Downloads: 1
229 lines (228 with data), 7.9 kB
T1 Age 2 13 66-year-old T2 Sex 14 17 man T3 Clinical_event 22 30 admitted E1 Clinical_event:T3 T4 Nonbiological_location 40 48 Hospital R1 MODIFY Arg1:T4 Arg2:E1 T5 Date 52 65 November 2008 E2 Date:T5 T6 Sign_symptom 71 83 splenomegaly E3 Sign_symptom:T6 T7 Diagnostic_procedure 92 106 red cell count E4 Diagnostic_procedure:T7 T9 Diagnostic_procedure 122 142 serum erythropoietin E5 Diagnostic_procedure:T9 T11 Diagnostic_procedure 151 171 Cytogenetic analysis E6 Diagnostic_procedure:T11 T12 Diagnostic_procedure 193 202 karyotype E7 Diagnostic_procedure:T12 R6 SUB_PROCEDURE Arg1:E7 Arg2:E6 T15 Diagnostic_procedure 204 221 Molecular studies E8 Diagnostic_procedure:T15 T22 Disease_disorder 351 353 PV E12 Disease_disorder:T22 #1 AnnotatorNotes E12 Polycythemia Vera T8 Lab_value 87 91 high E13 Lab_value:T8 R2 MODIFY Arg1:E13 Arg2:E4 T10 Lab_value 112 121 subnormal E14 Lab_value:T10 R3 MODIFY Arg1:E14 Arg2:E5 T13 Lab_value 181 187 normal E15 Lab_value:T13 T14 Lab_value 188 192 male E16 Lab_value:T14 R4 MODIFY Arg1:E16 Arg2:E7 R5 MODIFY Arg1:E15 Arg2:E7 T16 Sign_symptom 244 266 BCR-ABL1 rearrangement E9 Sign_symptom:T16 A1 POLARITY E9 NEG T17 Sign_symptom 285 303 JAK2V617F mutation E10 Sign_symptom:T17 T18 Lab_value 312 334 allele burden of 44.9% E11 Lab_value:T18 R7 MODIFY Arg1:E11 Arg2:E10 T19 Diagnostic_procedure 395 415 bone marrow analysis E17 Diagnostic_procedure:T19 T20 Detailed_description 381 394 morphological R8 MODIFY Arg1:T20 Arg2:E17 T21 Detailed_description 433 450 WHO 2008 criteria R9 MODIFY Arg1:T21 Arg2:E17 T23 Medication 479 486 aspirin E18 Medication:T23 T24 Medication 488 499 hydroxyurea E19 Medication:T24 T25 Therapeutic_procedure 505 517 phlebotomies E20 Therapeutic_procedure:T25 T26 Date 553 568 Six years later E21 Date:T26 T27 Diagnostic_procedure 583 593 ultrasound E22 Diagnostic_procedure:T27 T28 Biological_structure 573 582 abdominal R10 MODIFY Arg1:T28 Arg2:E22 T29 Sign_symptom 652 664 infiltration E23 Sign_symptom:T29 T30 Biological_structure 640 651 perinephric T31 Detailed_description 630 639 bilateral T32 Detailed_description 624 629 dense R11 MODIFY Arg1:T31 Arg2:E23 R12 MODIFY Arg1:T30 Arg2:E23 R13 MODIFY Arg1:T32 Arg2:E23 T33 Diagnostic_procedure 723 725 CT E24 Diagnostic_procedure:T33 T34 Diagnostic_procedure 702 721 computed tomography E25 Diagnostic_procedure:T34 T35 Biological_structure 691 701 whole-body R14 MODIFY Arg1:T35 Arg2:E25 R15 IDENTICAL Arg1:E24 Arg2:E25 T36 Diagnostic_procedure 739 797 fluotine-18 fluordeoxyglucose positron emission tomography E26 Diagnostic_procedure:T36 T37 Diagnostic_procedure 799 808 F-FDG-PET E27 Diagnostic_procedure:T37 R16 IDENTICAL Arg1:E27 Arg2:E26 T38 Diagnostic_procedure 838 852 glucose uptake E28 Diagnostic_procedure:T38 T39 Lab_value 828 837 increased E29 Lab_value:T39 R17 MODIFY Arg1:E29 Arg2:E28 T40 Biological_structure 860 904 medullary channels of both humeri and femurs R18 MODIFY Arg1:T40 Arg2:E28 T41 Diagnostic_procedure 920 940 bone marrow analysis E30 Diagnostic_procedure:T41 T42 Detailed_description 906 919 Morphological R19 MODIFY Arg1:T42 Arg2:E30 T43 Disease_disorder 977 979 PV E31 Disease_disorder:T43 T44 Disease_disorder 1039 1047 fibrosis E32 Disease_disorder:T44 T45 Biological_structure 1027 1038 bone marrow R20 MODIFY Arg1:T45 Arg2:E32 T46 Diagnostic_procedure 1071 1087 EUMNET consensus E33 Diagnostic_procedure:T46 T47 Lab_value 1049 1053 MF-0 E34 Lab_value:T47 R21 MODIFY Arg1:E34 Arg2:E33 T48 Diagnostic_procedure 1100 1120 cytogenetic analysis E35 Diagnostic_procedure:T48 T49 Diagnostic_procedure 1157 1166 karyotype E36 Diagnostic_procedure:T49 T50 Lab_value 1152 1156 male E37 Lab_value:T50 R22 MODIFY Arg1:E37 Arg2:E36 T51 Lab_value 1168 1222 47,XY,+9[2/20],47,XY,add(6)(p25),+9[2/20],46,XY[16/20] E38 Lab_value:T51 T52 Diagnostic_procedure 1228 1247 histological nature E39 Diagnostic_procedure:T52 T53 Sign_symptom 1267 1279 infiltration E40 Sign_symptom:T53 T54 Biological_structure 1255 1266 perinephric R23 MODIFY Arg1:T54 Arg2:E40 T55 Diagnostic_procedure 1324 1330 biopsy E41 Diagnostic_procedure:T55 T56 Detailed_description 1319 1323 core T57 Sign_symptom 1338 1344 lesion E42 Sign_symptom:T57 T58 Detailed_description 1309 1318 CT-guided R24 MODIFY Arg1:T56 Arg2:E41 R25 MODIFY Arg1:T58 Arg2:E41 T59 Diagnostic_procedure 1346 1368 Morphological analysis E43 Diagnostic_procedure:T59 T60 Diagnostic_procedure 1443 1447 CD68 E44 Diagnostic_procedure:T60 T61 Sign_symptom 1402 1419 foamy histiocytes E45 Sign_symptom:T61 T62 Lab_value 1430 1438 positive E46 Lab_value:T62 T63 Diagnostic_procedure 1492 1496 CD1a E47 Diagnostic_procedure:T63 T64 Diagnostic_procedure 1501 1505 S100 E48 Diagnostic_procedure:T64 T65 Disease_disorder 1521 1529 fibrosis E49 Disease_disorder:T65 T66 Lab_value 1452 1460 negative E50 Lab_value:T66 R26 MODIFY Arg1:E46 Arg2:E44 R27 MODIFY Arg1:E45 Arg2:E44 R28 MODIFY Arg1:E45 Arg2:E47 R29 MODIFY Arg1:E45 Arg2:E48 R30 MODIFY Arg1:E50 Arg2:E47 R31 MODIFY Arg1:E50 Arg2:E48 T67 Sign_symptom 1560 1570 infiltrate E51 Sign_symptom:T67 T68 Detailed_description 1543 1559 lympho-monocytic T69 Detailed_description 1536 1542 scanty R32 MODIFY Arg1:T68 Arg2:E51 R33 MODIFY Arg1:T69 Arg2:E51 T70 Sign_symptom 1615 1633 BRAFV600E mutation E52 Sign_symptom:T70 T71 Disease_disorder 1656 1659 ECD E53 Disease_disorder:T71 #2 AnnotatorNotes E53 Erdheim-Chester disease T72 Diagnostic_procedure 1669 1695 magnetic resonance imaging E54 Diagnostic_procedure:T72 T73 Diagnostic_procedure 1697 1700 MRI E55 Diagnostic_procedure:T73 R34 IDENTICAL Arg1:E55 Arg2:E54 T74 Biological_structure 1661 1668 Cardiac R35 MODIFY Arg1:T74 Arg2:E54 T75 Sign_symptom 1726 1738 infiltration E56 Sign_symptom:T75 T76 Detailed_description 1711 1725 pseudo-tumoral R36 MODIFY Arg1:T76 Arg2:E56 T77 Biological_structure 1746 1767 atrioventricular wall R37 MODIFY Arg1:T77 Arg2:E56 T78 Diagnostic_procedure 1777 1786 bone scan E57 Diagnostic_procedure:T78 T79 Sign_symptom 1830 1836 uptake E58 Sign_symptom:T79 T80 Detailed_description 1794 1817 symmetrically irregular R38 MODIFY Arg1:T80 Arg2:E58 T81 Biological_structure 1844 1867 long bones of the limbs R39 MODIFY Arg1:T81 Arg2:E58 T82 Disease_disorder 1884 1887 ECD E59 Disease_disorder:T82 T83 Diagnostic_procedure 1949 1956 imaging E60 Diagnostic_procedure:T83 T84 Biological_structure 1939 1948 pulmonary T85 Biological_structure 1926 1934 cerebral R40 MODIFY Arg1:T84 Arg2:E60 R41 MODIFY Arg1:T85 Arg2:E60 T86 Lab_value 1962 1970 negative E61 Lab_value:T86 R42 MODIFY Arg1:E61 Arg2:E60 T87 Disease_disorder 2039 2042 ECD E62 Disease_disorder:T87 T88 Medication 2088 2110 interferon (IFN)-alpha E63 Medication:T88 T89 Detailed_description 2078 2087 pegylated R43 MODIFY Arg1:T89 Arg2:E63 T90 Date 2116 2130 after 3 months E64 Date:T90 T91 Diagnostic_procedure 2161 2171 ultrasound E65 Diagnostic_procedure:T91 T92 Biological_structure 2151 2160 abdominal R44 MODIFY Arg1:T92 Arg2:E65 T93 Sign_symptom 2245 2257 infiltration E66 Sign_symptom:T93 A2 POLARITY E66 NEG T94 Diagnostic_procedure 2288 2305 blood cell counts E67 Diagnostic_procedure:T94 T95 Lab_value 2267 2280 normalization E68 Lab_value:T95 R45 MODIFY Arg1:E68 Arg2:E67 T96 Biological_structure 2233 2244 perinephric T97 Detailed_description 2223 2232 bilateral T98 Detailed_description 2217 2222 dense R46 MODIFY Arg1:T98 Arg2:E66 R47 MODIFY Arg1:T97 Arg2:E66 R48 MODIFY Arg1:T96 Arg2:E66 * OVERLAP E1 E2 E3 E4 E5 E6 E8 E9 E10 E12 E17 R49 BEFORE Arg1:E17 Arg2:E18 * OVERLAP E18 E19 E20 R50 BEFORE Arg1:E20 Arg2:E21 * OVERLAP E21 E22 E23 E25 E26 E28 E30 E31 E32 E33 E35 E39 E40 E41 E42 E43 E45 E44 E47 E48 E49 E51 E52 E53 E54 E56 E57 E58 E59 E60 E62 R51 SUB_PROCEDURE Arg1:E36 Arg2:E35 R52 MODIFY Arg1:E38 Arg2:E36 R53 BEFORE Arg1:E62 Arg2:E63 R54 BEFORE Arg1:E63 Arg2:E64 * OVERLAP E64 E65 E66 E67