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T1 Age 2 13 50-year-old T2 Sex 14 18 male T3 Clinical_event 31 39 admitted E1 Clinical_event:T3 T4 Nonbiological_location 47 57 Department R1 MODIFY Arg1:T4 Arg2:E1 T5 Sign_symptom 72 78 nodule E2 Sign_symptom:T5 T6 Biological_structure 64 71 thyroid R2 MODIFY Arg1:T6 Arg2:E2 T7 Biological_structure 86 108 right side of the neck R3 MODIFY Arg1:T7 Arg2:E2 T8 Diagnostic_procedure 161 171 ultrasound E3 Diagnostic_procedure:T8 T9 Detailed_description 153 160 Doppler R4 MODIFY Arg1:T9 Arg2:E3 T10 Biological_structure 145 152 carotid R5 MODIFY Arg1:T10 Arg2:E3 T11 Diagnostic_procedure 178 209 Fine-needle aspiration cytology E4 Diagnostic_procedure:T11 T12 Diagnostic_procedure 211 215 FNAC E5 Diagnostic_procedure:T12 R6 IDENTICAL Arg1:E5 Arg2:E4 T13 Sign_symptom 237 243 lesion E6 Sign_symptom:T13 T14 Detailed_description 226 236 follicular R7 MODIFY Arg1:T14 Arg2:E6 T15 Diagnostic_procedure 264 274 evaluation E7 Diagnostic_procedure:T15 T16 Diagnostic_procedure 300 306 health E8 Diagnostic_procedure:T16 T17 Lab_value 295 299 good E9 Lab_value:T17 R8 MODIFY Arg1:E9 Arg2:E8 T18 History 337 349 hypertension T19 History 351 359 vitiligo T20 History 365 379 celiac disease T21 Sign_symptom 337 349 hypertension E10 Sign_symptom:T21 T22 Disease_disorder 351 359 vitiligo E11 Disease_disorder:T22 T23 Disease_disorder 365 379 celiac disease E12 Disease_disorder:T23 T24 Diagnostic_procedure 384 404 physical examination E13 Diagnostic_procedure:T24 T25 Sign_symptom 414 420 nodule E14 Sign_symptom:T25 T26 Detailed_description 408 413 small R9 MODIFY Arg1:T26 Arg2:E14 T27 Distance 422 426 1 cm R10 MODIFY Arg1:T27 Arg2:E14 T28 Biological_structure 448 466 right thyroid lobe R11 MODIFY Arg1:T28 Arg2:E14 T29 Sign_symptom 471 479 enlarged E15 Sign_symptom:T29 A1 POLARITY E15 NEG T30 Biological_structure 480 496 neck lymph nodes R12 MODIFY Arg1:T30 Arg2:E15 T31 Diagnostic_procedure 517 527 ultrasound E16 Diagnostic_procedure:T31 T32 Biological_structure 512 516 Neck R13 MODIFY Arg1:T32 Arg2:E16 T33 Distance 537 543 1.3 cm T34 Sign_symptom 555 561 nodule E17 Sign_symptom:T34 T35 Detailed_description 544 554 hypoechoic R14 MODIFY Arg1:T35 Arg2:E17 R15 MODIFY Arg1:T33 Arg2:E17 T36 Detailed_description 567 584 irregular margins R16 MODIFY Arg1:T36 Arg2:E17 T37 Biological_structure 592 610 right thyroid lobe R17 MODIFY Arg1:T37 Arg2:E17 T38 Sign_symptom 649 656 nodules E18 Sign_symptom:T38 T39 Biological_structure 641 648 thyroid R18 MODIFY Arg1:T39 Arg2:E18 T40 Detailed_description 625 634 bilateral T41 Detailed_description 635 640 small R19 MODIFY Arg1:T41 Arg2:E18 R20 MODIFY Arg1:T40 Arg2:E18 T42 Distance 658 664 4–5 mm R21 MODIFY Arg1:T42 Arg2:E18 T43 Sign_symptom 685 693 enlarged E19 Sign_symptom:T43 A2 POLARITY E19 NEG T44 Biological_structure 694 724 cervical bilateral lymph nodes R22 MODIFY Arg1:T44 Arg2:E19 T45 Diagnostic_procedure 726 748 Thyroid function tests E20 Diagnostic_procedure:T45 T46 Lab_value 754 760 normal E21 Lab_value:T46 R23 MODIFY Arg1:E21 Arg2:E20 T47 Sign_symptom 781 803 thyroid autoantibodies E22 Sign_symptom:T47 A3 POLARITY E22 NEG T48 Diagnostic_procedure 811 818 calcium E23 Diagnostic_procedure:T48 T49 Detailed_description 805 810 Serum R24 MODIFY Arg1:T49 Arg2:E23 T50 Lab_value 823 829 normal E24 Lab_value:T50 R25 MODIFY Arg1:E24 Arg2:E23 T51 Lab_value 831 840 9.7 mg/dl E25 Lab_value:T51 R26 MODIFY Arg1:E25 Arg2:E23 T52 Diagnostic_procedure 876 879 PTH E26 Diagnostic_procedure:T52 T53 Lab_value 982 999 slightly elevated E27 Lab_value:T53 R27 MODIFY Arg1:E27 Arg2:E26 T54 Lab_value 1001 1009 68 pg/mL E28 Lab_value:T54 R28 MODIFY Arg1:E28 Arg2:E26 T55 Diagnostic_procedure 920 927 calcium E29 Diagnostic_procedure:T55 T56 Detailed_description 914 919 serum R29 MODIFY Arg1:T56 Arg2:E29 T57 Therapeutic_procedure 973 980 surgery E30 Therapeutic_procedure:T57 T58 Biological_structure 965 972 thyroid R30 MODIFY Arg1:T58 Arg2:E30 T59 Nonbiological_location 935 941 Center R31 MODIFY Arg1:T59 Arg2:E29 R32 MODIFY Arg1:T59 Arg2:E26 T60 Diagnostic_procedure 1114 1118 FNAC E31 Diagnostic_procedure:T60 T61 Sign_symptom 1142 1148 lesion E32 Sign_symptom:T61 T62 Biological_structure 1131 1141 follicular R33 MODIFY Arg1:T62 Arg2:E32 T63 Diagnostic_procedure 1169 1177 cytology E33 Diagnostic_procedure:T63 T64 Therapeutic_procedure 1407 1416 lobectomy E34 Therapeutic_procedure:T64 T65 Detailed_description 1401 1406 right R34 MODIFY Arg1:T65 Arg2:E34 T66 Diagnostic_procedure 1430 1441 exploration E35 Diagnostic_procedure:T66 T67 Biological_structure 1425 1429 neck R35 MODIFY Arg1:T67 Arg2:E35 T68 Diagnostic_procedure 1594 1603 histology E36 Diagnostic_procedure:T68 T69 Diagnostic_procedure 1883 1909 light microscopic findings E37 Diagnostic_procedure:T69 T70 Diagnostic_procedure 1918 1945 immunohistochemical profile E38 Diagnostic_procedure:T70 T71 Disease_disorder 1579 1581 PC E39 Disease_disorder:T71 A4 POLARITY E39 UNCERTAIN #1 AnnotatorNotes E39 Parathyroid carcinoma T72 Disease_disorder 1976 1978 PC E40 Disease_disorder:T72 #2 AnnotatorNotes E40 Parathyroid carcinoma T73 Diagnostic_procedure 2000 2007 calcium E41 Diagnostic_procedure:T73 T74 Diagnostic_procedure 2024 2033 phosphate E42 Diagnostic_procedure:T74 T75 Diagnostic_procedure 2108 2115 calcium E43 Diagnostic_procedure:T75 T76 Diagnostic_procedure 2127 2130 PTH E44 Diagnostic_procedure:T76 T77 Diagnostic_procedure 2179 2189 ultrasound E45 Diagnostic_procedure:T77 T78 Diagnostic_procedure 2205 2224 computed tomography E46 Diagnostic_procedure:T78 T79 Date 2278 2296 Eight months later E47 Date:T79 T80 Diagnostic_procedure 2304 2311 calcium E48 Diagnostic_procedure:T80 T81 Diagnostic_procedure 2447 2457 ultrasound E49 Diagnostic_procedure:T81 T82 Biological_structure 2442 2446 Neck R36 MODIFY Arg1:T82 Arg2:E49 T83 Sign_symptom 2488 2495 lesions E50 Sign_symptom:T83 A5 POLARITY E50 NEG T84 Detailed_description 2475 2487 pathological R37 MODIFY Arg1:T84 Arg2:E50 T85 Disease_disorder 2536 2540 PHPT E51 Disease_disorder:T85 A6 POLARITY E51 NEG T86 Disease_disorder 2551 2553 PC E52 Disease_disorder:T86 T87 Sign_symptom 2591 2596 tumor E53 Sign_symptom:T87 T88 Detailed_description 2576 2590 nonfunctioning R38 MODIFY Arg1:T88 Arg2:E53 T89 Diagnostic_procedure 2626 2633 calcium E54 Diagnostic_procedure:T89 T90 Detailed_description 2620 2625 serum R39 MODIFY Arg1:T90 Arg2:E54 T91 Biological_structure 2638 2642 neck T92 Diagnostic_procedure 2643 2653 ultrasound E55 Diagnostic_procedure:T92 T93 Subject 2661 2683 first-degree relatives R40 MODIFY Arg1:T93 Arg2:E55 R41 MODIFY Arg1:T91 Arg2:E55 R42 MODIFY Arg1:T93 Arg2:E54 T94 Lab_value 2688 2694 normal E56 Lab_value:T94 R43 MODIFY Arg1:E56 Arg2:E55 R44 MODIFY Arg1:E56 Arg2:E54 T95 Detailed_description 2316 2322 plasma T96 Detailed_description 2298 2303 serum R45 MODIFY Arg1:T96 Arg2:E48 T97 Diagnostic_procedure 2323 2326 PTH E57 Diagnostic_procedure:T97 R46 MODIFY Arg1:T95 Arg2:E57 T98 Lab_value 2339 2352 9.1–9.2 mg/dl E58 Lab_value:T98 T99 Lab_value 2357 2368 38–44 pg/ml E59 Lab_value:T99 R47 MODIFY Arg1:E58 Arg2:E48 R48 MODIFY Arg1:E59 Arg2:E57 T100 Biological_structure 2174 2178 Neck T101 Biological_structure 2194 2204 total body R49 MODIFY Arg1:T100 Arg2:E45 R50 MODIFY Arg1:T101 Arg2:E46 T102 Disease_disorder 2269 2276 disease E60 Disease_disorder:T102 A7 POLARITY E60 NEG T103 Detailed_description 2258 2268 metastatic T104 Detailed_description 2248 2253 local R51 MODIFY Arg1:T103 Arg2:E60 R52 MODIFY Arg1:T104 Arg2:E60 T105 Therapeutic_procedure 2093 2100 surgery E61 Therapeutic_procedure:T105 T106 Date 2077 2092 One month after E62 Date:T106 T107 Detailed_description 2102 2107 serum T108 Detailed_description 2120 2126 plasma R53 MODIFY Arg1:T107 Arg2:E43 R54 MODIFY Arg1:T108 Arg2:E44 T109 Lab_value 2136 2145 9.6 mg/dL E63 Lab_value:T109 T110 Lab_value 2150 2158 47 pg/mL E64 Lab_value:T110 R55 MODIFY Arg1:E63 Arg2:E43 R56 MODIFY Arg1:E64 Arg2:E44 T111 Detailed_description 1994 1999 serum R57 MODIFY Arg1:T111 Arg2:E41 T112 Lab_value 2009 2018 8.7 mg/dl E65 Lab_value:T112 R58 MODIFY Arg1:E65 Arg2:E41 T113 Lab_value 2035 2042 3 mg/dl E66 Lab_value:T113 R59 MODIFY Arg1:E66 Arg2:E42 T114 Lab_value 2063 2075 normal range E67 Lab_value:T114 R60 MODIFY Arg1:E67 Arg2:E41 R61 MODIFY Arg1:E67 Arg2:E42 T115 Diagnostic_procedure 1740 1754 Immunostaining E68 Diagnostic_procedure:T115 T116 Diagnostic_procedure 1759 1772 thyroglobulin E69 Diagnostic_procedure:T116 T117 Diagnostic_procedure 1808 1822 chromogranin A E70 Diagnostic_procedure:T117 T118 Diagnostic_procedure 1827 1830 PTH E71 Diagnostic_procedure:T118 R62 SUB_PROCEDURE Arg1:E69 Arg2:E68 R63 SUB_PROCEDURE Arg1:E70 Arg2:E68 R64 SUB_PROCEDURE Arg1:E71 Arg2:E68 T119 Lab_value 1840 1857 strong reactivity E72 Lab_value:T119 R65 MODIFY Arg1:E72 Arg2:E71 R66 MODIFY Arg1:E72 Arg2:E70 T120 Lab_value 1777 1785 negative E73 Lab_value:T120 R67 MODIFY Arg1:E73 Arg2:E69 T121 Sign_symptom 1659 1664 tumor E74 Sign_symptom:T121 T122 Sign_symptom 1632 1651 infiltrative growth E75 Sign_symptom:T122 T123 Sign_symptom 1670 1678 invasion E76 Sign_symptom:T123 T124 Biological_structure 1686 1700 thyroid tissue T125 Biological_structure 1705 1726 cervical soft tissues R68 MODIFY Arg1:T124 Arg2:E76 R69 MODIFY Arg1:T125 Arg2:E76 T126 Sign_symptom 1484 1492 invasion E77 Sign_symptom:T126 A8 POLARITY E77 NEG T127 Detailed_description 1478 1483 local T128 Detailed_description 1457 1474 macroscopic signs R70 MODIFY Arg1:T127 Arg2:E77 R71 MODIFY Arg1:T128 Arg2:E77 T129 Diagnostic_procedure 1528 1552 pathological examination E78 Diagnostic_procedure:T129 T130 Detailed_description 1513 1527 frozen-section T131 Detailed_description 1498 1512 intraoperative R72 MODIFY Arg1:T130 Arg2:E78 R73 MODIFY Arg1:T131 Arg2:E78 T132 Detailed_description 1622 1631 irregular R74 MODIFY Arg1:T132 Arg2:E75 T133 Sign_symptom 1185 1191 nodule E79 Sign_symptom:T133 T134 Sign_symptom 1347 1354 lesions E80 Sign_symptom:T134 T135 Biological_structure 1328 1346 thyroid follicular R75 MODIFY Arg1:T135 Arg2:E80 T136 Other_event 1199 1305 epithelial cells with hyperchromatic nuclei organized in small cohesive clusters resembling microfollicles E81 Other_event:T136 #3 AnnotatorNotes E81 Cytology results R76 AFTER Arg1:E1 Arg2:E2 * OVERLAP E2 E3 E4 E6 R77 BEFORE Arg1:E6 Arg2:E7 * OVERLAP E7 E8 R78 AFTER Arg1:E8 Arg2:E10 * OVERLAP E10 E11 E12 R79 BEFORE Arg1:E12 Arg2:E13 * OVERLAP E13 E14 E82 E15 E83 E16 E17 E18 E19 E20 E22 E23 E26 E29 E31 E32 E33 E79 E80 T137 Sign_symptom 432 440 palpable E82 Sign_symptom:T137 R80 MODIFY Arg1:E14 Arg2:E82 T138 Sign_symptom 502 510 palpable E83 Sign_symptom:T138 R81 MODIFY Arg1:T30 Arg2:E83 A9 POLARITY E83 NEG R82 MODIFY Arg1:E81 Arg2:E33 R83 BEFORE Arg1:E80 Arg2:E34 * OVERLAP E34 E35 E77 E78 E39 R84 BEFORE Arg1:E39 Arg2:E36 * OVERLAP E36 E75 E74 E76 E68 E37 E38 E40 R85 BEFORE Arg1:E40 Arg2:E41 * OVERLAP E41 E42 R86 BEFORE Arg1:E42 Arg2:E62 R87 AFTER Arg1:E62 Arg2:E61 R88 BEFORE Arg1:E61 Arg2:E43 * OVERLAP E43 E44 E45 E46 E60 R89 BEFORE Arg1:E60 Arg2:E47 * OVERLAP E47 E48 E57 E49 E50 E51 E52 E53 E54 E55