198 lines (197 with data), 6.6 kB

T1	Age 17 28	19-year-old
T2	Sex 29 34	woman
T3	Family_history 82 113	family history was unremarkable
T4	Family_history 36 76	first child of healthy unrelated parents
T5	History 123 160	born at term after a normal pregnancy
T6	Diagnostic_procedure 206 223	early development
E1	Diagnostic_procedure:T6 
T7	Lab_value 243 249	normal
R1	MODIFY Arg1:T7 Arg2:E1	
T8	Diagnostic_procedure 166 182	perinatal period
E2	Diagnostic_procedure:T8 
T9	Lab_value 187 197	uneventful
R2	MODIFY Arg1:T9 Arg2:E2	
T10	Date 261 274	1 year of age
E3	Date:T10 
T11	Disease_disorder 276 293	psychomotor delay
E4	Disease_disorder:T11 
T12	Diagnostic_procedure 367 374	balance
E5	Diagnostic_procedure:T12 
T13	Lab_value 362 366	poor
R3	MODIFY Arg1:T13 Arg2:E5	
T14	Sign_symptom 388 393	falls
E6	Sign_symptom:T14 
T15	Frequency 379 387	frequent
R4	MODIFY Arg1:T15 Arg2:E6	
T16	Date 346 355	22 months
E7	Date:T16 
T17	Activity 322 329	walking
E8	Activity:T17 
T18	Detailed_description 330 342	autonomously
R5	MODIFY Arg1:T18 Arg2:E8	
T19	Date 398 412	3 years of age
E9	Date:T19 
T20	Disease_disorder 430 467	demyelinating sensorimotor neuropathy
E10	Disease_disorder:T20 
T21	Diagnostic_procedure 480 483	MRI
E11	Diagnostic_procedure:T21 
T22	Biological_structure 474 479	brain
R6	MODIFY Arg1:T22 Arg2:E11	
T23	Disease_disorder 509 523	leukodystrophy
E12	Disease_disorder:T23 
T24	Biological_structure 494 508	supratentorial
R7	MODIFY Arg1:T24 Arg2:E12	
T25	Diagnostic_procedure 551 565	clinical signs
E13	Diagnostic_procedure:T25 
T26	Lab_value 575 581	stable
R8	MODIFY Arg1:T26 Arg2:E13	
T27	Date 586 594	10 years
E14	Date:T27 
T28	Disease_disorder 600 620	walking difficulties
E15	Disease_disorder:T28 
A1	TREND E15 INC
T29	Lab_value 621 629	worsened
R9	MODIFY Arg1:T29 Arg2:E15	
T30	Sign_symptom 640 648	weakness
E16	Sign_symptom:T30 
T31	Biological_structure 635 639	limb
R10	MODIFY Arg1:T31 Arg2:E16	
T32	Sign_symptom 653 659	tremor
E17	Sign_symptom:T32 
T33	Diagnostic_procedure 672 695	neurological evaluation
E18	Diagnostic_procedure:T33 
T34	Sign_symptom 703 713	dysarthria
E19	Sign_symptom:T34 
T35	Sign_symptom 715 724	dysmetria
E20	Sign_symptom:T35 
T36	Diagnostic_procedure 733 737	gait
E21	Diagnostic_procedure:T36 
T37	Lab_value 726 732	ataxic
R11	MODIFY Arg1:T37 Arg2:E21	
T38	Sign_symptom 742 754	hyporeflexia
E22	Sign_symptom:T38 
T39	Biological_structure 762 772	four limbs
R12	MODIFY Arg1:T39 Arg2:E22	
T40	Disease_disorder 778 792	muscle wasting
E23	Disease_disorder:T40 
T41	Diagnostic_procedure 857 861	gait
E24	Diagnostic_procedure:T41 
T42	Lab_value 850 856	ataxic
R13	MODIFY Arg1:T42 Arg2:E24	
T43	Disease_disorder 868 888	cognitive impairment
E25	Disease_disorder:T43 
T44	Severity 863 867	Mild
R14	MODIFY Arg1:T44 Arg2:E25	
T45	Diagnostic_procedure 905 907	IQ
E26	Diagnostic_procedure:T45 
T46	Detailed_description 912 924	WISC-R scale
R15	MODIFY Arg1:T46 Arg2:E26	
T47	Lab_value 908 910	75
R16	MODIFY Arg1:T47 Arg2:E26	
T48	Activity 810 814	walk
E27	Activity:T48 
T49	Lab_value 821 841	only for a few steps
T50	Detailed_description 815 820	alone
R17	MODIFY Arg1:T50 Arg2:E27	
R18	MODIFY Arg1:T49 Arg2:E27	
T51	Diagnostic_procedure 927 948	Histological analysis
E28	Diagnostic_procedure:T51 
T52	Diagnostic_procedure 961 967	biopsy
E29	Diagnostic_procedure:T52 
T53	Biological_structure 954 960	muscle
R19	MODIFY Arg1:T53 Arg2:E29	
R20	SUB_PROCEDURE Arg1:E29 Arg2:E28	
T54	Sign_symptom 975 987	hypo/atrophy
E30	Sign_symptom:T54 
T55	Biological_structure 991 997	fibres
R21	MODIFY Arg1:T55 Arg2:E30	
T56	Diagnostic_procedure 1003 1021	clinical evolution
E31	Diagnostic_procedure:T56 
T57	Lab_value 1026 1044	slowly progressive
R22	MODIFY Arg1:T57 Arg2:E31	
T58	Clinical_event 1058 1067	follow-up
E32	Clinical_event:T58 
T59	Date 1084 1099	19 years of age
E33	Date:T59 
T60	Activity 1117 1121	walk
E34	Activity:T60 
T61	Detailed_description 1122 1127	alone
R23	MODIFY Arg1:T61 Arg2:E34	
T62	Therapeutic_procedure 1149 1162	orthotic aids
E35	Therapeutic_procedure:T62 
T63	Detailed_description 1138 1148	ankle-foot
R24	MODIFY Arg1:T63 Arg2:E35	
R25	MODIFY Arg1:E35 Arg2:E34	
T64	Disease_disorder 1204 1213	scoliosis
E36	Disease_disorder:T64 
T65	Biological_structure 1190 1203	dorsal-lumbar
R26	MODIFY Arg1:T65 Arg2:E36	
T66	Severity 1183 1189	marked
R27	MODIFY Arg1:T66 Arg2:E36	
T67	Diagnostic_procedure 1221 1235	clinical signs
E37	Diagnostic_procedure:T67 
T68	Lab_value 1241 1247	stable
R28	MODIFY Arg1:T68 Arg2:E37	
T69	Diagnostic_procedure 1249 1275	Neurophysiological studies
E38	Diagnostic_procedure:T69 
T70	Disease_disorder 1316 1351	demyelinating peripheral neuropathy
E39	Disease_disorder:T70 
T71	Lab_value 1286 1295	worsening
T72	Biological_structure 1309 1315	axonal
T73	Detailed_description 1303 1308	mixed
R29	MODIFY Arg1:T72 Arg2:E39	
R30	MODIFY Arg1:T73 Arg2:E39	
R31	MODIFY Arg1:T71 Arg2:E39	
A2	TREND E39 INC
T74	Diagnostic_procedure 1375 1378	MRI
E40	Diagnostic_procedure:T74 
T75	Biological_structure 1363 1374	spinal cord
T76	Biological_structure 1353 1358	Brain
R32	MODIFY Arg1:T75 Arg2:E40	
R33	MODIFY Arg1:T76 Arg2:E40	
T77	Sign_symptom 1404 1424	signal abnormalities
E41	Sign_symptom:T77 
T78	Sign_symptom 1439 1450	cavitations
E42	Sign_symptom:T78 
T79	Severity 1429 1438	extensive
T80	Lab_value 1391 1400	extension
T81	Severity 1386 1390	mild
R34	MODIFY Arg1:T81 Arg2:T80	
R35	MODIFY Arg1:T79 Arg2:E42	
R36	MODIFY Arg1:T80 Arg2:E41	
T82	Biological_structure 1458 1479	cerebral white matter
R37	MODIFY Arg1:T82 Arg2:E42	
T83	Sign_symptom 1573 1580	lesions
E43	Sign_symptom:T83 
A3	POLARITY E43 NEG
T84	Detailed_description 1567 1572	focal
R38	MODIFY Arg1:T84 Arg2:E43	
T85	Diagnostic_procedure 1594 1608	Plasma lactate
E44	Diagnostic_procedure:T85 
T86	Lab_value 1613 1619	2.9 mM
R39	MODIFY Arg1:T86 Arg2:E44	
T87	Sign_symptom 1546 1550	thin
E45	Sign_symptom:T87 
T88	Biological_structure 1530 1541	spinal cord
R40	MODIFY Arg1:T88 Arg2:E45	
R41	MODIFY Arg1:T88 Arg2:E43	
T89	Sign_symptom 1515 1521	spared
E46	Sign_symptom:T89 
T90	Biological_structure 1500 1509	brainstem
T91	Biological_structure 1485 1495	cerebellum
R42	MODIFY Arg1:T90 Arg2:E46	
R43	MODIFY Arg1:T91 Arg2:E46	
R44	BEFORE Arg1:E2 Arg2:E1	
R45	BEFORE Arg1:E1 Arg2:E3	
*	OVERLAP E3 E4
T92	Severity 301 308	evident
R46	MODIFY Arg1:T92 Arg2:E4	
R47	BEFORE Arg1:E4 Arg2:E8	
*	OVERLAP E8 E7 E5 E6
R48	BEFORE Arg1:E6 Arg2:E9	
*	OVERLAP E9 E10 E11 E12
R49	BEFORE Arg1:E12 Arg2:E13	
R50	BEFORE Arg1:E13 Arg2:E14	
*	OVERLAP E14 E15 E16 E17 E18 E19 E20 E21 E22 E23 E27 E24 E25 E26 E28 E30 E31
R51	BEFORE Arg1:E31 Arg2:E32	
*	OVERLAP E32 E33 E34 E35 E36 E37 E38 E39 E40 E41 E42 E46 E45 E43 E44