--- a
+++ b/processing/MACCROBAT/26361640.ann
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+T1	Age 2 13	68-year-old
+T2	Sex 14 20	female
+T3	History 21 30	nonsmoker
+T4	History 32 42	nondrinker
+T5	Disease_disorder 69 81	hypertension
+E1	Disease_disorder:T5 
+T6	History 69 81	hypertension
+T7	Clinical_event 82 91	presented
+E2	Clinical_event:T7 
+T8	Sign_symptom 116 124	jaundice
+E3	Sign_symptom:T8 
+T9	Sign_symptom 129 137	pruritus
+E4	Sign_symptom:T9 
+T10	Detailed_description 97 106	new-onset
+T11	Detailed_description 107 115	painless
+R1	MODIFY Arg1:T11 Arg2:E3	
+R2	MODIFY Arg1:T10 Arg2:E3	
+T12	Duration 141 152	three-month
+E5	Duration:T12 
+T13	Sign_symptom 171 182	weight loss
+E6	Sign_symptom:T13 
+T14	Lab_value 164 170	9.9 kg
+R3	MODIFY Arg1:T14 Arg2:E6	
+T15	Sign_symptom 195 203	diarrhea
+E7	Sign_symptom:T15 
+T16	Detailed_description 187 194	chronic
+R4	MODIFY Arg1:T16 Arg2:E7	
+T17	Diagnostic_procedure 228 243	bowel movements
+E8	Diagnostic_procedure:T17 
+T18	Lab_value 222 227	loose
+T19	Lab_value 209 221	four to five
+R5	MODIFY Arg1:T19 Arg2:E8	
+R6	MODIFY Arg1:T18 Arg2:E8	
+T20	Detailed_description 244 251	per day
+R7	MODIFY Arg1:T20 Arg2:E8	
+T21	Medication 253 264	Medications
+E9	Medication:T21 
+T22	Medication 274 283	vitamin D
+E10	Medication:T22 
+T23	Medication 285 295	amlodipine
+E11	Medication:T23 
+T24	Medication 300 310	eprosartan
+E12	Medication:T24 
+T25	Diagnostic_procedure 312 332	Physical examination
+E13	Diagnostic_procedure:T25 
+T26	Lab_value 337 343	normal
+R8	MODIFY Arg1:T26 Arg2:E13	
+T27	Sign_symptom 355 363	jaundice
+E14	Sign_symptom:T27 
+T28	Disease_disorder 368 382	muscle wasting
+E15	Disease_disorder:T28 
+T29	Diagnostic_procedure 391 402	colonoscopy
+E16	Diagnostic_procedure:T29 
+T30	Lab_value 412 418	normal
+R9	MODIFY Arg1:T30 Arg2:E16	
+T31	Diagnostic_procedure 437 446	bilirubin
+E17	Diagnostic_procedure:T31 
+T32	Lab_value 459 469	6.84 mg/dL
+T33	Lab_value 471 484	116.96 μmol/L
+T34	Lab_value 490 500	9.18 mg/dL
+T35	Lab_value 502 515	156.98 μmol/L
+R10	MODIFY Arg1:T32 Arg2:E17	
+R11	MODIFY Arg1:T33 Arg2:E17	
+R12	MODIFY Arg1:T34 Arg2:E17	
+R13	MODIFY Arg1:T35 Arg2:E17	
+T36	Detailed_description 420 425	Total
+T37	Detailed_description 430 436	direct
+R14	MODIFY Arg1:T37 Arg2:T34	
+R15	MODIFY Arg1:T37 Arg2:T35	
+R16	MODIFY Arg1:T36 Arg2:T32	
+R17	MODIFY Arg1:T36 Arg2:T33	
+T38	Diagnostic_procedure 558 588	international normalized ratio
+E18	Diagnostic_procedure:T38 
+T39	Lab_value 592 595	1.0
+R18	MODIFY Arg1:T39 Arg2:E18	
+T40	Diagnostic_procedure 597 621	alanine aminotransferase
+E19	Diagnostic_procedure:T40 
+T41	Lab_value 628 635	247 U/L
+R19	MODIFY Arg1:T41 Arg2:E19	
+T42	Diagnostic_procedure 654 680	aspartate aminotransferase
+E20	Diagnostic_procedure:T42 
+T43	Lab_value 687 694	139 U/L
+R20	MODIFY Arg1:T43 Arg2:E20	
+T44	Diagnostic_procedure 716 736	alkaline phosphatase
+E21	Diagnostic_procedure:T44 
+T45	Lab_value 743 750	524 U/L
+R21	MODIFY Arg1:T45 Arg2:E21	
+T46	Diagnostic_procedure 775 801	Viral hepatitis serologies
+E22	Diagnostic_procedure:T46 
+T47	Diagnostic_procedure 807 833	antimitochondrial antibody
+E23	Diagnostic_procedure:T47 
+T48	Diagnostic_procedure 838 865	anti-smooth muscle antibody
+E24	Diagnostic_procedure:T48 
+T49	Lab_value 877 885	negative
+R22	MODIFY Arg1:T49 Arg2:E24	
+R23	MODIFY Arg1:T49 Arg2:E23	
+R24	MODIFY Arg1:T49 Arg2:E22	
+T50	Diagnostic_procedure 891 908	alpha-fetoprotein
+E25	Diagnostic_procedure:T50 
+T51	Lab_value 919 928	2.4 ng/mL
+R25	MODIFY Arg1:T51 Arg2:E25	
+T52	Diagnostic_procedure 948 975	total immunoglobulin (Ig) G
+E26	Diagnostic_procedure:T52 
+T53	Lab_value 980 990	1880 mg/dL
+R26	MODIFY Arg1:T53 Arg2:E26	
+T54	Diagnostic_procedure 1012 1037	carbohydrate antigen 19-9
+E27	Diagnostic_procedure:T54 
+T55	Lab_value 1042 1050	856 U/mL
+R27	MODIFY Arg1:T55 Arg2:E27	
+T56	Diagnostic_procedure 1073 1077	IgG4
+E28	Diagnostic_procedure:T56 
+T57	Lab_value 1082 1089	890 g/L
+R28	MODIFY Arg1:T57 Arg2:E28	
+T58	Diagnostic_procedure 1115 1125	ultrasound
+E29	Diagnostic_procedure:T58 
+T59	Detailed_description 1107 1114	Doppler
+R29	MODIFY Arg1:T59 Arg2:E29	
+T60	Diagnostic_procedure 1127 1170	magnetic resonance cholangiopancreatography
+E30	Diagnostic_procedure:T60 
+T61	Diagnostic_procedure 1175 1201	magnetic resonance imaging
+E31	Diagnostic_procedure:T61 
+T62	Biological_structure 1209 1214	liver
+R30	MODIFY Arg1:T62 Arg2:E31	
+T63	Sign_symptom 1254 1258	mass
+E32	Sign_symptom:T63 
+T64	Detailed_description 1237 1253	subtly enhancing
+R31	MODIFY Arg1:T64 Arg2:E32	
+T65	Distance 1260 1276	2.8 cm to 4.2 cm
+R32	MODIFY Arg1:T65 Arg2:E32	
+T66	Biological_structure 1311 1316	hilum
+T67	Biological_structure 1321 1334	porta hepatis
+R33	MODIFY Arg1:T66 Arg2:E32	
+R34	MODIFY Arg1:T67 Arg2:E32	
+T68	Sign_symptom 1336 1347	obstructing
+E33	Sign_symptom:T68 
+T69	Biological_structure 1357 1385	right and left hepatic ducts
+R35	MODIFY Arg1:T69 Arg2:E33	
+T70	Diagnostic_procedure 1409 1433	cholangiopancreatography
+E34	Diagnostic_procedure:T70 
+T71	Detailed_description 1398 1408	retrograde
+T72	Detailed_description 1387 1397	Endoscopic
+R36	MODIFY Arg1:T71 Arg2:E34	
+R37	MODIFY Arg1:T72 Arg2:E34	
+T73	Sign_symptom 1445 1455	strictures
+E35	Sign_symptom:T73 
+T74	Biological_structure 1463 1514	central portions of the right and left hepatic duct
+R38	MODIFY Arg1:T74 Arg2:E35	
+T75	Disease_disorder 1541 1559	cholangiocarcinoma
+E36	Disease_disorder:T75 
+A1	POLARITY E36 UNCERTAIN
+T77	Diagnostic_procedure 1572 1589	Biliary brushings
+E38	Diagnostic_procedure:T77 
+T76	Lab_value 1595 1618	negative for malignancy
+R39	MODIFY Arg1:T76 Arg2:E38	
+T78	Diagnostic_procedure 1620 1646	Esophagogastroduodenoscopy
+E37	Diagnostic_procedure:T78 
+T79	Lab_value 1651 1657	normal
+R40	MODIFY Arg1:T79 Arg2:E37	
+T80	Diagnostic_procedure 1659 1667	Biopsies
+E39	Diagnostic_procedure:T80 
+T81	Biological_structure 1675 1691	ampulla of Vater
+R41	MODIFY Arg1:T81 Arg2:E39	
+T82	Disease_disorder 1716 1726	duodenitis
+E40	Disease_disorder:T82 
+T83	Detailed_description 1709 1715	active
+T84	Detailed_description 1701 1708	chronic
+R42	MODIFY Arg1:T83 Arg2:E40	
+R43	MODIFY Arg1:T84 Arg2:E40	
+T85	Diagnostic_procedure 1756 1770	ancillary test
+E41	Diagnostic_procedure:T85 
+T86	Lab_value 1771 1794	confirmed the diagnosis
+R44	MODIFY Arg1:T86 Arg2:E41	
+T87	Medication 1822 1837	corticosteroids
+E42	Medication:T87 
+T88	Disease_disorder 1892 1905	abnormalities
+E43	Disease_disorder:T88 
+A2	POLARITY E43 NEG
+T89	Date 1906 1925	within three months
+E44	Date:T89 
+T90	Detailed_description 1863 1874	biochemical
+T91	Detailed_description 1879 1891	radiological
+R45	MODIFY Arg1:T91 Arg2:E43	
+R46	MODIFY Arg1:T90 Arg2:E43	
+R47	BEFORE Arg1:E1 Arg2:E2	
+*	OVERLAP E2 E3 E4
+R48	AFTER Arg1:E4 Arg2:E5	
+*	OVERLAP E5 E6 E7 E8 E9
+R49	SUB_PROCEDURE Arg1:E10 Arg2:E9	
+R50	SUB_PROCEDURE Arg1:E11 Arg2:E9	
+R51	SUB_PROCEDURE Arg1:E12 Arg2:E9	
+R52	BEFORE Arg1:E9 Arg2:E13	
+*	OVERLAP E13 E14 E15
+R53	AFTER Arg1:E15 Arg2:E16	
+R54	BEFORE Arg1:E16 Arg2:E17	
+*	OVERLAP E17 E18 E19 E20 E21 E22 E23 E24 E25 E26 E27 E28 E29 E30 E31 E32 E33 E34 E35 E36 E38 E37 E39 E40 E41
+R55	BEFORE Arg1:E41 Arg2:E42	
+R56	BEFORE Arg1:E42 Arg2:E43	
+*	OVERLAP E43 E44