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T1 Age 2 13 42-year-old T2 Sex 14 19 woman T3 Sign_symptom 50 54 lump E1 Sign_symptom:T3 T4 Biological_structure 37 49 right breast R1 MODIFY Arg1:T4 Arg2:E1 T5 Sign_symptom 67 71 pain E2 Sign_symptom:T5 T6 Biological_structure 56 66 lower back R2 MODIFY Arg1:T6 Arg2:E2 T7 Sign_symptom 73 87 loss of height E3 Sign_symptom:T7 T8 Sign_symptom 96 104 kyphosis E4 Sign_symptom:T8 T9 Sign_symptom 109 121 hepatomegaly E5 Sign_symptom:T9 T10 Diagnostic_procedure 128 136 biopsies E6 Diagnostic_procedure:T10 T11 Biological_structure 146 157 breast lump R3 MODIFY Arg1:T11 Arg2:E6 T12 Disease_disorder 165 181 ductal carcinoma E7 Disease_disorder:T12 T13 Diagnostic_procedure 275 281 biopsy E8 Diagnostic_procedure:T13 T14 Biological_structure 290 321 ipsilateral axillary lymph node R4 MODIFY Arg1:T14 Arg2:E8 T15 Disease_disorder 349 370 ductal adenocarcinoma E9 Disease_disorder:T15 T16 Detailed_description 338 348 metastatic R5 MODIFY Arg1:T16 Arg2:E9 T17 Diagnostic_procedure 399 418 Computed tomography E10 Diagnostic_procedure:T17 T18 Disease_disorder 444 462 metastatic disease E11 Disease_disorder:T18 T19 Biological_structure 466 471 bones R6 MODIFY Arg1:T19 Arg2:E11 T20 Biological_structure 473 479 pleura T21 Biological_structure 484 489 liver R7 MODIFY Arg1:T20 Arg2:E11 R8 MODIFY Arg1:T21 Arg2:E11 T22 Detailed_description 433 443 widespread R9 MODIFY Arg1:T22 Arg2:E11 T23 Medication 581 592 trastuzumab E12 Medication:T23 T24 Medication 597 622 taxane-based chemotherapy E13 Medication:T24 T25 Sign_symptom 651 659 response E14 Sign_symptom:T25 T26 Detailed_description 643 650 partial T27 Detailed_description 631 642 significant R10 MODIFY Arg1:T26 Arg2:E14 R11 MODIFY Arg1:T27 Arg2:E14 T28 Medication 699 711 chemotherapy E15 Medication:T28 T29 Detailed_description 689 698 induction R12 MODIFY Arg1:T29 Arg2:E15 T30 Medication 735 744 tamoxifen E16 Medication:T30 T31 Medication 749 760 trastuzumab E17 Medication:T31 T32 Duration 768 777 19 months E18 Duration:T32 T33 Sign_symptom 811 819 seizures E19 Sign_symptom:T33 T34 Diagnostic_procedure 829 848 computed tomography E20 Diagnostic_procedure:T34 T35 Biological_structure 824 828 head R13 MODIFY Arg1:T35 Arg2:E20 T36 Sign_symptom 866 876 metastasis E21 Sign_symptom:T36 T37 Biological_structure 884 901 left frontal lobe R14 MODIFY Arg1:T37 Arg2:E21 T38 Therapeutic_procedure 935 943 resected E22 Therapeutic_procedure:T38 T39 Medication 965 974 tamoxifen E23 Medication:T39 T40 Medication 979 990 trastuzumab E24 Medication:T40 T41 Diagnostic_procedure 1023 1037 plasma samples E25 Diagnostic_procedure:T41 T42 Date 1069 1086 Four months after E26 Date:T42 T43 Sign_symptom 1120 1127 lesions E27 Sign_symptom:T43 T44 Biological_structure 1114 1119 liver T45 Detailed_description 1104 1113 enlarging R15 MODIFY Arg1:T44 Arg2:E27 R16 MODIFY Arg1:T45 Arg2:E27 T46 Sign_symptom 1138 1156 metastatic deposit E28 Sign_symptom:T46 T47 Biological_structure 1164 1174 left ovary R17 MODIFY Arg1:T47 Arg2:E28 T48 Medication 1241 1250 lapatinib E29 Medication:T48 T49 Medication 1255 1267 capecitabine E30 Medication:T49 T50 Sign_symptom 1282 1296 stable disease E31 Sign_symptom:T50 T51 Duration 1301 1310 12 months E32 Duration:T51 T52 Sign_symptom 1334 1355 General deterioration E33 Sign_symptom:T52 T53 Sign_symptom 1376 1395 disease progression E34 Sign_symptom:T53 T54 Biological_structure 1403 1408 chest R18 MODIFY Arg1:T54 Arg2:E34 T55 Disease_disorder 1443 1460 pleural effusions E35 Disease_disorder:T55 T56 Detailed_description 1433 1442 bilateral R19 MODIFY Arg1:T56 Arg2:E35 T57 Sign_symptom 1424 1431 nodules E36 Sign_symptom:T57 T58 Biological_structure 1414 1423 pulmonary R20 MODIFY Arg1:T58 Arg2:E36 T59 Sign_symptom 1486 1490 mass E37 Sign_symptom:T59 T60 Biological_structure 1465 1485 posterior chest wall R21 MODIFY Arg1:T60 Arg2:E37 T61 Outcome 1611 1615 died E38 Outcome:T61 T62 Therapeutic_procedure 1573 1582 Treatment E39 Therapeutic_procedure:T62 A1 POLARITY E39 NEG T63 Date 1617 1631 4 months later E40 Date:T63 T64 Clinical_event 20 29 presented E41 Clinical_event:T64 * OVERLAP E41 E1 E2 E3 E4 E5 E6 E7 E8 E9 E10 E11 R22 BEFORE Arg1:E11 Arg2:E12 * OVERLAP E12 E13 E14 E15 R23 BEFORE Arg1:E15 Arg2:E16 * OVERLAP E16 E17 E18 R24 BEFORE Arg1:E18 Arg2:E19 * OVERLAP E19 E20 E21 E22 R25 BEFORE Arg1:E22 Arg2:E23 * OVERLAP E23 E24 E25 R26 BEFORE Arg1:E25 Arg2:E26 * OVERLAP E26 E27 E28 R27 BEFORE Arg1:E28 Arg2:E29 * OVERLAP E29 E30 R28 BEFORE Arg1:E30 Arg2:E31 * OVERLAP E31 E32 R29 BEFORE Arg1:E32 Arg2:E33 * OVERLAP E33 E34 E36 E35 E37 E42 T65 Diagnostic_procedure 1513 1566 Eastern Cooperative Oncology Group performance status E42 Diagnostic_procedure:T65 T66 Lab_value 1567 1570 2–3 R30 MODIFY Arg1:T66 Arg2:E42 R31 BEFORE Arg1:E42 Arg2:E39 R32 BEFORE Arg1:E39 Arg2:E38 * OVERLAP E38 E40