--- a
+++ b/processing/MACCROBAT/24294397.ann
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+T1	Age 2 13	67-year-old
+T2	Personal_background 14 22	Japanese
+T3	Sex 23 29	female
+T4	Sign_symptom 60 65	tumor
+E1	Sign_symptom:T4 
+T5	Biological_structure 47 59	left buttock
+R1	MODIFY Arg1:T5 Arg2:E1	
+T6	Clinical_event 30 39	presented
+E2	Clinical_event:T6 
+T7	Date 111 125	1 year earlier
+E3	Date:T7 
+T8	Disease_disorder 2275 2294	sebaceous carcinoma
+E4	Disease_disorder:T8 
+T9	Disease_disorder 2311 2326	Bowen’s disease
+E5	Disease_disorder:T9 
+T10	Disease_disorder 2196 2215	sebaceous carcinoma
+E6	Disease_disorder:T10 
+T11	Disease_disorder 2220 2235	Bowen’s disease
+E7	Disease_disorder:T11 
+T12	Detailed_description 144 162	gradually enlarged
+R2	MODIFY Arg1:T12 Arg2:E1	
+T13	Diagnostic_procedure 164 184	Physical examination
+E8	Diagnostic_procedure:T13 
+T14	Sign_symptom 239 244	tumor
+E9	Sign_symptom:T14 
+T15	Detailed_description 250 264	hyperkeratosis
+T16	Color 226 238	skin-colored
+T17	Detailed_description 207 225	well-circumscribed
+R3	MODIFY Arg1:T17 Arg2:E9	
+R4	MODIFY Arg1:T16 Arg2:E9	
+R5	MODIFY Arg1:T15 Arg2:E9	
+T18	Area 276 298	43 x 38 mm in diameter
+R6	MODIFY Arg1:T18 Arg2:E9	
+T19	Biological_structure 307 319	left buttock
+R7	MODIFY Arg1:T19 Arg2:E9	
+T20	Disease_disorder 350 365	Bowen’s disease
+E10	Disease_disorder:T20 
+T21	Diagnostic_procedure 325 331	biopsy
+E11	Diagnostic_procedure:T21 
+T22	Disease_disorder 367 398	squamous cell carcinoma in situ
+E12	Disease_disorder:T22 
+R8	IDENTICAL Arg1:E12 Arg2:E10	
+T23	Therapeutic_procedure 425 434	resection
+E13	Therapeutic_procedure:T23 
+T24	Sign_symptom 442 447	tumor
+E14	Sign_symptom:T24 
+R9	MODIFY Arg1:E14 Arg2:E13	
+T25	Detailed_description 419 424	total
+R10	MODIFY Arg1:T25 Arg2:E13	
+T26	Diagnostic_procedure 463 486	Histopathological study
+E15	Diagnostic_procedure:T26 
+T27	Sign_symptom 521 534	proliferation
+E16	Sign_symptom:T27 
+T28	Detailed_description 538 561	atypical squamous cells
+R11	MODIFY Arg1:T28 Arg2:E16	
+T29	Sign_symptom 625 643	hyperparakeratosis
+E17	Sign_symptom:T29 
+T30	Sign_symptom 589 599	acanthotic
+E18	Sign_symptom:T30 
+T31	Biological_structure 600 609	epidermis
+R12	MODIFY Arg1:T31 Arg2:E16	
+T32	Diagnostic_procedure 719 725	nuclei
+E19	Diagnostic_procedure:T32 
+T33	Lab_value 704 718	hyperchromatic
+E20	Lab_value:T33 
+T34	Lab_value 691 699	enlarged
+E21	Lab_value:T34 
+T35	Biological_structure 672 686	squamous cells
+R13	MODIFY Arg1:E20 Arg2:E19	
+R14	MODIFY Arg1:E21 Arg2:E19	
+R15	MODIFY Arg1:T35 Arg2:E19	
+T36	Sign_symptom 743 757	multinucleated
+E22	Sign_symptom:T36 
+T37	Biological_structure 767 781	squamous cells
+R16	MODIFY Arg1:T37 Arg2:E22	
+T38	Biological_structure 851 881	upper portion of the epidermis
+T39	Sign_symptom 801 816	Mitotic figures
+E23	Sign_symptom:T39 
+R17	MODIFY Arg1:T38 Arg2:E23	
+T40	Sign_symptom 892 907	mitotic figures
+E24	Sign_symptom:T40 
+T41	Sign_symptom 952 969	neoplastic growth
+E25	Sign_symptom:T41 
+A1	POLARITY E25 NEG
+T42	Detailed_description 943 951	invasive
+R18	MODIFY Arg1:T42 Arg2:E25	
+T43	Sign_symptom 1018 1024	lesion
+E26	Sign_symptom:T43 
+T44	Disease_disorder 1061 1076	Bowen’s disease
+E27	Disease_disorder:T44 
+T45	Disease_disorder 1078 1109	squamous cell carcinoma in situ
+E28	Disease_disorder:T45 
+R19	IDENTICAL Arg1:E28 Arg2:E27	
+T46	Quantitative_concept 1007 1010	95%
+R20	MODIFY Arg1:T46 Arg2:E26	
+R21	MODIFY Arg1:E27 Arg2:T46	
+T47	Disease_disorder 1128 1147	sebaceous carcinoma
+E29	Disease_disorder:T47 
+T48	Detailed_description 1116 1127	superficial
+R22	MODIFY Arg1:T48 Arg2:E29	
+T49	Sign_symptom 1187 1193	lesion
+E30	Sign_symptom:T49 
+T50	Detailed_description 1167 1179	central area
+R23	MODIFY Arg1:T50 Arg2:E30	
+R24	MODIFY Arg1:E29 Arg2:T50	
+T51	Diagnostic_procedure 2116 2127	adipophilin
+E31	Diagnostic_procedure:T51 
+T52	Lab_value 2103 2111	positive
+E32	Lab_value:T52 
+R25	MODIFY Arg1:E32 Arg2:E31	
+T53	Diagnostic_procedure 2159 2170	p53 protein
+E33	Diagnostic_procedure:T53 
+T54	Lab_value 2141 2155	Overexpression
+E34	Lab_value:T54 
+R26	MODIFY Arg1:E34 Arg2:E33	
+T55	Diagnostic_procedure 1617 1644	Immunohistochemical studies
+E35	Diagnostic_procedure:T55 
+T56	Detailed_description 1669 1680	autostainer
+R27	MODIFY Arg1:T56 Arg2:E35	
+T57	Diagnostic_procedure 1741 1768	Epithelial membrane antigen
+E36	Diagnostic_procedure:T57 
+T58	Detailed_description 1682 1689	Ventana
+R28	MODIFY Arg1:T58 Arg2:T56	
+T59	Diagnostic_procedure 1770 1773	EMA
+E37	Diagnostic_procedure:T59 
+R29	IDENTICAL Arg1:E37 Arg2:E36	
+T60	Diagnostic_procedure 1776 1789	cytokeratin 7
+E38	Diagnostic_procedure:T60 
+T61	Diagnostic_procedure 1795 1806	adipophilin
+E39	Diagnostic_procedure:T61 
+T62	Lab_value 1812 1821	expressed
+E40	Lab_value:T62 
+T63	Lab_value 1864 1867	not
+E41	Lab_value:T63 
+R30	MODIFY Arg1:E40 Arg2:E39	
+R31	MODIFY Arg1:E40 Arg2:E38	
+R32	MODIFY Arg1:E40 Arg2:E36	
+T64	Disease_disorder 1829 1848	sebaceous carcinoma
+E42	Disease_disorder:T64 
+R33	MODIFY Arg1:E42 Arg2:E40	
+T65	Disease_disorder 1871 1886	Bowen’s disease
+E43	Disease_disorder:T65 
+R34	MODIFY Arg1:E43 Arg2:E41	
+R35	MODIFY Arg1:E41 Arg2:E39	
+R36	MODIFY Arg1:E41 Arg2:E38	
+R37	MODIFY Arg1:E41 Arg2:E36	
+T66	Diagnostic_procedure 1900 1917	Androgen receptor
+E44	Diagnostic_procedure:T66 
+T67	Lab_value 1927 1936	expressed
+E45	Lab_value:T67 
+R38	MODIFY Arg1:E45 Arg2:E44	
+T69	Disease_disorder 1971 1990	sebaceous carcinoma
+E47	Disease_disorder:T69 
+R39	MODIFY Arg1:E47 Arg2:E45	
+T68	Lab_value 1996 1999	not
+E46	Lab_value:T68 
+T70	Disease_disorder 2003 2018	Bowen’s disease
+E48	Disease_disorder:T70 
+R40	MODIFY Arg1:E46 Arg2:E44	
+R41	MODIFY Arg1:E48 Arg2:E46	
+T71	Disease_disorder 2077 2092	Bowen’s disease
+E49	Disease_disorder:T71 
+T72	Sign_symptom 2039 2055	vacuolated cells
+E50	Sign_symptom:T72 
+R42	MODIFY Arg1:E49 Arg2:E50	
+R43	MODIFY Arg1:E49 Arg2:E32	
+T73	Sign_symptom 1480 1517	cells containing vacuolated cytoplasm
+E51	Sign_symptom:T73 
+T74	Disease_disorder 1552 1567	Bowen’s disease
+E52	Disease_disorder:T74 
+T75	Disease_disorder 1584 1603	sebaceous carcinoma
+E53	Disease_disorder:T75 
+R44	MODIFY Arg1:E52 Arg2:E51	
+T76	Disease_disorder 1378 1397	Sebaceous carcinoma
+E54	Disease_disorder:T76 
+T77	Sign_symptom 1402 1409	invaded
+E55	Sign_symptom:T77 
+T78	Biological_structure 1419 1447	superficial reticular dermis
+R45	MODIFY Arg1:T78 Arg2:E55	
+R46	CAUSE Arg1:E54 Arg2:E55	
+T79	Sign_symptom 1268 1305	cells with vacuolated clear cytoplasm
+E56	Sign_symptom:T79 
+T80	Sign_symptom 1316 1354	nuclei containing conspicuous nucleoli
+E57	Sign_symptom:T80 
+R47	AFTER Arg1:E2 Arg2:E1	
+*	OVERLAP E1 E3
+R48	BEFORE Arg1:E3 Arg2:E8	
+*	OVERLAP E8 E9 E11 E10
+R49	BEFORE Arg1:E10 Arg2:E13	
+R50	BEFORE Arg1:E13 Arg2:E15	
+*	OVERLAP E15 E16 E18 E17 E19 E22 E23 E24 E25 E26 E27 E29 E30 E56 E57 E54 E55 E51 E53 E35 E36 E38 E39 E44 E50 E49 E31 E33 E6 E7 E4 E5
+R51	MODIFY Arg1:T31 Arg2:E18