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T1 Age 2 13 33-year-old T2 Sex 14 17 man T3 Sign_symptom 49 53 ache E1 Sign_symptom:T3 T4 Detailed_description 44 48 dull R1 MODIFY Arg1:T4 Arg2:E1 T5 Biological_structure 33 43 left flank R2 MODIFY Arg1:T5 Arg2:E1 T6 Diagnostic_procedure 72 91 computed tomography E2 Diagnostic_procedure:T6 T7 Biological_structure 62 71 abdominal R3 MODIFY Arg1:T7 Arg2:E2 T8 Sign_symptom 107 111 mass E3 Sign_symptom:T8 T9 Biological_structure 101 106 renal T10 Detailed_description 95 100 solid R4 MODIFY Arg1:T9 Arg2:E3 R5 MODIFY Arg1:T10 Arg2:E3 T11 Biological_structure 119 151 upper portion of the left kidney R6 MODIFY Arg1:T11 Arg2:E3 T12 Coreference 172 176 mass E4 Coreference:T12 R7 IDENTICAL Arg1:E4 Arg2:E3 T13 Volume 190 214 2.8 cm × 2.8 cm × 2.5 cm R8 MODIFY Arg1:T13 Arg2:E4 T14 Detailed_description 228 240 well-defined R9 MODIFY Arg1:T14 Arg2:E4 T15 Sign_symptom 261 284 other abnormal findings E5 Sign_symptom:T15 A1 POLARITY E5 NEG T16 Sign_symptom 312 322 metastasis E6 Sign_symptom:T16 A2 POLARITY E6 NEG T17 Detailed_description 304 311 distant R10 MODIFY Arg1:T17 Arg2:E6 T18 Sign_symptom 337 347 metastasis E7 Sign_symptom:T18 A3 POLARITY E7 NEG T19 Biological_structure 326 336 lymph node R11 MODIFY Arg1:T19 Arg2:E7 T20 Therapeutic_procedure 357 368 nephrectomy E8 Therapeutic_procedure:T20 T21 Detailed_description 349 356 Radical R12 MODIFY Arg1:T21 Arg2:E8 T22 Date 386 395 14/9/2005 E9 Date:T22 T23 Diagnostic_procedure 400 417 gross examination E10 Diagnostic_procedure:T23 T24 Detailed_description 423 443 nephrectomy specimen T25 Volume 453 478 11.5 cm × 6.5 cm × 4.5 cm R13 MODIFY Arg1:T25 Arg2:T24 R14 MODIFY Arg1:T24 Arg2:E10 T26 Coreference 487 492 tumor E11 Coreference:T26 R15 IDENTICAL Arg1:E11 Arg2:E4 T27 Color 506 519 grayish-brown T28 Coreference 520 524 mass E12 Coreference:T28 R16 IDENTICAL Arg1:E12 Arg2:E11 T29 Detailed_description 499 504 solid R17 MODIFY Arg1:T29 Arg2:E12 R18 MODIFY Arg1:T27 Arg2:E12 T30 Volume 534 558 3.5 cm × 2.5 cm × 2.2 cm R19 MODIFY Arg1:T30 Arg2:E12 T31 Diagnostic_procedure 568 590 Histologic examination E13 Diagnostic_procedure:T31 T37 Diagnostic_procedure 673 682 cytoplasm E16 Diagnostic_procedure:T37 R23 SUB_PROCEDURE Arg1:E16 Arg2:E13 T32 Lab_value 604 638 trabecular and ribbonlike patterns T33 Lab_value 644 667 minimal fibrotic stroma R20 MODIFY Arg1:T32 Arg2:E13 R21 MODIFY Arg1:T33 Arg2:E13 T34 Lab_value 687 695 granular T35 Lab_value 700 712 eosinophilic R22 MODIFY Arg1:T34 Arg2:E16 R24 MODIFY Arg1:T35 Arg2:E16 T36 Lab_value 718 746 uniform round to oval nuclei R25 MODIFY Arg1:T36 Arg2:E16 T38 Lab_value 752 777 finely stippled chromatin T39 Lab_value 782 804 inconspicuous nucleoli R26 MODIFY Arg1:T38 Arg2:E16 R27 MODIFY Arg1:T39 Arg2:E16 T40 Diagnostic_procedure 861 870 H&E stain E14 Diagnostic_procedure:T40 T41 Lab_value 819 828 not found T42 Lab_value 830 856 0 per 10 high-power fields T43 Diagnostic_procedure 882 904 pathologic examination E15 Diagnostic_procedure:T43 T44 Disease_disorder 936 968 neuroendocrine (carcinoid) tumor E17 Disease_disorder:T44 T45 Detailed_description 916 935 well-differentiated R30 MODIFY Arg1:T45 Arg2:E17 T46 Biological_structure 985 991 kidney R31 MODIFY Arg1:T46 Arg2:E17 T47 Diagnostic_procedure 1001 1027 Immunohistochemical stains E18 Diagnostic_procedure:T47 T48 Diagnostic_procedure 1055 1067 chromogranin E19 Diagnostic_procedure:T48 T49 Diagnostic_procedure 1069 1092 neuron-specific enolase E20 Diagnostic_procedure:T49 T50 Diagnostic_procedure 1097 1110 synaptophysin E21 Diagnostic_procedure:T50 T51 Lab_value 1041 1049 labeling R32 MODIFY Arg1:T51 Arg2:E19 R33 MODIFY Arg1:T51 Arg2:E20 R34 MODIFY Arg1:T51 Arg2:E21 R35 SUB_PROCEDURE Arg1:E19 Arg2:E18 R36 SUB_PROCEDURE Arg1:E20 Arg2:E18 R37 SUB_PROCEDURE Arg1:E21 Arg2:E18 T52 Diagnostic_procedure 1128 1147 proliferation index E22 Diagnostic_procedure:T52 T53 Lab_value 1152 1165 less than 2 % R38 MODIFY Arg1:T53 Arg2:E22 T54 Diagnostic_procedure 1181 1211 immunohistochemistry for Ki-67 E23 Diagnostic_procedure:T54 R39 SUB_PROCEDURE Arg1:E23 Arg2:E22 T55 Therapeutic_procedure 1221 1230 radiation E24 Therapeutic_procedure:T55 A4 POLARITY E24 NEG T56 Medication 1235 1247 chemotherapy E25 Medication:T56 A5 POLARITY E25 NEG T57 Date 1267 1283 Nine years after E26 Date:T57 T58 Diagnostic_procedure 1305 1324 computed tomography E27 Diagnostic_procedure:T58 T59 Biological_structure 1332 1339 abdomen R40 MODIFY Arg1:T59 Arg2:E27 T60 Sign_symptom 1374 1378 mass E28 Sign_symptom:T60 T61 Detailed_description 1369 1373 cyst T62 Area 1355 1368 2 cm × 1.8 cm R41 MODIFY Arg1:T62 Arg2:E28 R42 MODIFY Arg1:T61 Arg2:E28 T63 Biological_structure 1386 1397 right liver R43 MODIFY Arg1:T63 Arg2:E28 T64 Sign_symptom 1411 1430 high density shadow E29 Sign_symptom:T64 T65 Detailed_description 1402 1410 multiple R44 MODIFY Arg1:T65 Arg2:E29 T66 Biological_structure 1434 1445 gallbladder R45 MODIFY Arg1:T66 Arg2:E29 T67 Sign_symptom 1450 1458 enlarged E30 Sign_symptom:T67 T68 Biological_structure 1459 1470 lymph nodes R46 MODIFY Arg1:T68 Arg2:E30 A6 POLARITY E30 NEG T69 Biological_structure 1489 1505 abdominal cavity R47 MODIFY Arg1:T69 Arg2:E30 T70 Therapeutic_procedure 1507 1522 Cholecystectomy E31 Therapeutic_procedure:T70 T71 Therapeutic_procedure 1527 1538 extirpation E32 Therapeutic_procedure:T71 T72 Disease_disorder 1543 1555 hepatic cyst E33 Disease_disorder:T72 T73 Therapeutic_procedure 1574 1593 laparoscopy surgery E34 Therapeutic_procedure:T73 R48 SUB_PROCEDURE Arg1:E34 Arg2:E32 R49 SUB_PROCEDURE Arg1:E34 Arg2:E31 T74 Diagnostic_procedure 1595 1617 Histologic examination E35 Diagnostic_procedure:T74 T75 Lab_value 1631 1662 trabecular and glandlike growth R50 MODIFY Arg1:T75 Arg2:E35 T76 Lab_value 1672 1699 moderate and uniform nuclei R51 MODIFY Arg1:T76 Arg2:E35 T78 Diagnostic_procedure 806 813 Mitoses E36 Diagnostic_procedure:T78 R28 SUB_PROCEDURE Arg1:E36 Arg2:E14 R29 MODIFY Arg1:T41 Arg2:E36 R52 MODIFY Arg1:T42 Arg2:E36 T77 Diagnostic_procedure 1704 1711 mitoses E37 Diagnostic_procedure:T77 T79 Lab_value 1712 1725 weren't found R53 MODIFY Arg1:T79 Arg2:E37 T80 Lab_value 1727 1753 0 per 10 high-power fields R54 MODIFY Arg1:T80 Arg2:E37 T81 Diagnostic_procedure 1765 1785 immunohistochemistry E38 Diagnostic_procedure:T81 T82 Detailed_description 1756 1764 Advanced R55 MODIFY Arg1:T82 Arg2:E38 T83 Coreference 1804 1810 lesion E39 Coreference:T83 #1 AnnotatorNotes E39 Not actually sure which of two lesions this refers to R56 IDENTICAL Arg1:E39 Arg2:E33 T84 Lab_value 1815 1823 positive T85 Diagnostic_procedure 1828 1841 synaptophysin E40 Diagnostic_procedure:T85 T86 Diagnostic_procedure 1877 1889 chromogranin E41 Diagnostic_procedure:T86 T87 Diagnostic_procedure 1894 1917 neuron-specific enolase E42 Diagnostic_procedure:T87 T88 Lab_value 1864 1872 negative R57 MODIFY Arg1:T84 Arg2:E40 R58 SUB_PROCEDURE Arg1:E40 Arg2:E38 R59 SUB_PROCEDURE Arg1:E41 Arg2:E38 R60 SUB_PROCEDURE Arg1:E42 Arg2:E38 R61 MODIFY Arg1:T88 Arg2:E41 R62 MODIFY Arg1:T88 Arg2:E42 T89 Disease_disorder 1953 1973 neuroendocrine tumor E43 Disease_disorder:T89 T90 Disease_disorder 2119 2134 carcinoid tumor E44 Disease_disorder:T90 T91 Biological_structure 2142 2153 left kidney R63 MODIFY Arg1:T91 Arg2:E44 T92 Sign_symptom 2165 2175 metastasis E45 Sign_symptom:T92 T93 Biological_structure 2159 2164 liver R64 MODIFY Arg1:T93 Arg2:E45 T94 Clinical_event 18 27 presented E46 Clinical_event:T94 * OVERLAP E46 E1 E2 E3 E5 E6 E7 R65 BEFORE Arg1:E7 Arg2:E8 * OVERLAP E8 E10 E13 E14 R66 BEFORE Arg1:E14 Arg2:E15 * OVERLAP E15 E17 E18 E22 R67 BEFORE Arg1:E22 Arg2:E24 * OVERLAP E24 E25 R68 BEFORE Arg1:E25 Arg2:E26 * OVERLAP E26 E27 E28 E29 E30 E31 E32 E33 E35 E37 E38 E43 R69 BEFORE Arg1:E43 Arg2:E44 * OVERLAP E44 E45