285 lines (284 with data), 10.1 kB

T1	Age 18 29	18-year-old
T2	Personal_background 30 33	Han
T3	Sex 34 40	female
T4	Clinical_event 41 49	admitted
E1	Clinical_event:T4 
T5	Nonbiological_location 53 90	Peking Union Medical College Hospital
R1	MODIFY Arg1:T5 Arg2:E1	
T6	Disease_disorder 126 135	pneumonia
E2	Disease_disorder:T6 
T7	Disease_disorder 98 112	adrenal crisis
E3	Disease_disorder:T7 
R2	CAUSE Arg1:E2 Arg2:E3	
T8	Disease_disorder 177 187	infections
E4	Disease_disorder:T8 
T9	Biological_structure 165 176	respiratory
T10	Detailed_description 155 164	recurrent
R3	MODIFY Arg1:T9 Arg2:E4	
R4	MODIFY Arg1:T10 Arg2:E4	
T11	Date 194 199	age 5
E5	Date:T11 
T12	Medication 259 271	vaccinations
E6	Medication:T12 
T13	Detailed_description 226 234	multiple
R5	MODIFY Arg1:T13 Arg2:E6	
T14	Detailed_description 235 252	hepatitis B virus
R6	MODIFY Arg1:T14 Arg2:E6	
T15	Detailed_description 254 257	HBV
R7	IDENTICAL Arg1:T15 Arg2:T14	
T16	Diagnostic_procedure 287 295	cortisol
E7	Diagnostic_procedure:T16 
T17	Diagnostic_procedure 300 304	ACTH
E8	Diagnostic_procedure:T17 
T18	Detailed_description 281 286	serum
R8	MODIFY Arg1:T18 Arg2:E7	
R9	MODIFY Arg1:T18 Arg2:E8	
T19	Lab_value 273 280	Reduced
R10	MODIFY Arg1:T19 Arg2:E7	
R11	MODIFY Arg1:T19 Arg2:E8	
T20	Date 331 333	16
E9	Date:T20 
#1	AnnotatorNotes E9	Age 16
T21	History 155 199	recurrent respiratory infections since age 5
T22	History 205 271	failed to respond to multiple hepatitis B virus (HBV) vaccinations
T23	History 273 333	Reduced serum cortisol and ACTH levels were discovered at 16
T24	Medication 339 365	glucocorticoid replacement
E10	Medication:T24 
T25	History 339 365	glucocorticoid replacement
T26	Sign_symptom 394 403	hair loss
E11	Sign_symptom:T26 
T27	Date 417 422	age 4
E12	Date:T27 
T28	History 394 422	hair loss started from age 4
T29	Sign_symptom 428 462	absence of pubic and axillary hair
E13	Sign_symptom:T29 
T30	Other_event 481 516	development of regular menstruation
E14	Other_event:T30 
#2	AnnotatorNotes E14	Not a date, but relevant to observations in a temporal way
T31	History 428 516	absence of pubic and axillary hair was noticed after development of regular menstruation
T32	Disease_disorder 539 557	nephrotic syndrome
E15	Disease_disorder:T32 
T33	History 539 557	nephrotic syndrome
T34	Disease_disorder 585 611	minimal change nephropathy
E16	Disease_disorder:T34 
T35	Diagnostic_procedure 621 627	biopsy
E17	Diagnostic_procedure:T35 
T36	Biological_structure 615 620	renal
R12	MODIFY Arg1:T36 Arg2:E17	
T37	History 585 627	minimal change nephropathy by renal biopsy
T38	Diagnostic_procedure 629 649	Physical examination
E18	Diagnostic_procedure:T38 
T39	Disease_disorder 672 688	alopecia totalis
E19	Disease_disorder:T39 
T40	Disease_disorder 695 706	candidiasis
E20	Disease_disorder:T40 
T41	Biological_structure 690 694	oral
R13	MODIFY Arg1:T41 Arg2:E20	
T42	Disease_disorder 708 720	hypohidrosis
E21	Disease_disorder:T42 
T43	Sign_symptom 726 739	trachyonychia
E22	Sign_symptom:T43 
T44	Family_history 798 808	only child
T45	Sign_symptom 758 771	abnormalities
E23	Sign_symptom:T45 
A1	POLARITY E23 NEG
T46	Biological_structure 751 757	dental
T47	Biological_structure 741 747	Facial
R14	MODIFY Arg1:T46 Arg2:E23	
R15	MODIFY Arg1:T47 Arg2:E23	
T48	Family_history 824 920	Symptom and signs of the above disorders were not identified among her nonconsanguineous parents
T49	Diagnostic_procedure 930 947	immunologic tests
E24	Diagnostic_procedure:T49 
T50	Sign_symptom 968 992	panhypogammaglobulinemia
E25	Sign_symptom:T50 
T51	Diagnostic_procedure 1005 1016	cell counts
E26	Diagnostic_procedure:T51 
R16	SUB_PROCEDURE Arg1:E26 Arg2:E24	
T52	Lab_value 997 1004	reduced
R17	MODIFY Arg1:T52 Arg2:E26	
T53	Diagnostic_procedure 1020 1027	B cells
E27	Diagnostic_procedure:T53 
T54	Diagnostic_procedure 1029 1036	T cells
E28	Diagnostic_procedure:T54 
T55	Diagnostic_procedure 1042 1067	natural killer (NK) cells
E29	Diagnostic_procedure:T55 
R18	SUB_PROCEDURE Arg1:E27 Arg2:E26	
R19	SUB_PROCEDURE Arg1:E28 Arg2:E26	
R20	SUB_PROCEDURE Arg1:E29 Arg2:E26	
T56	Diagnostic_procedure 1089 1102	CD4/CD8 ratio
E30	Diagnostic_procedure:T56 
T57	Diagnostic_procedure 1115 1132	expression levels
E31	Diagnostic_procedure:T57 
T58	Diagnostic_procedure 1144 1169	T-cell activation markers
E32	Diagnostic_procedure:T58 
R21	SUB_PROCEDURE Arg1:E32 Arg2:E31	
T59	Lab_value 1178 1190	normal range
R22	MODIFY Arg1:T59 Arg2:E32	
T60	Diagnostic_procedure 1209 1242	proportion of CD8+/HLA-DR+ subset
E33	Diagnostic_procedure:T60 
T61	Lab_value 1199 1208	increased
R23	MODIFY Arg1:T61 Arg2:E33	
R24	SUB_PROCEDURE Arg1:E33 Arg2:E31	
T62	Diagnostic_procedure 1244 1266	Antinuclear antibodies
E34	Diagnostic_procedure:T62 
T63	Diagnostic_procedure 1268 1271	ANA
E35	Diagnostic_procedure:T63 
T64	Diagnostic_procedure 1277 1314	antineutrophil cytoplasmic antibodies
E36	Diagnostic_procedure:T64 
T65	Diagnostic_procedure 1316 1320	ANCA
E37	Diagnostic_procedure:T65 
R25	IDENTICAL Arg1:E37 Arg2:E36	
R26	IDENTICAL Arg1:E35 Arg2:E34	
T66	Lab_value 1327 1335	negative
R27	MODIFY Arg1:T66 Arg2:E36	
R28	MODIFY Arg1:T66 Arg2:E34	
T67	Medication 1350 1376	hydrocortisone replacement
E38	Medication:T67 
A2	POLARITY E38 NEG
T68	Diagnostic_procedure 1410 1418	cortisol
E39	Diagnostic_procedure:T68 
T69	Detailed_description 1404 1409	serum
R29	MODIFY Arg1:T69 Arg2:E39	
T70	Time 1396 1403	8:00 am
E40	Time:T70 
R30	MODIFY Arg1:E40 Arg2:E39	
T71	Lab_value 1435 1445	0.93 μg/dL
R31	MODIFY Arg1:T71 Arg2:E39	
T72	Diagnostic_procedure 1452 1456	ACTH
E41	Diagnostic_procedure:T72 
T73	Lab_value 1457 1468	<5.00 pg/mL
R32	MODIFY Arg1:T73 Arg2:E41	
T74	Diagnostic_procedure 1492 1519	anterior pituitary hormones
E42	Diagnostic_procedure:T74 
T75	Detailed_description 1470 1475	Serum
R33	MODIFY Arg1:T75 Arg2:E42	
T76	Diagnostic_procedure 1548 1558	osmolality
E43	Diagnostic_procedure:T76 
T77	Detailed_description 1532 1537	serum
T78	Detailed_description 1542 1547	urine
R34	MODIFY Arg1:T78 Arg2:E43	
R35	MODIFY Arg1:T77 Arg2:E43	
T79	Lab_value 1564 1586	within reference range
R36	MODIFY Arg1:T79 Arg2:E42	
R37	MODIFY Arg1:T79 Arg2:E43	
T80	Diagnostic_procedure 1593 1616	antiperoxidase antibody
E44	Diagnostic_procedure:T80 
T81	Diagnostic_procedure 1621 1647	antithyroglobulin antibody
E45	Diagnostic_procedure:T81 
T82	Lab_value 1653 1661	negative
R38	MODIFY Arg1:T82 Arg2:E45	
R39	MODIFY Arg1:T82 Arg2:E44	
T83	Diagnostic_procedure 1680 1721	antiprotein tyrosine phosphatase antibody
E46	Diagnostic_procedure:T83 
T84	Lab_value 1671 1679	positive
R40	MODIFY Arg1:T84 Arg2:E46	
T85	Diagnostic_procedure 1728 1749	fasting blood glucose
E47	Diagnostic_procedure:T85 
T86	Lab_value 1753 1763	5.9 mmol/L
R41	MODIFY Arg1:T86 Arg2:E47	
T87	Diagnostic_procedure 1765 1791	Magnetic resonance imaging
E48	Diagnostic_procedure:T87 
T88	Detailed_description 1797 1805	contrast
R42	MODIFY Arg1:T88 Arg2:E48	
T89	Diagnostic_procedure 1825 1834	pituitary
E49	Diagnostic_procedure:T89 
T90	Lab_value 1818 1824	normal
R43	MODIFY Arg1:T90 Arg2:E49	
T91	Disease_disorder 1859 1863	CVID
E50	Disease_disorder:T91 
#3	AnnotatorNotes E50	Common variable immune deficiency
T92	Disease_disorder 1865 1889	isolated ACTH deficiency
E51	Disease_disorder:T92 
#4	AnnotatorNotes E51	isolated adrenocorticotropic hormone deficiency
T93	Disease_disorder 1895 1915	ectodermal dysplasia
E52	Disease_disorder:T93 
T94	Sign_symptom 1929 1934	fever
E53	Sign_symptom:T94 
T95	Sign_symptom 1936 1941	cough
E54	Sign_symptom:T95 
T96	Sign_symptom 1947 1955	vomiting
E55	Sign_symptom:T96 
A3	POLARITY E55 NEG
A4	POLARITY E54 NEG
A5	POLARITY E53 NEG
T97	Medication 1969 1980	antibiotics
E56	Medication:T97 
T98	Medication 1997 2011	hydrocortisone
E57	Medication:T98 
T99	Detailed_description 1985 1996	stress-dose
R44	MODIFY Arg1:T99 Arg2:E57	
T100	Medication 2023 2049	Intravenous immunoglobulin
E58	Medication:T100 
T101	Medication 2051 2055	IVIG
E59	Medication:T101 
R45	IDENTICAL Arg1:E59 Arg2:E58	
A6	POLARITY E58 NEG
T102	Clinical_event 2109 2118	follow-up
E60	Clinical_event:T102 
T103	Date 2119 2131	1 year after
E61	Date:T103 
T104	Disease_disorder 2163 2172	infection
E62	Disease_disorder:T104 
A7	POLARITY E62 NEG
T105	Duration 2180 2204	during the previous year
E63	Duration:T105 
T106	Clinical_event 2212 2218	stayed
E64	Clinical_event:T106 
T107	Nonbiological_location 2222 2226	home
R46	MODIFY Arg1:T107 Arg2:E64	
T108	Activity 2239 2257	outdoor activities
E65	Activity:T108 
A8	POLARITY E65 NEG
T109	Medication 2263 2289	glucocorticoid replacement
E66	Medication:T109 
A9	POLARITY E66 NEG
T110	Date 2304 2318	4 months after
E67	Date:T110 
T111	Medication 2356 2384	traditional Chinese medicine
E68	Medication:T111 
T112	Diagnostic_procedure 2397 2420	Lymphocyte subsets test
E69	Diagnostic_procedure:T112 
T113	Diagnostic_procedure 2474 2481	B cells
E70	Diagnostic_procedure:T113 
T114	Diagnostic_procedure 2486 2493	T cells
E71	Diagnostic_procedure:T114 
T115	Lab_value 2454 2463	increased
R47	MODIFY Arg1:T115 Arg2:E70	
R48	MODIFY Arg1:T115 Arg2:E71	
R49	SUB_PROCEDURE Arg1:E70 Arg2:E69	
R50	SUB_PROCEDURE Arg1:E71 Arg2:E69	
T116	Diagnostic_procedure 2501 2514	NK cell count
E72	Diagnostic_procedure:T116 
T117	Lab_value 2524 2542	below normal limit
R51	MODIFY Arg1:T117 Arg2:E72	
T118	Diagnostic_procedure 2578 2603	flow cytometric procedure
E73	Diagnostic_procedure:T118 
*	OVERLAP E1 E3
R52	AFTER Arg1:E3 Arg2:E4	
R54	BEFORE Arg1:E6 Arg2:E7	
*	OVERLAP E7 E8 E9 E10
*	OVERLAP E4 E5
R53	BEFORE Arg1:E5 Arg2:E6	
R55	AFTER Arg1:E10 Arg2:E11	
*	OVERLAP E11 E12
R56	BEFORE Arg1:E12 Arg2:E13	
R57	AFTER Arg1:E13 Arg2:E14	
R58	BEFORE Arg1:E14 Arg2:E15	
*	OVERLAP E15 E16 E17
R59	BEFORE Arg1:E17 Arg2:E18	
*	OVERLAP E18 E19 E20 E21 E22 E23 E24 E25 E30 E31 E34 E36
R60	BEFORE Arg1:E36 Arg2:E38	
*	OVERLAP E38 E40 E39 E41 E42 E43 E44 E45 E46 E47 E48 E49
R61	BEFORE Arg1:E49 Arg2:E50	
*	OVERLAP E50 E51 E52
R62	BEFORE Arg1:E52 Arg2:E53	
*	OVERLAP E53 E54 E55 E56 E57
R63	BEFORE Arg1:E57 Arg2:E58	
R64	BEFORE Arg1:E58 Arg2:E60	
*	OVERLAP E60 E61 E62
R65	AFTER Arg1:E62 Arg2:E63	
*	OVERLAP E63 E64 E65
R66	BEFORE Arg1:E65 Arg2:E66	
*	OVERLAP E66 E67 E68
R67	BEFORE Arg1:E68 Arg2:E69	
*	OVERLAP E69 E72 E73