165 lines (164 with data), 5.5 kB

T1	Age 2 13	73-year-old
T2	Sex 14 19	woman
T3	Clinical_event 34 42	referred
E1	Clinical_event:T3 
T4	Date 43 57	19 months prio
E2	Date:T4 
T5	Disease_disorder 188 191	CNV
E3	Disease_disorder:T5 
#1	AnnotatorNotes E3	Choroidal neovascularization
T6	Biological_structure 199 207	left eye
R1	MODIFY Arg1:T6 Arg2:E3	
T7	Detailed_description 219 246	not been previously treated
R2	MODIFY Arg1:T7 Arg2:E3	
T8	Detailed_description 180 187	classic
T9	Detailed_description 170 179	subfoveal
R3	MODIFY Arg1:T9 Arg2:E3	
T10	Detailed_description 157 169	medium-sized
R4	MODIFY Arg1:T10 Arg2:E3	
T11	Diagnostic_procedure 136 147	angiography
E4	Diagnostic_procedure:T11 
T12	Detailed_description 118 135	indocyanine green
T13	Detailed_description 102 113	fluorescein
R5	MODIFY Arg1:T12 Arg2:E4	
R6	MODIFY Arg1:T13 Arg2:E4	
T14	Therapeutic_procedure 271 280	treatment
E5	Therapeutic_procedure:T14 
A1	POLARITY E5 NEG
T15	Sign_symptom 328 344	decreased vision
E6	Sign_symptom:T15 
T16	Biological_structure 352 360	left eye
R7	MODIFY Arg1:T16 Arg2:E6	
T17	Diagnostic_procedure 366 394	best-corrected visual acuity
E7	Diagnostic_procedure:T17 
T18	Diagnostic_procedure 396 400	BCVA
E8	Diagnostic_procedure:T18 
R8	IDENTICAL Arg1:E8 Arg2:E7	
T19	Lab_value 406 412	20/100
R9	MODIFY Arg1:T19 Arg2:E7	
T20	Diagnostic_procedure 414 435	Slit lamp examination
E9	Diagnostic_procedure:T20 
T21	Sign_symptom 461 466	patch
E10	Sign_symptom:T21 
T22	Color 451 460	yellowish
T23	Detailed_description 445 450	small
R10	MODIFY Arg1:T22 Arg2:E10	
R11	MODIFY Arg1:T23 Arg2:E10	
T24	Biological_structure 474 491	perifoveal region
R12	MODIFY Arg1:T24 Arg2:E10	
T25	Sign_symptom 496 509	retinal edema
E11	Sign_symptom:T25 
T26	Diagnostic_procedure 522 525	OCT
E12	Diagnostic_procedure:T26 
#2	AnnotatorNotes E12	Optical coherence tomography
T27	Sign_symptom 539 556	retinal elevation
E13	Sign_symptom:T27 
T28	Detailed_description 511 521	Structural
R13	MODIFY Arg1:T28 Arg2:E12	
T29	Sign_symptom 558 574	subretinal fluid
E14	Sign_symptom:T29 
T30	Sign_symptom 598 612	elongated area
E15	Sign_symptom:T30 
T31	Biological_structure 581 597	hyper-reflective
R14	MODIFY Arg1:T31 Arg2:E15	
T32	Biological_structure 613 622	above RPE
#3	AnnotatorNotes T32	Retinal pigment epithelium
R15	MODIFY Arg1:T32 Arg2:E15	
T33	Disease_disorder 642 645	CNV
E16	Disease_disorder:T33 
T34	Lab_value 634 641	type II
R16	MODIFY Arg1:T34 Arg2:E16	
T35	Therapeutic_procedure 647 672	Anti-angiogenic treatment
E17	Therapeutic_procedure:T35 
T36	Medication 691 702	aflibercept
E18	Medication:T36 
T37	Administration 678 690	intravitreal
R17	MODIFY Arg1:T37 Arg2:E18	
T38	Administration 703 713	injections
R18	MODIFY Arg1:T38 Arg2:E18	
T39	Detailed_description 739 763	treat-and-extend regimen
R19	MODIFY Arg1:T39 Arg2:E17	
R20	SUB_PROCEDURE Arg1:E18 Arg2:E17	
T40	Diagnostic_procedure 765 768	OCT
E19	Diagnostic_procedure:T40 
T41	Detailed_description 769 779	angiograms
R21	MODIFY Arg1:T41 Arg2:E19	
T42	Diagnostic_procedure 819 832	CNV flow area
E20	Diagnostic_procedure:T42 
T43	Lab_value 795 815	noticeable reduction
R22	MODIFY Arg1:T43 Arg2:E20	
T44	Date 836 849	1–2 days post
E21	Date:T44 
T45	Lab_value 866 885	continued reduction
R23	MODIFY Arg1:E21 Arg2:T43	
R24	MODIFY Arg1:T45 Arg2:E20	
T46	Date 889 907	1 week and 2 weeks
E22	Date:T46 
R25	MODIFY Arg1:E22 Arg2:T45	
T47	Diagnostic_procedure 909 922	CNV flow area
E23	Diagnostic_procedure:T47 
T48	Diagnostic_procedure 927 941	vessel density
E24	Diagnostic_procedure:T48 
T49	Lab_value 947 954	reduced
R26	MODIFY Arg1:T49 Arg2:E24	
R27	MODIFY Arg1:T49 Arg2:E23	
T50	Disease_disorder 1069 1072	CNV
E25	Disease_disorder:T50 
T51	Lab_value 1052 1065	re-appearance
T52	Severity 1040 1051	Significant
R28	MODIFY Arg1:T51 Arg2:E25	
R29	MODIFY Arg1:T52 Arg2:E25	
T53	Date 1091 1098	4 weeks
E26	Date:T53 
T54	Date 1138 1145	6 weeks
E27	Date:T54 
T55	Disease_disorder 1214 1217	CNV
E28	Disease_disorder:T55 
T56	Detailed_description 1202 1213	re-enlarged
R30	MODIFY Arg1:T56 Arg2:E28	
T57	Diagnostic_procedure 1580 1583	OCT
E29	Diagnostic_procedure:T57 
T58	Detailed_description 1584 1595	angiography
R31	MODIFY Arg1:T58 Arg2:E29	
T59	Diagnostic_procedure 1625 1638	CNV flow area
E30	Diagnostic_procedure:T59 
T60	Lab_value 1612 1621	reduction
R32	MODIFY Arg1:T60 Arg2:E30	
T61	Diagnostic_procedure 1643 1653	flow index
E31	Diagnostic_procedure:T61 
R33	MODIFY Arg1:T60 Arg2:E31	
T62	Duration 1654 1676	over the first 2 weeks
E32	Duration:T62 
T63	Sign_symptom 1915 1935	fluid re-accumulated
E33	Sign_symptom:T63 
T64	Biological_structure 1936 1952	under the retina
R34	MODIFY Arg1:T64 Arg2:E33	
T65	Date 1953 1960	6 weeks
E34	Date:T65 
T66	Sign_symptom 1701 1718	Retinal thickness
E35	Sign_symptom:T66 
T67	Duration 1756 1778	over the first 4 weeks
E36	Duration:T67 
T68	Date 1828 1835	2 weeks
E37	Date:T68 
T69	Diagnostic_procedure 1986 1999	Visual acuity
E38	Diagnostic_procedure:T69 
T70	Lab_value 2009 2029	continued to improve
R35	MODIFY Arg1:T70 Arg2:E38	
*	OVERLAP E1 E2 E4 E3
R36	BEFORE Arg1:E3 Arg2:E5	
R37	BEFORE Arg1:E5 Arg2:E6	
*	OVERLAP E6 E7 E9 E10 E11 E12 E13 E14 E15 E16 E17
R38	BEFORE Arg1:E17 Arg2:E19	
*	OVERLAP E19 E20 E21
R39	BEFORE Arg1:E21 Arg2:E22	
*	OVERLAP E22 E23 E24
R40	BEFORE Arg1:E24 Arg2:E25	
*	OVERLAP E25 E26
R41	BEFORE Arg1:E26 Arg2:E27	
R42	MODIFY Arg1:E26 Arg2:E25	
R43	MODIFY Arg1:E27 Arg2:E25	
*	OVERLAP E27 E28 E29 E30 E31 E32 E35 E36 E37
R44	AFTER Arg1:E37 Arg2:E33	
*	OVERLAP E33 E34
R45	BEFORE Arg1:E34 Arg2:E38