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T1 Age 43 54 28-year-old T2 Sex 55 60 woman T3 Personal_background 62 76 Afro-Brazilian T4 History 24 42 previously healthy T5 History 85 100 first pregnancy T6 Clinical_event 207 216 presented E1 Clinical_event:T6 T7 Nonbiological_location 224 244 emergency department R1 MODIFY Arg1:T7 Arg2:E1 T8 History 180 201 allergy to diclofenac T9 Sign_symptom 278 282 pain E2 Sign_symptom:T9 T10 Sign_symptom 284 292 jaundice E3 Sign_symptom:T10 T11 Sign_symptom 294 300 nausea E4 Sign_symptom:T11 T12 Sign_symptom 305 313 vomiting E5 Sign_symptom:T12 T13 Disease_disorder 332 346 encephalopathy E6 Disease_disorder:T13 A1 POLARITY E6 NEG T14 Biological_structure 268 277 abdominal R2 MODIFY Arg1:T14 Arg2:E2 T15 Clinical_event 2593 2603 discharged E7 Clinical_event:T15 T16 Clinical_event 2670 2680 discharged E8 Clinical_event:T16 T17 Date 147 166 36th pregnancy week E9 Date:T17 T18 Detailed_description 253 258 acute R3 MODIFY Arg1:T18 Arg2:E2 R4 MODIFY Arg1:T18 Arg2:E3 R5 MODIFY Arg1:T18 Arg2:E4 R6 MODIFY Arg1:T18 Arg2:E5 T19 Diagnostic_procedure 352 375 arterial blood pressure E10 Diagnostic_procedure:T19 T20 Lab_value 380 390 110/60mmHg E11 Lab_value:T20 R7 MODIFY Arg1:E11 Arg2:E10 T21 Diagnostic_procedure 392 402 heart rate E12 Diagnostic_procedure:T21 T22 Lab_value 407 412 98bpm E13 Lab_value:T22 R8 MODIFY Arg1:E13 Arg2:E12 T23 Diagnostic_procedure 414 434 axillary temperature E14 Diagnostic_procedure:T23 T24 Lab_value 439 443 35°C E15 Lab_value:T24 R9 MODIFY Arg1:E15 Arg2:E14 T25 Sign_symptom 462 472 dehydrated E16 Sign_symptom:T25 T26 Severity 453 461 severely R10 MODIFY Arg1:T26 Arg2:E16 T27 Diagnostic_procedure 492 512 peripheral perfusion E17 Diagnostic_procedure:T27 T28 Lab_value 482 491 decreased E18 Lab_value:T28 R11 MODIFY Arg1:E18 Arg2:E17 T29 Diagnostic_procedure 518 541 laboratory examinations E19 Diagnostic_procedure:T29 T30 Diagnostic_procedure 551 561 hemoglobin E20 Diagnostic_procedure:T30 T31 Lab_value 562 570 12.3g/dL E21 Lab_value:T31 R12 MODIFY Arg1:E21 Arg2:E20 T32 Diagnostic_procedure 572 582 leukocytes E22 Diagnostic_procedure:T32 T33 Lab_value 583 594 13 × 109/mL E23 Lab_value:T33 R13 MODIFY Arg1:E23 Arg2:E22 T34 Diagnostic_procedure 596 605 platelets E24 Diagnostic_procedure:T34 T35 Lab_value 606 618 97 × 103/mm3 E25 Lab_value:T35 R14 MODIFY Arg1:E25 Arg2:E24 T36 Diagnostic_procedure 620 652 international nationalized ratio E26 Diagnostic_procedure:T36 T37 Diagnostic_procedure 654 657 INR E27 Diagnostic_procedure:T37 R15 IDENTICAL Arg1:E27 Arg2:E26 T38 Lab_value 659 662 6.9 E28 Lab_value:T38 R16 MODIFY Arg1:E28 Arg2:E26 T39 Diagnostic_procedure 664 674 fibrinogen E29 Diagnostic_procedure:T39 T40 Diagnostic_procedure 684 699 total bilirubin E30 Diagnostic_procedure:T40 T41 Diagnostic_procedure 717 727 creatinine E31 Diagnostic_procedure:T41 T42 Diagnostic_procedure 744 770 aspartate aminotransferase E32 Diagnostic_procedure:T42 T43 Diagnostic_procedure 772 775 AST E33 Diagnostic_procedure:T43 R17 IDENTICAL Arg1:E33 Arg2:E32 T44 Diagnostic_procedure 791 815 alanine aminotransferase E34 Diagnostic_procedure:T44 T45 Diagnostic_procedure 817 820 ALP E35 Diagnostic_procedure:T45 R18 IDENTICAL Arg1:E35 Arg2:E34 T46 Diagnostic_procedure 830 850 arterial bicarbonate E36 Diagnostic_procedure:T46 T47 Diagnostic_procedure 860 871 arterial pH E37 Diagnostic_procedure:T47 T48 Diagnostic_procedure 878 891 blood glucose E38 Diagnostic_procedure:T48 T49 Diagnostic_procedure 904 917 ionic calcium E39 Diagnostic_procedure:T49 T50 Lab_value 675 682 98mg/dL E40 Lab_value:T50 T51 Lab_value 700 709 14.2mg/dL E41 Lab_value:T51 R19 MODIFY Arg1:E40 Arg2:E29 R20 MODIFY Arg1:E41 Arg2:E30 T52 Detailed_description 711 716 serum R21 MODIFY Arg1:T52 Arg2:E31 T53 Lab_value 728 736 3.4mg/dL E42 Lab_value:T53 R22 MODIFY Arg1:E42 Arg2:E31 T54 Detailed_description 738 743 serum R23 MODIFY Arg1:T54 Arg2:E32 T55 Lab_value 777 783 306U/L E43 Lab_value:T55 R24 MODIFY Arg1:E43 Arg2:E32 T56 Detailed_description 785 790 serum R25 MODIFY Arg1:T56 Arg2:E34 T57 Lab_value 822 828 302U/L E44 Lab_value:T57 R26 MODIFY Arg1:E44 Arg2:E34 T58 Lab_value 851 858 11mEq/L E45 Lab_value:T58 R27 MODIFY Arg1:E45 Arg2:E36 T59 Lab_value 872 876 7.21 E46 Lab_value:T59 R28 MODIFY Arg1:E46 Arg2:E37 T60 Lab_value 892 899 65mg/dL E47 Lab_value:T60 R29 MODIFY Arg1:E47 Arg2:E38 T61 Lab_value 918 928 1.02mmol/L E48 Lab_value:T61 R30 MODIFY Arg1:E48 Arg2:E39 R31 SUB_PROCEDURE Arg1:E20 Arg2:E19 R32 SUB_PROCEDURE Arg1:E22 Arg2:E19 R33 SUB_PROCEDURE Arg1:E24 Arg2:E19 R34 SUB_PROCEDURE Arg1:E26 Arg2:E19 R35 SUB_PROCEDURE Arg1:E29 Arg2:E19 R36 SUB_PROCEDURE Arg1:E30 Arg2:E19 R37 SUB_PROCEDURE Arg1:E31 Arg2:E19 R38 SUB_PROCEDURE Arg1:E32 Arg2:E19 R39 SUB_PROCEDURE Arg1:E34 Arg2:E19 R40 SUB_PROCEDURE Arg1:E36 Arg2:E19 R41 SUB_PROCEDURE Arg1:E37 Arg2:E19 R42 SUB_PROCEDURE Arg1:E38 Arg2:E19 R43 SUB_PROCEDURE Arg1:E39 Arg2:E19 T62 Diagnostic_procedure 943 953 ultrasound E49 Diagnostic_procedure:T62 T63 Biological_structure 933 942 abdominal R44 MODIFY Arg1:T63 Arg2:E49 T64 Sign_symptom 963 981 fatty infiltration E50 Sign_symptom:T64 T65 Biological_structure 989 994 liver R45 MODIFY Arg1:T65 Arg2:E50 T66 Diagnostic_procedure 1009 1024 fetal viability E51 Diagnostic_procedure:T66 T67 Lab_value 999 1008 confirmed E52 Lab_value:T67 R46 MODIFY Arg1:E52 Arg2:E51 T69 Medication 1058 1068 fluid load E54 Medication:T69 T68 Medication 1074 1086 crystalloids E53 Medication:T68 R47 SUB_PROCEDURE Arg1:E53 Arg2:E54 T70 Diagnostic_procedure 1092 1099 calcium E55 Diagnostic_procedure:T70 T71 Diagnostic_procedure 1101 1108 glucose E56 Diagnostic_procedure:T71 T72 Disease_disorder 1113 1124 hypothermia E57 Disease_disorder:T72 A2 POLARITY E57 NEG T73 Lab_value 1130 1138 reversed E58 Lab_value:T73 R48 MODIFY Arg1:E58 Arg2:E56 R49 MODIFY Arg1:E58 Arg2:E55 T74 Disease_disorder 1157 1161 AFLP E59 Disease_disorder:T74 #1 AnnotatorNotes E59 Acute fatty liver of pregnancy T75 Diagnostic_procedure 1190 1208 Swansea’s criteria E60 Diagnostic_procedure:T75 T76 Therapeutic_procedure 1227 1243 cesarean section E61 Therapeutic_procedure:T76 T77 Therapeutic_procedure 1261 1279 thromboelastometry E62 Therapeutic_procedure:T77 T78 Detailed_description 1281 1320 ROTEM®, Pentapharm Co., Munich, Germany R50 MODIFY Arg1:T78 Arg2:E62 T79 Coreference 1360 1367 surgery E63 Coreference:T79 R51 IDENTICAL Arg1:E63 Arg2:E61 T80 Diagnostic_procedure 1373 1400 thromboelastometry analysis E64 Diagnostic_procedure:T80 T81 Sign_symptom 1442 1462 hypocoagulable state E65 Sign_symptom:T81 T82 Detailed_description 1431 1441 structural T83 Detailed_description 1419 1426 kinetic T84 Severity 1411 1418 intense R52 MODIFY Arg1:T82 Arg2:E65 R53 MODIFY Arg1:T83 Arg2:E65 R54 MODIFY Arg1:T84 Arg2:E65 T85 Diagnostic_procedure 1488 1494 FIBTEM E66 Diagnostic_procedure:T85 R55 SUB_PROCEDURE Arg1:E66 Arg2:E64 T86 Diagnostic_procedure 1559 1564 EXTEM E67 Diagnostic_procedure:T86 R56 SUB_PROCEDURE Arg1:E67 Arg2:E64 T87 Disease_disorder 1507 1548 impairment in fibrinogen function quality E68 Disease_disorder:T87 T88 Disease_disorder 1576 1605 coagulation factor deficiency E69 Disease_disorder:T88 T89 Diagnostic_procedure 1654 1660 FIBTEM E70 Diagnostic_procedure:T89 R57 SUB_PROCEDURE Arg1:E70 Arg2:E64 T90 Diagnostic_procedure 1661 1682 maximum clot firmness E71 Diagnostic_procedure:T90 R58 SUB_PROCEDURE Arg1:E71 Arg2:E70 T91 Diagnostic_procedure 1684 1687 MCF E72 Diagnostic_procedure:T91 R59 IDENTICAL Arg1:E72 Arg2:E71 T92 Lab_value 1690 1693 0mm E73 Lab_value:T92 R60 MODIFY Arg1:E73 Arg2:E71 T93 Diagnostic_procedure 1708 1713 EXTEM E74 Diagnostic_procedure:T93 R61 SUB_PROCEDURE Arg1:E74 Arg2:E64 T94 Diagnostic_procedure 1714 1727 clotting time E75 Diagnostic_procedure:T94 R62 SUB_PROCEDURE Arg1:E75 Arg2:E74 T95 Diagnostic_procedure 1729 1731 CT E76 Diagnostic_procedure:T95 R63 IDENTICAL Arg1:E76 Arg2:E75 T96 Lab_value 1734 1738 228s E77 Lab_value:T96 R64 MODIFY Arg1:E77 Arg2:E75 T97 Medication 1758 1768 fibrinogen E78 Medication:T97 T98 Dosage 1750 1754 4.0g R65 MODIFY Arg1:T98 Arg2:E78 T99 Administration 1769 1780 concentrate R66 MODIFY Arg1:T99 Arg2:E78 T100 Dosage 1837 1843 1000UI T101 Medication 1847 1866 prothrombin complex E79 Medication:T101 R67 MODIFY Arg1:T100 Arg2:E79 T102 Administration 1867 1878 concentrate R68 MODIFY Arg1:T102 Arg2:E79 T103 Detailed_description 1782 1831 Haemocomplettan® P, CSL Behring, Marburg, Germany R69 MODIFY Arg1:T103 Arg2:E78 T104 Detailed_description 1880 1930 Beriplex® P/N 500UI, CSL Behring, Marburg, Germany R70 MODIFY Arg1:T104 Arg2:E79 T105 Therapeutic_procedure 1974 1990 cesarean section E80 Therapeutic_procedure:T105 T106 Medication 1996 2007 fluid input E81 Medication:T106 T107 Medication 2009 2021 crystalloids E82 Medication:T107 R71 SUB_PROCEDURE Arg1:E82 Arg2:E81 T108 Diagnostic_procedure 2027 2033 output E83 Diagnostic_procedure:T108 #2 AnnotatorNotes E83 fluid output T109 Therapeutic_procedure 2045 2062 caesarian section E84 Therapeutic_procedure:T109 T110 Dosage 2083 2089 2000mL R72 MODIFY Arg1:T110 Arg2:E81 T111 Lab_value 2094 2099 200mL E85 Lab_value:T111 R73 MODIFY Arg1:E85 Arg2:E83 T112 Therapeutic_procedure 2105 2121 cesarean section E86 Therapeutic_procedure:T112 T113 Lab_value 2122 2131 succeeded E87 Lab_value:T113 R74 MODIFY Arg1:E87 Arg2:E86 T114 Sign_symptom 2146 2154 bleeding E88 Sign_symptom:T114 A3 POLARITY E88 NEG T115 Severity 2140 2145 major R75 MODIFY Arg1:T115 Arg2:E88 T116 Therapeutic_procedure 2165 2183 hemostatic therapy E89 Therapeutic_procedure:T116 T117 Medication 2196 2209 hemocomponent E90 Medication:T117 A4 POLARITY E90 NEG T118 Administration 2210 2221 transfusion R76 MODIFY Arg1:T118 Arg2:E90 T119 Medication 2231 2250 fresh frozen plasma E91 Medication:T119 T120 Medication 2258 2273 cryoprecipitate E92 Medication:T120 T121 Medication 2275 2284 platelets E93 Medication:T121 T122 Medication 2288 2306 blood concentrates E94 Medication:T122 T123 Medication 2252 2255 FFP E95 Medication:T123 R77 IDENTICAL Arg1:E95 Arg2:E91 R78 SUB_PROCEDURE Arg1:E91 Arg2:E90 R79 SUB_PROCEDURE Arg1:E92 Arg2:E90 R80 SUB_PROCEDURE Arg1:E93 Arg2:E90 R81 SUB_PROCEDURE Arg1:E94 Arg2:E90 T124 Diagnostic_procedure 2336 2363 thromboelastometry analysis E96 Diagnostic_procedure:T124 T125 Coreference 2392 2399 surgery E97 Coreference:T125 R82 IDENTICAL Arg1:E97 Arg2:E86 T126 Sign_symptom 2439 2460 hypocoagulation state E98 Sign_symptom:T126 T127 Severity 2434 2438 mild R83 MODIFY Arg1:T127 Arg2:E98 T128 Clinical_event 2478 2486 admitted E99 Clinical_event:T128 T129 Nonbiological_location 2494 2513 intensive care unit T130 Nonbiological_location 2515 2518 ICU R84 IDENTICAL Arg1:T130 Arg2:T129 R85 MODIFY Arg1:T129 Arg2:E99 T131 Sign_symptom 2533 2539 stable E100 Sign_symptom:T131 T132 Sign_symptom 2549 2557 bleeding E101 Sign_symptom:T132 A5 POLARITY E101 NEG T133 Therapeutic_procedure 2569 2583 recovery phase E102 Therapeutic_procedure:T133 T134 Nonbiological_location 2613 2616 ICU R86 MODIFY Arg1:T134 Arg2:E7 T135 Date 2617 2629 3 days after E103 Date:T135 T136 Clinical_event 2630 2639 admission E104 Clinical_event:T136 T137 Date 2649 2661 3 days later E105 Date:T137 T138 Nonbiological_location 2690 2698 hospital R87 MODIFY Arg1:T138 Arg2:E8 * OVERLAP E9 E1 E2 E3 E4 E5 E6 E10 E12 E14 E16 E17 E19 E49 E50 E51 R88 BEFORE Arg1:E51 Arg2:E54 R89 BEFORE Arg1:E54 Arg2:E55 * OVERLAP E55 E56 E57 E59 E60 R90 BEFORE Arg1:E60 Arg2:E61 * OVERLAP E61 E62 E63 E64 E78 E79 E81 E83 E84 E86 E88 E89 E90 E96 E97 E98 R91 BEFORE Arg1:E98 Arg2:E99 * OVERLAP E99 E100 R92 BEFORE Arg1:E100 Arg2:E101 * OVERLAP E101 E102 R93 BEFORE Arg1:E102 Arg2:E7 * OVERLAP E7 E103 R94 AFTER Arg1:E103 Arg2:E104 R95 BEFORE Arg1:E104 Arg2:E105 * OVERLAP E105 E8