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T1 Sex 2 7 woman T2 Age 15 18 60s T3 Outcome 2048 2052 died E1 Outcome:T3 T4 Date 2053 2073 several months later E2 Date:T4 T5 Therapeutic_procedure 2031 2043 chemotherapy E3 Therapeutic_procedure:T5 T6 Detailed_description 2020 2030 palliative R1 MODIFY Arg1:T6 Arg2:E3 T7 Diagnostic_procedure 37 43 screen E4 Diagnostic_procedure:T7 T8 Disease_disorder 70 86 breast carcinoma E5 Disease_disorder:T8 T9 Detailed_description 62 69 lobular T10 Detailed_description 53 61 invasive R2 MODIFY Arg1:T9 Arg2:E5 R3 MODIFY Arg1:T10 Arg2:E5 T11 Biological_structure 94 106 right breast R4 MODIFY Arg1:T11 Arg2:E5 T12 Disease_disorder 120 136 ductal carcinoma E6 Disease_disorder:T12 T13 Detailed_description 111 119 invasive R5 MODIFY Arg1:T13 Arg2:E6 T14 Detailed_description 138 153 no special type R6 MODIFY Arg1:T14 Arg2:E6 T15 Biological_structure 162 173 left breast R7 MODIFY Arg1:T15 Arg2:E6 T16 Diagnostic_procedure 183 193 CT imaging E7 Diagnostic_procedure:T16 T17 Therapeutic_procedure 203 213 mastectomy E8 Therapeutic_procedure:T17 T18 Sign_symptom 236 240 mass E9 Sign_symptom:T18 T19 Biological_structure 229 235 pelvic R8 MODIFY Arg1:T19 Arg2:E9 T20 Distance 223 228 12 cm R9 MODIFY Arg1:T20 Arg2:E9 T21 Sign_symptom 289 296 fibroid E10 Sign_symptom:T21 A1 POLARITY E10 UNCERTAIN T22 Biological_structure 297 303 uterus R10 MODIFY Arg1:T22 Arg2:E10 T23 Sign_symptom 331 339 bleeding E11 Sign_symptom:T23 T24 Detailed_description 316 330 postmenopausal R11 MODIFY Arg1:T24 Arg2:E11 T25 Diagnostic_procedure 383 389 biopsy E12 Diagnostic_procedure:T25 T26 Diagnostic_procedure 366 378 hysteroscopy E13 Diagnostic_procedure:T26 T27 Diagnostic_procedure 354 364 ultrasound E14 Diagnostic_procedure:T27 T28 Biological_structure 347 353 pelvic R12 MODIFY Arg1:T28 Arg2:E14 T29 Diagnostic_procedure 395 401 biopsy E15 Diagnostic_procedure:T29 T30 Disease_disorder 426 433 sarcoma E16 Disease_disorder:T30 T31 Detailed_description 409 425 undifferentiated R13 MODIFY Arg1:T31 Arg2:E16 T32 Diagnostic_procedure 455 475 immunohistochemistry E17 Diagnostic_procedure:T32 T33 Lab_value 435 449 unclassifiable R14 MODIFY Arg1:T33 Arg2:E17 R15 MODIFY Arg1:E16 Arg2:E17 T34 Sign_symptom 563 569 tumour E18 Sign_symptom:T34 T35 Biological_structure 555 562 uterine R16 MODIFY Arg1:T35 Arg2:E18 T36 Detailed_description 585 603 primary malignancy R17 MODIFY Arg1:T36 Arg2:E18 T37 Disease_disorder 616 626 metastasis E19 Disease_disorder:T37 A2 POLARITY E19 MAYBE_NEG T38 Biological_structure 636 642 breast R18 MODIFY Arg1:T38 Arg2:E19 T39 Therapeutic_procedure 644 656 Hysterectomy E20 Therapeutic_procedure:T39 T40 Therapeutic_procedure 671 692 salpingo-oophorectomy E21 Therapeutic_procedure:T40 T41 Detailed_description 661 670 bilateral R19 MODIFY Arg1:T41 Arg2:E21 T42 Diagnostic_procedure 809 833 Histological examination E22 Diagnostic_procedure:T42 T43 Sign_symptom 888 894 tumour E23 Sign_symptom:T43 T44 Detailed_description 869 887 partially necrotic R20 MODIFY Arg1:T44 Arg2:E23 T45 Detailed_description 902 918 discrete outline R21 MODIFY Arg1:T45 Arg2:E23 T46 Biological_structure 963 973 myometrium R22 MODIFY Arg1:T46 Arg2:E23 T47 Coreference 979 985 tumour E24 Coreference:T47 R23 IDENTICAL Arg1:E24 Arg2:E23 T48 Detailed_description 1002 1025 malignant spindle cells R24 MODIFY Arg1:T48 Arg2:E24 T49 Detailed_description 1073 1090 pleomorphic cells R25 MODIFY Arg1:T49 Arg2:E24 T50 Detailed_description 1105 1127 eosinophilic cytoplasm R26 MODIFY Arg1:T50 Arg2:T49 T51 Sign_symptom 1155 1166 giant cells E25 Sign_symptom:T51 T52 Detailed_description 1129 1138 Plentiful R27 MODIFY Arg1:T52 Arg2:E25 T53 Detailed_description 1139 1154 osteoclast-like R28 MODIFY Arg1:T53 Arg2:E25 T54 Diagnostic_procedure 1193 1200 Mitoses E26 Diagnostic_procedure:T54 T55 Lab_value 1206 1214 numerous R29 MODIFY Arg1:T55 Arg2:E26 T56 Sign_symptom 1219 1246 structurally abnormal forms E27 Sign_symptom:T56 T57 Diagnostic_procedure 1558 1577 immunohistochemical E28 Diagnostic_procedure:T57 T58 Coreference 1260 1276 Neoplastic cells E29 Coreference:T58 T59 Coreference 1538 1550 Tumour cells E30 Coreference:T59 T60 Diagnostic_procedure 1593 1601 vimentin E31 Diagnostic_procedure:T60 T61 Diagnostic_procedure 1603 1622 smooth muscle actin E32 Diagnostic_procedure:T61 T62 Diagnostic_procedure 1624 1627 SMA E33 Diagnostic_procedure:T62 R30 IDENTICAL Arg1:E33 Arg2:E32 T63 Diagnostic_procedure 1630 1636 desmin E34 Diagnostic_procedure:T63 T65 Diagnostic_procedure 1651 1655 CD99 E36 Diagnostic_procedure:T65 T66 Diagnostic_procedure 1657 1675 Epithelial markers E37 Diagnostic_procedure:T66 T67 Lab_value 1681 1694 not expressed R32 MODIFY Arg1:T67 Arg2:E37 T68 Lab_value 1578 1588 expression R33 SUB_PROCEDURE Arg1:E31 Arg2:E28 R34 SUB_PROCEDURE Arg1:E32 Arg2:E28 R35 SUB_PROCEDURE Arg1:E34 Arg2:E28 R31 SUB_PROCEDURE Arg1:E36 Arg2:E28 T64 Lab_value 1638 1645 focally R36 MODIFY Arg1:T64 Arg2:E34 R37 MODIFY Arg1:T68 Arg2:E31 R38 MODIFY Arg1:T68 Arg2:E32 R39 MODIFY Arg1:T68 Arg2:E34 R40 MODIFY Arg1:T68 Arg2:E36 T69 Disease_disorder 1811 1823 osteosarcoma E35 Disease_disorder:T69 T70 Detailed_description 1771 1807 primary uterine osteoblastic variant R41 MODIFY Arg1:T70 Arg2:E35 T71 Diagnostic_procedure 1867 1877 CT imaging E38 Diagnostic_procedure:T71 T72 Sign_symptom 1938 1946 deposits E39 Sign_symptom:T72 T73 Biological_structure 1928 1937 pulmonary T74 Biological_structure 1913 1923 peritoneal T75 Detailed_description 1904 1912 multiple R42 MODIFY Arg1:T73 Arg2:E39 R43 MODIFY Arg1:T74 Arg2:E39 R44 MODIFY Arg1:T75 Arg2:E39 T76 Disease_disorder 1985 1997 osteosarcoma E40 Disease_disorder:T76 T77 Detailed_description 1974 1984 metastatic R45 MODIFY Arg1:T77 Arg2:E40 T78 Diagnostic_procedure 1961 1967 biopsy E41 Diagnostic_procedure:T78 R46 BEFORE Arg1:E4 Arg2:E5 * OVERLAP E5 E6 R47 BEFORE Arg1:E6 Arg2:E7 R48 BEFORE Arg1:E7 Arg2:E8 R49 AFTER Arg1:E8 Arg2:E9 * OVERLAP E9 E10 E11 R50 BEFORE Arg1:E11 Arg2:E14 * OVERLAP E14 E13 E12 E15 E16 E17 R51 BEFORE Arg1:E17 Arg2:E18 * OVERLAP E18 E19 R52 BEFORE Arg1:E19 Arg2:E20 * OVERLAP E20 E21 T79 Therapeutic_procedure 791 807 adjuvant therapy E42 Therapeutic_procedure:T79 R53 BEFORE Arg1:E21 Arg2:E42 R54 BEFORE Arg1:E42 Arg2:E22 * OVERLAP E22 E23 E24 E25 E26 E27 E29 E43 E44 E30 E28 E37 E35 R55 IDENTICAL Arg1:E29 Arg2:E24 T80 Sign_symptom 1423 1453 neoplastic epithelial elements E43 Sign_symptom:T80 A3 POLARITY E43 NEG T81 Disease_disorder 1503 1535 malignant mixed Müllerian tumour E44 Disease_disorder:T81 A4 POLARITY E44 NEG R56 IDENTICAL Arg1:E30 Arg2:E29 R57 BEFORE Arg1:E35 Arg2:E38 * OVERLAP E38 E39 E41 E40 R58 BEFORE Arg1:E40 Arg2:E3 R59 BEFORE Arg1:E3 Arg2:E1 * OVERLAP E1 E2