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T1 Age 2 13 20-year-old T2 Sex 14 18 male T3 History 24 39 cystic fibrosis T4 Clinical_event 44 55 transferred E1 Clinical_event:T4 T5 Nonbiological_location 59 85 Houston Methodist Hospital R1 MODIFY Arg1:T5 Arg2:E1 T6 Date 89 101 January 2013 E2 Date:T6 T7 Clinical_event 108 117 evaluated E3 Clinical_event:T7 T8 Therapeutic_procedure 138 148 transplant E4 Therapeutic_procedure:T8 T9 Biological_structure 131 137 kidney T10 Biological_structure 122 126 lung T11 Disease_disorder 327 351 pancreatic insufficiency E5 Disease_disorder:T11 T12 Sign_symptom 327 351 pancreatic insufficiency E6 Sign_symptom:T12 T13 Disease_disorder 483 505 respiratory infections E7 Disease_disorder:T13 T14 Medication 973 982 meropenem E8 Medication:T14 R2 MODIFY Arg1:T10 Arg2:E4 R3 MODIFY Arg1:T9 Arg2:E4 T15 History 327 351 pancreatic insufficiency T16 Therapeutic_procedure 359 374 transplantation E9 Therapeutic_procedure:T16 T17 Biological_structure 353 358 liver R4 MODIFY Arg1:T17 Arg2:E9 T18 Date 378 382 2004 E10 Date:T18 T19 History 353 382 liver transplantation in 2004 T20 Disease_disorder 400 408 diabetes E11 Disease_disorder:T20 T21 Medication 384 391 steroid E12 Medication:T21 R5 CAUSE Arg1:E12 Arg2:E11 T22 History 384 408 steroid-induced diabetes T23 Disease_disorder 410 433 end-stage renal disease E13 Disease_disorder:T23 T24 History 410 433 end-stage renal disease T25 Disease_disorder 439 456 testicular cancer E14 Disease_disorder:T25 T26 History 439 456 testicular cancer T27 History 483 563 respiratory infections with several multidrug-resistant bacteria, including MRSA T28 Disease_disorder 559 563 MRSA E15 Disease_disorder:T28 T29 Disease_disorder 519 547 multidrug-resistant bacteria E16 Disease_disorder:T29 R6 CAUSE Arg1:E16 Arg2:E7 R7 CAUSE Arg1:E15 Arg2:E7 T30 Medication 585 596 ceftaroline E17 Medication:T30 T31 Nonbiological_location 603 619 outside hospital R8 MODIFY Arg1:T31 Arg2:E17 T32 Clinical_event 641 649 transfer E18 Clinical_event:T32 T33 Nonbiological_location 653 679 Houston Methodist Hospital R9 MODIFY Arg1:T33 Arg2:E18 T34 Clinical_event 710 722 hospitalized E19 Clinical_event:T34 T35 Frequency 697 709 periodically R10 MODIFY Arg1:T35 Arg2:E19 T36 Duration 728 748 January to July 2013 E20 Duration:T36 T37 Disease_disorder 812 822 infections E21 Disease_disorder:T37 T38 Detailed_description 795 811 catheter-related T39 Biological_structure 779 790 respiratory R11 MODIFY Arg1:T38 Arg2:E21 R12 MODIFY Arg1:T39 Arg2:E21 T40 Disease_disorder 833 837 MRSA E22 Disease_disorder:T40 R13 CAUSE Arg1:E22 Arg2:E21 T41 Disease_disorder 842 884 multidrug-resistant Pseudomonas aeruginosa E23 Disease_disorder:T41 R14 CAUSE Arg1:E23 Arg2:E21 T42 Medication 890 900 antibiotic E24 Medication:T42 T43 Medication 984 995 ceftazidime E25 Medication:T43 T44 Medication 997 1008 doxycycline E26 Medication:T44 T45 Medication 1010 1020 vancomycin E27 Medication:T45 T46 Medication 1022 1031 linezolid E28 Medication:T46 T47 Medication 1033 1041 cefepime E29 Medication:T47 T48 Medication 1043 1056 ciprofloxacin E30 Medication:T48 T49 Medication 1083 1091 colistin E31 Medication:T49 T50 Medication 1096 1106 tobramycin E32 Medication:T50 T51 Administration 1062 1069 inhaled T52 Administration 1074 1082 systemic R15 MODIFY Arg1:T52 Arg2:E31 R16 MODIFY Arg1:T52 Arg2:E32 R17 MODIFY Arg1:T51 Arg2:E31 R18 MODIFY Arg1:T51 Arg2:E32 T53 Clinical_event 1128 1138 readmitted E33 Clinical_event:T53 T54 Nonbiological_location 1146 1154 hospital R19 MODIFY Arg1:T54 Arg2:E33 T55 Date 1158 1167 June 2013 E34 Date:T55 T56 Disease_disorder 1169 1173 MRSA E35 Disease_disorder:T56 T57 Diagnostic_procedure 1189 1197 cultures E36 Diagnostic_procedure:T57 T58 Biological_structure 1201 1206 blood T59 Biological_structure 1211 1232 respiratory specimens R20 MODIFY Arg1:T59 Arg2:E36 R21 MODIFY Arg1:T58 Arg2:E36 T60 Coreference 1244 1252 isolates E37 Coreference:T60 R22 IDENTICAL Arg1:E37 Arg2:E36 T61 Diagnostic_procedure 1271 1282 clindamycin E38 Diagnostic_procedure:T61 #1 AnnotatorNotes E38 Note that these are diagnostics here because they are being tested for resistance, not being administered to the patient T62 Diagnostic_procedure 1284 1293 linezolid E39 Diagnostic_procedure:T62 T63 Diagnostic_procedure 1295 1304 oxacillin E40 Diagnostic_procedure:T63 T64 Diagnostic_procedure 1310 1339 trimethoprim-sulfamethoxazole E41 Diagnostic_procedure:T64 T65 Diagnostic_procedure 1386 1396 vancomycin E42 Diagnostic_procedure:T65 T66 Diagnostic_procedure 1372 1380 rifampin E43 Diagnostic_procedure:T66 T67 Diagnostic_procedure 1359 1370 minocycline E44 Diagnostic_procedure:T67 T68 Lab_value 1344 1355 susceptible R23 MODIFY Arg1:T68 Arg2:E44 R24 MODIFY Arg1:T68 Arg2:E43 R25 MODIFY Arg1:T68 Arg2:E42 T69 Lab_value 1258 1267 resistant R26 MODIFY Arg1:T69 Arg2:E38 R27 MODIFY Arg1:T69 Arg2:E39 R28 MODIFY Arg1:T69 Arg2:E40 R29 MODIFY Arg1:T69 Arg2:E41 T70 Diagnostic_procedure 1408 1415 isolate E45 Diagnostic_procedure:T70 T71 Biological_structure 1402 1407 blood R30 MODIFY Arg1:T71 Arg2:E45 T72 Diagnostic_procedure 1444 1467 ceftaroline Etest strip E46 Diagnostic_procedure:T72 T73 Lab_value 1416 1432 grew confluently T74 Lab_value 1481 1500 MIC of >32 mg/liter R31 MODIFY Arg1:T73 Arg2:E46 R32 MODIFY Arg1:T74 Arg2:E46 R33 SUB_PROCEDURE Arg1:E46 Arg2:E45 T75 Diagnostic_procedure 1546 1554 isolates E47 Diagnostic_procedure:T75 T76 Biological_structure 1528 1545 respiratory tract R34 MODIFY Arg1:T76 Arg2:E47 T77 Disease_disorder 1518 1527 S. aureus E48 Disease_disorder:T77 R35 MODIFY Arg1:E48 Arg2:E47 T78 Lab_value 1502 1506 Five R36 MODIFY Arg1:T78 Arg2:E47 * OVERLAP E1 E2 E3 R37 BEFORE Arg1:E3 Arg2:E4 A1 POLARITY E4 UNCERTAIN #2 AnnotatorNotes E4 This transplant may not have been done R38 AFTER Arg1:E4 Arg2:E5 * OVERLAP E5 E6 E9 E10 E12 E11 E13 E14 E7 E16 E15 R39 BEFORE Arg1:E15 Arg2:E17 R40 BEFORE Arg1:E17 Arg2:E18 R41 BEFORE Arg1:E18 Arg2:E19 * OVERLAP E19 E20 E21 E22 E23 E24 R42 SUB_PROCEDURE Arg1:E8 Arg2:E24 R43 SUB_PROCEDURE Arg1:E25 Arg2:E24 R44 SUB_PROCEDURE Arg1:E26 Arg2:E24 R45 SUB_PROCEDURE Arg1:E27 Arg2:E24 R46 SUB_PROCEDURE Arg1:E28 Arg2:E24 R47 SUB_PROCEDURE Arg1:E29 Arg2:E24 R48 SUB_PROCEDURE Arg1:E30 Arg2:E24 R49 SUB_PROCEDURE Arg1:E31 Arg2:E24 R50 SUB_PROCEDURE Arg1:E32 Arg2:E24 R51 BEFORE Arg1:E24 Arg2:E33 * OVERLAP E33 E34 E35 E36 E37 E38 E39 E40 E41 E44 E43 E42 E45 E46 E48 E47