--- a
+++ b/processing/MACCROBAT/26313770.ann
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+T1	Age 10 21	53-year-old
+T2	Sex 22 26	male
+T3	Sign_symptom 96 104	bleeding
+E1	Sign_symptom:T3 
+T4	Duration 109 114	1 day
+E2	Duration:T4 
+T5	Clinical_event 39 43	went
+E3	Clinical_event:T5 
+T6	Nonbiological_location 51 59	hospital
+R1	MODIFY Arg1:T6 Arg2:E3	
+T7	Severity 84 91	massive
+T8	Biological_structure 92 95	gum
+R2	MODIFY Arg1:T8 Arg2:E1	
+R3	MODIFY Arg1:T7 Arg2:E1	
+T9	History 145 164	chronic hepatitis C
+T10	Detailed_description 145 152	chronic
+T11	Disease_disorder 153 164	hepatitis C
+E4	Disease_disorder:T11 
+T12	Medication 166 178	PEG-IFN-α-2a
+E5	Medication:T12 
+T13	Dosage 180 186	180 μg
+R4	MODIFY Arg1:T13 Arg2:E5	
+T14	Medication 193 202	ribavirin
+E6	Medication:T14 
+T15	Dosage 204 215	1200 mg/day
+R5	MODIFY Arg1:T15 Arg2:E6	
+T16	Duration 248 268	since March 17, 2014
+E7	Duration:T16 
+T17	History 273 305	denied any autoimmune conditions
+T18	Diagnostic_procedure 337 353	virological data
+E8	Diagnostic_procedure:T18 
+T19	Diagnostic_procedure 368 378	virus load
+E9	Diagnostic_procedure:T19 
+R6	SUB_PROCEDURE Arg1:E9 Arg2:E8	
+T21	Diagnostic_procedure 380 387	HCV RNA
+E10	Diagnostic_procedure:T21 
+R8	SUB_PROCEDURE Arg1:E10 Arg2:E9	
+T22	Lab_value 388 403	2.1 × 106 IU/mL
+R9	MODIFY Arg1:T22 Arg2:E10	
+T23	Diagnostic_procedure 410 418	genotype
+E11	Diagnostic_procedure:T23 
+R10	SUB_PROCEDURE Arg1:E11 Arg2:E8	
+#1	AnnotatorNotes E8	Specifically, of Hepatitis C
+T25	Diagnostic_procedure 487 494	HCV RNA
+E12	Diagnostic_procedure:T25 
+T26	Lab_value 496 512	2.12 × 106 IU/mL
+R12	MODIFY Arg1:T26 Arg2:E12	
+T27	Clinical_event 2874 2884	discharged
+E13	Clinical_event:T27 
+T20	Lab_value 419 421	1b
+E14	Lab_value:T20 
+R7	MODIFY Arg1:E14 Arg2:E11	
+T24	Lab_value 363 367	high
+E15	Lab_value:T24 
+R11	BEFORE Arg1:E15 Arg2:E9	
+T28	Sign_symptom 429 449	virological response
+E16	Sign_symptom:T28 
+A1	POLARITY E16 NEG
+T29	Detailed_description 423 428	Rapid
+R13	MODIFY Arg1:T29 Arg2:E16	
+T30	Date 474 485	fourth week
+E17	Date:T30 
+T31	Sign_symptom 529 549	virological response
+E18	Sign_symptom:T31 
+T32	Detailed_description 523 528	early
+T33	Detailed_description 515 522	Partial
+R14	MODIFY Arg1:T32 Arg2:E18	
+R15	MODIFY Arg1:T33 Arg2:E18	
+T34	Diagnostic_procedure 551 558	HCV RNA
+E19	Diagnostic_procedure:T34 
+T35	Diagnostic_procedure 616 623	HCV RNA
+E20	Diagnostic_procedure:T35 
+T36	Lab_value 560 569	103 IU/mL
+E21	Lab_value:T36 
+T37	Lab_value 625 634	<15 IU/mL
+E22	Lab_value:T37 
+R16	MODIFY Arg1:E22 Arg2:E20	
+R17	MODIFY Arg1:E21 Arg2:E19	
+T38	Date 573 580	week 12
+E23	Date:T38 
+T39	Date 638 645	Week 24
+E24	Date:T39 
+T40	Sign_symptom 668 675	fatigue
+E25	Sign_symptom:T40 
+T41	Sign_symptom 677 683	anemia
+E26	Sign_symptom:T41 
+T42	Sign_symptom 689 708	depression syndrome
+E27	Sign_symptom:T42 
+A2	TREND E27 INC
+A3	TREND E26 INC
+A4	TREND E25 INC
+T43	Date 728 737	30th week
+E28	Date:T43 
+T44	Date 782 789	Week 36
+E29	Date:T44 
+T45	Medication 769 778	treatment
+E30	Medication:T45 
+A5	POLARITY E30 NEG
+T46	Date 813 829	end-of-treatment
+E31	Date:T46 
+T47	Diagnostic_procedure 795 805	viral load
+E32	Diagnostic_procedure:T47 
+T48	Lab_value 840 852	undetectable
+E33	Lab_value:T48 
+R18	MODIFY Arg1:E33 Arg2:E32	
+T49	Date 2845 2856	December 15
+E34	Date:T49 
+T50	Sign_symptom 2892 2908	stable condition
+E35	Sign_symptom:T50 
+T51	Diagnostic_procedure 2914 2929	platelet counts
+E36	Diagnostic_procedure:T51 
+T52	Lab_value 2930 2939	elevating
+E37	Lab_value:T52 
+R19	MODIFY Arg1:E37 Arg2:E36	
+T53	Lab_value 2943 2961	117 × 103 cells/μL
+E38	Lab_value:T53 
+R20	MODIFY Arg1:E38 Arg2:E36	
+T54	Diagnostic_procedure 2984 2999	laboratory data
+E39	Diagnostic_procedure:T54 
+T55	Sign_symptom 3034 3052	virologic response
+E40	Sign_symptom:T55 
+T56	Detailed_description 3024 3033	sustained
+R21	MODIFY Arg1:T56 Arg2:E40	
+T57	Date 3000 3014	after 5 months
+E41	Date:T57 
+T58	Diagnostic_procedure 3054 3068	platelet count
+E42	Diagnostic_procedure:T58 
+T59	Lab_value 3069 3093	above 150 × 103 cells/μL
+E43	Lab_value:T59 
+R22	MODIFY Arg1:E43 Arg2:E42	
+T60	Diagnostic_procedure 3109 3129	anti-cardiolipin IgG
+E44	Diagnostic_procedure:T60 
+T61	Lab_value 3099 3108	decreased
+E45	Lab_value:T61 
+R23	MODIFY Arg1:E45 Arg2:E44	
+T62	Lab_value 3131 3138	30.5GPL
+E46	Lab_value:T62 
+R24	MODIFY Arg1:E46 Arg2:E44	
+T63	Diagnostic_procedure 3144 3165	anti-phospholipid IgG
+E47	Diagnostic_procedure:T63 
+T64	Lab_value 3167 3174	73.21 U
+E48	Lab_value:T64 
+R25	BEFORE Arg1:E48 Arg2:E47	
+R26	MODIFY Arg1:E45 Arg2:E47	
+T65	Diagnostic_procedure 858 872	platelet count
+E49	Diagnostic_procedure:T65 
+T66	Date 876 879	EOT
+E50	Date:T66 
+T67	Date 831 834	EOT
+E51	Date:T67 
+R27	IDENTICAL Arg1:E51 Arg2:E31	
+T68	Lab_value 884 901	92 × 103 cells/μL
+E52	Lab_value:T68 
+R28	MODIFY Arg1:E52 Arg2:E49	
+T69	Lab_value 906 914	elevated
+E53	Lab_value:T69 
+T70	Lab_value 918 936	159 × 103 cells/μL
+E54	Lab_value:T70 
+T71	Date 937 949	1 week later
+E55	Date:T71 
+R29	MODIFY Arg1:E53 Arg2:E49	
+R30	MODIFY Arg1:E54 Arg2:E49	
+T72	Date 951 974	Two weeks following EOT
+E56	Date:T72 
+T73	Sign_symptom 1010 1018	bleeding
+E57	Sign_symptom:T73 
+T74	Biological_structure 1006 1009	gum
+R31	MODIFY Arg1:T74 Arg2:E57	
+T75	Severity 998 1005	massive
+R32	MODIFY Arg1:T75 Arg2:E57	
+T76	Sign_symptom 1065 1074	petechiae
+E58	Sign_symptom:T76 
+T77	Quantitative_concept 1056 1064	multiple
+R33	MODIFY Arg1:T77 Arg2:E58	
+T78	Biological_structure 1082 1093	extremities
+R34	MODIFY Arg1:T78 Arg2:E58	
+T79	Diagnostic_procedure 1024 1044	physical examination
+E59	Diagnostic_procedure:T79 
+T80	Sign_symptom 1129 1139	hemorrhage
+E60	Sign_symptom:T80 
+A6	POLARITY E60 NEG
+T81	Biological_structure 1115 1128	intracerebral
+R35	MODIFY Arg1:T81 Arg2:E60	
+T82	Biological_structure 1141 1157	gastrointestinal
+T83	Sign_symptom 1158 1166	bleeding
+E61	Sign_symptom:T83 
+A7	POLARITY E61 NEG
+R36	MODIFY Arg1:T82 Arg2:E61	
+T84	Diagnostic_procedure 1208 1222	platelet count
+E62	Diagnostic_procedure:T84 
+T85	Detailed_description 1200 1207	initial
+R37	MODIFY Arg1:T85 Arg2:E62	
+T86	Lab_value 1227 1242	4 × 103cells/μL
+E63	Lab_value:T86 
+R38	MODIFY Arg1:E63 Arg2:E62	
+T87	Diagnostic_procedure 1244 1263	Coagulation profile
+E64	Diagnostic_procedure:T87 
+T88	Lab_value 1271 1277	normal
+E65	Lab_value:T88 
+T89	Diagnostic_procedure 1278 1294	prothrombin time
+E66	Diagnostic_procedure:T89 
+R39	MODIFY Arg1:E65 Arg2:E66	
+R40	SUB_PROCEDURE Arg1:E66 Arg2:E64	
+T90	Diagnostic_procedure 1296 1333	activated partial thromboplastin time
+E67	Diagnostic_procedure:T90 
+T91	Diagnostic_procedure 1335 1345	fibrinogen
+E68	Diagnostic_procedure:T91 
+T92	Diagnostic_procedure 1347 1354	d-dimer
+E69	Diagnostic_procedure:T92 
+T93	Diagnostic_procedure 1360 1386	fibrin degradation product
+E70	Diagnostic_procedure:T93 
+R41	MODIFY Arg1:E65 Arg2:E67	
+R42	MODIFY Arg1:E65 Arg2:E68	
+R43	MODIFY Arg1:E65 Arg2:E69	
+R44	MODIFY Arg1:E65 Arg2:E70	
+R45	SUB_PROCEDURE Arg1:E67 Arg2:E64	
+R46	SUB_PROCEDURE Arg1:E68 Arg2:E64	
+R47	SUB_PROCEDURE Arg1:E69 Arg2:E64	
+R48	SUB_PROCEDURE Arg1:E70 Arg2:E64	
+T94	Diagnostic_procedure 1388 1410	Peripheral blood smear
+E71	Diagnostic_procedure:T94 
+T95	Sign_symptom 1426 1452	fragmented red blood cells
+E72	Sign_symptom:T95 
+A8	POLARITY E72 NEG
+T96	Sign_symptom 1454 1466	helmet cells
+E73	Sign_symptom:T96 
+A9	POLARITY E73 NEG
+T97	Sign_symptom 1471 1500	abnormal platelet aggregation
+E74	Sign_symptom:T97 
+A10	POLARITY E74 NEG
+T98	Disease_disorder 1525 1551	connective tissue diseases
+E75	Disease_disorder:T98 
+A11	POLARITY E75 NEG
+T99	Disease_disorder 1560 1588	systemic lupus erythematosus
+E76	Disease_disorder:T99 
+A12	POLARITY E76 NEG
+T100	Disease_disorder 1592 1608	cryoglobulinemia
+E77	Disease_disorder:T100 
+A13	POLARITY E77 NEG
+T101	Diagnostic_procedure 1639 1660	anti-nuclear antibody
+E78	Diagnostic_procedure:T101 
+T102	Diagnostic_procedure 1665 1677	cryoglobulin
+E79	Diagnostic_procedure:T102 
+T103	Lab_value 1630 1638	negative
+E80	Lab_value:T103 
+R49	MODIFY Arg1:E80 Arg2:E78	
+R50	MODIFY Arg1:E80 Arg2:E79	
+T104	Diagnostic_procedure 1698 1718	anti-cardiolipin IgG
+E81	Diagnostic_procedure:T104 
+T105	Lab_value 1689 1697	positive
+E82	Lab_value:T105 
+R51	MODIFY Arg1:E82 Arg2:E81	
+T106	Lab_value 1720 1727	116 GPL
+E83	Lab_value:T106 
+R52	MODIFY Arg1:E83 Arg2:E81	
+T107	Diagnostic_procedure 1755 1776	anti-phospholipid IgG
+E84	Diagnostic_procedure:T107 
+T108	Lab_value 1778 1783	165 U
+E85	Lab_value:T108 
+R53	MODIFY Arg1:E85 Arg2:E84	
+T109	Disease_disorder 1806 1832	Anti-phospholipid syndrome
+E86	Disease_disorder:T109 
+A14	POLARITY E86 NEG
+T110	History 1853 1886	no previous thromboembolic events
+T111	Diagnostic_procedure 1906 1922	Sapporo criteria
+E87	Diagnostic_procedure:T111 
+T112	Detailed_description 1901 1905	2006
+R54	MODIFY Arg1:T112 Arg2:E87	
+T113	Diagnostic_procedure 1938 1944	biopsy
+E88	Diagnostic_procedure:T113 
+T114	Biological_structure 1926 1937	Bone marrow
+R55	MODIFY Arg1:T114 Arg2:E88	
+T115	Sign_symptom 1980 1992	hypocellular
+E89	Sign_symptom:T115 
+T116	Diagnostic_procedure 2010 2031	cellular distribution
+E90	Diagnostic_procedure:T116 
+T117	Biological_structure 1993 1999	marrow
+R56	MODIFY Arg1:T117 Arg2:E89	
+R57	MODIFY Arg1:T117 Arg2:E90	
+T118	Lab_value 2005 2009	even
+E91	Lab_value:T118 
+R58	MODIFY Arg1:E91 Arg2:E90	
+T119	Disease_disorder 2056 2074	lymphoid neoplasia
+E92	Disease_disorder:T119 
+A15	POLARITY E92 NEG
+T120	Medication 2510 2522	Azathioprine
+E93	Medication:T120 
+T121	Medication 2578 2596	Hydroxychloroquine
+E94	Medication:T121 
+T122	Dosage 2524 2530	100 mg
+T123	Dosage 2538 2548	once daily
+T124	Administration 2532 2536	oral
+R59	MODIFY Arg1:T122 Arg2:E93	
+R60	MODIFY Arg1:T123 Arg2:E93	
+R61	MODIFY Arg1:T124 Arg2:E93	
+T125	Dosage 2598 2604	400 mg
+T126	Administration 2606 2610	oral
+T127	Dosage 2612 2622	once daily
+R62	MODIFY Arg1:T127 Arg2:E94	
+R63	MODIFY Arg1:T125 Arg2:E94	
+R64	MODIFY Arg1:T126 Arg2:E94	
+T128	Diagnostic_procedure 2660 2688	anti-phospholipid antibodies
+E95	Diagnostic_procedure:T128 
+T129	Lab_value 2651 2659	positive
+E96	Lab_value:T129 
+R65	MODIFY Arg1:E96 Arg2:E95	
+T130	Diagnostic_procedure 2690 2704	Platelet count
+E97	Diagnostic_procedure:T130 
+T131	Lab_value 2715 2724	increased
+E98	Lab_value:T131 
+R66	MODIFY Arg1:E98 Arg2:E97	
+T132	Lab_value 2728 2745	93 × 103 cells/μL
+E99	Lab_value:T132 
+R67	MODIFY Arg1:E99 Arg2:E97	
+T133	Date 2746 2769	17 days after admission
+E100	Date:T133 
+T134	Medication 2774 2792	methylprednisolone
+E101	Medication:T134 
+T135	Administration 2808 2812	oral
+R68	MODIFY Arg1:T135 Arg2:E101	
+T136	Dosage 2829 2840	tapered off
+R69	MODIFY Arg1:T136 Arg2:E101	
+T137	Date 2560 2576	since December 3
+E102	Date:T137 
+T138	Sign_symptom 2497 2508	improvement
+E103	Sign_symptom:T138 
+A16	POLARITY E103 NEG
+T139	Medication 2354 2372	methylprednisolone
+E104	Medication:T139 
+T140	Administration 2342 2353	intravenous
+T141	Dosage 2382 2402	40 mg, 3 times daily
+R70	MODIFY Arg1:T141 Arg2:E104	
+R71	MODIFY Arg1:T140 Arg2:E104	
+T142	Date 2407 2418	November 27
+E105	Date:T142 
+T143	Therapeutic_procedure 2433 2464	platelet transfusion treatments
+E106	Therapeutic_procedure:T143 
+T144	Disease_disorder 2289 2320	immune thrombocytopenic purpura
+E107	Disease_disorder:T144 
+T145	Therapeutic_procedure 2142 2159	Blood transfusion
+E108	Therapeutic_procedure:T145 
+T146	Diagnostic_procedure 2196 2204	response
+E109	Diagnostic_procedure:T146 
+T147	Lab_value 2191 2195	poor
+E110	Lab_value:T147 
+R72	MODIFY Arg1:E110 Arg2:E109	
+T148	Diagnostic_procedure 2227 2241	platelet count
+E111	Diagnostic_procedure:T148 
+T149	Lab_value 2210 2223	rapid decline
+E112	Lab_value:T149 
+R73	MODIFY Arg1:E112 Arg2:E111	
+T150	Date 2249 2257	next day
+E113	Date:T150 
+T151	Medication 2090 2125	drugs that may cause platelet lysis
+E114	Medication:T151 
+A17	POLARITY E114 NEG
+R74	AFTER Arg1:E3 Arg2:E1	
+*	OVERLAP E1 E2
+R75	AFTER Arg1:E2 Arg2:E4	
+*	OVERLAP E4 E5 E6 E7
+R76	BEFORE Arg1:E7 Arg2:E8	
+R77	BEFORE Arg1:E8 Arg2:E16	
+*	OVERLAP E16 E17 E12
+R78	BEFORE Arg1:E12 Arg2:E18	
+*	OVERLAP E18 E19 E23
+R79	BEFORE Arg1:E23 Arg2:E20	
+*	OVERLAP E20 E24
+R80	BEFORE Arg1:E24 Arg2:E25	
+*	OVERLAP E25 E26 E27 E28
+R81	BEFORE Arg1:E28 Arg2:E30	
+*	OVERLAP E30 E29
+R82	BEFORE Arg1:E29 Arg2:E32	
+*	OVERLAP E32 E31 E49 E50
+R83	BEFORE Arg1:E50 Arg2:E55	
+R84	MODIFY Arg1:E55 Arg2:E53	
+R85	MODIFY Arg1:E55 Arg2:E54	
+R86	BEFORE Arg1:E55 Arg2:E56	
+*	OVERLAP E56 E57
+R87	BEFORE Arg1:E57 Arg2:E59	
+*	OVERLAP E59 E58 E60 E61 E62 E64 E71 E72 E73 E74 E75 E76 E77 E78 E79 E81 E84 E86 E87 E88 E89 E90 E92 E114 E108
+R88	BEFORE Arg1:E108 Arg2:E109	
+*	OVERLAP E109 E111 E113 E115
+T152	Therapeutic_procedure 2261 2272	transfusion
+E115	Therapeutic_procedure:T152 
+R89	BEFORE Arg1:E115 Arg2:E107	
+R90	BEFORE Arg1:E107 Arg2:E104	
+*	OVERLAP E104 E105 E106
+R91	BEFORE Arg1:E106 Arg2:E103	
+R92	BEFORE Arg1:E103 Arg2:E93	
+*	OVERLAP E93 E102 E94 E95
+R93	BEFORE Arg1:E95 Arg2:E97	
+*	OVERLAP E97 E100 E101
+R94	BEFORE Arg1:E101 Arg2:E34	
+*	OVERLAP E34 E13 E35 E36
+R95	BEFORE Arg1:E36 Arg2:E39	
+*	OVERLAP E39 E41 E40 E42 E44 E47