292 lines (291 with data), 10.9 kB

T1	Age 2 13	60-year-old
T2	Personal_background 14 19	white
T3	Personal_background 20 29	Brazilian
T4	Sex 30 33	man
T5	Clinical_event 3127 3137	discharged
E1	Clinical_event:T5 
T6	Time 3142 3154	next morning
E2	Time:T6 
T7	History 40 63	controlled hypertension
T8	History 68 83	stage 2 obesity
T9	Clinical_event 84 93	presented
E3	Clinical_event:T9 
T10	Nonbiological_location 101 112	institution
R1	MODIFY Arg1:T10 Arg2:E3	
T11	Sign_symptom 145 152	fatigue
E4	Sign_symptom:T11 
T12	Detailed_description 158 184	moderate to light exertion
R2	MODIFY Arg1:T12 Arg2:E4	
T13	Detailed_description 133 144	progressive
R3	MODIFY Arg1:T13 Arg2:E4	
T14	Duration 188 208	approximately 1 year
E5	Duration:T14 
T15	Diagnostic_procedure 279 291	scintigraphy
E6	Diagnostic_procedure:T15 
T16	Detailed_description 258 278	myocardial perfusion
R4	MODIFY Arg1:T16 Arg2:E6	
T17	Disease_disorder 312 340	obstructive ischemic disease
E7	Disease_disorder:T17 
A1	POLARITY E7 NEG
T18	Disease_disorder 382 395	heart failure
E8	Disease_disorder:T18 
A2	POLARITY E8 NEG
T19	Detailed_description 373 381	systolic
R5	MODIFY Arg1:T19 Arg2:E8	
T20	Date 450 468	3 years previously
E9	Date:T20 
T21	Therapeutic_procedure 425 449	mitral valve replacement
E10	Therapeutic_procedure:T21 
T22	Detailed_description 414 424	biological
R6	MODIFY Arg1:T22 Arg2:E10	
T23	Disease_disorder 473 494	mitral valve stenosis
E11	Disease_disorder:T23 
T24	Therapeutic_procedure 513 521	ablation
E12	Therapeutic_procedure:T24 
T25	Date 568 588	18 months previously
E13	Date:T25 
T26	Sign_symptom 556 567	tachycardia
E14	Sign_symptom:T26 
T27	Biological_structure 525 555	atrioventricular nodal reentry
R7	MODIFY Arg1:T27 Arg2:E14	
T28	Disease_disorder 658 689	pulmonary arterial hypertension
E15	Disease_disorder:T28 
A3	POLARITY E15 NEG
T30	Medication 730 737	aspirin
E16	Medication:T30 
T31	Dosage 738 748	100 mg/day
R9	MODIFY Arg1:T31 Arg2:E16	
T32	Medication 750 760	carvedilol
E17	Medication:T32 
T33	Dosage 761 770	50 mg/day
R10	MODIFY Arg1:T33 Arg2:E17	
T34	Medication 772 784	atorvastatin
E18	Medication:T34 
T35	Dosage 785 794	10 mg/day
R11	MODIFY Arg1:T35 Arg2:E18	
T36	Medication 800 808	losartan
E19	Medication:T36 
T37	Dosage 809 818	25 mg/day
R12	MODIFY Arg1:T37 Arg2:E19	
T38	Diagnostic_procedure 824 838	echocardiogram
E20	Diagnostic_procedure:T38 
T39	Lab_value 846 861	normal function
T40	Biological_structure 867 884	mitral prosthesis
R13	MODIFY Arg1:T39 Arg2:E20	
R14	MODIFY Arg1:T40 Arg2:T39	
T41	Diagnostic_procedure 886 927	global left ventricular systolic function
E21	Diagnostic_procedure:T41 
R15	SUB_PROCEDURE Arg1:E21 Arg2:E20	
T42	Lab_value 928 948	within normal limits
R16	MODIFY Arg1:T42 Arg2:E21	
T43	Diagnostic_procedure 950 984	left ventricular ejection fraction
E22	Diagnostic_procedure:T43 
T44	Detailed_description 999 1025	using the Teichholz method
R17	MODIFY Arg1:T44 Arg2:E22	
T45	Lab_value 985 989	62 %
R18	MODIFY Arg1:T45 Arg2:E22	
T46	Disease_disorder 1036 1057	diastolic dysfunction
E23	Disease_disorder:T46 
T47	Lab_value 1028 1035	stage I
R19	MODIFY Arg1:T47 Arg2:E23	
T48	Diagnostic_procedure 1096 1110	blood pressure
E24	Diagnostic_procedure:T48 
T49	Detailed_description 1087 1095	systolic
T50	Biological_structure 1068 1086	pulmonary arterial
T51	Detailed_description 1063 1067	mean
R20	MODIFY Arg1:T49 Arg2:E24	
R21	MODIFY Arg1:T50 Arg2:E24	
R22	MODIFY Arg1:T51 Arg2:E24	
T52	Lab_value 1114 1121	50 mmHg
R23	MODIFY Arg1:T52 Arg2:E24	
T53	Diagnostic_procedure 1139 1148	walk test
E25	Diagnostic_procedure:T53 
T54	Detailed_description 1130 1138	6-minute
R24	MODIFY Arg1:T54 Arg2:E25	
T55	Lab_value 1169 1179	104 meters
R25	MODIFY Arg1:T55 Arg2:E25	
T56	Diagnostic_procedure 1191 1206	Catheterization
E26	Diagnostic_procedure:T56 
T57	Biological_structure 1214 1234	right heart chambers
R26	MODIFY Arg1:T57 Arg2:E26	
T58	Biological_structure 1239 1257	pulmonary arteries
R27	MODIFY Arg1:T58 Arg2:E26	
T29	Disease_disorder 1285 1307	pulmonary hypertension
E27	Disease_disorder:T29 
T59	Coreference 605 622	valve replacement
E28	Coreference:T59 
R8	IDENTICAL Arg1:E28 Arg2:E10	
T60	Clinical_event 1330 1339	follow-up
E29	Clinical_event:T60 
T61	Medication 1361 1371	nifedipine
E30	Medication:T61 
T62	Medication 1376 1386	sildenafil
E31	Medication:T62 
T63	Sign_symptom 1430 1441	hypotension
E32	Sign_symptom:T63 
T64	Detailed_description 1418 1429	orthostatic
R28	MODIFY Arg1:T64 Arg2:E32	
T65	Therapeutic_procedure 1487 1495	ablation
E33	Therapeutic_procedure:T65 
T66	Detailed_description 1472 1486	radiofrequency
R29	MODIFY Arg1:T66 Arg2:E33	
T67	Biological_structure 1503 1525	pulmonary artery trunk
R30	MODIFY Arg1:T67 Arg2:E33	
T68	Clinical_event 1459 1467	referred
E34	Clinical_event:T68 
T69	Disease_disorder 1558 1580	pulmonary hypertension
E35	Disease_disorder:T69 
T70	Detailed_description 1547 1557	refractory
R31	MODIFY Arg1:T70 Arg2:E35	
T71	Nonbiological_location 1617 1643	catheterization laboratory
R32	MODIFY Arg1:T71 Arg2:E33	
T72	Detailed_description 1649 1715	direct visualization using fluoroscopy and radiopaque contrast dye
R33	MODIFY Arg1:T72 Arg2:E33	
T73	Therapeutic_procedure 1756 1764	sedation
E36	Therapeutic_procedure:T73 
T74	Sign_symptom 3170 3177	changes
E37	Sign_symptom:T74 
A4	POLARITY E37 NEG
T75	Clinical_event 3218 3227	discharge
E38	Clinical_event:T75 
T76	Detailed_description 3245 3300	radiographic or echocardiographic laboratory parameters
R34	MODIFY Arg1:T76 Arg2:E37	
T77	Diagnostic_procedure 3326 3340	blood pressure
E39	Diagnostic_procedure:T77 
T78	Biological_structure 3344 3373	both the right heart chambers
T79	Biological_structure 3382 3398	pulmonary artery
R35	MODIFY Arg1:T78 Arg2:E39	
R36	MODIFY Arg1:T79 Arg2:E39	
T80	Detailed_description 3415 3436	using catheterization
R37	MODIFY Arg1:T80 Arg2:E39	
T81	Date 3451 3471	3 and 6 months after
E40	Date:T81 
T82	Date 3538 3545	3-month
E41	Date:T82 
T83	Clinical_event 3546 3555	follow-up
E42	Clinical_event:T83 
T84	Diagnostic_procedure 3597 3645	functional class for fatigue with major exertion
E43	Diagnostic_procedure:T84 
T85	Lab_value 3582 3593	improvement
R38	MODIFY Arg1:T85 Arg2:E43	
T86	Diagnostic_procedure 3713 3722	walk test
E44	Diagnostic_procedure:T86 
T87	Detailed_description 3704 3712	6-minute
R39	MODIFY Arg1:T87 Arg2:E44	
T88	Lab_value 3671 3689	increased distance
R40	MODIFY Arg1:T88 Arg2:E44	
T89	Diagnostic_procedure 3744 3753	pressures
E45	Diagnostic_procedure:T89 
T90	Lab_value 3727 3736	reduction
R41	MODIFY Arg1:T90 Arg2:E45	
T91	Biological_structure 3766 3780	right cavities
T92	Biological_structure 3789 3805	pulmonary artery
R42	MODIFY Arg1:T91 Arg2:E45	
R43	MODIFY Arg1:T92 Arg2:E45	
T93	Duration 3823 3831	6 months
E46	Duration:T93 
T94	Clinical_event 3844 3853	follow-up
E47	Clinical_event:T94 
T95	Diagnostic_procedure 3892 3917	functional classification
E48	Diagnostic_procedure:T95 
T96	Lab_value 3877 3888	improvement
R44	MODIFY Arg1:T96 Arg2:E48	
T97	Activity 3925 3945	pedaling his bicycle
E49	Activity:T97 
T98	Diagnostic_procedure 1766 1781	Catheterization
E50	Diagnostic_procedure:T98 
T99	Biological_structure 1789 1809	right femoral artery
R45	MODIFY Arg1:T99 Arg2:E50	
T100	Detailed_description 1818 1846	standard Seldinger technique
R46	MODIFY Arg1:T100 Arg2:E50	
T101	Detailed_description 1861 1898	using an 8-French valved short sheath
R47	MODIFY Arg1:T101 Arg2:E50	
T102	Medication 1933 1949	local anesthetic
E51	Medication:T102 
T103	Administration 1918 1927	injection
T104	Administration 1905 1917	subcutaneous
R48	MODIFY Arg1:T103 Arg2:E51	
R49	MODIFY Arg1:T104 Arg2:E51	
T105	Detailed_description 1970 2018	sheath was replaced with a steerable long sheath
T106	Detailed_description 2020 2064	Agilis®; St. Jude Medical, St. Paul, MN, USA
T107	Detailed_description 2066 2108	using the standard over-the-wire technique
R50	MODIFY Arg1:T106 Arg2:T105	
R51	MODIFY Arg1:T107 Arg2:T105	
R52	MODIFY Arg1:T105 Arg2:E50	
T108	Medication 2110 2132	Unfractionated heparin
E52	Medication:T108 
T109	Administration 2150 2163	intravenously
R53	MODIFY Arg1:T109 Arg2:E52	
T110	Diagnostic_procedure 2178 2204	activated coagulation time
E53	Diagnostic_procedure:T110 
T111	Lab_value 2205 2232	between 250 and 350 seconds
R54	MODIFY Arg1:T111 Arg2:E53	
T112	Diagnostic_procedure 2234 2264	Electroanatomic reconstruction
E54	Diagnostic_procedure:T112 
T113	Biological_structure 2277 2308	right ventricular outflow tract
T114	Biological_structure 2313 2329	pulmonary artery
R55	MODIFY Arg1:T113 Arg2:E54	
R56	MODIFY Arg1:T114 Arg2:E54	
T115	Detailed_description 2354 2392	EnSite Velocity Cardiac Mapping System
R57	MODIFY Arg1:T115 Arg2:E54	
T116	Detailed_description 2394 2409	St.Jude Medical
R58	MODIFY Arg1:T116 Arg2:E54	
T117	Detailed_description 2417 2450	direct fluoroscopic visualization
R59	MODIFY Arg1:T117 Arg2:E54	
T118	Diagnostic_procedure 2530 2561	computed tomography angiography
E55	Diagnostic_procedure:T118 
T119	Biological_structure 2522 2529	cardiac
R60	MODIFY Arg1:T119 Arg2:E55	
T120	Therapeutic_procedure 2729 2746	ablation catheter
E56	Therapeutic_procedure:T120 
T121	Diagnostic_procedure 2583 2602	sheath was advanced
E57	Diagnostic_procedure:T121 
T122	Detailed_description 2575 2582	Agilis®
R61	MODIFY Arg1:T122 Arg2:E57	
T123	Biological_structure 2612 2643	right ventricular outflow tract
R62	MODIFY Arg1:T123 Arg2:E57	
T124	Biological_structure 2649 2684	before reaching the pulmonary valve
R63	MODIFY Arg1:T124 Arg2:E57	
T125	Detailed_description 2755 2773	open irrigated tip
R64	MODIFY Arg1:T125 Arg2:E56	
T126	Detailed_description 2775 2790	St.Jude Medical
R65	MODIFY Arg1:T126 Arg2:T125	
T127	Lab_value 2877 2889	power of 5 W
R66	MODIFY Arg1:T127 Arg2:E56	
T128	Lab_value 2891 2919	maximum temperature of 48 °C
R67	MODIFY Arg1:T128 Arg2:E56	
T129	Lab_value 2921 2952	60-second duration in each spot
R68	MODIFY Arg1:T129 Arg2:E56	
T130	Lab_value 2954 3010	maximum impedance variation of 10 % from baseline values
R69	MODIFY Arg1:T130 Arg2:E56	
T131	Lab_value 3019 3055	irrigation flow rate of 17 ml/minute
R70	MODIFY Arg1:T131 Arg2:E56	
T132	Therapeutic_procedure 3063 3079	created a circle
E58	Therapeutic_procedure:T132 
R71	SUB_PROCEDURE Arg1:E58 Arg2:E56	
T133	Biological_structure 3087 3109	pulmonary artery trunk
R72	MODIFY Arg1:T133 Arg2:E58	
R73	AFTER Arg1:E3 Arg2:E4	
*	OVERLAP E4 E5 E6 E7 E8
R74	AFTER Arg1:E8 Arg2:E10	
*	OVERLAP E10 E9 E11
R75	AFTER Arg1:E11 Arg2:E12	
*	OVERLAP E12 E14 E13
R76	BEFORE Arg1:E13 Arg2:E28	
*	OVERLAP E28 E15
R77	BEFORE Arg1:E15 Arg2:E16	
*	OVERLAP E16 E17 E18 E19 E20 E22 E23 E24 E25 E26 E27
R78	BEFORE Arg1:E27 Arg2:E29	
*	OVERLAP E29 E30 E31 E32
A5	POLARITY E31 MAYBE_POS
A6	POLARITY E30 MAYBE_POS
R79	BEFORE Arg1:E32 Arg2:E34	
*	OVERLAP E34 E33 E35
R80	BEFORE Arg1:E35 Arg2:E36	
*	OVERLAP E36 E50 E51 E52 E53 E54 E55 E57 E56
R81	BEFORE Arg1:E56 Arg2:E1	
*	OVERLAP E1 E2 E37 E38
R82	BEFORE Arg1:E38 Arg2:E39	
*	OVERLAP E39 E40 E41 E42 E43 E44 E45
R83	BEFORE Arg1:E45 Arg2:E46	
*	OVERLAP E46 E47 E48 E49