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T1 Age 2 13 19-year-old T2 Sex 14 19 woman T3 Sign_symptom 37 41 lump E1 Sign_symptom:T3 T4 Biological_structure 49 61 right breast R1 MODIFY Arg1:T4 Arg2:E1 T5 Disease_disorder 71 83 macrocephaly E2 Disease_disorder:T5 T6 Sign_symptom 99 106 papules E3 Sign_symptom:T6 T7 Biological_attribute 88 98 milimetric T8 Biological_structure 114 120 tongue R2 MODIFY Arg1:T7 Arg2:E3 R3 MODIFY Arg1:T8 Arg2:E3 T9 Texture 130 142 cobble stone R4 MODIFY Arg1:T9 Arg2:E3 T10 Biological_structure 159 165 breast T11 Diagnostic_procedure 166 181 ultrasonography E4 Diagnostic_procedure:T11 T12 Diagnostic_procedure 183 185 US E5 Diagnostic_procedure:T12 R5 IDENTICAL Arg1:E5 Arg2:E4 R6 MODIFY Arg1:T10 Arg2:E4 T13 Lab_value 194 210 more than twenty T14 Disease_disorder 231 237 masses E6 Disease_disorder:T14 T15 Shape 226 230 oval T16 Detailed_description 211 224 circumscribed R7 MODIFY Arg1:T16 Arg2:E6 R8 MODIFY Arg1:T15 Arg2:E6 R9 MODIFY Arg1:T13 Arg2:E6 T17 Biological_structure 246 252 breast R10 MODIFY Arg1:T17 Arg2:E6 T18 Diagnostic_procedure 272 278 biopsy E7 Diagnostic_procedure:T18 T19 Detailed_description 257 271 US-guided core R11 MODIFY Arg1:T19 Arg2:E7 T20 Disease_disorder 310 316 masses E8 Disease_disorder:T20 T21 Detailed_description 301 309 palpable T22 Disease_disorder 350 363 fibroadenomas E9 Disease_disorder:T22 T23 Detailed_description 341 349 juvenile R12 MODIFY Arg1:T23 Arg2:E9 A1 POLARITY E9 POS R13 MODIFY Arg1:T21 Arg2:E8 T24 Diagnostic_procedure 392 394 US E10 Diagnostic_procedure:T24 T25 Biological_structure 385 391 breast R14 MODIFY Arg1:T25 Arg2:E10 T26 Frequency 417 437 every 6 or 12 months T27 Duration 442 449 3 years E11 Duration:T27 R16 MODIFY Arg1:T26 Arg2:E10 R17 MODIFY Arg1:E11 Arg2:E10 R18 BEFORE Arg1:E7 Arg2:E10 R19 MODIFY Arg1:E6 Arg2:E5 * OVERLAP E6 E7 R20 MODIFY Arg1:E8 Arg2:E7 R21 MODIFY Arg1:E9 Arg2:E7 T29 Diagnostic_procedure 488 496 biopsies E13 Diagnostic_procedure:T29 T30 Detailed_description 483 487 core R22 MODIFY Arg1:T30 Arg2:E13 T31 Quantitative_concept 512 521 six times T32 Diagnostic_procedure 566 582 needle excisions E14 Diagnostic_procedure:T32 T33 Diagnostic_procedure 586 604 surgical excisions E15 Diagnostic_procedure:T33 T34 Detailed_description 535 544 US-guided T35 Detailed_description 545 560 vacuum-assisted T36 Detailed_description 561 565 core R23 MODIFY Arg1:T34 Arg2:E14 R24 MODIFY Arg1:T35 Arg2:E14 R25 MODIFY Arg1:T36 Arg2:E14 R26 MODIFY Arg1:T34 Arg2:E15 R27 MODIFY Arg1:T35 Arg2:E15 R28 MODIFY Arg1:T36 Arg2:E15 T37 Disease_disorder 608 615 lesions E16 Disease_disorder:T37 T38 Lab_value 621 636 increased sizes R29 MODIFY Arg1:T38 Arg2:E16 R30 BEFORE Arg1:E13 Arg2:E14 T39 Disease_disorder 662 674 fibroadenoma E17 Disease_disorder:T39 T40 Disease_disorder 676 691 tubular adenoma E18 Disease_disorder:T40 T42 Disease_disorder 695 722 atypical ductal hyperplasia E19 Disease_disorder:T42 T43 Disease_disorder 724 727 ADH E20 Disease_disorder:T43 R32 IDENTICAL Arg1:E20 Arg2:E19 T45 Age 760 775 age of 19 years T46 Biological_structure 801 805 neck T47 Diagnostic_procedure 806 808 US E21 Diagnostic_procedure:T47 T48 Disease_disorder 824 828 mass E22 Disease_disorder:T48 T49 Biological_structure 836 845 left neck T50 Detailed_description 815 823 palpable R34 MODIFY Arg1:T50 Arg2:E22 R35 MODIFY Arg1:T49 Arg2:E22 R36 MODIFY Arg1:T46 Arg2:E21 R37 MODIFY Arg1:E22 Arg2:E21 T51 Sign_symptom 869 876 nodules E23 Sign_symptom:T51 T52 Detailed_description 855 868 indeterminate R38 MODIFY Arg1:T52 Arg2:E23 T53 Biological_structure 899 913 thyroid glands T54 Lab_value 894 898 both R39 MODIFY Arg1:T54 Arg2:T53 R40 MODIFY Arg1:T53 Arg2:E23 T55 Diagnostic_procedure 927 929 US E24 Diagnostic_procedure:T55 T56 Detailed_description 917 926 follow-up R41 MODIFY Arg1:T56 Arg2:E24 T28 Lab_value 966 983 increased in size T57 Lab_value 944 948 some T58 Sign_symptom 958 965 nodules E12 Sign_symptom:T58 R15 MODIFY Arg1:T28 Arg2:E12 R42 MODIFY Arg1:T57 Arg2:E12 R43 BEFORE Arg1:E12 Arg2:E24 T59 Therapeutic_procedure 1015 1028 thyroidectomy E25 Therapeutic_procedure:T59 T60 Detailed_description 1009 1014 total R44 MODIFY Arg1:T60 Arg2:E25 T61 Disease_disorder 1076 1096 follicular carcinoma E26 Disease_disorder:T61 T62 Detailed_description 1067 1075 invasive R45 MODIFY Arg1:T62 Arg2:E26 T63 Biological_structure 1104 1116 left thyroid R46 MODIFY Arg1:T63 Arg2:E26 T64 Disease_disorder 1121 1139 follicular adenoma E27 Disease_disorder:T64 T41 Biological_structure 1147 1160 right thyroid R31 MODIFY Arg1:T41 Arg2:E27 T66 Nonbiological_location 1211 1219 hospital T67 Biological_structure 1245 1255 left cheek T68 Sign_symptom 1229 1237 swelling E28 Sign_symptom:T68 R47 MODIFY Arg1:T67 Arg2:E28 T69 Clinical_event 1199 1206 visited E29 Clinical_event:T69 T70 Diagnostic_procedure 1271 1278 CT scan E30 Diagnostic_procedure:T70 T71 Biological_structure 1257 1261 Head T72 Biological_structure 1266 1270 neck R48 MODIFY Arg1:T71 Arg2:E30 R49 MODIFY Arg1:T72 Arg2:E30 T73 Disease_disorder 1299 1303 mass E31 Disease_disorder:T73 T74 Biological_structure 1290 1298 vascular R50 MODIFY Arg1:T74 Arg2:E31 T75 Biological_structure 1311 1329 left parotid gland R51 MODIFY Arg1:T75 Arg2:E31 T76 Biological_structure 1348 1361 left forehead R52 MODIFY Arg1:T76 Arg2:E31 T77 Diagnostic_procedure 1383 1394 angiography E32 Diagnostic_procedure:T77 T78 Biological_structure 1366 1382 external carotid R53 MODIFY Arg1:T78 Arg2:E32 T79 Biological_structure 1465 1495 left internal maxillary artery T81 Therapeutic_procedure 1626 1644 genetic counseling E34 Therapeutic_procedure:T81 T82 Disease_disorder 1671 1686 Cowden syndrome E35 Disease_disorder:T82 A2 POLARITY E35 UNCERTAIN T83 Diagnostic_procedure 1695 1699 PTEN E36 Diagnostic_procedure:T83 A3 POLARITY E36 UNCERTAIN T84 Diagnostic_procedure 1727 1739 blood sample E37 Diagnostic_procedure:T84 T85 Diagnostic_procedure 1700 1719 DNA sequencing test E38 Diagnostic_procedure:T85 R54 SUB_PROCEDURE Arg1:E37 Arg2:E38 R55 MODIFY Arg1:E35 Arg2:E38 R56 SUB_PROCEDURE Arg1:E36 Arg2:E38 T86 Diagnostic_procedure 1772 1781 c.301dupA E39 Diagnostic_procedure:T86 T87 Diagnostic_procedure 1783 1794 p.I101NfsX6 E40 Diagnostic_procedure:T87 T88 Diagnostic_procedure 1751 1770 frameshift mutation E41 Diagnostic_procedure:T88 R57 IDENTICAL Arg1:E40 Arg2:E39 R58 MODIFY Arg1:E39 Arg2:E41 T90 Disease_disorder 1850 1854 mass E42 Disease_disorder:T90 T91 Lab_value 1860 1874 increased size T92 Biological_structure 1908 1919 left breast T93 Lab_value 1879 1900 increased vascularity R59 MODIFY Arg1:T91 Arg2:E42 R60 MODIFY Arg1:T93 Arg2:E42 R61 MODIFY Arg1:T92 Arg2:E42 T94 Diagnostic_procedure 1955 1970 needle excision E43 Diagnostic_procedure:T94 T95 Detailed_description 1924 1933 US-guided T96 Detailed_description 1934 1949 vacuum-assisted T97 Detailed_description 1950 1954 core R62 MODIFY Arg1:T95 Arg2:E43 R63 MODIFY Arg1:T96 Arg2:E43 R64 MODIFY Arg1:T97 Arg2:E43 T98 Disease_disorder 1982 2006 ductal carcinoma in situ E44 Disease_disorder:T98 T99 Disease_disorder 2008 2012 DCIS E45 Disease_disorder:T99 R65 IDENTICAL Arg1:E45 Arg2:E44 T100 Detailed_description 2017 2032 non-comedo type T101 Lab_value 2039 2048 low grade R66 MODIFY Arg1:T100 Arg2:E45 T102 Disease_disorder 2059 2071 fibroadenoma E46 Disease_disorder:T102 R67 MODIFY Arg1:T101 Arg2:E46 * OVERLAP E45 E46 E47 R68 MODIFY Arg1:E44 Arg2:E43 R69 MODIFY Arg1:E46 Arg2:E43 T103 Diagnostic_procedure 2111 2114 MRI E47 Diagnostic_procedure:T103 T104 Detailed_description 2086 2103 contrast-enhanced T105 Biological_structure 2104 2110 breast R70 MODIFY Arg1:T105 Arg2:E47 R71 MODIFY Arg1:T104 Arg2:E47 T106 Lab_value 2160 2168 multiple T107 Detailed_description 2170 2188 well-circumscribed T108 Disease_disorder 2200 2206 masses E48 Disease_disorder:T108 T109 Biological_structure 2215 2222 breasts T110 Lab_value 2210 2214 both R72 MODIFY Arg1:T110 Arg2:T109 R73 MODIFY Arg1:T109 Arg2:E48 R74 MODIFY Arg1:T107 Arg2:E48 R75 MODIFY Arg1:T106 Arg2:E48 T111 Lab_value 2190 2199 enhancing R76 MODIFY Arg1:T111 Arg2:E48 T112 Disease_disorder 2237 2243 masses E49 Disease_disorder:T112 T113 Lab_value 2233 2236 All R77 MODIFY Arg1:T113 Arg2:E49 T114 Diagnostic_procedure 2272 2288 signal intensity E50 Diagnostic_procedure:T114 T115 Diagnostic_procedure 2292 2310 T2-weighted images E51 Diagnostic_procedure:T115 T116 Severity 2251 2255 high T117 Severity 2259 2271 intermediate R78 SUB_PROCEDURE Arg1:E50 Arg2:E51 R79 MODIFY Arg1:E49 Arg2:E50 R80 MODIFY Arg1:T116 Arg2:E50 R81 MODIFY Arg1:T117 Arg2:E50 T118 Disease_disorder 2329 2335 masses E52 Disease_disorder:T118 T119 Lab_value 2321 2328 Several R82 MODIFY Arg1:T119 Arg2:E52 T120 Detailed_description 2346 2369 early rapid enhancement T121 Disease_disorder 2476 2486 malignancy E53 Disease_disorder:T121 A4 POLARITY E53 MAYBE_POS T122 Therapeutic_procedure 2522 2532 mastectomy E54 Therapeutic_procedure:T122 T123 Detailed_description 2499 2521 bilateral prophylactic R83 MODIFY Arg1:T123 Arg2:E54 T124 Therapeutic_procedure 2548 2569 breast reconstruction E55 Therapeutic_procedure:T124 T125 Detailed_description 2538 2547 immediate R84 MODIFY Arg1:T125 Arg2:E55 R85 SUB_PROCEDURE Arg1:E55 Arg2:E54 T126 Disease_disorder 2621 2627 masses E56 Disease_disorder:T126 T127 Biological_structure 2614 2620 breast T128 Lab_value 2595 2603 multiple T129 Detailed_description 2604 2613 bilateral R86 MODIFY Arg1:T127 Arg2:E56 R87 MODIFY Arg1:T129 Arg2:E56 R88 MODIFY Arg1:T128 Arg2:E56 T130 Diagnostic_procedure 2644 2660 kinetic features E57 Diagnostic_procedure:T130 T131 Detailed_description 2633 2643 suspicious R89 MODIFY Arg1:T131 Arg2:E57 T132 Diagnostic_procedure 2671 2674 MRI E58 Diagnostic_procedure:T132 T133 Biological_structure 2664 2670 breast R90 MODIFY Arg1:T133 Arg2:E58 R91 SUB_PROCEDURE Arg1:E58 Arg2:E57 T134 Disease_disorder 2695 2708 breast cancer E59 Disease_disorder:T134 A5 POLARITY E59 MAYBE_POS T135 Disease_disorder 2712 2727 Cowden syndrome E60 Disease_disorder:T135 R92 MODIFY Arg1:E60 Arg2:E59 T136 Disease_disorder 2766 2769 ADH E61 Disease_disorder:T136 T137 Disease_disorder 2780 2795 tubular adenoma E62 Disease_disorder:T137 T138 Disease_disorder 2968 2981 breast cancer E63 Disease_disorder:T138 A6 POLARITY E63 NEG T139 Family_history 2968 2981 breast cancer T140 Disease_disorder 2985 3000 Cowden syndrome E64 Disease_disorder:T140 A7 POLARITY E64 NEG T141 Family_history 2985 3000 Cowden syndrome T142 Biological_structure 2830 2841 left breast T143 Disease_disorder 2813 2822 carcinoma E65 Disease_disorder:T143 A8 POLARITY E65 NEG T144 Detailed_description 2804 2812 residual R93 MODIFY Arg1:T144 Arg2:E65 R94 MODIFY Arg1:E62 Arg2:E61 R95 MODIFY Arg1:E65 Arg2:E61 R96 MODIFY Arg1:T142 Arg2:E65 T145 Disease_disorder 2855 2871 tubular adenomas E66 Disease_disorder:T145 T146 Lab_value 2846 2854 multiple R97 MODIFY Arg1:T146 Arg2:E66 T147 Disease_disorder 2873 2886 fibroadenomas E67 Disease_disorder:T147 R98 MODIFY Arg1:T146 Arg2:E67 T148 Disease_disorder 2891 2913 intraductal papillomas E68 Disease_disorder:T148 T149 Biological_structure 2922 2929 breasts T150 Lab_value 2917 2921 both R99 MODIFY Arg1:T150 Arg2:T149 R100 MODIFY Arg1:T146 Arg2:E68 R101 MODIFY Arg1:T149 Arg2:E68 R102 MODIFY Arg1:T149 Arg2:E67 R103 MODIFY Arg1:T149 Arg2:E66 * OVERLAP E66 E67 E68 E65 T151 Diagnostic_procedure 2733 2756 surgical histopathology E69 Diagnostic_procedure:T151 R104 MODIFY Arg1:E61 Arg2:E69 * OVERLAP E60 E69 * OVERLAP E58 E59 * OVERLAP E55 E56 R105 MODIFY Arg1:E57 Arg2:E56 R106 MODIFY Arg1:T120 Arg2:E52 T152 Diagnostic_procedure 2375 2398 washout kinetic pattern E70 Diagnostic_procedure:T152 T153 Diagnostic_procedure 2402 2440 time-signal intensity curve evaluation E71 Diagnostic_procedure:T153 R107 MODIFY Arg1:E53 Arg2:E70 R108 SUB_PROCEDURE Arg1:E71 Arg2:E70 R109 MODIFY Arg1:E70 Arg2:E52 * OVERLAP E53 E54 * OVERLAP E51 E52 * OVERLAP E48 E49 R110 MODIFY Arg1:E48 Arg2:E47 * OVERLAP E42 E43 E72 R111 BEFORE Arg1:E40 Arg2:E72 T154 Date 1797 1819 At the age of 22 years E72 Date:T154 R112 SUB_PROCEDURE Arg1:E41 Arg2:E37 * OVERLAP E34 E38 E75 T80 Disease_disorder 1425 1428 AVM E33 Disease_disorder:T80 T155 Disease_disorder 1566 1569 AVM E73 Disease_disorder:T155 R113 MODIFY Arg1:E33 Arg2:E32 T156 Biological_structure 1434 1447 feeder vessel R114 MODIFY Arg1:T79 Arg2:T156 R115 MODIFY Arg1:T156 Arg2:E33 T157 Therapeutic_procedure 1516 1528 embolization E74 Therapeutic_procedure:T157 T158 Detailed_description 1508 1515 partial R116 MODIFY Arg1:T158 Arg2:E74 T159 Coreference 1583 1604 the patient's symptom E75 Coreference:T159 R117 IDENTICAL Arg1:E75 Arg2:E28 A9 POLARITY E75 NEG A10 TREND E75 DEC T160 Diagnostic_procedure 1543 1553 blood flow E76 Diagnostic_procedure:T160 T161 Lab_value 1529 1538 decreased A11 TREND E76 DEC R119 MODIFY Arg1:T161 Arg2:E76 R120 CAUSE Arg1:E74 Arg2:E76 R118 MODIFY Arg1:E73 Arg2:E76 R121 CAUSE Arg1:E76 Arg2:E75 T162 Date 1171 1193 At the age of 21 years E77 Date:T162 * OVERLAP E77 E29 E28 E30 R122 MODIFY Arg1:T66 Arg2:E29 R123 MODIFY Arg1:E31 Arg2:E30 * OVERLAP E31 E32 R124 BEFORE Arg1:E33 Arg2:E74 R125 BEFORE Arg1:E25 Arg2:E26 * OVERLAP E26 E27 R126 BEFORE Arg1:E27 Arg2:E77 * OVERLAP E12 E25 R127 BEFORE Arg1:E23 Arg2:E24 T163 Date 753 775 At the age of 19 years E78 Date:T163 * OVERLAP E78 E21 * OVERLAP E22 E23 T44 Disease_disorder 739 751 fibroadenoma E79 Disease_disorder:T44 R33 MODIFY Arg1:E79 Arg2:E20 R128 MODIFY Arg1:E16 Arg2:E15 R129 MODIFY Arg1:E16 Arg2:E14 * OVERLAP E10 E13 R130 MODIFY Arg1:T31 Arg2:E13 T164 Coreference 638 656 Pathologic results E80 Coreference:T164 R131 IDENTICAL Arg1:E80 Arg2:E13 R132 MODIFY Arg1:E17 Arg2:E80 R133 MODIFY Arg1:E18 Arg2:E80 R134 MODIFY Arg1:E19 Arg2:E80 R135 BEFORE Arg1:E79 Arg2:E78 * OVERLAP E1 E2 E3 E4