408 lines (407 with data), 14.1 kB

T1	Age 2 13	68-year-old
T2	Sex 14 17	man
T3	Subject 34 49	his optometrist
T4	Clinical_event 22 30	referred
E1	Clinical_event:T4 
T5	Nonbiological_location 53 56	HES
T6	Disease_disorder 72 75	LTG
E2	Disease_disorder:T6 
A1	POLARITY E2 MAYBE_POS
T7	Diagnostic_procedure 104 129	visual field test results
E3	Diagnostic_procedure:T7 
T8	Detailed_description 83 103	repeatedly irregular
R1	MODIFY Arg1:T8 Arg2:E3	
T9	Diagnostic_procedure 167 188	intraocular pressures
E4	Diagnostic_procedure:T9 
T10	Diagnostic_procedure 190 194	IOPs
E5	Diagnostic_procedure:T10 
R2	IDENTICAL Arg1:E5 Arg2:E4	
T11	Disease_disorder 220 228	glaucoma
E6	Disease_disorder:T11 
T12	Family_history 220 228	glaucoma
T13	Diagnostic_procedure 140 158	optic disc cupping
E7	Diagnostic_procedure:T13 
T14	Detailed_description 131 139	advanced
R3	MODIFY Arg1:T14 Arg2:E7	
T15	Lab_value 160 166	normal
R4	MODIFY Arg1:T15 Arg2:E4	
T16	Biological_structure 286 294	left eye
T17	Biological_structure 296 298	LE
R5	IDENTICAL Arg1:T17 Arg2:T16	
T18	Lab_value 339 345	6/6 N5
T19	Date 370 386	6 months earlier
E8	Date:T19 
T20	Diagnostic_procedure 322 335	visual acuity
E9	Diagnostic_procedure:T20 
T21	Detailed_description 280 284	good
R6	MODIFY Arg1:T21 Arg2:T16	
R7	MODIFY Arg1:T18 Arg2:E9	
R8	BEFORE Arg1:E9 Arg2:E8	
T22	Lab_value 438 446	6/7.5 N6
T23	Coreference 413 415	it
E10	Coreference:T23 
R9	IDENTICAL Arg1:E10 Arg2:E11	
R10	MODIFY Arg1:T22 Arg2:E10	
R11	BEFORE Arg1:E8 Arg2:E10	
T24	Sign_symptom 265 271	vision
E11	Sign_symptom:T24 
R12	MODIFY Arg1:T16 Arg2:E11	
T25	Detailed_description 358 369	deteriorate
R13	MODIFY Arg1:T25 Arg2:E11	
A2	TREND E11 DEC
*	OVERLAP E11 E8 E2
R14	AFTER Arg1:E11 Arg2:E9	
A3	TREND E10 INC
T26	Biological_structure 452 461	right eye
T27	Biological_structure 463 465	RE
R15	IDENTICAL Arg1:T27 Arg2:T26	
T28	Disease_disorder 483 492	amblyopic
E12	Disease_disorder:T28 
T29	Lab_value 517 525	6/18 N12
T30	Diagnostic_procedure 500 513	visual acuity
E13	Diagnostic_procedure:T30 
R16	MODIFY Arg1:T29 Arg2:E13	
R17	MODIFY Arg1:E12 Arg2:T27	
R18	MODIFY Arg1:E13 Arg2:T27	
T31	Disease_disorder 617 629	hypertension
E14	Disease_disorder:T31 
T32	Disease_disorder 631 652	hypercholesterolaemia
E15	Disease_disorder:T32 
T33	Lab_value 654 667	50 pack-years
T34	History 671 678	smoking
T35	Disease_disorder 683 698	type 2 diabetes
E16	Disease_disorder:T35 
T36	Disease_disorder 707 727	diabetic retinopathy
E17	Disease_disorder:T36 
A4	POLARITY E17 NEG
T37	History 617 629	hypertension
T38	History 631 652	hypercholesterolaemia
T39	Disease_disorder 595 607	vasculopathy
E18	Disease_disorder:T39 
T40	Detailed_description 586 594	systemic
R19	MODIFY Arg1:T40 Arg2:E18	
T41	Sign_symptom 569 581	risk factors
E19	Sign_symptom:T41 
R20	BEFORE Arg1:E18 Arg2:E19	
T42	History 569 581	risk factors
A5	POLARITY E18 UNCERTAIN
R21	MODIFY Arg1:E14 Arg2:E19	
R22	MODIFY Arg1:E15 Arg2:E19	
R23	MODIFY Arg1:T33 Arg2:T34	
R24	MODIFY Arg1:T34 Arg2:E19	
R25	MODIFY Arg1:E16 Arg2:E19	
R26	MODIFY Arg1:E17 Arg2:E19	
T43	Sign_symptom 773 794	new systemic symptoms
E20	Sign_symptom:T43 
A6	POLARITY E20 NEG
T44	Sign_symptom 829 837	lethargy
E21	Sign_symptom:T44 
T45	Lab_value 819 828	increased
R27	MODIFY Arg1:T45 Arg2:E21	
*	OVERLAP E20 E21 E22 E13
T46	Nonbiological_location 863 866	HES
T47	Diagnostic_procedure 839 859	Clinical examination
E22	Diagnostic_procedure:T47 
R28	MODIFY Arg1:T46 Arg2:E22	
T48	Diagnostic_procedure 895 913	cupped optic discs
E23	Diagnostic_procedure:T48 
T49	Detailed_description 876 894	advanced bilateral
R29	MODIFY Arg1:T49 Arg2:E23	
R30	SUB_PROCEDURE Arg1:E23 Arg2:E22	
T50	Diagnostic_procedure 921 938	cup-to-disc ratio
E24	Diagnostic_procedure:T50 
R31	SUB_PROCEDURE Arg1:E24 Arg2:E23	
T51	Lab_value 945 948	0.9
T52	Lab_value 950 953	90%
T53	Lab_value 964 967	0.8
T54	Lab_value 969 972	80%
R32	IDENTICAL Arg1:T54 Arg2:T53	
R33	IDENTICAL Arg1:T52 Arg2:T51	
T55	Subject 1030 1041	optometrist
R34	MODIFY Arg1:T51 Arg2:E24	
R36	MODIFY Arg1:T53 Arg2:E24	
T57	Detailed_description 939 944	right
R37	MODIFY Arg1:T57 Arg2:T51	
T56	Detailed_description 959 963	left
R35	MODIFY Arg1:T56 Arg2:T53	
T58	Detailed_description 1020 1029	referring
R38	MODIFY Arg1:T58 Arg2:T55	
T59	Diagnostic_procedure 1097 1101	IOPs
E25	Diagnostic_procedure:T59 
T60	Diagnostic_procedure 1079 1092	eye movements
E26	Diagnostic_procedure:T60 
T61	Lab_value 1072 1078	normal
R39	MODIFY Arg1:T61 Arg2:E26	
T62	Age 1105 1114	mid-teens
R40	MODIFY Arg1:T62 Arg2:E25	
R41	MODIFY Arg1:T62 Arg2:E26	
T63	Diagnostic_procedure 1131 1153	Computerised perimetry
E27	Diagnostic_procedure:T63 
T64	Diagnostic_procedure 1173 1186	visual fields
E28	Diagnostic_procedure:T64 
T65	Detailed_description 1161 1172	constricted
R42	MODIFY Arg1:T65 Arg2:E28	
R43	SUB_PROCEDURE Arg1:E28 Arg2:E27	
T66	Biological_structure 1195 1199	eyes
T67	Lab_value 1190 1194	both
R44	MODIFY Arg1:T67 Arg2:T66	
R45	MODIFY Arg1:T66 Arg2:E28	
T68	Lab_value 1260 1276	in excess of 30%
T69	Lab_value 1213 1232	considerably raised
T70	Diagnostic_procedure 1233 1259	false-negative error rates
E29	Diagnostic_procedure:T70 
R46	MODIFY Arg1:T69 Arg2:E29	
R47	MODIFY Arg1:T68 Arg2:E29	
R48	SUB_PROCEDURE Arg1:E29 Arg2:E28	
T71	Diagnostic_procedure 1045 1070	equal and reactive pupils
E30	Diagnostic_procedure:T71 
T72	Diagnostic_procedure 1002 1010	findings
E31	Diagnostic_procedure:T72 
R49	MODIFY Arg1:T55 Arg2:E31	
R50	SUB_PROCEDURE Arg1:E30 Arg2:E31	
R51	SUB_PROCEDURE Arg1:E26 Arg2:E31	
R52	SUB_PROCEDURE Arg1:E25 Arg2:E31	
R53	MODIFY Arg1:T62 Arg2:E30	
T73	History 1097 1101	IOPs
T74	History 1072 1092	normal eye movements
T75	History 1045 1070	equal and reactive pupils
T76	History 1002 1010	findings
T77	History 683 698	type 2 diabetes
T78	History 707 727	diabetic retinopathy
T79	Biological_structure 1412 1414	RE
T80	Disease_disorder 1402 1411	amblyopic
E32	Disease_disorder:T80 
R54	MODIFY Arg1:E32 Arg2:T79	
T81	Diagnostic_procedure 1420 1430	field test
E33	Diagnostic_procedure:T81 
T82	Date 1444 1457	4 weeks later
E34	Date:T82 
*	OVERLAP E33 E34 E35
T83	Detailed_description 1458 1478	with similar results
R55	MODIFY Arg1:T83 Arg2:E33	
T84	Biological_structure 1567 1569	LE
T85	Detailed_description 1561 1565	good
R56	MODIFY Arg1:T85 Arg2:T84	
T86	Lab_value 1531 1552	further deterioration
R57	MODIFY Arg1:T86 Arg2:T84	
T87	Clinical_event 1500 1505	visit
E35	Clinical_event:T87 
R58	MODIFY Arg1:T84 Arg2:E35	
T88	Diagnostic_procedure 1571 1586	Visual acuities
E36	Diagnostic_procedure:T88 
T89	Lab_value 1596 1600;1628 1631	6/24 N36
T90	Detailed_description 1602 1626	loss of one Snellen line
R59	MODIFY Arg1:T89 Arg2:E36	
R60	MODIFY Arg1:T90 Arg2:T89	
T91	Biological_structure 1649 1651	RE
T92	Disease_disorder 1639 1648	amblyopic
E37	Disease_disorder:T92 
R61	MODIFY Arg1:E37 Arg2:T91	
T93	Lab_value 1657 1661;1690 1693	6/18 N36
T94	Detailed_description 1663 1688	loss of two Snellen lines
R62	MODIFY Arg1:T93 Arg2:E36	
R63	MODIFY Arg1:T94 Arg2:T93	
T95	Biological_structure 1701 1703	LE
R64	MODIFY Arg1:T91 Arg2:T89	
R65	MODIFY Arg1:T95 Arg2:T93	
T96	Diagnostic_procedure 1737 1750	colour vision
E38	Diagnostic_procedure:T96 
T97	Lab_value 1727 1736	depressed
R66	MODIFY Arg1:T97 Arg2:E38	
R67	SUB_PROCEDURE Arg1:E38 Arg2:E36	
T98	Diagnostic_procedure 1762 1766	scan
E39	Diagnostic_procedure:T98 
T99	Detailed_description 1755 1761	urgent
R68	MODIFY Arg1:T99 Arg2:E39	
T100	Biological_structure 1784 1788	head
T101	Biological_structure 1793 1798	orbit
R69	MODIFY Arg1:T100 Arg2:E39	
R70	MODIFY Arg1:T101 Arg2:E39	
T102	Disease_disorder 1839 1845	lesion
E40	Disease_disorder:T102 
A7	POLARITY E40 MAYBE_NEG
T103	Detailed_description 1827 1838	compressive
R71	MODIFY Arg1:T103 Arg2:E40	
T104	Diagnostic_procedure 1850 1864	blood analysis
E41	Diagnostic_procedure:T104 
T105	Disease_disorder 1911 1927	optic neuropathy
E42	Disease_disorder:T105 
T106	Diagnostic_procedure 1938 1949	vitamin B12
E43	Diagnostic_procedure:T106 
T107	Diagnostic_procedure 1951 1964	folate levels
E44	Diagnostic_procedure:T107 
T108	Diagnostic_procedure 1969 1989	inflammatory markers
E45	Diagnostic_procedure:T108 
T109	Diagnostic_procedure 1895 1927	other causes of optic neuropathy
E46	Diagnostic_procedure:T109 
R72	SUB_PROCEDURE Arg1:E43 Arg2:E46	
R73	SUB_PROCEDURE Arg1:E44 Arg2:E46	
R74	SUB_PROCEDURE Arg1:E45 Arg2:E46	
R75	SUB_PROCEDURE Arg1:E46 Arg2:E41	
T110	Diagnostic_procedure 1991 1994	MRI
E47	Diagnostic_procedure:T110 
T111	Disease_disorder 2012 2016	mass
E48	Disease_disorder:T111 
T112	Biological_attribute 2006 2011	large
R76	MODIFY Arg1:T112 Arg2:E48	
T113	Biological_structure 2032 2047	pituitary fossa
T114	Volume 2072 2093	4.5 cm×5.1 cm× 4.8 cm
R77	MODIFY Arg1:T114 Arg2:E48	
R78	MODIFY Arg1:T113 Arg2:E48	
R79	MODIFY Arg1:E48 Arg2:E47	
T115	Biological_structure 2127 2146	suprasellar cistern
T116	Biological_structure 2151 2179	infrasellar sphenoid sinuses
R80	MODIFY Arg1:T115 Arg2:E48	
R81	MODIFY Arg1:T116 Arg2:E48	
T117	Biological_structure 2185 2197	optic chiasm
T118	Biological_structure 2207 2219	optic nerves
T119	Lab_value 2202 2206	both
R82	MODIFY Arg1:T119 Arg2:T118	
T120	Detailed_description 2225 2245	displaced superiorly
T121	Detailed_description 2250 2274	compressed on both sides
R83	MODIFY Arg1:T120 Arg2:T118	
R84	MODIFY Arg1:T120 Arg2:T117	
R85	MODIFY Arg1:T121 Arg2:T118	
R86	MODIFY Arg1:T121 Arg2:T117	
T122	Disease_disorder 2280 2284	mass
E49	Disease_disorder:T122 
T123	Diagnostic_procedure 2306 2308;2316 2323	T1 signals
E50	Diagnostic_procedure:T123 
T124	Diagnostic_procedure 2313 2323	T2 signals
E51	Diagnostic_procedure:T124 
T125	Diagnostic_procedure 2338 2350	fluid levels
E52	Diagnostic_procedure:T125 
T126	Lab_value 2329 2337	multiple
R87	MODIFY Arg1:T126 Arg2:E52	
T127	Detailed_description 2292 2305	heterogeneous
R88	MODIFY Arg1:T127 Arg2:E50	
R89	MODIFY Arg1:T127 Arg2:E51	
R90	MODIFY Arg1:E51 Arg2:E49	
R91	MODIFY Arg1:E50 Arg2:E49	
R92	MODIFY Arg1:E52 Arg2:E49	
T128	Disease_disorder 2379 2390	haemorrhage
E53	Disease_disorder:T128 
T129	History 2379 2390	haemorrhage
T130	Disease_disorder 2428 2442	calcifications
E54	Disease_disorder:T130 
A8	POLARITY E54 MAYBE_POS
T131	Diagnostic_procedure 2395 2416	low-signal components
E55	Diagnostic_procedure:T131 
T132	History 2395 2416	low-signal components
R93	CAUSE Arg1:E53 Arg2:E52	
R94	CAUSE Arg1:E55 Arg2:E52	
R95	MODIFY Arg1:E54 Arg2:E55	
T133	Disease_disorder 2481 2498	craniopharyngioma
E56	Disease_disorder:T133 
T134	Disease_disorder 2515 2532	pituitary adenoma
E57	Disease_disorder:T134 
T135	Nonbiological_location 2575 2592	neurosurgery unit
T136	Clinical_event 2550 2558	referred
E58	Clinical_event:T136 
T137	Diagnostic_procedure 2631 2647	prolactin levels
E59	Diagnostic_procedure:T137 
T138	Lab_value 2651 2677	greater than 200 000 mIU/L
T139	Disease_disorder 2715 2727	prolactinoma
E60	Disease_disorder:T139 
T140	Severity 2709 2714	giant
R96	MODIFY Arg1:T140 Arg2:E60	
A9	POLARITY E60 POS
R97	MODIFY Arg1:T135 Arg2:E58	
T141	Lab_value 2615 2630	markedly raised
R98	MODIFY Arg1:T141 Arg2:E59	
*	OVERLAP E58 E59 E60
T142	Medication 2800 2811	cabergoline
E61	Medication:T142 
T143	Dosage 2812 2818	500 µg
T144	Medication 2823 2836	dexamethasone
E62	Medication:T144 
T145	Dosage 2837 2841	8 mg	 
R99	MODIFY Arg1:T145 Arg2:E62	
R100	MODIFY Arg1:T143 Arg2:E61	
T146	Nonbiological_location 2753 2780	local endocrinology service
T147	Date 2843 2856	Within a week
E63	Date:T147 
R101	BEFORE Arg1:E60 Arg2:E61	
*	OVERLAP E61 E62
R102	BEFORE Arg1:E62 Arg2:E63	
T149	Diagnostic_procedure 2909 2935	visual fields and acuities
E65	Diagnostic_procedure:T149 
A11	TREND E65 INC
T150	Lab_value 2939 2943	6/18
T151	Lab_value 2954 2957	6/9
T152	Biological_structure 2944 2946	RE
T153	Biological_structure 2958 2960	LE
R103	MODIFY Arg1:T153 Arg2:T151	
R104	MODIFY Arg1:T152 Arg2:T150	
T154	Diagnostic_procedure 2966 2982	prolactin levels
E66	Diagnostic_procedure:T154 
T155	Lab_value 3045 3054	336 mIU/L
R105	MODIFY Arg1:T155 Arg2:E66	
A12	TREND E66 DEC
T156	Date 3056 3074	Three months later
E67	Date:T156 
R106	BEFORE Arg1:E66 Arg2:E67	
T157	Diagnostic_procedure 3079 3092	visual acuity
E68	Diagnostic_procedure:T157 
T158	Biological_structure 3100 3102	RE
T159	Biological_structure 3107 3109	LE
T160	Lab_value 3115 3119	6/18
T161	Lab_value 3124 3127	6/5
R107	MODIFY Arg1:T160 Arg2:E68	
R108	MODIFY Arg1:T161 Arg2:E68	
R109	MODIFY Arg1:T159 Arg2:T161	
R110	MODIFY Arg1:T158 Arg2:T160	
T162	Diagnostic_procedure 3147 3171	visual field examination
E69	Diagnostic_procedure:T162 
T163	Detailed_description 3202 3223	almost normal results
T164	Detailed_description 3179 3196	striking recovery
R111	MODIFY Arg1:T164 Arg2:E69	
R112	MODIFY Arg1:T163 Arg2:E69	
*	OVERLAP E67 E68 E69
T148	Lab_value 2871 2891	dramatic improvement
R113	MODIFY Arg1:T148 Arg2:E65	
R114	MODIFY Arg1:T150 Arg2:E65	
R115	MODIFY Arg1:T151 Arg2:E65	
*	OVERLAP E63 E65 E66
T165	Lab_value 3000 3041	dramatic response with levels coming down
R116	MODIFY Arg1:T165 Arg2:E66	
A10	POLARITY E56 MAYBE_POS
A13	POLARITY E57 MAYBE_POS
T166	Detailed_description 2502 2514	haemorrhagic
R117	MODIFY Arg1:T166 Arg2:E57	
T167	Sign_symptom 1325 1338	concentration
E64	Sign_symptom:T167 
T168	Sign_symptom 1343 1357	attention span
E70	Sign_symptom:T168 
T169	Severity 1320 1324	poor
R118	MODIFY Arg1:T169 Arg2:E64	
R119	MODIFY Arg1:T169 Arg2:E70	
*	OVERLAP E64 E70
T170	Detailed_description 1358 1381	with testing compounded
T171	Coreference 1296 1300	this
E71	Coreference:T171 
R120	IDENTICAL Arg1:E71 Arg2:E29	
R121	MODIFY Arg1:T3 Arg2:E1	
R122	MODIFY Arg1:T5 Arg2:E1	
R123	CAUSE Arg1:E64 Arg2:E71	
R124	CAUSE Arg1:E70 Arg2:E71	
R125	MODIFY Arg1:T170 Arg2:E71	
R126	MODIFY Arg1:T79 Arg2:E71	
R127	BEFORE Arg1:E70 Arg2:E33	
*	OVERLAP E38 E39
R128	MODIFY Arg1:E40 Arg2:E39	
*	OVERLAP E40 E41
*	OVERLAP E45 E47 E49
T172	Coreference 2444 2458	The appearance
E72	Coreference:T172 
R129	IDENTICAL Arg1:E72 Arg2:E49	
R130	MODIFY Arg1:E56 Arg2:E72	
R131	MODIFY Arg1:E57 Arg2:E72	
*	OVERLAP E54 E72
R132	BEFORE Arg1:E57 Arg2:E58	
*	OVERLAP E24 E27
R133	MODIFY Arg1:E3 Arg2:E2	
R134	MODIFY Arg1:E7 Arg2:E2	
R135	MODIFY Arg1:E4 Arg2:E2	
R136	MODIFY Arg1:E6 Arg2:E2	
R137	AFTER Arg1:E1 Arg2:E2