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T1 Age 3 14 11-year-old T2 Sex 15 18 boy T3 Clinical_event 19 28 presented E1 Clinical_event:T3 T4 Duration 96 110 several months E2 Duration:T4 T5 Sign_symptom 47 56 headaches E3 Sign_symptom:T5 T6 Sign_symptom 61 69 vomiting E4 Sign_symptom:T6 T7 Disease_disorder 140 151 papilledema E5 Disease_disorder:T7 T8 Disease_disorder 186 207 neurological deficits E6 Disease_disorder:T8 A1 POLARITY E6 NEG T9 Diagnostic_procedure 112 132 Physical examination E7 Diagnostic_procedure:T9 T10 Diagnostic_procedure 209 235 Magnetic resonance imaging E8 Diagnostic_procedure:T10 T11 Diagnostic_procedure 237 240 MRI E9 Diagnostic_procedure:T11 R1 IDENTICAL Arg1:E9 Arg2:E8 T12 Sign_symptom 270 274 mass E10 Sign_symptom:T12 T13 Biological_structure 259 269 prepontine T14 Detailed_description 253 258 large R2 MODIFY Arg1:T13 Arg2:E10 R3 MODIFY Arg1:T14 Arg2:E10 T15 Sign_symptom 287 299 displacement E11 Sign_symptom:T15 T16 Detailed_description 280 286 dorsal T17 Biological_structure 307 316 brainstem R4 MODIFY Arg1:T16 Arg2:E11 R5 MODIFY Arg1:T17 Arg2:E11 T18 Disease_disorder 345 358 hydrocephalus E12 Disease_disorder:T18 T19 Detailed_description 333 344 obstructive T20 Detailed_description 323 332 secondary R6 MODIFY Arg1:T19 Arg2:E12 R7 MODIFY Arg1:T20 Arg2:E12 T21 Sign_symptom 366 377 compression E13 Sign_symptom:T21 T22 Biological_structure 385 393 aqueduct R8 MODIFY Arg1:T22 Arg2:E13 R9 CAUSE Arg1:E13 Arg2:E12 T23 Coreference 399 405 lesion E14 Coreference:T23 R10 IDENTICAL Arg1:E14 Arg2:E10 T24 Sign_symptom 427 445 hypointense aspect E15 Sign_symptom:T24 T25 Detailed_description 413 426 inhomogeneous R11 MODIFY Arg1:T25 Arg2:E15 T26 Diagnostic_procedure 453 470 T1-weighted image E16 Diagnostic_procedure:T26 R12 SUB_PROCEDURE Arg1:E16 Arg2:E8 T27 Diagnostic_procedure 472 476 T1WI E17 Diagnostic_procedure:T27 R13 IDENTICAL Arg1:E17 Arg2:E16 T28 Sign_symptom 499 518 hyperintense aspect E18 Sign_symptom:T28 T29 Diagnostic_procedure 526 543 T2-weighted image E19 Diagnostic_procedure:T29 T30 Diagnostic_procedure 545 549 T2WI E20 Diagnostic_procedure:T30 R14 IDENTICAL Arg1:E20 Arg2:E19 R15 SUB_PROCEDURE Arg1:E19 Arg2:E8 R16 MODIFY Arg1:E18 Arg2:E19 R17 MODIFY Arg1:E15 Arg2:E16 T31 Detailed_description 485 498 inhomogeneous R18 MODIFY Arg1:T31 Arg2:E18 T32 Medication 579 589 gadolinium E21 Medication:T32 T33 Administration 576 578 IV R19 MODIFY Arg1:T33 Arg2:E21 T34 Sign_symptom 620 631 enhancement E22 Sign_symptom:T34 T35 Detailed_description 606 619 inhomogeneous R20 MODIFY Arg1:T35 Arg2:E22 T36 Diagnostic_procedure 641 660 Computed tomography E23 Diagnostic_procedure:T36 T37 Diagnostic_procedure 662 664 CT E24 Diagnostic_procedure:T37 R21 IDENTICAL Arg1:E24 Arg2:E23 T38 Sign_symptom 684 700 bone involvement E25 Sign_symptom:T38 A2 POLARITY E25 NEG T39 Therapeutic_procedure 753 758 shunt E26 Therapeutic_procedure:T39 T40 Detailed_description 732 752 ventriculoperitoneal R22 MODIFY Arg1:T40 Arg2:E26 T41 Biological_structure 781 804 right lateral ventricle R23 MODIFY Arg1:T41 Arg2:E26 T42 Coreference 818 831 hydrocephalus E27 Coreference:T42 R24 IDENTICAL Arg1:E27 Arg2:E12 T43 Therapeutic_procedure 990 1011 transsylvian approach E28 Therapeutic_procedure:T43 T44 Detailed_description 975 989 frontotemporal T45 Detailed_description 970 974 left R25 MODIFY Arg1:T44 Arg2:E28 R26 MODIFY Arg1:T45 Arg2:E28 T46 Disease_disorder 2274 2282 chordoma E29 Disease_disorder:T46 T47 Sign_symptom 1060 1066 tumour E30 Sign_symptom:T47 T48 Detailed_description 1071 1091 well-defined margins T49 Biological_structure 1124 1140 intradural plane R27 MODIFY Arg1:T48 Arg2:E30 R28 MODIFY Arg1:T49 Arg2:E30 T50 Sign_symptom 1156 1167 attachments E31 Sign_symptom:T50 A3 POLARITY E31 NEG T51 Biological_structure 1175 1189 cranial nerves T52 Biological_structure 1193 1202 brainstem R29 MODIFY Arg1:T51 Arg2:E31 R30 MODIFY Arg1:T52 Arg2:E31 T53 Therapeutic_procedure 1227 1236 resection E32 Therapeutic_procedure:T53 T54 Detailed_description 1206 1217 macroscopic T55 Detailed_description 1218 1226 complete R31 MODIFY Arg1:T55 Arg2:E32 R32 MODIFY Arg1:T54 Arg2:E32 T56 Disease_disorder 1313 1324 nerve palsy E33 Disease_disorder:T56 T57 Biological_structure 1297 1312 left oculomotor R33 MODIFY Arg1:T57 Arg2:E33 T58 Date 1353 1376 within the next 4 weeks E34 Date:T58 T59 Sign_symptom 1343 1352 recovered E35 Sign_symptom:T59 T60 Diagnostic_procedure 1396 1399 MRI E36 Diagnostic_procedure:T60 T61 Sign_symptom 1433 1439 tumour E37 Sign_symptom:T61 A4 POLARITY E37 NEG T62 Detailed_description 1409 1425 complete removal R34 MODIFY Arg1:T62 Arg2:E37 T63 Therapeutic_procedure 1564 1581 radiation therapy E38 Therapeutic_procedure:T63 A5 POLARITY E38 NEG T64 Clinical_event 1586 1595 follow-up E39 Clinical_event:T64 T65 Date 1596 1622 one and a half years later E40 Date:T65 T66 Sign_symptom 1663 1675 asymptomatic E41 Sign_symptom:T66 T67 Sign_symptom 1700 1717 tumour recurrence E42 Sign_symptom:T67 A6 POLARITY E42 NEG T68 Diagnostic_procedure 1725 1728 MRI E43 Diagnostic_procedure:T68 T69 Clinical_event 1740 1749 follow-up E44 Clinical_event:T69 T70 Date 1753 1770 more than 6 years E45 Date:T70 T71 Sign_symptom 1817 1834 tumour recurrence E46 Sign_symptom:T71 A7 POLARITY E46 NEG T72 Diagnostic_procedure 1842 1845 MRI E47 Diagnostic_procedure:T72 T73 Sign_symptom 1905 1911 tumour E48 Sign_symptom:T73 T74 Diagnostic_procedure 1852 1876 Histological examination E49 Diagnostic_procedure:T74 T75 Shape 1886 1904 slightly lobulated R35 MODIFY Arg1:T75 Arg2:E48 T76 Detailed_description 1928 1948 chondromyxoid matrix R36 MODIFY Arg1:T76 Arg2:E48 T77 Coreference 1954 1966 tumour cells E50 Coreference:T77 R37 IDENTICAL Arg1:E50 Arg2:E48 T78 Diagnostic_procedure 1996 2005 cytoplasm E51 Diagnostic_procedure:T78 T79 Lab_value 1976 1986 vacuolated T80 Lab_value 1991 1995 pale R38 MODIFY Arg1:T80 Arg2:E51 R39 MODIFY Arg1:T79 Arg2:E51 R40 SUB_PROCEDURE Arg1:E51 Arg2:E49 T81 Sign_symptom 2016 2036 nuclear polymorphism E52 Sign_symptom:T81 T82 Severity 2007 2015 Moderate R41 MODIFY Arg1:T82 Arg2:E52 T83 Sign_symptom 2065 2081 mitotic activity E53 Sign_symptom:T83 A8 POLARITY E53 NEG T84 Sign_symptom 2096 2110 calcifications E54 Sign_symptom:T84 T85 Diagnostic_procedure 2160 2171 pan-keratin E55 Diagnostic_procedure:T85 T86 Diagnostic_procedure 2173 2178 S-100 E56 Diagnostic_procedure:T86 T87 Diagnostic_procedure 2183 2210 epithelial membrane antigen E57 Diagnostic_procedure:T87 T88 Diagnostic_procedure 2212 2215 EMA E58 Diagnostic_procedure:T88 R42 IDENTICAL Arg1:E58 Arg2:E57 T89 Lab_value 2147 2155 positive R43 MODIFY Arg1:T89 Arg2:E55 R44 MODIFY Arg1:T89 Arg2:E56 R45 MODIFY Arg1:T89 Arg2:E57 T90 Coreference 2126 2138 tumour cells E59 Coreference:T90 R46 IDENTICAL Arg1:E59 Arg2:E50 R47 AFTER Arg1:E1 Arg2:E3 * OVERLAP E3 E4 E2 R48 BEFORE Arg1:E2 Arg2:E7 * OVERLAP E7 E5 E6 E8 E10 E11 E12 E13 E15 E18 R49 BEFORE Arg1:E18 Arg2:E21 * OVERLAP E21 E22 E23 E25 R50 BEFORE Arg1:E25 Arg2:E26 * OVERLAP E26 E28 E30 E31 E32 R51 BEFORE Arg1:E32 Arg2:E33 R52 BEFORE Arg1:E33 Arg2:E35 * OVERLAP E35 E34 R53 AFTER Arg1:E34 Arg2:E36 * OVERLAP E36 E37 E38 R54 BEFORE Arg1:E38 Arg2:E39 * OVERLAP E39 E40 E41 E42 E43 R55 BEFORE Arg1:E43 Arg2:E44 * OVERLAP E44 E45 E46 E47 R56 BEFORE Arg1:E47 Arg2:E49 * OVERLAP E49 E48 E50 E51 E52 E53 E54 E59 E55 E56 E57 E29