--- a +++ b/processing/MACCROBAT/26216058.txt @@ -0,0 +1,24 @@ +An 11-year-old boy presented with a history of headaches and vomiting that had been present for several months. +Physical examination showed papilledema without the presence of any other neurological deficits. +Magnetic resonance imaging (MRI) revealed a large prepontine mass with dorsal displacement of the brainstem and a secondary obstructive hydrocephalus due to compression of the aqueduct. +The lesion had an inhomogeneous hypointense aspect on the T1-weighted image (T1WI) and an inhomogeneous hyperintense aspect on the T2-weighted image (T2WI). +After administration of IV gadolinium, there was some inhomogeneous enhancement (Fig.1). +Computed tomography (CT) imaging showed no bone involvement. +During the first operation, a ventriculoperitoneal shunt was inserted into the right lateral ventricle to treat the hydrocephalus. +A careful study of the MRI suggested that this infra- and supratentorially located tumour might be resected through a single approach. +A left frontotemporal transsylvian approach was performed to gain access to the tumour. +The tumour had well-defined margins and was entirely located in the intradural plane. +There were no attachments to the cranial nerves or brainstem. +A macroscopic complete resection was performed. +Postoperatively, the patient had developed a left oculomotor nerve palsy, which completely recovered within the next 4 weeks. +The postoperative MRI showed a complete removal of the tumour (Fig.2). +After careful consideration by a multidisciplinary team, we decided that there was no indication for postoperative radiation therapy. +At follow-up one and a half years later, the patient was found to have remained asymptomatic. +There were no signs of tumour recurrence on the MRI scan. +At a follow-up of more than 6 years after treatment, there were still no signs of tumour recurrence on the MRI scan. +Histological examination showed a slightly lobulated tumour consisting of a chondromyxoid matrix. +The tumour cells showed a vacuolated and pale cytoplasm. +Moderate nuclear polymorphism was observed but no obvious mitotic activity (Fig.3). +Some calcifications were seen. +The tumour cells stained positive for pan-keratin, S-100 and epithelial membrane antigen (EMA). +These findings suggest a histopathological diagnosis of chordoma.