--- a
+++ b/processing/MACCROBAT/26336183.ann
@@ -0,0 +1,427 @@
+T1	Age 2 13	35-year-old
+T2	Sex 14 19	woman
+T3	Duration 40 45	5-day
+E1	Duration:T3 
+T4	Clinical_event 24 32	admitted
+E2	Clinical_event:T4 
+T5	Sign_symptom 68 78	drowsiness
+E3	Sign_symptom:T5 
+A1	TREND E3 INC
+T6	Sign_symptom 80 87	fatigue
+E4	Sign_symptom:T6 
+A2	TREND E4 INC
+T7	Sign_symptom 89 108	personality changes
+E5	Sign_symptom:T7 
+A3	TREND E5 INC
+T8	Sign_symptom 122 130	weakness
+E6	Sign_symptom:T8 
+A4	TREND E6 INC
+T9	Detailed_description 110 121	generalised
+R1	MODIFY Arg1:T9 Arg2:E6	
+T10	Diagnostic_procedure 149 157	mobility
+E7	Diagnostic_procedure:T10 
+T11	Qualitative_concept 135 148	deteriorating
+R2	MODIFY Arg1:T11 Arg2:E7	
+T12	History 190 234	10-year history of schizo-affective disorder
+T13	History 236 270	lithium-induced diabetes insipidus
+T14	History 275 289	hypothyroidism
+T15	Duration 190 197	10-year
+E8	Duration:T15 
+T16	Disease_disorder 209 234	schizo-affective disorder
+E9	Disease_disorder:T16 
+T17	Disease_disorder 252 270	diabetes insipidus
+E10	Disease_disorder:T17 
+T18	Detailed_description 236 251	lithium-induced
+R3	MODIFY Arg1:T18 Arg2:E10	
+T19	Disease_disorder 275 289	hypothyroidism
+E11	Disease_disorder:T19 
+T20	Medication 316 332	sodium valproate
+E12	Medication:T20 
+T21	Dosage 333 348	1 g twice daily
+R4	MODIFY Arg1:T21 Arg2:E12	
+T22	Medication 350 363	carbamazepine
+E13	Medication:T22 
+T23	Medication 365 375	quetiapine
+E14	Medication:T23 
+T24	Medication 380 387	lithium
+E15	Medication:T24 
+T25	Sign_symptom 419 425	drowsy
+E16	Sign_symptom:T25 
+T26	Sign_symptom 427 445	difficult to rouse
+E17	Sign_symptom:T26 
+T27	Activity 447 455	sleeping
+E18	Activity:T27 
+T28	Detailed_description 456 486	all night and in the afternoon
+R5	MODIFY Arg1:T28 Arg2:E18	
+T29	Activity 392 401	admission
+E19	Activity:T29 
+T30	Diagnostic_procedure 493 511	Glasgow Coma Scale
+E20	Diagnostic_procedure:T30 
+T31	Diagnostic_procedure 513 516	GCS
+E21	Diagnostic_procedure:T31 
+R6	IDENTICAL Arg1:E21 Arg2:E20	
+T32	Quantitative_concept 522 527	14/15
+R7	MODIFY Arg1:T32 Arg2:E20	
+T33	Diagnostic_procedure 545 567	mini-mental test score
+E22	Diagnostic_procedure:T33 
+T34	Quantitative_concept 572 576	6/10
+R8	MODIFY Arg1:T34 Arg2:E22	
+T35	Qualitative_concept 601 605	slow
+R9	MODIFY Arg1:T35 Arg2:E22	
+T36	Diagnostic_procedure 624 648	Neurological examination
+E23	Diagnostic_procedure:T36 
+T37	Diagnostic_procedure 835 847	examinations
+E24	Diagnostic_procedure:T37 
+T38	Biological_structure 818 834	gastrointestinal
+T39	Biological_structure 802 813	respiratory
+T40	Biological_structure 786 800	Cardiovascular
+R10	MODIFY Arg1:T38 Arg2:E24	
+R11	MODIFY Arg1:T39 Arg2:E24	
+R12	MODIFY Arg1:T40 Arg2:E24	
+T42	Disease_disorder 909 924	hepatic disease
+E25	Disease_disorder:T42 
+A5	POLARITY E25 NEG
+T43	Diagnostic_procedure 934 946	biochemistry
+E26	Diagnostic_procedure:T43 
+T44	Qualitative_concept 951 963	unremarkable
+R14	MODIFY Arg1:T44 Arg2:E26	
+T45	Detailed_description 926 933	Routine
+R15	MODIFY Arg1:T45 Arg2:E26	
+T46	Diagnostic_procedure 1147 1150	B12
+E27	Diagnostic_procedure:T46 
+T47	Diagnostic_procedure 1155 1161	folate
+E28	Diagnostic_procedure:T47 
+T48	Detailed_description 1141 1146	serum
+R16	MODIFY Arg1:T48 Arg2:E27	
+R17	MODIFY Arg1:T48 Arg2:E28	
+T49	Qualitative_concept 1134 1140	normal
+R18	MODIFY Arg1:T49 Arg2:E27	
+R19	MODIFY Arg1:T49 Arg2:E28	
+T50	Diagnostic_procedure 979 999	alanine transaminase
+E29	Diagnostic_procedure:T50 
+T51	Lab_value 1004 1009	7 u/L
+R20	MODIFY Arg1:T51 Arg2:E29	
+T52	Diagnostic_procedure 1018 1038	alkaline phosphatase
+E30	Diagnostic_procedure:T52 
+T53	Lab_value 1039 1045	61 u/L
+R21	MODIFY Arg1:T53 Arg2:E30	
+T54	Diagnostic_procedure 1056 1078	γ-glutamyl transferase
+E31	Diagnostic_procedure:T54 
+T55	Lab_value 1079 1085	17 u/L
+R22	MODIFY Arg1:T55 Arg2:E31	
+T56	Diagnostic_procedure 1096 1105	bilirubin
+E32	Diagnostic_procedure:T56 
+T57	Lab_value 1110 1118	6 μmol/L
+R23	MODIFY Arg1:T57 Arg2:E32	
+T58	Diagnostic_procedure 1211 1218	lithium
+E33	Diagnostic_procedure:T58 
+T59	Qualitative_concept 1231 1259	within the therapeutic range
+R24	MODIFY Arg1:T59 Arg2:E33	
+T60	Detailed_description 1205 1210	Serum
+R25	MODIFY Arg1:T60 Arg2:E33	
+T61	Diagnostic_procedure 1181 1203	thyroid function tests
+E34	Diagnostic_procedure:T61 
+T62	Qualitative_concept 1174 1180	normal
+R26	MODIFY Arg1:T62 Arg2:E34	
+T63	Diagnostic_procedure 1271 1278	ammonia
+E35	Diagnostic_procedure:T63 
+T64	Diagnostic_procedure 664 669	power
+E36	Diagnostic_procedure:T64 
+T65	Qualitative_concept 656 663	reduced
+R27	MODIFY Arg1:T65 Arg2:E36	
+T66	Biological_structure 677 688	lower limbs
+R28	MODIFY Arg1:T66 Arg2:E36	
+T67	Quantitative_concept 690 695	3–4/5
+R29	MODIFY Arg1:T67 Arg2:E36	
+T68	Qualitative_concept 702 724	pyramidal distribution
+R30	MODIFY Arg1:T68 Arg2:E36	
+T69	Diagnostic_procedure 736 744	reflexes
+E37	Diagnostic_procedure:T69 
+T70	Diagnostic_procedure 757 766	sensation
+E38	Diagnostic_procedure:T70 
+T71	Qualitative_concept 730 735	brisk
+R31	MODIFY Arg1:T71 Arg2:E37	
+T72	Qualitative_concept 750 756	intact
+R32	MODIFY Arg1:T72 Arg2:E38	
+T73	Detailed_description 770 784	all modalities
+R33	MODIFY Arg1:T73 Arg2:E38	
+R34	SUB_PROCEDURE Arg1:E36 Arg2:E23	
+R35	SUB_PROCEDURE Arg1:E37 Arg2:E23	
+R36	SUB_PROCEDURE Arg1:E38 Arg2:E23	
+T74	Lab_value 1283 1292	47 μmol/L
+R37	MODIFY Arg1:T74 Arg2:E35	
+T75	Diagnostic_procedure 1309 1318	valproate
+E39	Diagnostic_procedure:T75 
+T76	Qualitative_concept 1339 1347	elevated
+R38	MODIFY Arg1:T76 Arg2:E39	
+T77	Lab_value 1348 1356	140 mg/L
+R39	MODIFY Arg1:T77 Arg2:E39	
+T78	Disease_disorder 1708 1720	encephalitis
+E40	Disease_disorder:T78 
+A6	POLARITY E40 NEG
+T79	Disease_disorder 1722 1745	Guillain-Barré syndrome
+E41	Disease_disorder:T79 
+A7	POLARITY E41 NEG
+T80	Disease_disorder 1750 1786	acute disseminated encephalomyelitis
+E42	Disease_disorder:T80 
+A8	POLARITY E42 NEG
+T81	Disease_disorder 1788 1792	ADEM
+E43	Disease_disorder:T81 
+R40	IDENTICAL Arg1:E43 Arg2:E42	
+T82	Disease_disorder 1910 1950	valproate hyperammonaemic encephalopathy
+E44	Disease_disorder:T82 
+T83	Disease_disorder 1952 1955	VHE
+E45	Disease_disorder:T83 
+R41	IDENTICAL Arg1:E45 Arg2:E44	
+T84	Diagnostic_procedure 1565 1568	EEG
+E46	Diagnostic_procedure:T84 
+T85	Diagnostic_procedure 1453 1468	Lumbar puncture
+E47	Diagnostic_procedure:T85 
+T86	Qualitative_concept 1482 1487	clear
+T87	Biological_structure 1488 1507	cerebrospinal fluid
+R42	MODIFY Arg1:T87 Arg2:T86	
+R43	MODIFY Arg1:T86 Arg2:E47	
+T88	Diagnostic_procedure 1509 1525	white cell count
+E48	Diagnostic_procedure:T88 
+T89	Diagnostic_procedure 1536 1543	protein
+E49	Diagnostic_procedure:T89 
+T90	Quantitative_concept 1526 1534	<1×106/L
+T91	Lab_value 1544 1552	0.25 g/L
+R44	MODIFY Arg1:T91 Arg2:E49	
+R45	MODIFY Arg1:T90 Arg2:E48	
+R46	SUB_PROCEDURE Arg1:E48 Arg2:E47	
+R47	SUB_PROCEDURE Arg1:E49 Arg2:E47	
+T92	Diagnostic_procedure 1865 1874	valproate
+E50	Diagnostic_procedure:T92 
+T93	Diagnostic_procedure 1879 1886	ammonia
+E51	Diagnostic_procedure:T93 
+T94	Lab_value 1858 1864	raised
+E52	Lab_value:T94 
+R48	MODIFY Arg1:E52 Arg2:E50	
+R49	MODIFY Arg1:E52 Arg2:E51	
+T95	Medication 1992 2008	sodium valproate
+E53	Medication:T95 
+T96	Dosage 2013 2028	reduced by half
+R50	MODIFY Arg1:T96 Arg2:E53	
+T97	Disease_disorder 2146 2171	schizo-affective disorder
+E54	Disease_disorder:T97 
+T98	Lab_value 2215 2226	improvement
+E55	Lab_value:T98 
+T99	Diagnostic_procedure 2234 2247	mental status
+E56	Diagnostic_procedure:T99 
+R51	MODIFY Arg1:E55 Arg2:E56	
+T100	Date 2173 2186	Within 3 days
+E57	Date:T100 
+T101	Activity 2273 2276	sit
+E58	Activity:T101 
+T102	Activity 2281 2292	communicate
+E59	Activity:T102 
+T103	Diagnostic_procedure 2316 2345	abbreviated mental test score
+E60	Diagnostic_procedure:T103 
+T104	Lab_value 2346 2354	improved
+E61	Lab_value:T104 
+T105	Lab_value 2358 2363	10/10
+E62	Lab_value:T105 
+R52	MODIFY Arg1:E61 Arg2:E60	
+R53	MODIFY Arg1:E62 Arg2:E60	
+T106	Date 2450 2462	After 4 days
+E63	Date:T106 
+T107	Clinical_event 2471 2481	discharged
+E64	Clinical_event:T107 
+T108	Nonbiological_location 2482 2486	home
+R54	MODIFY Arg1:T108 Arg2:E64	
+T109	Sign_symptom 1596 1603	slowing
+E65	Sign_symptom:T109 
+T110	Sign_symptom 1608 1643	irregularity of background activity
+E66	Sign_symptom:T110 
+T111	Severity 1582 1586	mild
+R55	MODIFY Arg1:T111 Arg2:E65	
+T112	Diagnostic_procedure 1391 1393	CT
+E67	Diagnostic_procedure:T112 
+T113	Diagnostic_procedure 1373 1380	imaging
+E68	Diagnostic_procedure:T113 
+T114	Biological_structure 1367 1372	Brain
+R56	MODIFY Arg1:T114 Arg2:E68	
+T115	Detailed_description 1265 1270	serum
+R57	MODIFY Arg1:T115 Arg2:E35	
+T116	Diagnostic_procedure 1398 1401	MRI
+E69	Diagnostic_procedure:T116 
+T117	Sign_symptom 1419 1430	haemorrhage
+E70	Sign_symptom:T117 
+A9	POLARITY E70 NEG
+T118	Sign_symptom 1447 1451	mass
+E71	Sign_symptom:T118 
+A10	POLARITY E71 NEG
+T119	Biological_structure 1434 1446	intracranial
+R58	MODIFY Arg1:T119 Arg2:E71	
+T120	Diagnostic_procedure 2374 2381	ammonia
+E72	Diagnostic_procedure:T120 
+T121	Lab_value 2382 2392	normalised
+E73	Lab_value:T121 
+T122	Detailed_description 2368 2373	serum
+T123	Medication 1309 1318	valproate
+E74	Medication:T123 
+R59	MODIFY Arg1:T122 Arg2:E72	
+R60	MODIFY Arg1:E73 Arg2:E72	
+T124	Diagnostic_procedure 2397 2406	valproate
+E75	Diagnostic_procedure:T124 
+T125	Medication 2397 2406	valproate
+E76	Medication:T125 
+T126	Lab_value 2414 2423	decreased
+E77	Lab_value:T126 
+R61	MODIFY Arg1:E77 Arg2:E75	
+T127	Lab_value 2431 2448	therapeutic range
+E78	Lab_value:T127 
+R62	MODIFY Arg1:E78 Arg2:E75	
+T128	Diagnostic_procedure 2499 2513	investigations
+E79	Diagnostic_procedure:T128 
+T129	Detailed_description 2521 2531	urea cycle
+R63	MODIFY Arg1:T129 Arg2:E79	
+T131	Date 2546 2557	Three weeks
+E81	Date:T131 
+T132	Clinical_event 2562 2571	discharge
+E82	Clinical_event:T132 
+T130	Diagnostic_procedure 2619 2637	mental functioning
+E80	Diagnostic_procedure:T130 
+T133	Lab_value 2600 2606	stable
+E83	Lab_value:T133 
+R64	MODIFY Arg1:E83 Arg2:E80	
+T134	Sign_symptom 2673 2682	confusion
+E84	Sign_symptom:T134 
+A11	POLARITY E84 NEG
+T135	Sign_symptom 2686 2696	drowsiness
+E85	Sign_symptom:T135 
+A12	POLARITY E85 NEG
+T136	Sign_symptom 2729 2736	fatigue
+E86	Sign_symptom:T136 
+T137	Sign_symptom 2741 2761	walking difficulties
+E87	Sign_symptom:T137 
+T138	Sign_symptom 2783 2791	weakness
+E88	Sign_symptom:T138 
+T139	Biological_structure 2779 2782	leg
+R65	MODIFY Arg1:T139 Arg2:E88	
+T140	Detailed_description 2770 2778	residual
+R66	MODIFY Arg1:T140 Arg2:E88	
+T141	Diagnostic_procedure 2815 2826	amino acids
+E89	Diagnostic_procedure:T141 
+T142	Detailed_description 2809 2814	serum
+R67	MODIFY Arg1:T142 Arg2:E89	
+T143	Disease_disorder 2857 2877	carnitine deficiency
+E90	Disease_disorder:T143 
+T144	Diagnostic_procedure 2893 2907	acyl-carnitine
+E91	Diagnostic_procedure:T144 
+T145	Lab_value 2889 2892	low
+E92	Lab_value:T145 
+R68	MODIFY Arg1:E92 Arg2:E91	
+T146	Diagnostic_procedure 2924 2933	carnitine
+E93	Diagnostic_procedure:T146 
+T147	Detailed_description 2918 2923	serum
+T148	Detailed_description 2913 2917	free
+R69	MODIFY Arg1:T147 Arg2:E93	
+R70	MODIFY Arg1:T148 Arg2:E93	
+T149	Lab_value 2909 2912	low
+E94	Lab_value:T149 
+R71	MODIFY Arg1:E94 Arg2:E93	
+T150	Lab_value 2935 2946	14.2 μmol/L
+E95	Lab_value:T150 
+R72	MODIFY Arg1:E95 Arg2:E93	
+T151	Diagnostic_procedure 2989 2998	carnitine
+E96	Diagnostic_procedure:T151 
+T152	Detailed_description 2977 2982	total
+T153	Detailed_description 2983 2988	serum
+R73	MODIFY Arg1:T153 Arg2:E96	
+R74	MODIFY Arg1:T152 Arg2:E96	
+T154	Lab_value 2973 2976	low
+E97	Lab_value:T154 
+R75	MODIFY Arg1:E97 Arg2:E96	
+T155	Lab_value 3000 3011	19.9 μmol/L
+E98	Lab_value:T155 
+R76	MODIFY Arg1:E98 Arg2:E96	
+T156	Medication 3059 3068	carnitine
+E99	Medication:T156 
+T157	Administration 3054 3058	oral
+R77	MODIFY Arg1:T157 Arg2:E99	
+T158	Dosage 3069 3084	1 g twice daily
+R78	MODIFY Arg1:T158 Arg2:E99	
+T159	Date 3086 3100	Within 2 weeks
+E100	Date:T159 
+T160	Sign_symptom 3106 3114	symptoms
+E101	Sign_symptom:T160 
+A13	POLARITY E101 NEG
+T161	Diagnostic_procedure 3163 3172	carnitine
+E102	Diagnostic_procedure:T161 
+T162	Detailed_description 3157 3162	serum
+R79	MODIFY Arg1:T162 Arg2:E102	
+T163	Lab_value 3140 3153	normalisation
+E103	Lab_value:T163 
+R80	MODIFY Arg1:E103 Arg2:E102	
+T164	Diagnostic_procedure 3186 3195	carnitine
+E104	Diagnostic_procedure:T164 
+T165	Diagnostic_procedure 3218 3227	carnitine
+E105	Diagnostic_procedure:T165 
+T166	Detailed_description 3212 3217	total
+T167	Detailed_description 3181 3185	free
+R81	MODIFY Arg1:T167 Arg2:E104	
+R82	MODIFY Arg1:T166 Arg2:E105	
+T168	Lab_value 3231 3242	41.3 μmol/L
+E106	Lab_value:T168 
+T169	Lab_value 3196 3207	25.2 μmol/L
+E107	Lab_value:T169 
+R83	MODIFY Arg1:E107 Arg2:E104	
+R84	MODIFY Arg1:E106 Arg2:E105	
+R85	SUB_PROCEDURE Arg1:E104 Arg2:E102	
+R86	SUB_PROCEDURE Arg1:E105 Arg2:E102	
+T170	Medication 3249 3265	sodium valproate
+E108	Medication:T170 
+A14	POLARITY E108 NEG
+T171	Disease_disorder 3346 3371	schizo-affective disorder
+E109	Disease_disorder:T171 
+T172	Detailed_description 3321 3328	relapse
+R87	MODIFY Arg1:T172 Arg2:E109	
+T173	Medication 3413 3422	valproate
+E110	Medication:T173 
+T174	Dosage 3423 3437	1 g once daily
+R88	MODIFY Arg1:T174 Arg2:E110	
+T175	Medication 3452 3473	carnitine supplements
+E111	Medication:T175 
+T176	Detailed_description 3442 3451	long-term
+R89	MODIFY Arg1:T176 Arg2:E111	
+T177	Sign_symptom 3405 3409	well
+E112	Sign_symptom:T177 
+R90	AFTER Arg1:E2 Arg2:E1	
+*	OVERLAP E1 E3 E4 E5 E6 E7
+R91	AFTER Arg1:E7 Arg2:E8	
+*	OVERLAP E8 E9 E10 E11
+R92	BEFORE Arg1:E11 Arg2:E12	
+*	OVERLAP E12 E13 E14 E15
+R93	BEFORE Arg1:E15 Arg2:E19	
+*	OVERLAP E19 E16 E17 E18 E20 E22 E23 E24 E25 E26 E29 E30 E31 E32 E27 E28 E34 E33 E35 E74 E39 E68 E70 E71 E47 E46 E65 E66 E114
+T41	Lab_value 853 865	unremarkable
+E113	Lab_value:T41 
+R13	MODIFY Arg1:E113 Arg2:E24	
+R94	SUB_PROCEDURE Arg1:E67 Arg2:E68	
+R95	SUB_PROCEDURE Arg1:E69 Arg2:E68	
+T178	Medication 1659 1669	medication
+E114	Medication:T178 
+R96	BEFORE Arg1:E114 Arg2:E40	
+*	OVERLAP E40 E41 E42 E50 E51 E44
+R97	BEFORE Arg1:E44 Arg2:E53	
+*	OVERLAP E53 E54
+R98	BEFORE Arg1:E54 Arg2:E57	
+*	OVERLAP E57 E56 E58 E59 E60 E72 E75 E76
+R99	BEFORE Arg1:E76 Arg2:E63	
+*	OVERLAP E63 E64
+R100	BEFORE Arg1:E64 Arg2:E79	
+R101	BEFORE Arg1:E79 Arg2:E81	
+R102	AFTER Arg1:E81 Arg2:E82	
+R103	BEFORE Arg1:E82 Arg2:E80	
+*	OVERLAP E80 E84 E85 E86 E87 E88
+R104	BEFORE Arg1:E88 Arg2:E89	
+*	OVERLAP E89 E90 E91 E93 E96
+R105	BEFORE Arg1:E96 Arg2:E99	
+R106	BEFORE Arg1:E99 Arg2:E100	
+*	OVERLAP E100 E101 E102
+R107	BEFORE Arg1:E102 Arg2:E108	
+R108	BEFORE Arg1:E108 Arg2:E109	
+R109	BEFORE Arg1:E109 Arg2:E112	
+*	OVERLAP E112 E110 E111