnostic_procedure 269 297 Multidisciplinary evaluation E7 Diagnostic_procedure:T11 T12 Diagnostic_procedure 333 359 standardized levodopa test E8 Diagnostic_procedure:T12 T13 Lab_value 303 316 75 % positive E9 Lab_value:T13 R4 MODIFY Arg1:E9 Arg2:E8 T14 Disease_disorder 374 391 cognitive decline E10 Disease_disorder:T14 A1 POLARITY E10 NEG T15 Disease_disorder 395 418 psychiatric comorbitity E11 Disease_disorder:T15 A2 POLARITY E11 NEG T16 Disease_disorder 446 458 brain damage E12 Disease_disorder:T16 A3 POLARITY E12 NEG T17 Therapeutic_procedure 536 539 DBS E13 Therapeutic_procedure:T17 T18 Medication 637 645 levodopa E14 Medication:T18 T19 Medication 660 669 piribedil E15 Medication:T19 T20 Dosage 624 633 1112.5 mg T21 Dosage 650 656 150 mg R5 MODIFY Arg1:T21 Arg2:E15 R6 MODIFY Arg1:T20 Arg2:E14 T22 Diagnostic_procedure 3923 3937 Cardiac workup E16 Diagnostic_procedure:T22 T23 Lab_value 3942 3950 negative E17 Lab_value:T23 R7 MODIFY Arg1:E17 Arg2:E16 T24 History 681 725 no history of orofacial or cervical dystonia T25 Disease_disorder 717 725 dystonia E18 Disease_disorder:T25 T26 Biological_structure 708 716 cervical T27 Biological_structure 695 704 orofacial R8 MODIFY Arg1:T26 Arg2:E18 R9 MODIFY Arg1:T27 Arg2:E18 A4 POLARITY E18 NEG T28 Disease_disorder 130 141 dyskinesias E19 Disease_disorder:T28 T29 Sign_symptom 75 87 Fluctuations E20 Sign_symptom:T29 T31 Disease_disorder 4048 4050 PD E21 Disease_disorder:T31 T32 Diagnostic_procedure 813 839 Neuropsychological testing E22 Diagnostic_procedure:T32 T33 Lab_value 844 852 adequate E23 Lab_value:T33 R11 MODIFY Arg1:E23 Arg2:E22 T34 Other_event 734 744 “on” state E24 Other_event:T34 T35 Sign_symptom 761 766 alert E25 Sign_symptom:T35 T36 Sign_symptom 779 811 signs of psychiatric comorbidity E26 Sign_symptom:T36 A5 POLARITY E26 NEG T37 Diagnostic_procedure 895 905 swallowing E27 Diagnostic_procedure:T37 T38 Lab_value 910 916 normal E28 Lab_value:T38 R12 MODIFY Arg1:E28 Arg2:E27 T39 Sign_symptom 865 879 nerve deficits E29 Sign_symptom:T39 A6 POLARITY E29 NEG T40 Biological_structure 857 864 cranial R13 MODIFY Arg1:T40 Arg2:E29 T41 Diagnostic_procedure 927 945 postural stability E30 Diagnostic_procedure:T41 T42 Diagnostic_procedure 918 922 Gait E31 Diagnostic_procedure:T42 T43 Lab_value 950 956 normal E32 Lab_value:T43 R14 MODIFY Arg1:E32 Arg2:E30 R15 MODIFY Arg1:E32 Arg2:E31 T44 Sign_symptom 970 978 rigidity E33 Sign_symptom:T44 T45 Severity 962 969 minimal R16 MODIFY Arg1:T45 Arg2:E33 T46 Biological_structure 986 990 neck T47 Biological_structure 995 1004 right arm R17 MODIFY Arg1:T46 Arg2:E33 R18 MODIFY Arg1:T47 Arg2:E33 T48 Diagnostic_procedure 1006 1031 Coordinative motor skills E34 Diagnostic_procedure:T48 T49 Lab_value 1071 1081 restricted E35 Lab_value:T49 T50 Biological_structure 1089 1098 left hand R19 MODIFY Arg1:T50 Arg2:E35 T51 Diagnostic_procedure 1046 1065 pro- and supination E36 Diagnostic_procedure:T51 R20 SUB_PROCEDURE Arg1:E36 Arg2:E34 R21 MODIFY Arg1:E35 Arg2:E34 T52 Sign_symptom 1100 1111 Dyskinesias E37 Sign_symptom:T52 T53 Sign_symptom 1139 1149 impairment E38 Sign_symptom:T53 T54 Severity 1130 1138 moderate R22 MODIFY Arg1:T54 Arg2:E38 T55 Other_event 1158 1169 “off” state E39 Other_event:T55 T56 Medication 1180 1190 medication E40 Medication:T56 A7 POLARITY E40 NEG T57 Duration 1204 1208 12 h E41 Duration:T57 T58 Sign_symptom 1234 1244 dysarthria E42 Sign_symptom:T58 T59 Sign_symptom 1249 1258 dysphonia E43 Sign_symptom:T59 T60 Severity 1229 1233 mild R23 MODIFY Arg1:T60 Arg2:E42 R24 MODIFY Arg1:T60 Arg2:E43 T61 Sign_symptom 1268 1274 tremor E44 Sign_symptom:T61 T62 Detailed_description 1260 1267 resting R25 MODIFY Arg1:T62 Arg2:E44 T63 Biological_structure 1282 1291 right arm T64 Biological_structure 1296 1299 leg T65 Sign_symptom 1326 1332 tremor E45 Sign_symptom:T65 T66 Detailed_description 1319 1325 action T67 Severity 1312 1318 slight R26 MODIFY Arg1:T67 Arg2:E45 R27 MODIFY Arg1:T66 Arg2:E45 T68 Biological_structure 1340 1350 right hand R28 MODIFY Arg1:T68 Arg2:E45 T69 Sign_symptom 1352 1360 Rigidity E46 Sign_symptom:T69 T70 Severity 1365 1371 severe R29 MODIFY Arg1:T70 Arg2:E46 T71 Biological_structure 1379 1383 neck R30 MODIFY Arg1:T71 Arg2:T70 T72 Biological_structure 1399 1404 right T73 Biological_structure 1422 1431 left side T74 Severity 1385 1391 marked T75 Severity 1410 1414 mild R31 MODIFY Arg1:T72 Arg2:T74 R32 MODIFY Arg1:T73 Arg2:T75 R33 MODIFY Arg1:T74 Arg2:E46 R34 MODIFY Arg1:T75 Arg2:E46 T76 Diagnostic_procedure 1433 1445 Motor skills E47 Diagnostic_procedure:T76 T77 Biological_structure 1453 1458 hands R35 MODIFY Arg1:T77 Arg2:E47 T78 Lab_value 1473 1481 impaired E48 Lab_value:T78 R36 MODIFY Arg1:E48 Arg2:E47 T79 Diagnostic_procedure 1483 1487 Gait E49 Diagnostic_procedure:T79 T80 Lab_value 1492 1496 slow E50 Lab_value:T80 T81 Lab_value 1501 1508 unaided E51 Lab_value:T81 R37 MODIFY Arg1:E50 Arg2:E49 R38 MODIFY Arg1:E51 Arg2:E49 T82 Sign_symptom 1542 1550 freezing E52 Sign_symptom:T82 T83 Frequency 1529 1541 intermittent R39 MODIFY Arg1:T83 Arg2:E52 T84 Sign_symptom 1567 1585 dystonic posturing E53 Sign_symptom:T84 T85 Severity 1562 1566 mild R40 MODIFY Arg1:T85 Arg2:E53 T86 Biological_structure 1593 1603 right foot R41 MODIFY Arg1:T86 Arg2:E53 T87 Sign_symptom 1638 1644 spasms E54 Sign_symptom:T87 A8 POLARITY E54 NEG T88 Biological_structure 1628 1637 laryngeal R42 MODIFY Arg1:T88 Arg2:E54 T89 Therapeutic_procedure 1673 1680 surgery E55 Therapeutic_procedure:T89 T90 Medication 1699 1722 dopaminergic medication E56 Medication:T90 T91 Time 1743 1752 07:00 p.m E57 Time:T91 T92 Medication 1775 1783 levodopa E58 Medication:T92 A9 POLARITY E58 NEG T93 Diagnostic_procedure 1807 1829 intraoperative testing E59 Diagnostic_procedure:T93 T94 Administration 1759 1771 bedtime dose R43 MODIFY Arg1:T94 Arg2:E58 T95 Date 1838 1844 day of E60 Date:T95 T96 Therapeutic_procedure 1849 1858 operation E61 Therapeutic_procedure:T96 T97 Medication 1924 1941 local anaesthesia E62 Medication:T97 T98 Time 1949 1958 09:00 a.m E63 Time:T98 T99 Therapeutic_procedure 1899 1917 stereotactic frame E64 Therapeutic_procedure:T99 R44 SUB_PROCEDURE Arg1:E64 Arg2:E61 T100 Activity 2046 2067 semi-sitting position E65 Activity:T100 T101 Activity 2173 2179 flexed E66 Activity:T101 T102 Detailed_description 2180 2190 anteriorly T103 Biological_structure 2155 2159 head R45 MODIFY Arg1:T103 Arg2:E66 R46 MODIFY Arg1:T102 Arg2:E66 T104 Therapeutic_procedure 2213 2222 electrode E67 Therapeutic_procedure:T104 T105 Detailed_description 2208 2212 left R47 MODIFY Arg1:T105 Arg2:E67 T106 Therapeutic_procedure 2268 2276 bur hole E68 Therapeutic_procedure:T106 T107 Biological_structure 2284 2294 right side R48 MODIFY Arg1:T107 Arg2:E68 T108 Sign_symptom 2322 2330 cramping E69 Sign_symptom:T108 T109 Biological_structure 2338 2342 neck R49 MODIFY Arg1:T109 Arg2:E69 T110 Biological_structure 2347 2361 facial muscles R50 MODIFY Arg1:T110 Arg2:E69 T111 Sign_symptom 2373 2395 difficulties breathing E70 Sign_symptom:T111 T112 Diagnostic_procedure 2420 2434 pulse oximetry E71 Diagnostic_procedure:T112 T113 Lab_value 2442 2457 good saturation E72 Lab_value:T113 T114 Lab_value 2470 2475 ≥95 % E73 Lab_value:T114 R51 MODIFY Arg1:E72 Arg2:E71 R52 MODIFY Arg1:E73 Arg2:E71 T115 Sign_symptom 2494 2513 dystonic dysarthria E74 Sign_symptom:T115 T116 Diagnostic_procedure 2519 2544 Microelectrode recordings E75 Diagnostic_procedure:T116 T117 Diagnostic_procedure 2571 2602 macroelectrode test stimulation E76 Diagnostic_procedure:T117 T118 Sign_symptom 2672 2679 stridor E77 Sign_symptom:T118 T119 Detailed_description 2660 2671 inspiratory T120 Detailed_description 2647 2659 high-pitched R53 MODIFY Arg1:T119 Arg2:E77 R54 MODIFY Arg1:T120 Arg2:E77 T121 Diagnostic_procedure 2681 2695 Pulse oximetry E78 Diagnostic_procedure:T121 T122 Lab_value 2703 2731 decreasing oxygen saturation E79 Lab_value:T122 T123 Time 2735 2744 02:15 p.m E80 Time:T123 R55 MODIFY Arg1:E79 Arg2:E78 T124 Sign_symptom 2786 2797 tachycardia E81 Sign_symptom:T124 T125 Detailed_description 2771 2777 narrow T126 Detailed_description 2778 2785 complex R56 MODIFY Arg1:T126 Arg2:E81 R57 MODIFY Arg1:T125 Arg2:E81 T127 Sign_symptom 2845 2857 unresponsive E82 Sign_symptom:T127 T128 Time 2809 2824 Within a minute E83 Time:T128 T129 Therapeutic_procedure 2859 2880 Cardiac resuscitation E84 Therapeutic_procedure:T129 T130 Therapeutic_procedure 2930 2939 intubated E85 Therapeutic_procedure:T130 T131 Detailed_description 2915 2929 fiberoptically R58 MODIFY Arg1:T131 Arg2:E85 T132 Therapeutic_procedure 2978 2996 stereotactic frame E86 Therapeutic_procedure:T132 T133 Therapeutic_procedure 2961 2970 front bar E87 Therapeutic_procedure:T133 A11 POLARITY E87 NEG R59 MODIFY Arg1:E87 Arg2:E86 T134 Therapeutic_procedure 3016 3026 intubation E88 Therapeutic_procedure:T134 T135 Detailed_description 3005 3015 fiberoptic R60 MODIFY Arg1:T135 Arg2:E88 T136 Sign_symptom 3037 3042 spasm E89 Sign_symptom:T136 T138 Biological_structure 3027 3036 laryngeal R61 MODIFY Arg1:T138 Arg2:E89 T137 Diagnostic_procedure 3069 3097 transthoracic echocardiogram E90 Diagnostic_procedure:T137 T139 Sign_symptom 3168 3177 pathology E91 Sign_symptom:T139 A10 POLARITY E91 NEG T140 Biological_structure 3160 3167 cardiac R62 MODIFY Arg1:T140 Arg2:E91 T141 Sign_symptom 3185 3196 air bubbles E92 Sign_symptom:T141 A12 POLARITY E92 NEG T142 Therapeutic_procedure 3198 3209 Stimulation E93 Therapeutic_procedure:T142 A13 POLARITY E93 NEG T143 Therapeutic_procedure 3386 3395 electrode E94 Therapeutic_procedure:T143 T144 Detailed_description 3376 3385 permanent T145 Detailed_description 3370 3375 right R63 MODIFY Arg1:T144 Arg2:E94 R64 MODIFY Arg1:T145 Arg2:E94 T146 Diagnostic_procedure 3444 3469 microelectrode recordings E95 Diagnostic_procedure:T146 A14 POLARITY E95 NEG T147 Medication 3477 3485 levodopa E96 Medication:T147 T148 Dosage 3471 3476 50 mg R65 MODIFY Arg1:T148 Arg2:E96 T149 Administration 3510 3526 nasogastric tube R66 MODIFY Arg1:T149 Arg2:E96 T150 Dosage 3527 3542 every two hours R67 MODIFY Arg1:T150 Arg2:E96 T151 Diagnostic_procedure 3565 3585 postoperative period E97 Diagnostic_procedure:T151 T152 Diagnostic_procedure 3606 3608 CT E98 Diagnostic_procedure:T152 T153 Biological_structure 3601 3605 head R68 MODIFY Arg1:T153 Arg2:E98 T154 Clinical_event 3679 3690 transferred E99 Clinical_event:T154 T155 Nonbiological_location 3698 3717 intensive care unit R69 MODIFY Arg1:T155 Arg2:E99 T156 Therapeutic_procedure 3726 3735 extubated E100 Therapeutic_procedure:T156 T157 Time 3739 3748 02:00 p.m E101 Time:T157 T158 Date 3754 3767 following day E102 Date:T158 T159 Sign_symptom 3780 3800 neurological deficit E103 Sign_symptom:T159 A15 POLARITY E103 NEG T160 Sign_symptom 3823 3829 spasms E104 Sign_symptom:T160 A16 POLARITY E104 NEG T161 Biological_structure 3813 3822 laryngeal R70 MODIFY Arg1:T161 Arg2:E104 T162 Therapeutic_procedure 3844 3860 nasogastric tube E105 Therapeutic_procedure:T162 A17 POLARITY E105 NEG T163 Medication 3899 3909 medication E106 Medication:T163 T164 Therapeutic_procedure 588 595 surgery E107 Therapeutic_procedure:T164 T165 Medication 600 610 medication E108 Medication:T165 R71 SUB_PROCEDURE Arg1:E14 Arg2:E108 R72 SUB_PROCEDURE Arg1:E15 Arg2:E108 T166 Detailed_description 120 129 peak dose R73 MODIFY Arg1:T166 Arg2:E19 R74 BEFORE Arg1:E4 Arg2:E6 R75 AFTER Arg1:E6 Arg2:E7 * OVERLAP E7 E8 E10 E11 E12 R76 BEFORE Arg1:E12 Arg2:E13 R77 AFTER Arg1:E13 Arg2:E107 * OVERLAP E107 E108 R78 AFTER Arg1:E108 Arg2:E18 R79 BEFORE Arg1:E18 Arg2:E24 T167 Other_event 103 115 “off” states E109 Other_event:T167 * OVERLAP E2 E1 E20 E109 E19 E4 * OVERLAP E24 E25 E26 E22 E29 E27 E31 E30 E33 E34 E37 E38 R10 BEFORE Arg1:E38 Arg2:E39 * OVERLAP E39 E40 E41 E42 E43 E44 E45 E46 E47 E49 E52 E53 E54 R80 MODIFY Arg1:T63 Arg2:E44 R81 MODIFY Arg1:T64 Arg2:E44 T30 Date 1662 1672 day before E110 Date:T30 R82 BEFORE Arg1:E54 Arg2:E110 R83 BEFORE Arg1:E110 Arg2:E55 R84 AFTER Arg1:E55 Arg2:E56 * OVERLAP E56 E57 R85 BEFORE Arg1:E57 Arg2:E58 * OVERLAP E58 E59 R86 BEFORE Arg1:E59 Arg2:E60 * OVERLAP E60 E61 E62 E63 E65 E66 E67 E68 E69 E70 E71 E74 E75 E76 T168 Nonbiological_location 2075 2079 O.R. R87 MODIFY Arg1:T168 Arg2:E65 A18 POLARITY E76 UNCERTAIN R88 BEFORE Arg1:E76 Arg2:E77 * OVERLAP E77 E78 E80 R89 BEFORE Arg1:E80 Arg2:E81 * OVERLAP E81 E83 E82 R90 BEFORE Arg1:E82 Arg2:E84 * OVERLAP E84 E85 E87 E88 E89 E90 E91 E92 E93 E94 E95 R91 BEFORE Arg1:E95 Arg2:E96 * OVERLAP E96 E97 E98 R92 BEFORE Arg1:E98 Arg2:E99 R93 BEFORE Arg1:E99 Arg2:E100 * OVERLAP E100 E101 E102 E103 E104 E105 E106 E16 T169 Therapeutic_procedure 3956 3973 impulse generator E111 Therapeutic_procedure:T169 R94 BEFORE Arg1:E16 Arg2:E111 * OVERLAP E111 E3 E112 E21 T170 Diagnostic_procedure 4029 4044 symptom control E112 Diagnostic_procedure:T170 T171 Lab_value 4024 4028 good E113 Lab_value:T171 R95 MODIFY Arg1:E113 Arg2:E112