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T1 Age 2 13 60-year-old T2 Sex 14 18 male T3 History 85 93 diabetes T4 History 98 117 alcoholic hepatitis T5 Disease_disorder 98 117 alcoholic hepatitis E1 Disease_disorder:T5 T6 Disease_disorder 85 93 diabetes E2 Disease_disorder:T6 T7 Diagnostic_procedure 122 142 physical examination E3 Diagnostic_procedure:T7 T8 Activity 19 26 visited E4 Activity:T8 T9 Nonbiological_location 31 48 outpatient clinic R1 MODIFY Arg1:T9 Arg2:E4 T10 Sign_symptom 56 60 mass E5 Sign_symptom:T10 T11 Biological_structure 68 76 left hip R2 MODIFY Arg1:T11 Arg2:E5 T12 Sign_symptom 152 156 mass E6 Sign_symptom:T12 T13 Medication 2435 2447 chemotherapy E7 Medication:T13 T14 Medication 2457 2466 etoposide E8 Medication:T14 T15 Medication 2471 2480 cisplatin E9 Medication:T15 R3 SUB_PROCEDURE Arg1:E8 Arg2:E7 R4 SUB_PROCEDURE Arg1:E9 Arg2:E7 T16 Distance 167 172 10 cm R5 MODIFY Arg1:T16 Arg2:E6 T17 Sign_symptom 262 270 palpable E10 Sign_symptom:T17 T18 Biological_structure 233 257 left inguinal lymph node T19 Distance 228 232 5 cm R6 MODIFY Arg1:T19 Arg2:E10 R7 MODIFY Arg1:T18 Arg2:E10 T20 Biological_structure 205 208 hip R8 MODIFY Arg1:T20 Arg2:E6 T21 Diagnostic_procedure 290 303 tumor markers E11 Diagnostic_procedure:T21 T22 Detailed_description 284 289 Serum R9 MODIFY Arg1:T22 Arg2:E11 T23 Diagnostic_procedure 315 318 CEA E12 Diagnostic_procedure:T23 T24 Diagnostic_procedure 323 330 CA 19-9 E13 Diagnostic_procedure:T24 R10 SUB_PROCEDURE Arg1:E12 Arg2:E11 R11 SUB_PROCEDURE Arg1:E13 Arg2:E11 T25 Qualitative_concept 337 357 within normal limits R12 MODIFY Arg1:T25 Arg2:E11 T26 Diagnostic_procedure 373 380 amylase E14 Diagnostic_procedure:T26 T27 Lab_value 382 390 227 IU/L R13 MODIFY Arg1:T27 Arg2:E14 T28 Diagnostic_procedure 419 425 lipase E15 Diagnostic_procedure:T28 T29 Detailed_description 367 372 serum R14 MODIFY Arg1:T29 Arg2:E14 R15 MODIFY Arg1:T29 Arg2:E15 T30 Lab_value 427 435 378 IU/L R16 MODIFY Arg1:T30 Arg2:E15 T31 Diagnostic_procedure 457 476 fasting blood sugar E16 Diagnostic_procedure:T31 T32 Lab_value 478 487 144 mg/dL R17 MODIFY Arg1:T32 Arg2:E16 T33 Diagnostic_procedure 522 541 liver function test E17 Diagnostic_procedure:T33 T34 Diagnostic_procedure 560 586 aspartate aminotransferase E18 Diagnostic_procedure:T34 R18 SUB_PROCEDURE Arg1:E18 Arg2:E17 T35 Diagnostic_procedure 624 648 alanine aminotransferase E19 Diagnostic_procedure:T35 R19 SUB_PROCEDURE Arg1:E19 Arg2:E17 T36 Lab_value 588 596 178 IU/L R20 MODIFY Arg1:T36 Arg2:E18 T37 Lab_value 650 658 225 IU/L R21 MODIFY Arg1:T37 Arg2:E19 T38 Diagnostic_procedure 696 716 alkaline phosphatase E20 Diagnostic_procedure:T38 T39 Detailed_description 690 695 serum R22 MODIFY Arg1:T39 Arg2:E20 T40 Lab_value 718 726 370 IU/L R23 MODIFY Arg1:T40 Arg2:E20 T41 Qualitative_concept 766 785 above normal ranges R24 MODIFY Arg1:T41 Arg2:E17 R25 MODIFY Arg1:T41 Arg2:E14 R26 MODIFY Arg1:T41 Arg2:E15 R27 MODIFY Arg1:T41 Arg2:E16 T42 Diagnostic_procedure 800 823 computerized tomography E21 Diagnostic_procedure:T42 T43 Diagnostic_procedure 825 827 CT E22 Diagnostic_procedure:T43 R28 IDENTICAL Arg1:E22 Arg2:E21 T44 Biological_structure 790 799 abdominal R29 MODIFY Arg1:T44 Arg2:E21 T45 Sign_symptom 867 871 mass E23 Sign_symptom:T45 T46 Biological_structure 858 866 left hip R30 MODIFY Arg1:T46 Arg2:E23 T47 Sign_symptom 879 887 enlarged E24 Sign_symptom:T47 T48 Biological_structure 888 912 left inguinal lymph node R31 MODIFY Arg1:T48 Arg2:E24 T49 Sign_symptom 954 958 mass E25 Sign_symptom:T49 T50 Detailed_description 930 943 heterogeneous T51 Detailed_description 944 953 enhancing T52 Qualitative_concept 925 929 huge R32 MODIFY Arg1:T52 Arg2:E25 R33 MODIFY Arg1:T50 Arg2:E25 R34 MODIFY Arg1:T51 Arg2:E25 T53 Biological_structure 978 986 pancreas R35 MODIFY Arg1:T53 Arg2:E25 T54 Diagnostic_procedure 1005 1013 PET scan E26 Diagnostic_procedure:T54 T55 Disease_disorder 1026 1036 metastases E27 Disease_disorder:T55 A1 POLARITY E27 NEG T56 Therapeutic_procedure 1066 1080 staged surgery E28 Therapeutic_procedure:T56 T57 Therapeutic_procedure 1114 1127 mass excision E29 Therapeutic_procedure:T57 R36 SUB_PROCEDURE Arg1:E29 Arg2:E28 T58 Biological_structure 1105 1113 inguinal T59 Biological_structure 1097 1100 hip R37 MODIFY Arg1:T58 Arg2:E29 R38 MODIFY Arg1:T59 Arg2:E29 T60 Date 1131 1148 December 19, 2014 E30 Date:T60 T61 Diagnostic_procedure 1154 1178 histopathological report E31 Diagnostic_procedure:T61 T62 Disease_disorder 1212 1236 neuroendocrine carcinoma E32 Disease_disorder:T62 T63 Detailed_description 1190 1200 metastatic T64 Detailed_description 1201 1211 small cell R39 MODIFY Arg1:T64 Arg2:E32 R40 MODIFY Arg1:T63 Arg2:E32 T65 Distance 1244 1271 maximal diameter of 10.5 cm R41 MODIFY Arg1:T65 Arg2:E33 T66 Sign_symptom 1287 1291 mass E33 Sign_symptom:T66 T67 Sign_symptom 1303 1309 growth E34 Sign_symptom:T67 T68 Biological_structure 1279 1286 buttock R42 MODIFY Arg1:T68 Arg2:E33 T69 Distance 1298 1302 7 cm R43 MODIFY Arg1:T69 Arg2:E34 T70 Biological_structure 1316 1335 inguinal lymph node R44 MODIFY Arg1:T70 Arg2:E34 T71 Diagnostic_procedure 1341 1354 mitotic index E35 Diagnostic_procedure:T71 T72 Lab_value 1359 1385 over 50 mitoses per 50 HPF E36 Lab_value:T72 R45 MODIFY Arg1:E36 Arg2:E35 T73 Diagnostic_procedure 1394 1405 Ki-67 index E37 Diagnostic_procedure:T73 T74 Lab_value 1418 1421 50% E38 Lab_value:T74 R46 MODIFY Arg1:E38 Arg2:E37 T75 Date 1426 1442 January 21, 2015 E39 Date:T75 T76 Therapeutic_procedure 1465 1479 pancreatectomy E40 Therapeutic_procedure:T76 T77 Detailed_description 1459 1464 total T78 Detailed_description 1486 1491 total T79 Therapeutic_procedure 1492 1503 gastrectomy E41 Therapeutic_procedure:T79 R47 MODIFY Arg1:T78 Arg2:E41 R48 MODIFY Arg1:T77 Arg2:E40 T80 Sign_symptom 1535 1540 tumor E42 Sign_symptom:T80 T81 Biological_structure 1560 1568 pancreas R49 MODIFY Arg1:T81 Arg2:E42 T82 Area 1575 1598 9 cm × 6 cm in diameter R50 MODIFY Arg1:T82 Arg2:E42 T83 Biological_structure 1613 1632 left gastric artery T84 Biological_structure 1634 1648 splenic artery T85 Biological_structure 1654 1666 splenic vein R51 MODIFY Arg1:T83 Arg2:E42 T86 Diagnostic_procedure 1672 1696 histopathological report E43 Diagnostic_procedure:T86 R52 MODIFY Arg1:T84 Arg2:E42 R53 MODIFY Arg1:T85 Arg2:E42 T87 Sign_symptom 1734 1740 lesion E44 Sign_symptom:T87 T88 Detailed_description 1723 1733 metastatic R54 MODIFY Arg1:T88 Arg2:E44 T89 Sign_symptom 1760 1765 tumor E45 Sign_symptom:T89 T90 Biological_structure 1792 1803 lymph nodes R55 MODIFY Arg1:T90 Arg2:E45 T91 Quantitative_concept 1780 1791 8 of the 32 R56 MODIFY Arg1:T91 Arg2:T90 T92 Date 1824 1846 7th post-operative day E46 Date:T92 T93 Sign_symptom 1877 1882 fever E47 Sign_symptom:T93 T94 Sign_symptom 1887 1899 leukocytosis E48 Sign_symptom:T94 T95 Severity 1872 1876 high R57 MODIFY Arg1:T95 Arg2:E47 T96 Diagnostic_procedure 1930 1932 CT E49 Diagnostic_procedure:T96 T97 Biological_structure 1920 1929 abdominal R58 MODIFY Arg1:T97 Arg2:E49 T98 Sign_symptom 1963 1979 fluid collection E50 Sign_symptom:T98 T99 Detailed_description 1954 1962 infected R59 MODIFY Arg1:T99 Arg2:E50 T100 Biological_structure 1987 1997 lesser sac R60 MODIFY Arg1:T100 Arg2:E50 T101 Distance 2004 2016 4.7 cm-sized T102 Sign_symptom 2027 2031 mass E51 Sign_symptom:T102 T103 Detailed_description 2017 2026 recurring R61 MODIFY Arg1:T103 Arg2:E51 R62 MODIFY Arg1:T101 Arg2:E51 T104 Biological_structure 2079 2087 left hip R63 MODIFY Arg1:T104 Arg2:E51 T105 Disease_disorder 2117 2126 infection E52 Disease_disorder:T105 T106 Biological_structure 2134 2150 abdominal cavity R64 MODIFY Arg1:T106 Arg2:E52 T107 Medication 2166 2177 antibiotics E53 Medication:T107 T108 Therapeutic_procedure 2182 2189 removed E54 Therapeutic_procedure:T108 T109 Sign_symptom 2213 2217 mass E55 Sign_symptom:T109 R65 MODIFY Arg1:E55 Arg2:E54 T110 Detailed_description 2203 2212 recurring T111 Biological_structure 2194 2202 left hip R66 MODIFY Arg1:T110 Arg2:E55 R67 MODIFY Arg1:T111 Arg2:E55 T112 Date 2221 2237 February 3, 2015 E56 Date:T112 T113 Diagnostic_procedure 2243 2257 histopathology E57 Diagnostic_procedure:T113 T114 Distance 2305 2331 maximum diameter of 7.5 cm #1 AnnotatorNotes T114 Not connected as this is an implicit coreference T115 Disease_disorder 2374 2387 complications E58 Disease_disorder:T115 A2 POLARITY E58 NEG T116 Date 2391 2407 February 9, 2015 E59 Date:T116 * OVERLAP E4 E5 R68 AFTER Arg1:E5 Arg2:E2 * OVERLAP E2 E1 R69 BEFORE Arg1:E1 Arg2:E3 * OVERLAP E3 E6 E10 E11 E14 E15 E16 E17 E20 E21 E23 E24 E25 E26 E27 T117 Detailed_description 146 151 large R70 MODIFY Arg1:T117 Arg2:E6 R71 BEFORE Arg1:E27 Arg2:E28 * OVERLAP E28 E30 R72 BEFORE Arg1:E30 Arg2:E31 * OVERLAP E31 E32 E33 E34 E35 E37 R73 BEFORE Arg1:E37 Arg2:E39 * OVERLAP E39 E40 E41 E42 R74 BEFORE Arg1:E42 Arg2:E43 * OVERLAP E43 E44 E45 R75 BEFORE Arg1:E45 Arg2:E46 * OVERLAP E46 E47 E48 E49 E50 E51 E52 R76 BEFORE Arg1:E52 Arg2:E53 R77 BEFORE Arg1:E53 Arg2:E54 * OVERLAP E54 E56 R78 BEFORE Arg1:E56 Arg2:E57 T118 Clinical_event 2349 2359 discharged E60 Clinical_event:T118 R79 BEFORE Arg1:E57 Arg2:E60 * OVERLAP E60 E58 E59 R80 BEFORE Arg1:E59 Arg2:E7