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T1 Age 2 13 71-year-old T2 Personal_background 14 30 African-American T3 Sex 31 36 woman T4 Clinical_event 37 46 presented E1 Clinical_event:T4 T5 Sign_symptom 89 97 dyspnoea E2 Sign_symptom:T5 A1 TREND E2 INC T6 Detailed_description 78 88 exertional T7 Lab_value 68 77 worsening R1 MODIFY Arg1:T6 Arg2:E2 R2 MODIFY Arg1:T7 Arg2:E2 T8 Sign_symptom 114 124 orthopnoea E3 Sign_symptom:T8 T9 Sign_symptom 145 151 oedema E4 Sign_symptom:T9 T10 Biological_structure 129 144 lower extremity R3 MODIFY Arg1:T10 Arg2:E4 T11 Duration 156 163 3 weeks E5 Duration:T11 T12 History 200 212 hypertension T13 Sign_symptom 200 212 hypertension E6 Sign_symptom:T13 T14 Disease_disorder 228 243 G6PD deficiency E7 Disease_disorder:T14 T15 History 228 243 G6PD deficiency T16 Sign_symptom 267 277 haemolysis E8 Sign_symptom:T16 T17 History 289 312 former cigarette smoker T18 Family_history 341 356 G6PD deficiency T19 Subject 321 335 family members T20 Family_history 358 370 hypertension T21 Family_history 375 392 diabetes mellitus R4 MODIFY Arg1:T19 Arg2:T18 R5 MODIFY Arg1:T19 Arg2:T20 R6 MODIFY Arg1:T19 Arg2:T21 T22 Diagnostic_procedure 394 417 Vital signs measurement E9 Diagnostic_procedure:T22 T23 Diagnostic_procedure 429 443 blood pressure E10 Diagnostic_procedure:T23 R7 SUB_PROCEDURE Arg1:E10 Arg2:E9 T24 Lab_value 447 459 150/73 mm Hg R8 MODIFY Arg1:T24 Arg2:E10 T25 Diagnostic_procedure 461 471 pulse rate E11 Diagnostic_procedure:T25 T26 Lab_value 475 481 70 bpm R9 MODIFY Arg1:T26 Arg2:E11 T27 Diagnostic_procedure 483 499 respiratory rate E12 Diagnostic_procedure:T27 T28 Lab_value 503 517 24 breaths/min R10 MODIFY Arg1:T28 Arg2:E12 T29 Diagnostic_procedure 519 530 temperature E13 Diagnostic_procedure:T29 T30 Lab_value 534 540 36.6°C R11 MODIFY Arg1:T30 Arg2:E13 T31 Diagnostic_procedure 549 559 saturation E14 Diagnostic_procedure:T31 T32 Lab_value 545 548 97% R12 MODIFY Arg1:T32 Arg2:E14 T33 Detailed_description 563 572 room air. R13 MODIFY Arg1:T33 Arg2:E14 R14 SUB_PROCEDURE Arg1:E11 Arg2:E9 R15 SUB_PROCEDURE Arg1:E12 Arg2:E9 R16 SUB_PROCEDURE Arg1:E13 Arg2:E9 R17 SUB_PROCEDURE Arg1:E14 Arg2:E9 T34 Sign_symptom 581 592 comfortable E15 Sign_symptom:T34 T35 Detailed_description 596 600 rest R18 MODIFY Arg1:T35 Arg2:E15 T36 Diagnostic_procedure 606 626 physical examination E16 Diagnostic_procedure:T36 T37 Sign_symptom 634 643 distended E17 Sign_symptom:T37 T38 Biological_structure 644 657 jugular veins R19 MODIFY Arg1:T38 Arg2:E17 T39 Sign_symptom 671 679 crackles E18 Sign_symptom:T39 T40 Biological_structure 683 703 bilateral lung bases R20 MODIFY Arg1:T40 Arg2:E18 T41 Detailed_description 659 670 inspiratory R21 MODIFY Arg1:T41 Arg2:E18 T43 Diagnostic_procedure 727 741 apical impulse E20 Diagnostic_procedure:T43 T42 Lab_value 707 726 laterally displaced R22 MODIFY Arg1:T42 Arg2:E20 T44 Sign_symptom 754 760 oedema E19 Sign_symptom:T44 T45 Biological_structure 746 753 bipedal R23 MODIFY Arg1:T45 Arg2:E19 T46 Diagnostic_procedure 766 769 ECG E21 Diagnostic_procedure:T46 T47 Sign_symptom 794 805 hypertrophy E22 Sign_symptom:T47 T48 Biological_structure 777 793 left ventricular R24 MODIFY Arg1:T48 Arg2:E22 T49 Sign_symptom 824 841 T-wave inversions E23 Sign_symptom:T49 T50 Detailed_description 810 823 inferolateral R25 MODIFY Arg1:T50 Arg2:E23 T51 Diagnostic_procedure 849 860 radiography E24 Diagnostic_procedure:T51 T52 Biological_structure 843 848 Chest R26 MODIFY Arg1:T52 Arg2:E24 T53 Sign_symptom 870 882 cardiomegaly E25 Sign_symptom:T53 T54 Sign_symptom 902 908 oedema E26 Sign_symptom:T54 T55 Biological_structure 892 901 pulmonary R27 MODIFY Arg1:T55 Arg2:E26 T56 Severity 887 891 mild R28 MODIFY Arg1:T56 Arg2:E26 T57 Diagnostic_procedure 914 929 metabolic panel E27 Diagnostic_procedure:T57 T58 Diagnostic_procedure 934 942 troponin E28 Diagnostic_procedure:T58 T59 Lab_value 955 961 normal R29 MODIFY Arg1:T59 Arg2:E28 R30 MODIFY Arg1:T59 Arg2:E27 T60 Diagnostic_procedure 970 996 B-type natriuretic peptide E29 Diagnostic_procedure:T60 T61 Lab_value 1001 1010 increased T62 Lab_value 1014 1025 826.5 pg/mL R31 MODIFY Arg1:T61 Arg2:E29 R32 MODIFY Arg1:T62 Arg2:E29 T63 Diagnostic_procedure 1027 1043 Echocardiography E30 Diagnostic_procedure:T63 T64 Sign_symptom 1053 1060 dilated E31 Sign_symptom:T64 T65 Biological_structure 1061 1075 left ventricle R33 MODIFY Arg1:T65 Arg2:E31 T66 Diagnostic_procedure 1084 1101 ejection fraction E32 Diagnostic_procedure:T66 T67 Diagnostic_procedure 1103 1105 EF E33 Diagnostic_procedure:T67 R34 IDENTICAL Arg1:E33 Arg2:E32 T68 Lab_value 1110 1113 30% R35 MODIFY Arg1:T68 Arg2:E32 R36 MODIFY Arg1:T65 Arg2:E32 T69 Disease_disorder 1141 1161 systolic dysfunction E34 Disease_disorder:T69 T70 Biological_structure 1123 1140 right ventricular R37 MODIFY Arg1:T70 Arg2:E34 T71 Severity 1118 1122 mild R38 MODIFY Arg1:T71 Arg2:E34 T72 Therapeutic_procedure 1179 1194 catheterisation E35 Therapeutic_procedure:T72 T73 Biological_structure 1163 1178 Coronary artery R39 MODIFY Arg1:T73 Arg2:E35 T74 Diagnostic_procedure 1211 1231 coronary circulation E36 Diagnostic_procedure:T74 T75 Lab_value 1204 1210 normal R40 MODIFY Arg1:T75 Arg2:E36 T76 Medication 1233 1248 Ethacrynic acid E37 Medication:T76 T77 Dosage 1252 1263 50 mg daily R41 MODIFY Arg1:T77 Arg2:E37 T78 Sign_symptom 1293 1301 improved E38 Sign_symptom:T78 T79 Date 1302 1313 after a day E39 Date:T79 T80 Sign_symptom 1328 1336 dyspnoea E40 Sign_symptom:T80 T81 Medication 1350 1364 spironolactone E41 Medication:T81 T82 Medication 1380 1400 metoprolol succinate E42 Medication:T82 T83 Medication 1405 1413 losartan E43 Medication:T83 T84 Diagnostic_procedure 1457 1468 radiography E44 Diagnostic_procedure:T84 T85 Biological_structure 1451 1456 chest R42 MODIFY Arg1:T85 Arg2:E44 T86 Sign_symptom 1500 1506 oedema E45 Sign_symptom:T86 A2 POLARITY E45 NEG T87 Biological_structure 1490 1499 pulmonary R43 MODIFY Arg1:T87 Arg2:E45 T88 Diagnostic_procedure 1522 1540 laboratory results E46 Diagnostic_procedure:T88 T89 Sign_symptom 1588 1598 haemolysis E47 Sign_symptom:T89 A3 POLARITY E47 NEG T90 Sign_symptom 1603 1628 worsening kidney function E48 Sign_symptom:T90 A4 POLARITY E48 NEG T91 Sign_symptom 1650 1661 ototoxicity E49 Sign_symptom:T91 A5 POLARITY E49 NEG T92 Sign_symptom 1686 1698 asymptomatic E50 Sign_symptom:T92 T93 Clinical_event 1670 1680 discharged E51 Clinical_event:T93 T94 Nonbiological_location 1681 1685 home R44 MODIFY Arg1:T94 Arg2:E51 * OVERLAP E1 E2 R45 AFTER Arg1:E2 Arg2:E3 * OVERLAP E3 E4 E5 R46 AFTER Arg1:E5 Arg2:E6 * OVERLAP E6 E7 E8 R47 BEFORE Arg1:E8 Arg2:E9 * OVERLAP E9 E15 E16 E17 E18 E20 E19 E21 E22 E23 E24 E25 E26 E27 E28 E29 E30 E31 E32 E34 R48 BEFORE Arg1:E34 Arg2:E35 * OVERLAP E35 E36 R49 BEFORE Arg1:E36 Arg2:E37 R50 BEFORE Arg1:E37 Arg2:E38 * OVERLAP E38 E39 E40 R51 BEFORE Arg1:E40 Arg2:E41 R52 BEFORE Arg1:E41 Arg2:E42 * OVERLAP E42 E43 R53 BEFORE Arg1:E43 Arg2:E44 * OVERLAP E44 E45 E46 E47 E48 E49 R54 BEFORE Arg1:E49 Arg2:E51 * OVERLAP E51 E50