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+T1	Age 2 13	66-year-old
+T2	Sex 14 17	man
+T3	Clinical_event 22 30	admitted
+E1	Clinical_event:T3 
+T4	Nonbiological_location 40 48	Hospital
+R1	MODIFY Arg1:T4 Arg2:E1	
+T5	Date 52 65	November 2008
+E2	Date:T5 
+T6	Sign_symptom 71 83	splenomegaly
+E3	Sign_symptom:T6 
+T7	Diagnostic_procedure 92 106	red cell count
+E4	Diagnostic_procedure:T7 
+T9	Diagnostic_procedure 122 142	serum erythropoietin
+E5	Diagnostic_procedure:T9 
+T11	Diagnostic_procedure 151 171	Cytogenetic analysis
+E6	Diagnostic_procedure:T11 
+T12	Diagnostic_procedure 193 202	karyotype
+E7	Diagnostic_procedure:T12 
+R6	SUB_PROCEDURE Arg1:E7 Arg2:E6	
+T15	Diagnostic_procedure 204 221	Molecular studies
+E8	Diagnostic_procedure:T15 
+T22	Disease_disorder 351 353	PV
+E12	Disease_disorder:T22 
+#1	AnnotatorNotes E12	Polycythemia Vera
+T8	Lab_value 87 91	high
+E13	Lab_value:T8 
+R2	MODIFY Arg1:E13 Arg2:E4	
+T10	Lab_value 112 121	subnormal
+E14	Lab_value:T10 
+R3	MODIFY Arg1:E14 Arg2:E5	
+T13	Lab_value 181 187	normal
+E15	Lab_value:T13 
+T14	Lab_value 188 192	male
+E16	Lab_value:T14 
+R4	MODIFY Arg1:E16 Arg2:E7	
+R5	MODIFY Arg1:E15 Arg2:E7	
+T16	Sign_symptom 244 266	BCR-ABL1 rearrangement
+E9	Sign_symptom:T16 
+A1	POLARITY E9 NEG
+T17	Sign_symptom 285 303	JAK2V617F mutation
+E10	Sign_symptom:T17 
+T18	Lab_value 312 334	allele burden of 44.9%
+E11	Lab_value:T18 
+R7	MODIFY Arg1:E11 Arg2:E10	
+T19	Diagnostic_procedure 395 415	bone marrow analysis
+E17	Diagnostic_procedure:T19 
+T20	Detailed_description 381 394	morphological
+R8	MODIFY Arg1:T20 Arg2:E17	
+T21	Detailed_description 433 450	WHO 2008 criteria
+R9	MODIFY Arg1:T21 Arg2:E17	
+T23	Medication 479 486	aspirin
+E18	Medication:T23 
+T24	Medication 488 499	hydroxyurea
+E19	Medication:T24 
+T25	Therapeutic_procedure 505 517	phlebotomies
+E20	Therapeutic_procedure:T25 
+T26	Date 553 568	Six years later
+E21	Date:T26 
+T27	Diagnostic_procedure 583 593	ultrasound
+E22	Diagnostic_procedure:T27 
+T28	Biological_structure 573 582	abdominal
+R10	MODIFY Arg1:T28 Arg2:E22	
+T29	Sign_symptom 652 664	infiltration
+E23	Sign_symptom:T29 
+T30	Biological_structure 640 651	perinephric
+T31	Detailed_description 630 639	bilateral
+T32	Detailed_description 624 629	dense
+R11	MODIFY Arg1:T31 Arg2:E23	
+R12	MODIFY Arg1:T30 Arg2:E23	
+R13	MODIFY Arg1:T32 Arg2:E23	
+T33	Diagnostic_procedure 723 725	CT
+E24	Diagnostic_procedure:T33 
+T34	Diagnostic_procedure 702 721	computed tomography
+E25	Diagnostic_procedure:T34 
+T35	Biological_structure 691 701	whole-body
+R14	MODIFY Arg1:T35 Arg2:E25	
+R15	IDENTICAL Arg1:E24 Arg2:E25	
+T36	Diagnostic_procedure 739 797	fluotine-18 fluordeoxyglucose positron emission tomography
+E26	Diagnostic_procedure:T36 
+T37	Diagnostic_procedure 799 808	F-FDG-PET
+E27	Diagnostic_procedure:T37 
+R16	IDENTICAL Arg1:E27 Arg2:E26	
+T38	Diagnostic_procedure 838 852	glucose uptake
+E28	Diagnostic_procedure:T38 
+T39	Lab_value 828 837	increased
+E29	Lab_value:T39 
+R17	MODIFY Arg1:E29 Arg2:E28	
+T40	Biological_structure 860 904	medullary channels of both humeri and femurs
+R18	MODIFY Arg1:T40 Arg2:E28	
+T41	Diagnostic_procedure 920 940	bone marrow analysis
+E30	Diagnostic_procedure:T41 
+T42	Detailed_description 906 919	Morphological
+R19	MODIFY Arg1:T42 Arg2:E30	
+T43	Disease_disorder 977 979	PV
+E31	Disease_disorder:T43 
+T44	Disease_disorder 1039 1047	fibrosis
+E32	Disease_disorder:T44 
+T45	Biological_structure 1027 1038	bone marrow
+R20	MODIFY Arg1:T45 Arg2:E32	
+T46	Diagnostic_procedure 1071 1087	EUMNET consensus
+E33	Diagnostic_procedure:T46 
+T47	Lab_value 1049 1053	MF-0
+E34	Lab_value:T47 
+R21	MODIFY Arg1:E34 Arg2:E33	
+T48	Diagnostic_procedure 1100 1120	cytogenetic analysis
+E35	Diagnostic_procedure:T48 
+T49	Diagnostic_procedure 1157 1166	karyotype
+E36	Diagnostic_procedure:T49 
+T50	Lab_value 1152 1156	male
+E37	Lab_value:T50 
+R22	MODIFY Arg1:E37 Arg2:E36	
+T51	Lab_value 1168 1222	47,XY,+9[2/20],47,XY,add(6)(p25),+9[2/20],46,XY[16/20]
+E38	Lab_value:T51 
+T52	Diagnostic_procedure 1228 1247	histological nature
+E39	Diagnostic_procedure:T52 
+T53	Sign_symptom 1267 1279	infiltration
+E40	Sign_symptom:T53 
+T54	Biological_structure 1255 1266	perinephric
+R23	MODIFY Arg1:T54 Arg2:E40	
+T55	Diagnostic_procedure 1324 1330	biopsy
+E41	Diagnostic_procedure:T55 
+T56	Detailed_description 1319 1323	core
+T57	Sign_symptom 1338 1344	lesion
+E42	Sign_symptom:T57 
+T58	Detailed_description 1309 1318	CT-guided
+R24	MODIFY Arg1:T56 Arg2:E41	
+R25	MODIFY Arg1:T58 Arg2:E41	
+T59	Diagnostic_procedure 1346 1368	Morphological analysis
+E43	Diagnostic_procedure:T59 
+T60	Diagnostic_procedure 1443 1447	CD68
+E44	Diagnostic_procedure:T60 
+T61	Sign_symptom 1402 1419	foamy histiocytes
+E45	Sign_symptom:T61 
+T62	Lab_value 1430 1438	positive
+E46	Lab_value:T62 
+T63	Diagnostic_procedure 1492 1496	CD1a
+E47	Diagnostic_procedure:T63 
+T64	Diagnostic_procedure 1501 1505	S100
+E48	Diagnostic_procedure:T64 
+T65	Disease_disorder 1521 1529	fibrosis
+E49	Disease_disorder:T65 
+T66	Lab_value 1452 1460	negative
+E50	Lab_value:T66 
+R26	MODIFY Arg1:E46 Arg2:E44	
+R27	MODIFY Arg1:E45 Arg2:E44	
+R28	MODIFY Arg1:E45 Arg2:E47	
+R29	MODIFY Arg1:E45 Arg2:E48	
+R30	MODIFY Arg1:E50 Arg2:E47	
+R31	MODIFY Arg1:E50 Arg2:E48	
+T67	Sign_symptom 1560 1570	infiltrate
+E51	Sign_symptom:T67 
+T68	Detailed_description 1543 1559	lympho-monocytic
+T69	Detailed_description 1536 1542	scanty
+R32	MODIFY Arg1:T68 Arg2:E51	
+R33	MODIFY Arg1:T69 Arg2:E51	
+T70	Sign_symptom 1615 1633	BRAFV600E mutation
+E52	Sign_symptom:T70 
+T71	Disease_disorder 1656 1659	ECD
+E53	Disease_disorder:T71 
+#2	AnnotatorNotes E53	Erdheim-Chester disease
+T72	Diagnostic_procedure 1669 1695	magnetic resonance imaging
+E54	Diagnostic_procedure:T72 
+T73	Diagnostic_procedure 1697 1700	MRI
+E55	Diagnostic_procedure:T73 
+R34	IDENTICAL Arg1:E55 Arg2:E54	
+T74	Biological_structure 1661 1668	Cardiac
+R35	MODIFY Arg1:T74 Arg2:E54	
+T75	Sign_symptom 1726 1738	infiltration
+E56	Sign_symptom:T75 
+T76	Detailed_description 1711 1725	pseudo-tumoral
+R36	MODIFY Arg1:T76 Arg2:E56	
+T77	Biological_structure 1746 1767	atrioventricular wall
+R37	MODIFY Arg1:T77 Arg2:E56	
+T78	Diagnostic_procedure 1777 1786	bone scan
+E57	Diagnostic_procedure:T78 
+T79	Sign_symptom 1830 1836	uptake
+E58	Sign_symptom:T79 
+T80	Detailed_description 1794 1817	symmetrically irregular
+R38	MODIFY Arg1:T80 Arg2:E58	
+T81	Biological_structure 1844 1867	long bones of the limbs
+R39	MODIFY Arg1:T81 Arg2:E58	
+T82	Disease_disorder 1884 1887	ECD
+E59	Disease_disorder:T82 
+T83	Diagnostic_procedure 1949 1956	imaging
+E60	Diagnostic_procedure:T83 
+T84	Biological_structure 1939 1948	pulmonary
+T85	Biological_structure 1926 1934	cerebral
+R40	MODIFY Arg1:T84 Arg2:E60	
+R41	MODIFY Arg1:T85 Arg2:E60	
+T86	Lab_value 1962 1970	negative
+E61	Lab_value:T86 
+R42	MODIFY Arg1:E61 Arg2:E60	
+T87	Disease_disorder 2039 2042	ECD
+E62	Disease_disorder:T87 
+T88	Medication 2088 2110	interferon (IFN)-alpha
+E63	Medication:T88 
+T89	Detailed_description 2078 2087	pegylated
+R43	MODIFY Arg1:T89 Arg2:E63	
+T90	Date 2116 2130	after 3 months
+E64	Date:T90 
+T91	Diagnostic_procedure 2161 2171	ultrasound
+E65	Diagnostic_procedure:T91 
+T92	Biological_structure 2151 2160	abdominal
+R44	MODIFY Arg1:T92 Arg2:E65	
+T93	Sign_symptom 2245 2257	infiltration
+E66	Sign_symptom:T93 
+A2	POLARITY E66 NEG
+T94	Diagnostic_procedure 2288 2305	blood cell counts
+E67	Diagnostic_procedure:T94 
+T95	Lab_value 2267 2280	normalization
+E68	Lab_value:T95 
+R45	MODIFY Arg1:E68 Arg2:E67	
+T96	Biological_structure 2233 2244	perinephric
+T97	Detailed_description 2223 2232	bilateral
+T98	Detailed_description 2217 2222	dense
+R46	MODIFY Arg1:T98 Arg2:E66	
+R47	MODIFY Arg1:T97 Arg2:E66	
+R48	MODIFY Arg1:T96 Arg2:E66	
+*	OVERLAP E1 E2 E3 E4 E5 E6 E8 E9 E10 E12 E17
+R49	BEFORE Arg1:E17 Arg2:E18	
+*	OVERLAP E18 E19 E20
+R50	BEFORE Arg1:E20 Arg2:E21	
+*	OVERLAP E21 E22 E23 E25 E26 E28 E30 E31 E32 E33 E35 E39 E40 E41 E42 E43 E45 E44 E47 E48 E49 E51 E52 E53 E54 E56 E57 E58 E59 E60 E62
+R51	SUB_PROCEDURE Arg1:E36 Arg2:E35	
+R52	MODIFY Arg1:E38 Arg2:E36	
+R53	BEFORE Arg1:E62 Arg2:E63	
+R54	BEFORE Arg1:E63 Arg2:E64	
+*	OVERLAP E64 E65 E66 E67