--- a
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+T1	Age 2 13	65-year-old
+T2	Sex 14 17	man
+T3	Clinical_event 22 30	admitted
+E1	Clinical_event:T3 
+T4	Nonbiological_location 38 69	China-Japan Friendship hospital
+R1	MODIFY Arg1:T4 Arg2:E1	
+T5	Sign_symptom 108 117	dysphagia
+E2	Sign_symptom:T5 
+T6	Duration 122 126	3 mo
+E3	Duration:T6 
+T7	Detailed_description 96 107	progressive
+R2	MODIFY Arg1:T7 Arg2:E2	
+T8	Sign_symptom 160 171	weight loss
+E4	Sign_symptom:T8 
+T9	Lab_value 175 179	8 kg
+R3	MODIFY Arg1:T9 Arg2:E4	
+T10	Duration 187 196	past 2 mo
+E5	Duration:T10 
+T11	Severity 152 159	drastic
+R4	MODIFY Arg1:T11 Arg2:E4	
+T12	History 201 264	denied a history of smoking, alcohol intake and substance abuse
+T13	History 293 302	gastritis
+T14	Duration 307 322	nearly 10 years
+E6	Duration:T14 
+T15	Disease_disorder 293 302	gastritis
+E7	Disease_disorder:T15 
+T16	Detailed_description 284 292	atrophic
+T17	Detailed_description 276 283	chronic
+R5	MODIFY Arg1:T16 Arg2:E7	
+R6	MODIFY Arg1:T17 Arg2:E7	
+T18	Family_history 340 389	no family history of genetic defect or malignancy
+T19	Diagnostic_procedure 391 411	Physical examination
+E8	Diagnostic_procedure:T19 
+T20	Lab_value 419 439	no palpable findings
+R7	MODIFY Arg1:T20 Arg2:E8	
+T21	Diagnostic_procedure 451 461	blood test
+E9	Diagnostic_procedure:T21 
+T22	Diagnostic_procedure 490 500	hemoglobin
+E10	Diagnostic_procedure:T22 
+T23	Lab_value 471 486	slight decrease
+R8	MODIFY Arg1:T23 Arg2:E10	
+R9	SUB_PROCEDURE Arg1:E10 Arg2:E9	
+T24	Lab_value 502 509	106 g/L
+R10	MODIFY Arg1:T24 Arg2:E10	
+T25	Diagnostic_procedure 540 551	examination
+E11	Diagnostic_procedure:T25 
+T26	Biological_structure 512 534	Upper gastrointestinal
+T27	Biological_structure 536 538	GI
+R11	IDENTICAL Arg1:T27 Arg2:T26	
+R12	MODIFY Arg1:T26 Arg2:E11	
+T28	Detailed_description 558 574	barium contrasts
+R13	MODIFY Arg1:T28 Arg2:E11	
+T29	Sign_symptom 590 595	tumor
+E12	Sign_symptom:T29 
+T30	Severity 584 589	large
+R14	MODIFY Arg1:T30 Arg2:E12	
+T31	Sign_symptom 596 604	blocking
+E13	Sign_symptom:T31 
+T32	Biological_structure 609 634	esophago-gastric junction
+R15	MODIFY Arg1:T32 Arg2:E13	
+R16	CAUSE Arg1:E12 Arg2:E13	
+T33	Diagnostic_procedure 648 667	Computed tomography
+E14	Diagnostic_procedure:T33 
+T34	Diagnostic_procedure 669 671	CT
+E15	Diagnostic_procedure:T34 
+R17	IDENTICAL Arg1:E15 Arg2:E14	
+T35	Sign_symptom 694 698	mass
+E16	Sign_symptom:T35 
+T36	Texture 689 693	soft
+R18	MODIFY Arg1:T36 Arg2:E16	
+T37	Biological_structure 706 731	esophago-gastric junction
+R19	MODIFY Arg1:T37 Arg2:E16	
+T38	Sign_symptom 748 758	metastasis
+E17	Sign_symptom:T38 
+T39	Biological_structure 737 747	lymph node
+R20	MODIFY Arg1:T39 Arg2:E17	
+T40	Biological_structure 766 797	lesser curvature of the stomach
+R21	MODIFY Arg1:T40 Arg2:E17	
+T41	Diagnostic_procedure 811 833	Endoscopic examination
+E18	Diagnostic_procedure:T41 
+T42	Sign_symptom 849 853	spot
+E19	Sign_symptom:T42 
+T43	Color 843 848	black
+R22	MODIFY Arg1:T43 Arg2:E19	
+T44	Biological_structure 861 876	lower esophagus
+R23	MODIFY Arg1:T44 Arg2:E19	
+T45	Sign_symptom 895 899	mass
+E20	Sign_symptom:T45 
+T46	Color 889 894	black
+T47	Detailed_description 883 888	bulky
+R24	MODIFY Arg1:T46 Arg2:E20	
+R25	MODIFY Arg1:T47 Arg2:E20	
+T48	Sign_symptom 900 908	blocking
+E21	Sign_symptom:T48 
+T49	Biological_structure 913 938	esophago-gastric junction
+R26	MODIFY Arg1:T49 Arg2:E21	
+R27	CAUSE Arg1:E20 Arg2:E21	
+T50	Sign_symptom 973 979	ulcers
+E22	Sign_symptom:T50 
+T51	Shape 961 972	crater-like
+T52	Color 955 960	black
+T53	Detailed_description 951 954	two
+R28	MODIFY Arg1:T51 Arg2:E22	
+R29	MODIFY Arg1:T52 Arg2:E22	
+R30	MODIFY Arg1:T53 Arg2:E22	
+T54	Biological_structure 987 1008	fundus of the stomach
+R31	MODIFY Arg1:T54 Arg2:E22	
+T55	Diagnostic_procedure 1022 1028	Biopsy
+E23	Diagnostic_procedure:T55 
+T56	Sign_symptom 1054 1059	tumor
+E24	Sign_symptom:T56 
+R32	MODIFY Arg1:E24 Arg2:E23	
+T57	Disease_disorder 1101 1115	adenocarcinoma
+E25	Disease_disorder:T57 
+T58	Detailed_description 1079 1100	poorly differentiated
+R33	MODIFY Arg1:T58 Arg2:E25	
+T59	Diagnostic_procedure 1130 1146	nutrition status
+E26	Diagnostic_procedure:T59 
+T60	Lab_value 1171 1172	2
+R34	MODIFY Arg1:T60 Arg2:E26	
+T61	Detailed_description 1186 1215	Nutrition Risk Screening 2002
+R35	MODIFY Arg1:T61 Arg2:E26	
+T62	Coreference 1246 1265	obstructive symptom
+E27	Coreference:T62 
+R36	IDENTICAL Arg1:E27 Arg2:E21	
+T63	Coreference 1280 1285	tumor
+E28	Coreference:T63 
+R37	IDENTICAL Arg1:E28 Arg2:E20	
+T64	Therapeutic_procedure 1289 1306	debulking surgery
+E29	Therapeutic_procedure:T64 
+T65	Therapeutic_procedure 1317 1330	esophagectomy
+E30	Therapeutic_procedure:T65 
+T66	Therapeutic_procedure 1344 1355	gastrectomy
+E31	Therapeutic_procedure:T66 
+T67	Detailed_description 1310 1316	distal
+R38	MODIFY Arg1:T67 Arg2:E30	
+T68	Detailed_description 1335 1343	proximal
+R39	MODIFY Arg1:T68 Arg2:E31	
+R40	SUB_PROCEDURE Arg1:E30 Arg2:E29	
+R41	SUB_PROCEDURE Arg1:E31 Arg2:E29	
+T69	Therapeutic_procedure 1387 1398	anastomosis
+E32	Therapeutic_procedure:T69 
+T70	Biological_structure 1371 1386	Esophagogastric
+R42	MODIFY Arg1:T70 Arg2:E32	
+T71	Therapeutic_procedure 1403 1417	reconstruction
+E33	Therapeutic_procedure:T71 
+T72	Therapeutic_procedure 1442 1457	stapling device
+E34	Therapeutic_procedure:T72 
+R43	SUB_PROCEDURE Arg1:E34 Arg2:E33	
+T73	Sign_symptom 1627 1634	ascites
+E35	Sign_symptom:T73 
+A1	POLARITY E35 NEG
+T74	Sign_symptom 1638 1664	dissemination of the tumor
+E36	Sign_symptom:T74 
+A2	POLARITY E36 NEG
+T75	Biological_structure 1685 1702	peritoneal cavity
+R44	MODIFY Arg1:T75 Arg2:E36	
+R45	MODIFY Arg1:T75 Arg2:E35	
+T76	Sign_symptom 1481 1486	tumor
+E37	Sign_symptom:T76 
+T77	Biological_structure 1512 1537	esophago-gastric junction
+R46	MODIFY Arg1:T77 Arg2:E37	
+T78	Coreference 1546 1551	tumor
+E38	Coreference:T78 
+R47	IDENTICAL Arg1:E38 Arg2:E37	
+T79	Sign_symptom 1552 1563	infiltrated
+E39	Sign_symptom:T79 
+T80	Sign_symptom 1596 1606	metastasis
+E40	Sign_symptom:T80 
+T81	Biological_structure 1610 1622	station four
+#1	AnnotatorNotes T81	lower paratracheal lymph nodes
+R48	MODIFY Arg1:T81 Arg2:E40	
+T82	Biological_structure 1585 1595	lymph node
+R49	MODIFY Arg1:T82 Arg2:E40	
+T83	Biological_structure 1568 1579	whole layer
+R50	MODIFY Arg1:T83 Arg2:E39	
+R51	MODIFY Arg1:E38 Arg2:E39	
+T84	Sign_symptom 1708 1713	tumor
+E41	Sign_symptom:T84 
+T85	Area 1723 1734	3 cm × 6 cm
+R52	MODIFY Arg1:T85 Arg2:E41	
+T86	Color 1748 1766	black pigmentation
+R53	MODIFY Arg1:T86 Arg2:E41	
+T87	Sign_symptom 1819 1826	nodules
+E42	Sign_symptom:T87 
+T88	Color 1799 1808	pigmented
+T89	Detailed_description 1791 1798	several
+T90	Detailed_description 1809 1818	satellite
+R54	MODIFY Arg1:T90 Arg2:E42	
+R55	MODIFY Arg1:T88 Arg2:E42	
+R56	MODIFY Arg1:T89 Arg2:E42	
+T91	Coreference 1838 1855	main tumor lesion
+E43	Coreference:T91 
+R57	IDENTICAL Arg1:E43 Arg2:E41	
+T92	Coreference 1861 1872	largest one
+E44	Coreference:T92 
+R58	IDENTICAL Arg1:E44 Arg2:E42	
+T93	Area 1879 1890	1 cm × 1 cm
+R59	MODIFY Arg1:T93 Arg2:E44	
+T94	Sign_symptom 1929 1936	lesions
+E45	Sign_symptom:T94 
+T95	Detailed_description 1918 1928	ulceration
+R60	MODIFY Arg1:T95 Arg2:E45	
+T96	Biological_structure 1955 1976	fundus of the stomach
+R61	MODIFY Arg1:T96 Arg2:E45	
+T97	Diagnostic_procedure 1978 1993	Microscopically
+E46	Diagnostic_procedure:T97 
+T98	Biological_structure 2007 2019	tumor tissue
+R62	MODIFY Arg1:T98 Arg2:E46	
+T99	Diagnostic_procedure 2143 2167	Pathological examination
+E47	Diagnostic_procedure:T99 
+T100	Diagnostic_procedure 2194 2199	stage
+E48	Diagnostic_procedure:T100 
+#2	AnnotatorNotes E48	cancer staging
+T101	Lab_value 2203 2206	IVA
+T102	Lab_value 2208 2215	T4aN1M0
+R63	MODIFY Arg1:T101 Arg2:E48	
+R64	MODIFY Arg1:T102 Arg2:E48	
+T103	Diagnostic_procedure 2066 2071	cells
+E49	Diagnostic_procedure:T103 
+T104	Lab_value 2054 2065	pleomorphic
+T105	Lab_value 2036 2049	non-organized
+T106	Diagnostic_procedure 2092 2098	nuclei
+E50	Diagnostic_procedure:T106 
+T107	Lab_value 2083 2091	atypical
+T108	Diagnostic_procedure 2113 2129	melanin granules
+E51	Diagnostic_procedure:T108 
+T109	Lab_value 2104 2112	abundant
+R65	MODIFY Arg1:T109 Arg2:E51	
+R66	MODIFY Arg1:T107 Arg2:E50	
+R67	MODIFY Arg1:T104 Arg2:E49	
+R68	MODIFY Arg1:T105 Arg2:E49	
+R69	SUB_PROCEDURE Arg1:E49 Arg2:E46	
+R70	SUB_PROCEDURE Arg1:E50 Arg2:E49	
+R71	SUB_PROCEDURE Arg1:E51 Arg2:E49	
+T110	Diagnostic_procedure 2218 2246	Immunohistochemical staining
+E52	Diagnostic_procedure:T110 
+T111	Coreference 2263 2268	tumor
+E53	Coreference:T111 
+R72	IDENTICAL Arg1:E53 Arg2:T98	
+T112	Diagnostic_procedure 2286 2291	S-100
+E54	Diagnostic_procedure:T112 
+T113	Diagnostic_procedure 2293 2299	HMB-45
+E55	Diagnostic_procedure:T113 
+T114	Diagnostic_procedure 2301 2309	mclean-A
+E56	Diagnostic_procedure:T114 
+T115	Diagnostic_procedure 2314 2322	Vimentin
+E57	Diagnostic_procedure:T115 
+T116	Diagnostic_procedure 2341 2354	cytokeratin 7
+E58	Diagnostic_procedure:T116 
+T117	Diagnostic_procedure 2359 2373	cytokeratin 20
+E59	Diagnostic_procedure:T117 
+T118	Lab_value 2273 2281	positive
+T119	Lab_value 2328 2336	negative
+R73	MODIFY Arg1:T118 Arg2:E54	
+R74	MODIFY Arg1:T118 Arg2:E55	
+R75	MODIFY Arg1:T118 Arg2:E56	
+R76	MODIFY Arg1:T118 Arg2:E57	
+R77	MODIFY Arg1:T119 Arg2:E58	
+R78	MODIFY Arg1:T119 Arg2:E59	
+R79	SUB_PROCEDURE Arg1:E54 Arg2:E52	
+R80	SUB_PROCEDURE Arg1:E55 Arg2:E52	
+R81	SUB_PROCEDURE Arg1:E56 Arg2:E52	
+R82	SUB_PROCEDURE Arg1:E57 Arg2:E52	
+R83	SUB_PROCEDURE Arg1:E58 Arg2:E52	
+R84	SUB_PROCEDURE Arg1:E59 Arg2:E52	
+T120	Disease_disorder 2460 2468	melanoma
+E60	Disease_disorder:T120 
+T121	Detailed_description 2443 2459	esophago-gastric
+T122	Severity 2434 2442	advanced
+T123	Detailed_description 2426 2433	primary
+R85	MODIFY Arg1:T121 Arg2:E60	
+R86	MODIFY Arg1:T122 Arg2:E60	
+R87	MODIFY Arg1:T123 Arg2:E60	
+T124	Therapeutic_procedure 2490 2510	postoperative course
+E61	Therapeutic_procedure:T124 
+T125	Lab_value 2515 2521	smooth
+R88	MODIFY Arg1:T125 Arg2:E61	
+T126	Sign_symptom 2534 2547	complications
+E62	Sign_symptom:T126 
+A3	POLARITY E62 NEG
+T127	Sign_symptom 2571 2580	recovered
+E63	Sign_symptom:T127 
+T128	Clinical_event 2589 2599	discharged
+E64	Clinical_event:T128 
+T129	Date 2600 2610	14 d after
+E65	Date:T129 
+T130	Medication 2658 2674	adjuvant therapy
+E66	Medication:T130 
+A4	POLARITY E66 NEG
+T131	Sign_symptom 2686 2696	recurrence
+E67	Sign_symptom:T131 
+T132	Biological_structure 2676 2685	abdominal
+R89	MODIFY Arg1:T132 Arg2:E67	
+T133	Sign_symptom 2709 2719	metastases
+E68	Sign_symptom:T133 
+T134	Biological_structure 2701 2708	hepatic
+R90	MODIFY Arg1:T134 Arg2:E68	
+T135	Date 2731 2747	within one month
+E69	Date:T135 
+T136	Clinical_event 2767 2776	follow-up
+E70	Clinical_event:T136 
+T137	Diagnostic_procedure 2777 2779	CT
+E71	Diagnostic_procedure:T137 
+T138	Therapeutic_procedure 2784 2809	other effective treatment
+E72	Therapeutic_procedure:T138 
+A5	POLARITY E72 NEG
+T139	Outcome 2851 2855	died
+E73	Outcome:T139 
+T140	Disease_disorder 2867 2885	metastatic disease
+E74	Disease_disorder:T140 
+T141	Detailed_description 2859 2866	diffuse
+R91	MODIFY Arg1:T141 Arg2:E74	
+T142	Date 2886 2896	2 mo later
+E75	Date:T142 
+R92	AFTER Arg1:E1 Arg2:E2	
+*	OVERLAP E2 E3
+R93	BEFORE Arg1:E3 Arg2:E4	
+*	OVERLAP E4 E5
+R94	AFTER Arg1:E5 Arg2:E7	
+*	OVERLAP E7 E6
+R95	BEFORE Arg1:E6 Arg2:E8	
+*	OVERLAP E8 E9 E10 E11 E12 E13 E14 E16 E17 E18 E19 E20 E21 E22
+R96	BEFORE Arg1:E22 Arg2:E23	
+*	OVERLAP E23 E25 E26 E27 E28
+R97	BEFORE Arg1:E28 Arg2:E29	
+*	OVERLAP E29 E32 E33 E37 E38 E39 E40 E35 E36 E41 E42 E45 E46 E47 E48 E52 E60
+R98	BEFORE Arg1:E60 Arg2:E61	
+*	OVERLAP E61 E62
+R99	BEFORE Arg1:E62 Arg2:E63	
+R100	BEFORE Arg1:E63 Arg2:E64	
+*	OVERLAP E64 E65
+R101	BEFORE Arg1:E65 Arg2:E66	
+*	OVERLAP E66 E67 E68 E69 E70 E71
+R102	BEFORE Arg1:E71 Arg2:E72	
+R103	BEFORE Arg1:E72 Arg2:E73	
+*	OVERLAP E73 E74 E75