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T1 Age 15 24 early 70s T2 Sex 2 7 woman T3 Clinical_event 25 34 presented E1 Clinical_event:T3 T4 Nonbiological_location 42 56 emergency room R1 MODIFY Arg1:T4 Arg2:E1 T5 Subject 74 81 husband T6 Time 57 69 30 min after E2 Time:T6 T8 Sign_symptom 118 122 pain E3 Sign_symptom:T8 T9 Lab_value 95 99 8/10 R3 MODIFY Arg1:T9 Arg2:E3 T10 Sign_symptom 139 150 diaphoresis E4 Sign_symptom:T10 T11 Sign_symptom 155 163 dyspnoea E5 Sign_symptom:T11 T12 Biological_structure 112 117 chest T13 Biological_structure 101 111 substernal R4 MODIFY Arg1:T13 Arg2:T12 R5 MODIFY Arg1:T12 Arg2:E3 T14 Subject 179 186 husband T15 Detailed_description 194 224 out-of-hospital cardiac arrest R6 MODIFY Arg1:T15 Arg2:T14 T16 Time 225 241 earlier that day E6 Time:T16 T17 Detailed_description 250 279 brought to our emergency room R7 MODIFY Arg1:T17 Arg2:T14 T18 Detailed_description 297 331 admitted to the coronary care unit R8 MODIFY Arg1:T18 Arg2:T14 T19 Coreference 333 335 He E7 Coreference:T19 R9 IDENTICAL Arg1:E7 Arg2:T14 T20 Detailed_description 340 374 recurrent ventricular fibrillation T21 Detailed_description 379 417 could not be successfully resuscitated R10 MODIFY Arg1:T20 Arg2:E7 R11 MODIFY Arg1:T21 Arg2:E7 T22 History 458 470 hypertension T23 History 495 538 denied having had a similar episode of pain T24 History 544 600 had regular appointments with her primary care physician T25 Medication 606 616 medication E8 Medication:T25 T26 Medication 631 641 furosemide E9 Medication:T26 T27 Medication 652 665 levothyroxine E10 Medication:T27 T28 Administration 626 630 oral T29 Dosage 642 647 20 mg T30 Dosage 666 672 100 µg R12 MODIFY Arg1:T29 Arg2:E9 R13 MODIFY Arg1:T30 Arg2:E10 T31 Dosage 679 689 once daily R14 MODIFY Arg1:T31 Arg2:E10 R15 MODIFY Arg1:T31 Arg2:E9 T32 History 695 711 denied allergies T33 Clinical_event 716 728 presentation E11 Clinical_event:T33 T34 Sign_symptom 746 754 afebrile E12 Sign_symptom:T34 T35 Diagnostic_procedure 763 777 blood pressure E13 Diagnostic_procedure:T35 T36 Lab_value 781 787 105/55 R16 MODIFY Arg1:T36 Arg2:E13 T37 Diagnostic_procedure 789 799 heart rate E14 Diagnostic_procedure:T37 T38 Lab_value 803 809 93 bpm R17 MODIFY Arg1:T38 Arg2:E14 T39 Diagnostic_procedure 811 827 respiratory rate E15 Diagnostic_procedure:T39 T40 Lab_value 831 837 20/min R18 MODIFY Arg1:T40 Arg2:E15 T41 Diagnostic_procedure 845 862 oxygen saturation E16 Diagnostic_procedure:T41 T42 Lab_value 866 869 98% T43 Detailed_description 873 881 room air R19 MODIFY Arg1:T43 Arg2:E16 R20 MODIFY Arg1:T42 Arg2:E16 T44 Diagnostic_procedure 886 906 physical examination E17 Diagnostic_procedure:T44 T45 Sign_symptom 947 951 pain E18 Sign_symptom:T45 T46 Sign_symptom 931 939 distress E19 Sign_symptom:T46 R21 CAUSE Arg1:E18 Arg2:E19 T47 Severity 919 930 significant R22 MODIFY Arg1:T47 Arg2:E19 T48 Diagnostic_procedure 957 961 skin E20 Diagnostic_procedure:T48 T49 Lab_value 966 970 warm T50 Lab_value 975 980 moist R23 MODIFY Arg1:T49 Arg2:E20 R24 MODIFY Arg1:T50 Arg2:E20 T51 Diagnostic_procedure 1007 1022 bilateral bases E21 Diagnostic_procedure:T51 T52 Lab_value 987 1003 minimal crackles R25 MODIFY Arg1:T52 Arg2:E21 T53 Diagnostic_procedure 1032 1047 rate and rhythm E22 Diagnostic_procedure:T53 T54 Lab_value 1024 1031 regular R26 MODIFY Arg1:T54 Arg2:E22 T55 Sign_symptom 1062 1068 murmur E23 Sign_symptom:T55 T56 Lab_value 1049 1061 2/6 systolic R27 MODIFY Arg1:T56 Arg2:E23 T57 Detailed_description 1069 1098 of the apex without radiation R28 MODIFY Arg1:T57 Arg2:E23 T58 Sign_symptom 1103 1107 rubs E24 Sign_symptom:T58 A1 POLARITY E24 NEG T59 Sign_symptom 1131 1141 distention E25 Sign_symptom:T59 T60 Biological_structure 1118 1130 jugular vein R29 MODIFY Arg1:T60 Arg2:E25 T61 Distance 1145 1149 8 cm R30 MODIFY Arg1:T61 Arg2:E25 T62 Lab_value 1109 1117 elevated R31 MODIFY Arg1:T62 Arg2:E25 T63 Sign_symptom 1194 1200 oedema E26 Sign_symptom:T63 A2 POLARITY E26 NEG T64 Detailed_description 1183 1193 peripheral R32 MODIFY Arg1:T64 Arg2:E26 T65 Diagnostic_procedure 1169 1175 pulses E27 Diagnostic_procedure:T65 T66 Lab_value 1151 1157 strong R33 MODIFY Arg1:T66 Arg2:E27 T67 Detailed_description 1158 1168 peripheral R34 MODIFY Arg1:T67 Arg2:E27 T68 Diagnostic_procedure 1206 1213 abdomen E28 Diagnostic_procedure:T68 T69 Lab_value 1218 1222 soft T70 Lab_value 1224 1234 non-tender T71 Lab_value 1236 1249 non-distended R35 MODIFY Arg1:T69 Arg2:E28 R36 MODIFY Arg1:T70 Arg2:E28 R37 MODIFY Arg1:T71 Arg2:E28 T72 Lab_value 1251 1268 with bowel sounds R38 MODIFY Arg1:T72 Arg2:E28 T73 Sign_symptom 1290 1295 alert E29 Sign_symptom:T73 T74 Sign_symptom 1300 1308 oriented E30 Sign_symptom:T74 T75 Sign_symptom 1323 1344 neurological deficits E31 Sign_symptom:T75 A3 POLARITY E31 NEG T76 Detailed_description 1317 1322 focal R39 MODIFY Arg1:T76 Arg2:E31 T77 Diagnostic_procedure 1350 1370 complete blood count E32 Diagnostic_procedure:T77 T78 Diagnostic_procedure 1372 1393 basic metabolic panel E33 Diagnostic_procedure:T78 T79 Diagnostic_procedure 1398 1415 coagulation tests E34 Diagnostic_procedure:T79 T80 Lab_value 1421 1441 within normal limits R40 MODIFY Arg1:T80 Arg2:E34 R41 MODIFY Arg1:T80 Arg2:E33 R42 MODIFY Arg1:T80 Arg2:E32 T81 Diagnostic_procedure 1447 1462 cardiac enzymes E35 Diagnostic_procedure:T81 T82 Lab_value 1468 1477 increased R43 MODIFY Arg1:T82 Arg2:E35 T83 Diagnostic_procedure 1485 1495 troponin I E36 Diagnostic_procedure:T83 T84 Lab_value 1499 1509 2.59 ng/mL T85 Diagnostic_procedure 1544 1566 creatine phosphokinase E37 Diagnostic_procedure:T85 T86 Lab_value 1570 1576 84 U/L R44 MODIFY Arg1:T86 Arg2:E37 T87 Diagnostic_procedure 1604 1607 ECG E38 Diagnostic_procedure:T87 T88 Clinical_event 1611 1620 admission E39 Clinical_event:T88 T89 Clinical_event 2188 2193 taken E40 Clinical_event:T89 T90 Nonbiological_location 2201 2235 cardiac catheterisation laboratory R45 MODIFY Arg1:T90 Arg2:E40 T91 Diagnostic_procedure 1637 1649 sinus rhythm E41 Diagnostic_procedure:T91 T92 Lab_value 1630 1636 normal R46 MODIFY Arg1:T92 Arg2:E41 T93 Lab_value 1655 1698 2–3 mm ST segment elevations in leads V2–V3 T94 Lab_value 1703 1725 Q waves in leads V1–V3 R47 MODIFY Arg1:T93 Arg2:E41 R48 MODIFY Arg1:T94 Arg2:E41 T95 Disease_disorder 1755 1762 infarct E42 Disease_disorder:T95 A4 POLARITY E42 MAYBE_POS T96 Biological_structure 1741 1754 anterior wall R49 MODIFY Arg1:T96 Arg2:E42 T97 Diagnostic_procedure 1778 1792 echocardiogram E43 Diagnostic_procedure:T97 T98 Diagnostic_procedure 1802 1836 left ventricular ejection fraction E44 Diagnostic_procedure:T98 T99 Lab_value 1840 1846 30–35% R50 MODIFY Arg1:T99 Arg2:E44 T100 Sign_symptom 1885 1896 hypertrophy E45 Sign_symptom:T100 T101 Biological_structure 1868 1884 left ventricular T102 Detailed_description 1857 1867 concentric T103 Severity 1852 1856 mild R51 MODIFY Arg1:T101 Arg2:E45 R52 MODIFY Arg1:T102 Arg2:E45 R53 MODIFY Arg1:T103 Arg2:E45 T104 Sign_symptom 1898 1906 akinesis E46 Sign_symptom:T104 T105 Biological_structure 1914 1918 apex R54 MODIFY Arg1:T105 Arg2:E46 T106 Biological_structure 1923 1946 2/3 of the inferoseptum R55 MODIFY Arg1:T106 Arg2:E46 T107 Biological_structure 1951 1989 apical inferior-anterior wall segments R56 MODIFY Arg1:T107 Arg2:E46 T108 Sign_symptom 2002 2018 ischaemic damage E47 Sign_symptom:T108 A5 POLARITY E47 MAYBE_POS T109 Biological_structure 2026 2057 left anterior descending artery R57 MODIFY Arg1:T109 Arg2:E47 T110 Disease_disorder 2078 2102 takotsubo cardiomyopathy E48 Disease_disorder:T110 A6 POLARITY E48 MAYBE_POS T111 Medication 2144 2151 aspirin E49 Medication:T111 T112 Medication 2163 2172 prasugrel E50 Medication:T112 T113 Dosage 2152 2158 162 mg T114 Dosage 2173 2178 60 mg R58 MODIFY Arg1:T114 Arg2:E50 R59 MODIFY Arg1:T113 Arg2:E49 T115 Diagnostic_procedure 2241 2250 angiogram E51 Diagnostic_procedure:T115 T116 Disease_disorder 2274 2297 coronary artery disease E52 Disease_disorder:T116 T117 Detailed_description 2258 2273 non-obstructive R60 MODIFY Arg1:T117 Arg2:E52 T118 Sign_symptom 2311 2325 irregularities E53 Sign_symptom:T118 T119 Biological_structure 2303 2310 luminal R61 MODIFY Arg1:T119 Arg2:E53 T120 Diagnostic_procedure 2350 2371 left ventriculography E54 Diagnostic_procedure:T120 T121 Diagnostic_procedure 2382 2399 ejection fraction E55 Diagnostic_procedure:T121 T122 Lab_value 2403 2406 35% R62 MODIFY Arg1:T122 Arg2:E55 T123 Sign_symptom 2412 2420 akinesis E56 Sign_symptom:T123 T124 Biological_structure 2424 2435 apical wall R63 MODIFY Arg1:T124 Arg2:E56 T125 Sign_symptom 2440 2452 hyperkinesis E57 Sign_symptom:T125 T126 Biological_structure 2456 2470 basal segments R64 MODIFY Arg1:T126 Arg2:E57 T127 Diagnostic_procedure 2511 2527 haemodynamically E58 Diagnostic_procedure:T127 T128 Lab_value 2528 2534 stable R65 MODIFY Arg1:T128 Arg2:E58 T129 Medication 2559 2584 heart failure medications E59 Medication:T129 T130 Administration 2554 2558 oral R66 MODIFY Arg1:T130 Arg2:E59 T131 Medication 2596 2606 lisinopril E60 Medication:T131 T132 Dosage 2607 2619 2.5 mg daily T133 Medication 2624 2643 metoprolol tartrate E61 Medication:T133 T134 Dosage 2644 2667 12.5 mg two times a day R67 MODIFY Arg1:T134 Arg2:E61 R68 MODIFY Arg1:T132 Arg2:E60 R69 SUB_PROCEDURE Arg1:E60 Arg2:E59 R70 SUB_PROCEDURE Arg1:E61 Arg2:E59 T135 Sign_symptom 2673 2677 pain E62 Sign_symptom:T135 A7 POLARITY E62 NEG T136 Sign_symptom 2682 2701 shortness of breath E63 Sign_symptom:T136 A8 POLARITY E63 NEG T137 Clinical_event 2723 2733 discharged E64 Clinical_event:T137 T138 Nonbiological_location 2734 2738 home R71 MODIFY Arg1:T138 Arg2:E64 T139 Date 2739 2749 after 48 h E65 Date:T139 T140 Diagnostic_procedure 2779 2788 condition E66 Diagnostic_procedure:T140 T141 Lab_value 2772 2778 stable R72 MODIFY Arg1:T141 Arg2:E66 T142 Diagnostic_procedure 2799 2813 echocardiogram E67 Diagnostic_procedure:T142 T143 Date 2814 2828 2 months later E68 Date:T143 T144 Disease_disorder 2854 2868 cardiomyopathy E69 Disease_disorder:T144 A9 POLARITY E69 NEG T145 Diagnostic_procedure 2876 2893 ejection fraction E70 Diagnostic_procedure:T145 T146 Lab_value 2897 2903 65–70% R73 MODIFY Arg1:T146 Arg2:E70 T147 Diagnostic_procedure 2917 2940 left ventricular motion E71 Diagnostic_procedure:T147 T148 Lab_value 2910 2916 normal R74 MODIFY Arg1:T148 Arg2:E71 * OVERLAP E1 E2 T7 Outcome 82 89 expired E72 Outcome:T7 R2 MODIFY Arg1:T5 Arg2:E72 R75 AFTER Arg1:E2 Arg2:E72 R76 BEFORE Arg1:E72 Arg2:E3 * OVERLAP E3 E4 E5 E8 E11 E12 E13 E14 E15 E16 E17 E19 E18 E20 E21 E22 E23 E24 E25 E27 E26 E28 E29 E30 E31 E32 E33 E34 E35 E36 E37 E38 E39 E41 E42 E43 E44 E45 E46 E47 E48 R77 SUB_PROCEDURE Arg1:E9 Arg2:E8 R78 SUB_PROCEDURE Arg1:E10 Arg2:E8 R79 MODIFY Arg1:T84 Arg2:E36 R80 BEFORE Arg1:E48 Arg2:E49 * OVERLAP E49 E50 R81 BEFORE Arg1:E50 Arg2:E40 * OVERLAP E40 E51 E52 E53 E54 E55 E56 E57 R82 BEFORE Arg1:E57 Arg2:E58 * OVERLAP E58 E59 R83 BEFORE Arg1:E59 Arg2:E62 * OVERLAP E62 E63 E64 E65 E66 R84 BEFORE Arg1:E66 Arg2:E67 * OVERLAP E67 E68 E69 E70 E71 T149 History 475 489 hypothyroidism