Downloads: 1
447 lines (446 with data), 15.2 kB
T1 Age 2 13 54-year-old T2 Sign_symptom 39 44 fever E1 Sign_symptom:T2 T3 Sign_symptom 46 54 diarrhea E2 Sign_symptom:T3 T4 Disease_disorder 66 79 renal failure E3 Disease_disorder:T4 T5 Detailed_description 60 65 acute R1 MODIFY Arg1:T5 Arg2:E3 T6 Clinical_event 26 34 admitted E4 Clinical_event:T6 T7 History 88 118 no significant medical history T8 Medication 137 147 medication E5 Medication:T8 A1 POLARITY E5 NEG T9 History 153 178 had not traveled recently T10 Family_history 187 215 no relevant familial history T11 Date 217 236 Fifteen days before E6 Date:T11 T12 Sign_symptom 265 270 fever E7 Sign_symptom:T12 T13 Sign_symptom 282 286 rash E8 Sign_symptom:T13 T14 Sign_symptom 288 296 diarrhea E9 Sign_symptom:T14 T15 Sign_symptom 302 306 pain E10 Sign_symptom:T15 T16 Biological_structure 314 320 joints R2 MODIFY Arg1:T16 Arg2:E10 T17 Detailed_description 272 281 fluctuant R3 MODIFY Arg1:T17 Arg2:E8 T18 Clinical_event 325 334 admission E11 Clinical_event:T18 T19 Diagnostic_procedure 336 350 blood pressure E12 Diagnostic_procedure:T19 T20 Lab_value 355 367 140/70 mm Hg T21 Diagnostic_procedure 369 380 temperature E13 Diagnostic_procedure:T21 T22 Lab_value 381 385 39°C R4 MODIFY Arg1:T22 Arg2:E13 R5 MODIFY Arg1:T20 Arg2:E12 T23 Diagnostic_procedure 387 407 Physical examination E14 Diagnostic_procedure:T23 T24 Sign_symptom 422 427 edema E15 Sign_symptom:T24 T25 Severity 415 421 severe R6 MODIFY Arg1:T25 Arg2:E15 T26 Biological_structure 443 464 lower and upper limbs R7 MODIFY Arg1:T26 Arg2:E15 T27 Sign_symptom 477 484 ascites E16 Sign_symptom:T27 T28 Sign_symptom 489 505 pleural effusion E17 Sign_symptom:T28 T29 Disease_disorder 545 562 lymphadenopathies E18 Disease_disorder:T29 T30 Qualitative_concept 528 544 infracentimetric #1 AnnotatorNotes T30 smaller than a centimeter in diameter R8 MODIFY Arg1:T30 Arg2:E18 T31 Biological_structure 520 527 axillar T32 Biological_structure 507 515 Cervical R9 MODIFY Arg1:T31 Arg2:E18 R10 MODIFY Arg1:T32 Arg2:E18 T33 Disease_disorder 591 609 hepatosplenomegaly E19 Disease_disorder:T33 T34 Diagnostic_procedure 624 643 computed tomography E20 Diagnostic_procedure:T34 T35 Diagnostic_procedure 645 647 CT E21 Diagnostic_procedure:T35 R11 IDENTICAL Arg1:E21 Arg2:E20 T36 Disease_disorder 665 674 arthritis E22 Disease_disorder:T36 T37 Detailed_description 655 664 Bilateral R12 MODIFY Arg1:T37 Arg2:E22 T38 Biological_structure 682 688 ankles R13 MODIFY Arg1:T38 Arg2:E22 A2 POLARITY E22 NEG T39 Diagnostic_procedure 713 727 Blood analysis E23 Diagnostic_procedure:T39 T40 Sign_symptom 758 770 leukocytosis E24 Sign_symptom:T40 T41 Diagnostic_procedure 779 789 hemoglobin E25 Diagnostic_procedure:T41 T43 Diagnostic_procedure 794 802 platelet E26 Diagnostic_procedure:T43 T44 Sign_symptom 835 844 hemolysis E27 Sign_symptom:T44 A3 POLARITY E27 NEG T45 Diagnostic_procedure 855 873 C-reactive protein E28 Diagnostic_procedure:T45 T47 Diagnostic_procedure 879 886 albumin E29 Diagnostic_procedure:T47 T49 Diagnostic_procedure 903 912 creatinin E30 Diagnostic_procedure:T49 T50 Detailed_description 897 902 serum R18 MODIFY Arg1:T50 Arg2:E30 T52 Sign_symptom 919 930 proteinuria E31 Sign_symptom:T52 T53 Severity 914 918 mild R20 MODIFY Arg1:T53 Arg2:E31 T54 Sign_symptom 938 947 hematuria E32 Sign_symptom:T54 A4 POLARITY E32 NEG R21 SUB_PROCEDURE Arg1:E25 Arg2:E23 R22 SUB_PROCEDURE Arg1:E26 Arg2:E23 R23 SUB_PROCEDURE Arg1:E28 Arg2:E23 R24 SUB_PROCEDURE Arg1:E29 Arg2:E23 R25 SUB_PROCEDURE Arg1:E30 Arg2:E23 T55 Therapeutic_procedure 969 980 rehydration E33 Therapeutic_procedure:T55 T56 Detailed_description 957 968 intravenous R26 MODIFY Arg1:T56 Arg2:E33 T57 Medication 987 993 saline E34 Medication:T57 T58 Medication 998 1005 albumin E35 Medication:T58 R27 SUB_PROCEDURE Arg1:E34 Arg2:E33 R28 SUB_PROCEDURE Arg1:E35 Arg2:E33 T59 Diagnostic_procedure 1007 1021 renal function E36 Diagnostic_procedure:T59 T61 Therapeutic_procedure 1056 1064 dialysis E37 Therapeutic_procedure:T61 T62 Disease_disorder 1114 1124 hemiplegia E38 Disease_disorder:T62 T63 Diagnostic_procedure 1141 1144 MRI E39 Diagnostic_procedure:T63 T64 Biological_structure 1135 1140 brain R30 MODIFY Arg1:T64 Arg2:E39 T65 Sign_symptom 1172 1179 lesions E40 Sign_symptom:T65 T66 Detailed_description 1163 1171 ischemic T67 Detailed_description 1152 1162 multifocal R31 MODIFY Arg1:T66 Arg2:E40 R32 MODIFY Arg1:T67 Arg2:E40 T68 Diagnostic_procedure 1209 1216 studies E41 Diagnostic_procedure:T68 T69 Detailed_description 1197 1208 rythmologic T70 Detailed_description 1181 1192 Echographic R33 MODIFY Arg1:T69 Arg2:E41 R34 MODIFY Arg1:T70 Arg2:E41 T71 Disease_disorder 1257 1263 stroke E42 Disease_disorder:T71 T72 Disease_disorder 1231 1248 cardiologic cause E43 Disease_disorder:T72 A5 POLARITY E43 NEG T73 Diagnostic_procedure 1273 1279 biopsy E44 Diagnostic_procedure:T73 T74 Biological_structure 1267 1272 renal R35 MODIFY Arg1:T74 Arg2:E44 T75 Diagnostic_procedure 1310 1330 Periodic acid–Schiff E45 Diagnostic_procedure:T75 T76 Diagnostic_procedure 1332 1335 PAS E46 Diagnostic_procedure:T76 R36 IDENTICAL Arg1:E46 Arg2:E45 T77 Disease_disorder 1353 1366 endotheliosis E47 Disease_disorder:T77 T78 Biological_structure 1374 1383 glomeruli R37 MODIFY Arg1:T78 Arg2:E47 T79 Disease_disorder 1418 1431 mesangiolysis E48 Disease_disorder:T79 T80 Sign_symptom 1436 1451 double contours E49 Sign_symptom:T80 T81 Diagnostic_procedure 1455 1470 silver staining E50 Diagnostic_procedure:T81 T82 Sign_symptom 1507 1515 thrombus E51 Sign_symptom:T82 A6 POLARITY E51 NEG T83 Biological_structure 1496 1506 arteriolar R38 MODIFY Arg1:T83 Arg2:E51 T84 Clinical_event 3235 3245 discharged E52 Clinical_event:T84 T85 Date 3246 3259 43 days after E53 Date:T85 T86 Disease_disorder 3274 3292 neurological event E54 Disease_disorder:T86 A7 POLARITY E54 NEG T87 Clinical_event 241 250 admission E55 Clinical_event:T87 T46 Lab_value 846 854 elevated E56 Lab_value:T46 R16 MODIFY Arg1:E56 Arg2:E28 T42 Lab_value 772 778 normal E57 Lab_value:T42 R14 MODIFY Arg1:E57 Arg2:E25 R15 MODIFY Arg1:E57 Arg2:E26 T48 Lab_value 875 878 low E58 Lab_value:T48 R17 MODIFY Arg1:E58 Arg2:E29 T51 Lab_value 888 896 elevated E59 Lab_value:T51 R19 MODIFY Arg1:E59 Arg2:E30 T60 Lab_value 1022 1030 worsened E60 Lab_value:T60 R29 MODIFY Arg1:E60 Arg2:E36 T88 Diagnostic_procedure 1072 1097 diagnostic investigations E61 Diagnostic_procedure:T88 T89 Sign_symptom 1534 1557 B lymphocyte infiltrate E62 Sign_symptom:T89 T90 Detailed_description 1528 1533 CD20+ T91 Severity 1519 1527 moderate R39 MODIFY Arg1:T91 Arg2:E62 R40 MODIFY Arg1:T90 Arg2:E62 T92 Biological_structure 1577 1589 interstitium R41 MODIFY Arg1:T92 Arg2:E62 T93 Sign_symptom 1598 1621 peritubularcapillaritis E63 Sign_symptom:T93 #2 AnnotatorNotes E63 should be "peritubular capillaritis" T94 Diagnostic_procedure 1623 1647 Immunofluorescence study E64 Diagnostic_procedure:T94 T95 Sign_symptom 1665 1672 deposit E65 Sign_symptom:T95 A8 POLARITY E65 NEG T96 Diagnostic_procedure 1685 1691 biopsy E66 Diagnostic_procedure:T96 T97 Biological_structure 1674 1684 Lymph node R42 MODIFY Arg1:T97 Arg2:E66 T98 Sign_symptom 1714 1722 abnormal E67 Sign_symptom:T98 T99 Biological_structure 1723 1732 follicles R43 MODIFY Arg1:T99 Arg2:E67 T100 Sign_symptom 1738 1751 hyalinization E68 Sign_symptom:T100 T101 Biological_structure 1755 1770 germinal center R44 MODIFY Arg1:T101 Arg2:E68 T102 Sign_symptom 1779 1796 onion-skin aspect E69 Sign_symptom:T102 T103 Biological_structure 1804 1815 mantle zone R45 MODIFY Arg1:T103 Arg2:E69 T104 Disease_disorder 1934 1937 MCD E70 Disease_disorder:T104 T105 Disease_disorder 1902 1932 multicentric Castleman disease E71 Disease_disorder:T105 R46 IDENTICAL Arg1:E70 Arg2:E71 T106 Detailed_description 1885 1901 hyaline-vascular R47 MODIFY Arg1:T106 Arg2:E71 T107 Diagnostic_procedure 3352 3354 CT E72 Diagnostic_procedure:T107 T108 Biological_structure 3334 3351 Thoraco-abdominal R48 MODIFY Arg1:T108 Arg2:E72 T109 Diagnostic_procedure 3441 3445 size E73 Diagnostic_procedure:T109 T110 Biological_structure 3424 3429 liver R49 MODIFY Arg1:T110 Arg2:E73 T111 Biological_structure 3434 3440 spleen R50 MODIFY Arg1:T111 Arg2:E73 T112 Lab_value 3417 3423 normal E74 Lab_value:T112 R51 MODIFY Arg1:E74 Arg2:E73 T113 Sign_symptom 3464 3475 enlargement E75 Sign_symptom:T113 A9 POLARITY E75 NEG T114 Biological_structure 3453 3463 lymph node R52 MODIFY Arg1:T114 Arg2:E75 T115 Medication 3393 3405 chemotherapy E76 Medication:T115 T116 Quantitative_concept 3380 3389 6 courses R53 MODIFY Arg1:T116 Arg2:E76 T117 Disease_disorder 3520 3523 MCD E77 Disease_disorder:T117 T118 Diagnostic_procedure 1854 1863 histology E78 Diagnostic_procedure:T118 T119 Biological_structure 1843 1853 lymph node R54 MODIFY Arg1:T119 Arg2:E78 T120 Diagnostic_procedure 1954 1962 serology E79 Diagnostic_procedure:T120 T121 Detailed_description 1948 1953 HHV-8 T122 Detailed_description 1940 1943 HIV R55 MODIFY Arg1:T121 Arg2:E79 R56 MODIFY Arg1:T122 Arg2:E79 T123 Diagnostic_procedure 1992 2007 tissue staining E80 Diagnostic_procedure:T123 T124 Biological_structure 1981 1991 lymph node T125 Detailed_description 1975 1980 HHV-8 R57 MODIFY Arg1:T124 Arg2:E80 R58 MODIFY Arg1:T125 Arg2:E80 T126 Lab_value 2014 2022 negative E81 Lab_value:T126 R59 MODIFY Arg1:E81 Arg2:E80 R60 MODIFY Arg1:E81 Arg2:E79 T127 Medication 2770 2782 chemotherapy E82 Medication:T127 T128 Medication 2806 2815 rituximab E83 Medication:T128 T129 Dosage 2817 2826 375 mg/m2 R61 MODIFY Arg1:T129 Arg2:E83 T130 Medication 2829 2845 cyclophosphamide E84 Medication:T130 T131 Dosage 2847 2856 750 mg/m2 R62 MODIFY Arg1:T131 Arg2:E84 T132 Medication 2863 2876 dexamethasone E85 Medication:T132 T133 Dosage 2878 2887 40 mg/day R63 MODIFY Arg1:T133 Arg2:E85 T134 Duration 2893 2907 day 1 to day 4 E86 Duration:T134 R64 MODIFY Arg1:E86 Arg2:E85 T135 Therapeutic_procedure 2935 2951 plasma exchanges E87 Therapeutic_procedure:T135 T136 Frequency 3040 3053 every 3 weeks T137 Coreference 3017 3024 Courses E88 Coreference:T137 R65 IDENTICAL Arg1:E88 Arg2:E82 R66 MODIFY Arg1:T136 Arg2:E88 T138 Disease_disorder 3082 3104 vascular leak syndrome E89 Disease_disorder:T138 A10 TREND E89 DEC T139 Diagnostic_procedure 3116 3130 renal function E90 Diagnostic_procedure:T139 T140 Lab_value 3131 3141 normalized E91 Lab_value:T140 R67 MODIFY Arg1:E91 Arg2:E90 T141 Diagnostic_procedure 3153 3157 VEGF E92 Diagnostic_procedure:T141 T142 Lab_value 3177 3186 825 pg/mL E93 Lab_value:T142 R68 MODIFY Arg1:E93 Arg2:E92 T143 Lab_value 3164 3173 decreased E94 Lab_value:T143 R69 MODIFY Arg1:E94 Arg2:E92 T144 Medication 3205 3217 chemotherapy E95 Medication:T144 T145 Quantitative_concept 3193 3201 1 course R70 MODIFY Arg1:T145 Arg2:E95 T146 Detailed_description 3147 3152 serum R71 MODIFY Arg1:T146 Arg2:E92 T147 Diagnostic_procedure 3549 3559 creatinine E96 Diagnostic_procedure:T147 T148 Detailed_description 3542 3548 plasma R72 MODIFY Arg1:T148 Arg2:E96 T149 Lab_value 3563 3572 86 μmol/L E97 Lab_value:T149 R73 MODIFY Arg1:E97 Arg2:E96 T150 Sign_symptom 3582 3593 proteinuria E98 Sign_symptom:T150 A11 POLARITY E98 NEG T151 Diagnostic_procedure 2066 2070 VEGF E99 Diagnostic_procedure:T151 T152 Diagnostic_procedure 2030 2064 vascular endothelium growth factor E100 Diagnostic_procedure:T152 T153 Lab_value 2076 2091 highly elevated E101 Lab_value:T153 R74 MODIFY Arg1:E101 Arg2:E100 T154 Detailed_description 2024 2029 Serum R75 MODIFY Arg1:T154 Arg2:E100 R76 IDENTICAL Arg1:E99 Arg2:E100 T155 Disease_disorder 2132 2158 thrombotic microangiopathy E102 Disease_disorder:T155 T156 Disease_disorder 2160 2163 TMA E103 Disease_disorder:T156 R77 IDENTICAL Arg1:E103 Arg2:E102 T157 Diagnostic_procedure 2180 2186 biopsy E104 Diagnostic_procedure:T157 T158 Diagnostic_procedure 2197 2200 MRI E105 Diagnostic_procedure:T158 T159 Biological_structure 2174 2179 renal T160 Biological_structure 2191 2196 brain R78 MODIFY Arg1:T159 Arg2:E104 R79 MODIFY Arg1:T160 Arg2:E105 T161 Disease_disorder 2248 2251 TMA E106 Disease_disorder:T161 T162 Biological_structure 2237 2247 neurologic T163 Biological_structure 2222 2232 glomerular R80 MODIFY Arg1:T162 Arg2:E106 R81 MODIFY Arg1:T163 Arg2:E106 T164 Sign_symptom 2299 2324 microvascular involvement E107 Sign_symptom:T164 T165 Detailed_description 2288 2298 thrombotic R82 MODIFY Arg1:T165 Arg2:E107 T166 Disease_disorder 2386 2413 shiga toxin-producing germs E108 Disease_disorder:T166 A12 POLARITY E108 NEG T167 Diagnostic_procedure 2415 2433 ADAMTS-13 activity E109 Diagnostic_procedure:T167 T168 Lab_value 2438 2447 decreased E110 Lab_value:T168 T169 Lab_value 2471 2479 above 5% E111 Lab_value:T169 T170 Lab_value 2448 2457 up to 14% E112 Lab_value:T170 R83 MODIFY Arg1:E110 Arg2:E109 R84 MODIFY Arg1:E112 Arg2:E109 R85 MODIFY Arg1:E111 Arg2:E109 T171 Diagnostic_procedure 2489 2519 alternative complement pathway E113 Diagnostic_procedure:T171 T172 Lab_value 2524 2530 normal E114 Lab_value:T172 R86 MODIFY Arg1:E114 Arg2:E113 T173 Therapeutic_procedure 2532 2547 Plasma exchange E115 Therapeutic_procedure:T173 T174 Sign_symptom 2593 2600 lesions E116 Sign_symptom:T174 T175 Biological_structure 2573 2579 kidney R87 MODIFY Arg1:T175 Arg2:E116 T176 Sign_symptom 2635 2642 lesions E117 Sign_symptom:T176 T177 Biological_structure 2629 2634 brain R88 MODIFY Arg1:T177 Arg2:E117 T178 Detailed_description 2620 2628 ischemic T179 Detailed_description 2609 2619 multifocal R89 MODIFY Arg1:T178 Arg2:E117 R90 MODIFY Arg1:T179 Arg2:E117 T180 Date 2664 2677 after 1 month E118 Date:T180 T181 Diagnostic_procedure 2730 2739 condition E119 Diagnostic_procedure:T181 T182 Lab_value 2749 2755 stable E120 Lab_value:T182 R91 MODIFY Arg1:E120 Arg2:E119 T183 Detailed_description 2651 2663 discontinued R92 MODIFY Arg1:E118 Arg2:T183 R93 MODIFY Arg1:T183 Arg2:E115 * OVERLAP E4 E1 E2 E3 E5 R94 AFTER Arg1:E5 Arg2:E6 R95 BEFORE Arg1:E6 Arg2:E55 R96 AFTER Arg1:E55 Arg2:E7 * OVERLAP E7 E8 E9 E10 R97 BEFORE Arg1:E10 Arg2:E11 * OVERLAP E11 E12 E13 E14 E15 E16 E17 E18 E19 E20 R98 BEFORE Arg1:E20 Arg2:E22 * OVERLAP E22 E23 E27 E31 E32 R99 BEFORE Arg1:E32 Arg2:E33 R100 BEFORE Arg1:E33 Arg2:E36 * OVERLAP E36 E37 E61 E38 E39 E40 E41 E43 E42 E44 E45 E47 E48 E49 E50 E51 E62 E63 E64 E65 E66 E67 E68 E69 E78 E71 E79 E80 E100 E102 E104 E105 E106 E107 E108 E109 E113 R101 BEFORE Arg1:E113 Arg2:E115 * OVERLAP E115 E116 E117 R102 BEFORE Arg1:E117 Arg2:E118 * OVERLAP E118 E119 R103 AFTER Arg1:E119 Arg2:E82 R104 SUB_PROCEDURE Arg1:E83 Arg2:E82 R105 SUB_PROCEDURE Arg1:E84 Arg2:E82 R106 SUB_PROCEDURE Arg1:E85 Arg2:E82 * OVERLAP E82 E87 E88 R107 BEFORE Arg1:E88 Arg2:E89 * OVERLAP E89 E90 E92 E95 R108 BEFORE Arg1:E95 Arg2:E52 * OVERLAP E52 E53 E54 E72 R109 AFTER Arg1:E72 Arg2:E76 R110 BEFORE Arg1:E76 Arg2:E73 * OVERLAP E73 E75 T184 Date 3477 3491 One year after E121 Date:T184 T185 Clinical_event 3496 3505 diagnosis E122 Clinical_event:T185 R111 BEFORE Arg1:E75 Arg2:E121 R112 AFTER Arg1:E121 Arg2:E122 R113 BEFORE Arg1:E122 Arg2:E77 * OVERLAP E77 E96 E98