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T1 Age 2 13 30-year-old T2 Sex 14 19 woman T3 History 38 41 HIV T4 History 46 49 HCV #1 AnnotatorNotes T4 Hepatitis C T5 Clinical_event 50 59 presented E1 Clinical_event:T5 T6 Disease_disorder 38 41 HIV E2 Disease_disorder:T6 T7 Disease_disorder 46 49 HCV E3 Disease_disorder:T7 T8 Nonbiological_location 67 87 emergency department R1 MODIFY Arg1:T8 Arg2:E1 T9 Duration 95 102 4-month E4 Duration:T9 T10 Sign_symptom 138 146 swelling E5 Sign_symptom:T10 T11 Biological_structure 154 165 lower limbs T12 Biological_structure 170 177 abdomen R2 MODIFY Arg1:T11 Arg2:E5 R3 MODIFY Arg1:T12 Arg2:E5 T13 Detailed_description 126 137 progressive T14 Detailed_description 114 121 gradual A1 TREND E5 INC R4 MODIFY Arg1:T13 Arg2:E5 R5 MODIFY Arg1:T14 Arg2:E5 T15 Sign_symptom 200 204 pain E6 Sign_symptom:T15 A2 POLARITY E6 NEG T16 Biological_structure 194 199 chest R6 MODIFY Arg1:T16 Arg2:E6 T17 Sign_symptom 206 214 dyspnoea E7 Sign_symptom:T17 A3 POLARITY E7 NEG T18 Sign_symptom 237 245 dyspnoea E8 Sign_symptom:T18 A4 POLARITY E8 NEG T19 Sign_symptom 249 259 orthopnoea E9 Sign_symptom:T19 A5 POLARITY E9 NEG T20 Detailed_description 227 236 nocturnal T21 Detailed_description 216 226 paroxysmal R7 MODIFY Arg1:T20 Arg2:E8 R8 MODIFY Arg1:T21 Arg2:E8 T22 Diagnostic_procedure 261 267 Vitals E10 Diagnostic_procedure:T22 T23 Lab_value 273 279 stable E11 Lab_value:T23 R9 MODIFY Arg1:E11 Arg2:E10 T24 Diagnostic_procedure 281 307 Cardiovascular examination E12 Diagnostic_procedure:T24 T25 Diagnostic_procedure 339 362 jugular venous pressure E13 Diagnostic_procedure:T25 T26 Diagnostic_procedure 364 367 JVP E14 Diagnostic_procedure:T26 R10 IDENTICAL Arg1:E14 Arg2:E13 T27 Lab_value 330 338 elevated E15 Lab_value:T27 R11 MODIFY Arg1:E15 Arg2:E13 T28 Lab_value 378 383 12 cm E16 Lab_value:T28 R12 MODIFY Arg1:E16 Arg2:E13 T29 Lab_value 391 413 pronounced ‘y’ descent E17 Lab_value:T29 R13 MODIFY Arg1:E17 Arg2:E13 T30 Sign_symptom 437 460 pericardial knock sound E18 Sign_symptom:T30 T31 Biological_structure 476 487 praecordium R14 MODIFY Arg1:T31 Arg2:E18 T32 Severity 427 436 prominent R15 MODIFY Arg1:T32 Arg2:E18 T33 Sign_symptom 502 517 pericardial rub E19 Sign_symptom:T33 A6 POLARITY E19 NEG T34 Sign_symptom 521 527 murmur E20 Sign_symptom:T34 A7 POLARITY E20 NEG T35 Diagnostic_procedure 553 565 auscultation E21 Diagnostic_procedure:T35 T36 Biological_structure 533 538 lungs R16 MODIFY Arg1:T36 Arg2:E21 T37 Lab_value 544 549 clear E22 Lab_value:T37 R17 MODIFY Arg1:E22 Arg2:E21 T38 Sign_symptom 592 602 oedematous E23 Sign_symptom:T38 T39 Biological_structure 612 619 abdomen T40 Biological_structure 627 638 lower limbs R18 MODIFY Arg1:T39 Arg2:E23 R19 MODIFY Arg1:T40 Arg2:E23 T41 Clinical_event 648 656 admitted E24 Clinical_event:T41 T42 Diagnostic_procedure 669 687 diagnostic work-up E25 Diagnostic_procedure:T42 T43 Therapeutic_procedure 692 702 management E26 Therapeutic_procedure:T43 T44 Disease_disorder 727 730 HIV E27 Disease_disorder:T44 T45 History 727 730 HIV R20 MODIFY Arg1:E4 Arg2:E5 T46 Date 738 746 May 2010 E28 Date:T46 T47 Medication 763 785 antiretroviral therapy E29 Medication:T47 T48 Activity 804 817 illicit drugs E30 Activity:T48 A8 POLARITY E30 NEG T49 Duration 822 845 approximately 5–6 years E31 Duration:T49 R21 MODIFY Arg1:E31 Arg2:E30 T50 Disease_disorder 847 873 Renal and hepatic diseases E32 Disease_disorder:T50 A9 POLARITY E32 NEG T51 Diagnostic_procedure 897 908 blood tests E33 Diagnostic_procedure:T51 T52 Diagnostic_procedure 913 920 imaging E34 Diagnostic_procedure:T52 T53 Disease_disorder 956 966 malignancy E35 Disease_disorder:T53 A10 POLARITY E35 NEG T54 Biological_structure 922 938 Peritoneal fluid R22 MODIFY Arg1:T54 Arg2:E35 T55 Diagnostic_procedure 968 982 Echocardiogram E36 Diagnostic_procedure:T55 T56 Biological_structure 1009 1020 pericardium T57 Biological_structure 1037 1055 right heart border R23 MODIFY Arg1:T56 Arg2:E36 R24 MODIFY Arg1:T57 Arg2:E36 T58 Lab_value 1002 1008 bright E37 Lab_value:T58 T59 Lab_value 992 1001 thickened E38 Lab_value:T59 R25 MODIFY Arg1:E37 Arg2:T56 R26 MODIFY Arg1:E38 Arg2:T56 T60 Lab_value 1157 1170 septal bounce E39 Lab_value:T60 R27 MODIFY Arg1:E39 Arg2:E36 T61 Lab_value 1183 1200 pericardial slide E40 Lab_value:T61 A11 POLARITY E40 NEG R28 MODIFY Arg1:E40 Arg2:E36 T62 Lab_value 1072 1133 parallel separation between epicardial and pericardial echoes E41 Lab_value:T62 R29 MODIFY Arg1:E41 Arg2:E36 T63 Diagnostic_procedure 1247 1254 Doppler E42 Diagnostic_procedure:T63 T64 Biological_structure 1240 1246 tissue R30 MODIFY Arg1:T64 Arg2:E42 T65 Sign_symptom 1202 1219 Annulus paradoxus E43 Sign_symptom:T65 T66 Diagnostic_procedure 1267 1301 Left ventricular ejection fraction E44 Diagnostic_procedure:T66 T67 Lab_value 1306 1309 64% E45 Lab_value:T67 R31 MODIFY Arg1:E45 Arg2:E44 T68 Diagnostic_procedure 1345 1349 size E46 Diagnostic_procedure:T68 T69 Diagnostic_procedure 1354 1362 function E47 Diagnostic_procedure:T69 T70 Biological_structure 1315 1330 right ventricle R32 MODIFY Arg1:T70 Arg2:E46 R33 MODIFY Arg1:T70 Arg2:E47 T71 Lab_value 1335 1341 normal E48 Lab_value:T71 R34 MODIFY Arg1:E48 Arg2:E46 R35 MODIFY Arg1:E48 Arg2:E47 T72 Sign_symptom 1383 1406 tricuspid regurgitation E49 Sign_symptom:T72 T73 Severity 1374 1382 moderate R36 MODIFY Arg1:T73 Arg2:E49 T74 Sign_symptom 1421 1441 pericardial effusion E50 Sign_symptom:T74 A12 POLARITY E50 NEG T75 Sign_symptom 1488 1494 debris E51 Sign_symptom:T75 T76 Biological_structure 1451 1468 pericardial space R37 MODIFY Arg1:T76 Arg2:E51 T77 Disease_disorder 1496 1519 Constrictive physiology E52 Disease_disorder:T77 T78 Diagnostic_procedure 1540 1547 Doppler E53 Diagnostic_procedure:T78 T79 Activity 1604 1615 inspiration E54 Activity:T79 T80 Activity 1620 1630 expiration E55 Activity:T80 T81 Sign_symptom 1632 1655 diastolic flow reversal E56 Sign_symptom:T81 T82 Biological_structure 1685 1698 hepatic veins R38 MODIFY Arg1:T82 Arg2:E56 T83 Activity 1706 1716 expiration E57 Activity:T83 R39 MODIFY Arg1:E57 Arg2:E56 T84 Other_event 1557 1585 tricuspid and mitral inflows E58 Other_event:T84 R40 MODIFY Arg1:E54 Arg2:E58 R41 MODIFY Arg1:E55 Arg2:E58 R42 MODIFY Arg1:E58 Arg2:E53 T85 Sign_symptom 1735 1745 dilatation E59 Sign_symptom:T85 T86 Biological_structure 1753 1771 inferior vena cava R43 MODIFY Arg1:T86 Arg2:E59 T87 Activity 1794 1805 inspiration E60 Activity:T87 T88 Activity 1809 1819 expiration E61 Activity:T88 T89 Diagnostic_procedure 1821 1823 CT E62 Diagnostic_procedure:T89 T90 Biological_structure 1831 1836 chest R44 MODIFY Arg1:T90 Arg2:E62 T91 Sign_symptom 1846 1856 thickening E63 Sign_symptom:T91 T92 Biological_structure 1864 1875 pericardium R45 MODIFY Arg1:T92 Arg2:E63 T93 Sign_symptom 1896 1909 calcification E64 Sign_symptom:T93 A13 POLARITY E64 NEG T94 Sign_symptom 1930 1937 nodules E65 Sign_symptom:T94 A14 POLARITY E65 NEG T95 Biological_structure 1925 1929 lung R46 MODIFY Arg1:T95 Arg2:E65 T96 Disease_disorder 1949 1966 pleural effusions E66 Disease_disorder:T96 T97 Detailed_description 1939 1948 Bilateral R47 MODIFY Arg1:T97 Arg2:E66 T98 Sign_symptom 1984 1994 thickening E67 Sign_symptom:T98 T99 Detailed_description 1971 1983 interstitial R48 MODIFY Arg1:T99 Arg2:E67 T100 Biological_structure 2015 2025 lung bases R49 MODIFY Arg1:T100 Arg2:E67 T101 Diagnostic_procedure 2035 2038 MRI E68 Diagnostic_procedure:T101 T102 Biological_structure 2027 2034 Cardiac R50 MODIFY Arg1:T102 Arg2:E68 T103 Biological_structure 2087 2098 pericardium T104 Sign_symptom 2077 2086 thickened E69 Sign_symptom:T104 T105 Detailed_description 2067 2076 diffusely R51 MODIFY Arg1:T105 Arg2:E69 R52 MODIFY Arg1:T103 Arg2:E69 T106 Lab_value 2102 2106 5 mm E70 Lab_value:T106 R53 MODIFY Arg1:E70 Arg2:E69 T107 Sign_symptom 2158 2167 plethoric E71 Sign_symptom:T107 T108 Biological_structure 2112 2130 inferior vena cava T109 Biological_structure 2135 2148 hepatic veins R54 MODIFY Arg1:T109 Arg2:E71 R55 MODIFY Arg1:T108 Arg2:E71 T110 Diagnostic_procedure 2187 2210 early diastolic filling E72 Diagnostic_procedure:T110 T111 Lab_value 2181 2186 rapid E73 Lab_value:T111 R56 MODIFY Arg1:E73 Arg2:E72 T112 Sign_symptom 2226 2249 diastolic septal bounce E74 Sign_symptom:T112 T113 Diagnostic_procedure 2272 2294 late diastolic filling E75 Diagnostic_procedure:T113 T114 Lab_value 2263 2271 hindered E76 Lab_value:T114 R57 MODIFY Arg1:E76 Arg2:E75 T115 Therapeutic_procedure 2345 2353 diuresis E77 Therapeutic_procedure:T115 T116 Diagnostic_procedure 2333 2341 response E78 Diagnostic_procedure:T116 T117 Lab_value 2328 2332 good E79 Lab_value:T117 R58 MODIFY Arg1:E79 Arg2:E78 T118 Therapeutic_procedure 2390 2405 catheterisation E80 Therapeutic_procedure:T118 T119 Biological_structure 2384 2389 heart R59 MODIFY Arg1:T119 Arg2:E80 T120 Detailed_description 2379 2383 left T121 Detailed_description 2369 2374 right R60 MODIFY Arg1:T120 Arg2:E80 R61 MODIFY Arg1:T121 Arg2:E80 T122 Disease_disorder 2417 2440 constrictive physiology E81 Disease_disorder:T122 * OVERLAP E2 E3 R62 BEFORE Arg1:E3 Arg2:E1 R63 AFTER Arg1:E1 Arg2:E4 * OVERLAP E4 E5 R64 BEFORE Arg1:E5 Arg2:E6 * OVERLAP E6 E7 E8 E9 E10 E12 E13 E18 E19 E20 E21 E23 R65 BEFORE Arg1:E23 Arg2:E24 * OVERLAP E24 E25 E26 R66 AFTER Arg1:E26 Arg2:E27 * OVERLAP E27 E28 E29 R67 BEFORE Arg1:E29 Arg2:E30 * OVERLAP E30 E31 R68 BEFORE Arg1:E31 Arg2:E32 * OVERLAP E32 E33 E34 E35 E36 E43 E42 E44 E46 E47 E49 E50 E51 E52 E53 E54 E55 E56 E57 E59 E60 E61 E62 E63 E64 E65 E66 E67 E68 E69 E71 E72 E74 E75 R69 BEFORE Arg1:E75 Arg2:E78 R70 AFTER Arg1:E78 Arg2:E77 R71 BEFORE Arg1:E77 Arg2:E80 * OVERLAP E80 E81