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T1 Age 2 13 58-year-old T2 Sex 14 17 man T3 Disease_disorder 67 79 hypertension E1 Disease_disorder:T3 T4 History 67 79 hypertension T5 Detailed_description 49 66 poorly controlled R1 MODIFY Arg1:T5 Arg2:E1 T6 Disease_disorder 84 99 type 2 diabetes E2 Disease_disorder:T6 T7 History 84 99 type 2 diabetes T8 Clinical_event 101 110 presented E3 Clinical_event:T8 T9 Nonbiological_location 118 121 ICU R2 MODIFY Arg1:T9 Arg2:E3 T10 Disease_disorder 128 145 cardiogenic shock E4 Disease_disorder:T10 T11 Disease_disorder 165 186 myocardial infarction E5 Disease_disorder:T11 T12 Detailed_description 159 164 acute R3 MODIFY Arg1:T12 Arg2:E5 T13 Diagnostic_procedure 188 208 Physical examination E6 Diagnostic_procedure:T13 T14 Diagnostic_procedure 226 248 level of consciousness E7 Diagnostic_procedure:T14 T15 Lab_value 218 225 reduced R4 MODIFY Arg1:T15 Arg2:E7 T16 Diagnostic_procedure 250 268 Glasgow Coma Scale E8 Diagnostic_procedure:T16 T17 Lab_value 269 274 10/15 R5 MODIFY Arg1:T17 Arg2:E8 T18 Diagnostic_procedure 285 296 vital signs E9 Diagnostic_procedure:T18 T19 Lab_value 280 284 weak R6 MODIFY Arg1:T19 Arg2:E9 T20 Diagnostic_procedure 300 314 blood pressure E10 Diagnostic_procedure:T20 T21 Lab_value 318 328 80/50 mmHg R7 MODIFY Arg1:T21 Arg2:E10 R8 SUB_PROCEDURE Arg1:E10 Arg2:E9 T22 Diagnostic_procedure 337 354 oxygen saturation E11 Diagnostic_procedure:T22 T23 Lab_value 330 333 80% R9 MODIFY Arg1:T23 Arg2:E11 R10 SUB_PROCEDURE Arg1:E11 Arg2:E9 T24 Diagnostic_procedure 366 379 blood glucose E12 Diagnostic_procedure:T24 T25 Detailed_description 356 365 capillary R11 MODIFY Arg1:T25 Arg2:E12 T26 Lab_value 383 391 2.26 g/L R12 MODIFY Arg1:T26 Arg2:E12 T27 Diagnostic_procedure 395 405 heart rate E13 Diagnostic_procedure:T27 T28 Lab_value 406 418 over 125 bpm R13 MODIFY Arg1:T28 Arg2:E13 R14 SUB_PROCEDURE Arg1:E12 Arg2:E9 R15 SUB_PROCEDURE Arg1:E13 Arg2:E9 T29 Sign_symptom 424 433 crackling E14 Sign_symptom:T29 T30 Diagnostic_procedure 437 459 pulmonary auscultation E15 Diagnostic_procedure:T30 T31 Diagnostic_procedure 461 487 Cardiovascular examination E16 Diagnostic_procedure:T31 T32 Sign_symptom 503 517 cardiac murmur E17 Sign_symptom:T32 A1 POLARITY E17 NEG T33 Sign_symptom 522 550 signs of right heart failure E18 Sign_symptom:T33 A2 POLARITY E18 NEG T34 Diagnostic_procedure 552 555 ECG E19 Diagnostic_procedure:T34 T35 Clinical_event 559 568 admission E20 Clinical_event:T35 T36 Diagnostic_procedure 589 595 rhythm E21 Diagnostic_procedure:T36 T37 Lab_value 576 582 normal R16 MODIFY Arg1:T37 Arg2:E21 T38 Detailed_description 583 588 sinus R17 MODIFY Arg1:T38 Arg2:E21 T39 Diagnostic_procedure 602 612 heart rate E22 Diagnostic_procedure:T39 T40 Lab_value 616 623 125 bpm R18 MODIFY Arg1:T40 Arg2:E22 T41 Sign_symptom 628 649 extended ST-elevation E23 Sign_symptom:T41 T42 Detailed_description 653 671 anterior territory R19 MODIFY Arg1:T42 Arg2:E23 T43 Diagnostic_procedure 673 691 Laboratory results E24 Diagnostic_procedure:T43 T44 Diagnostic_procedure 705 715 Troponin I E25 Diagnostic_procedure:T44 T45 Lab_value 725 735 6.41 ng/ml R20 MODIFY Arg1:T45 Arg2:E25 T46 Diagnostic_procedure 737 754 creatinine kinase E26 Diagnostic_procedure:T46 T47 Diagnostic_procedure 756 760 CKMB E27 Diagnostic_procedure:T47 R21 IDENTICAL Arg1:E27 Arg2:E26 T48 Lab_value 766 773 67 UI/L R22 MODIFY Arg1:T48 Arg2:E26 T49 Diagnostic_procedure 775 797 Lactate deshydrogenase E28 Diagnostic_procedure:T49 T50 Lab_value 802 810 281 UI/L T51 Diagnostic_procedure 812 819 glucose E29 Diagnostic_procedure:T51 R23 MODIFY Arg1:T50 Arg2:E28 T52 Lab_value 826 834 2.70 g/l R24 MODIFY Arg1:T52 Arg2:E29 T53 Diagnostic_procedure 836 840 urea E30 Diagnostic_procedure:T53 T54 Lab_value 841 849 0.40 g/l R25 MODIFY Arg1:T54 Arg2:E30 T55 Diagnostic_procedure 854 864 creatinine E31 Diagnostic_procedure:T55 T56 Lab_value 865 876 18.6 mg / L R26 MODIFY Arg1:T56 Arg2:E31 R27 SUB_PROCEDURE Arg1:E25 Arg2:E24 R28 SUB_PROCEDURE Arg1:E26 Arg2:E24 R29 SUB_PROCEDURE Arg1:E28 Arg2:E24 R30 SUB_PROCEDURE Arg1:E29 Arg2:E24 R31 SUB_PROCEDURE Arg1:E30 Arg2:E24 R32 SUB_PROCEDURE Arg1:E31 Arg2:E24 T57 Therapeutic_procedure 894 903 intubated E32 Therapeutic_procedure:T57 T58 Therapeutic_procedure 908 915 sedated E33 Therapeutic_procedure:T58 T59 Medication 917 933 inotropic agents E34 Medication:T59 T60 Medication 948 962 norepinephrine E35 Medication:T60 T61 Medication 980 990 dobutamine E36 Medication:T61 R33 SUB_PROCEDURE Arg1:E35 Arg2:E34 R34 SUB_PROCEDURE Arg1:E36 Arg2:E34 T62 Dosage 963 975 0.4µg/kg/min T63 Dosage 991 1002 20µg/kg/min R35 MODIFY Arg1:T62 Arg2:E35 R36 MODIFY Arg1:T63 Arg2:E36 T64 Diagnostic_procedure 1011 1017 X-rays E37 Diagnostic_procedure:T64 T65 Biological_structure 1005 1010 Chest R37 MODIFY Arg1:T65 Arg2:E37 T66 Disease_disorder 1033 1050 alveolar syndrome E38 Disease_disorder:T66 T67 Detailed_description 1025 1032 diffuse R38 MODIFY Arg1:T67 Arg2:E38 T68 Diagnostic_procedure 1066 1082 echocardiography E39 Diagnostic_procedure:T68 T69 Biological_structure 1052 1065 Transthoracic R39 MODIFY Arg1:T69 Arg2:E39 T70 Sign_symptom 1092 1117 wall motion abnormalities E40 Sign_symptom:T70 T71 Sign_symptom 1135 1143 akinesis E41 Sign_symptom:T71 T72 Severity 1125 1134 extensive R40 MODIFY Arg1:T72 Arg2:E41 T73 Biological_structure 1192 1197 walls T74 Biological_structure 1147 1159 anteroseptal T75 Biological_structure 1161 1169 anterior T76 Biological_structure 1171 1178 lateral T77 Biological_structure 1183 1191 inferior R41 MODIFY Arg1:T73 Arg2:E41 R42 MODIFY Arg1:T74 Arg2:T73 R43 MODIFY Arg1:T77 Arg2:T73 R44 MODIFY Arg1:T76 Arg2:T73 R45 MODIFY Arg1:T75 Arg2:T73 T78 Severity 1203 1209 severe T79 Sign_symptom 1210 1247 left ventricular systolic dysfunction E42 Sign_symptom:T79 T80 Diagnostic_procedure 1249 1266 ejection fraction E43 Diagnostic_procedure:T80 T81 Lab_value 1270 1273 29% R46 MODIFY Arg1:T81 Arg2:E43 T82 Therapeutic_procedure 1276 1294 Medical management E44 Therapeutic_procedure:T82 T83 Medication 1310 1323 anticoagulant E45 Medication:T83 T84 Medication 1383 1403 acetylsalicylic acid E46 Medication:T84 T85 Dosage 1373 1379 500 mg R47 MODIFY Arg1:T85 Arg2:E46 T86 Administration 1408 1420 subcutaneous T87 Medication 1421 1449 low-molecular-weight heparin E47 Medication:T87 R48 MODIFY Arg1:T86 Arg2:E47 T88 Medication 1460 1470 enoxaparin E48 Medication:T88 R49 IDENTICAL Arg1:E48 Arg2:E47 T89 Dosage 1451 1456 0.6ml R50 MODIFY Arg1:T89 Arg2:E48 R51 SUB_PROCEDURE Arg1:E46 Arg2:E45 R52 SUB_PROCEDURE Arg1:E47 Arg2:E45 T90 Disease_disorder 1336 1359 acute coronary syndrome E49 Disease_disorder:T90 T91 Therapeutic_procedure 1502 1530 myocardial revascularization E50 Therapeutic_procedure:T91 T92 Therapeutic_procedure 1543 1554 angioplasty E51 Therapeutic_procedure:T92 T93 Biological_structure 1534 1542 coronary R53 MODIFY Arg1:T93 Arg2:E51 R54 SUB_PROCEDURE Arg1:E51 Arg2:E50 T94 Diagnostic_procedure 1586 1605 neurological status E52 Diagnostic_procedure:T94 T95 Lab_value 1567 1582 non-improvement R55 MODIFY Arg1:T95 Arg2:E52 T96 Sign_symptom 1624 1632 seizures E53 Sign_symptom:T96 T97 Diagnostic_procedure 1642 1644 CT E54 Diagnostic_procedure:T97 T98 Biological_structure 1636 1641 brain R56 MODIFY Arg1:T98 Arg2:E54 T99 Sign_symptom 1695 1705 hemorrhage E55 Sign_symptom:T99 T100 Detailed_description 1687 1694 diffuse T101 Biological_structure 1672 1686 infratentorial R57 MODIFY Arg1:T101 Arg2:E55 R58 MODIFY Arg1:T100 Arg2:E55 T102 Diagnostic_procedure 1707 1719 Fisher grade E56 Diagnostic_procedure:T102 T103 Lab_value 1720 1723 III R59 MODIFY Arg1:T103 Arg2:E56 T104 Diagnostic_procedure 1746 1757 angiography E57 Diagnostic_procedure:T104 T105 Biological_structure 1737 1745 Cerebral R60 MODIFY Arg1:T105 Arg2:E57 T106 Disease_disorder 1770 1789 dissecting aneurysm E58 Disease_disorder:T106 T107 Biological_structure 1796 1814 anastomotic branch R61 MODIFY Arg1:T107 Arg2:E58 T108 Biological_structure 1823 1832 left PICA T109 Biological_structure 1841 1876 V4 segment of left vertebral artery R62 MODIFY Arg1:T109 Arg2:E58 R63 MODIFY Arg1:T108 Arg2:E58 T110 Therapeutic_procedure 1908 1917 embolized E59 Therapeutic_procedure:T110 T111 Date 1919 1933 After 24 hours E60 Date:T111 T112 Medication 1975 1991 vasoactive drugs E61 Medication:T112 A3 POLARITY E61 NEG T113 Date 1995 2003 24 hours E62 Date:T113 #1 AnnotatorNotes E62 Assuming this is a second 24-hour period T114 Sign_symptom 2024 2032 seizures E63 Sign_symptom:T114 T115 Biological_structure 2005 2023 Left hemicorporeal R64 MODIFY Arg1:T115 Arg2:E63 T116 Medication 2051 2065 anticonvulsant E64 Medication:T116 T117 Diagnostic_procedure 2091 2093 CT E65 Diagnostic_procedure:T117 T118 Biological_structure 2085 2090 brain R65 MODIFY Arg1:T118 Arg2:E65 T119 Sign_symptom 2109 2119 rebleeding E66 Sign_symptom:T119 A4 POLARITY E66 NEG T120 Diagnostic_procedure 2124 2135 angiography E67 Diagnostic_procedure:T120 T121 Disease_disorder 2169 2177 aneurysm E68 Disease_disorder:T121 A5 POLARITY E68 NEG T122 Diagnostic_procedure 2188 2191 EEG E69 Diagnostic_procedure:T122 T123 Disease_disorder 2211 2223 brain damage E70 Disease_disorder:T123 T124 Detailed_description 2203 2210 diffuse R66 MODIFY Arg1:T124 Arg2:E70 T125 Date 2225 2238 10 days after E71 Date:T125 T126 Clinical_event 2266 2276 discharged E72 Clinical_event:T126 T127 Diagnostic_procedure 2287 2296 condition E73 Diagnostic_procedure:T127 T128 Lab_value 2280 2286 stable R67 MODIFY Arg1:T128 Arg2:E73 T129 Disease_disorder 2320 2327 amnesia E74 Disease_disorder:T129 * OVERLAP E1 E2 R68 BEFORE Arg1:E2 Arg2:E3 * OVERLAP E3 E4 E5 R69 BEFORE Arg1:E5 Arg2:E6 * OVERLAP E6 E7 E8 E9 E14 E15 E16 E17 E18 R70 AFTER Arg1:E18 Arg2:E19 * OVERLAP E19 E20 E21 E22 E23 R71 BEFORE Arg1:E23 Arg2:E24 R72 BEFORE Arg1:E24 Arg2:E32 * OVERLAP E32 E33 E34 E37 E38 E39 E40 E41 E42 E43 R73 MODIFY Arg1:T78 Arg2:E42 R74 BEFORE Arg1:E43 Arg2:E44 * OVERLAP E44 E45 E49 R75 BEFORE Arg1:E49 Arg2:E50 R76 BEFORE Arg1:E50 Arg2:E52 * OVERLAP E52 E53 R77 BEFORE Arg1:E53 Arg2:E54 * OVERLAP E54 E55 E56 E57 E58 R78 BEFORE Arg1:E58 Arg2:E59 R79 BEFORE Arg1:E59 Arg2:E60 T130 Sign_symptom 1947 1955 improved E75 Sign_symptom:T130 * OVERLAP E60 E75 R80 BEFORE Arg1:E75 Arg2:E61 * OVERLAP E61 E62 E63 E64 E65 E66 E67 E68 E69 E70 R81 BEFORE Arg1:E70 Arg2:E71 * OVERLAP E71 E72 E73 R82 BEFORE Arg1:E73 Arg2:E74