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T1 Age 2 13 67-year-old T2 Personal_background 14 22 Japanese T3 Sex 23 29 female T4 Sign_symptom 60 65 tumor E1 Sign_symptom:T4 T5 Biological_structure 47 59 left buttock R1 MODIFY Arg1:T5 Arg2:E1 T6 Clinical_event 30 39 presented E2 Clinical_event:T6 T7 Date 111 125 1 year earlier E3 Date:T7 T8 Disease_disorder 2275 2294 sebaceous carcinoma E4 Disease_disorder:T8 T9 Disease_disorder 2311 2326 Bowen’s disease E5 Disease_disorder:T9 T10 Disease_disorder 2196 2215 sebaceous carcinoma E6 Disease_disorder:T10 T11 Disease_disorder 2220 2235 Bowen’s disease E7 Disease_disorder:T11 T12 Detailed_description 144 162 gradually enlarged R2 MODIFY Arg1:T12 Arg2:E1 T13 Diagnostic_procedure 164 184 Physical examination E8 Diagnostic_procedure:T13 T14 Sign_symptom 239 244 tumor E9 Sign_symptom:T14 T15 Detailed_description 250 264 hyperkeratosis T16 Color 226 238 skin-colored T17 Detailed_description 207 225 well-circumscribed R3 MODIFY Arg1:T17 Arg2:E9 R4 MODIFY Arg1:T16 Arg2:E9 R5 MODIFY Arg1:T15 Arg2:E9 T18 Area 276 298 43 x 38 mm in diameter R6 MODIFY Arg1:T18 Arg2:E9 T19 Biological_structure 307 319 left buttock R7 MODIFY Arg1:T19 Arg2:E9 T20 Disease_disorder 350 365 Bowen’s disease E10 Disease_disorder:T20 T21 Diagnostic_procedure 325 331 biopsy E11 Diagnostic_procedure:T21 T22 Disease_disorder 367 398 squamous cell carcinoma in situ E12 Disease_disorder:T22 R8 IDENTICAL Arg1:E12 Arg2:E10 T23 Therapeutic_procedure 425 434 resection E13 Therapeutic_procedure:T23 T24 Sign_symptom 442 447 tumor E14 Sign_symptom:T24 R9 MODIFY Arg1:E14 Arg2:E13 T25 Detailed_description 419 424 total R10 MODIFY Arg1:T25 Arg2:E13 T26 Diagnostic_procedure 463 486 Histopathological study E15 Diagnostic_procedure:T26 T27 Sign_symptom 521 534 proliferation E16 Sign_symptom:T27 T28 Detailed_description 538 561 atypical squamous cells R11 MODIFY Arg1:T28 Arg2:E16 T29 Sign_symptom 625 643 hyperparakeratosis E17 Sign_symptom:T29 T30 Sign_symptom 589 599 acanthotic E18 Sign_symptom:T30 T31 Biological_structure 600 609 epidermis R12 MODIFY Arg1:T31 Arg2:E16 T32 Diagnostic_procedure 719 725 nuclei E19 Diagnostic_procedure:T32 T33 Lab_value 704 718 hyperchromatic E20 Lab_value:T33 T34 Lab_value 691 699 enlarged E21 Lab_value:T34 T35 Biological_structure 672 686 squamous cells R13 MODIFY Arg1:E20 Arg2:E19 R14 MODIFY Arg1:E21 Arg2:E19 R15 MODIFY Arg1:T35 Arg2:E19 T36 Sign_symptom 743 757 multinucleated E22 Sign_symptom:T36 T37 Biological_structure 767 781 squamous cells R16 MODIFY Arg1:T37 Arg2:E22 T38 Biological_structure 851 881 upper portion of the epidermis T39 Sign_symptom 801 816 Mitotic figures E23 Sign_symptom:T39 R17 MODIFY Arg1:T38 Arg2:E23 T40 Sign_symptom 892 907 mitotic figures E24 Sign_symptom:T40 T41 Sign_symptom 952 969 neoplastic growth E25 Sign_symptom:T41 A1 POLARITY E25 NEG T42 Detailed_description 943 951 invasive R18 MODIFY Arg1:T42 Arg2:E25 T43 Sign_symptom 1018 1024 lesion E26 Sign_symptom:T43 T44 Disease_disorder 1061 1076 Bowen’s disease E27 Disease_disorder:T44 T45 Disease_disorder 1078 1109 squamous cell carcinoma in situ E28 Disease_disorder:T45 R19 IDENTICAL Arg1:E28 Arg2:E27 T46 Quantitative_concept 1007 1010 95% R20 MODIFY Arg1:T46 Arg2:E26 R21 MODIFY Arg1:E27 Arg2:T46 T47 Disease_disorder 1128 1147 sebaceous carcinoma E29 Disease_disorder:T47 T48 Detailed_description 1116 1127 superficial R22 MODIFY Arg1:T48 Arg2:E29 T49 Sign_symptom 1187 1193 lesion E30 Sign_symptom:T49 T50 Detailed_description 1167 1179 central area R23 MODIFY Arg1:T50 Arg2:E30 R24 MODIFY Arg1:E29 Arg2:T50 T51 Diagnostic_procedure 2116 2127 adipophilin E31 Diagnostic_procedure:T51 T52 Lab_value 2103 2111 positive E32 Lab_value:T52 R25 MODIFY Arg1:E32 Arg2:E31 T53 Diagnostic_procedure 2159 2170 p53 protein E33 Diagnostic_procedure:T53 T54 Lab_value 2141 2155 Overexpression E34 Lab_value:T54 R26 MODIFY Arg1:E34 Arg2:E33 T55 Diagnostic_procedure 1617 1644 Immunohistochemical studies E35 Diagnostic_procedure:T55 T56 Detailed_description 1669 1680 autostainer R27 MODIFY Arg1:T56 Arg2:E35 T57 Diagnostic_procedure 1741 1768 Epithelial membrane antigen E36 Diagnostic_procedure:T57 T58 Detailed_description 1682 1689 Ventana R28 MODIFY Arg1:T58 Arg2:T56 T59 Diagnostic_procedure 1770 1773 EMA E37 Diagnostic_procedure:T59 R29 IDENTICAL Arg1:E37 Arg2:E36 T60 Diagnostic_procedure 1776 1789 cytokeratin 7 E38 Diagnostic_procedure:T60 T61 Diagnostic_procedure 1795 1806 adipophilin E39 Diagnostic_procedure:T61 T62 Lab_value 1812 1821 expressed E40 Lab_value:T62 T63 Lab_value 1864 1867 not E41 Lab_value:T63 R30 MODIFY Arg1:E40 Arg2:E39 R31 MODIFY Arg1:E40 Arg2:E38 R32 MODIFY Arg1:E40 Arg2:E36 T64 Disease_disorder 1829 1848 sebaceous carcinoma E42 Disease_disorder:T64 R33 MODIFY Arg1:E42 Arg2:E40 T65 Disease_disorder 1871 1886 Bowen’s disease E43 Disease_disorder:T65 R34 MODIFY Arg1:E43 Arg2:E41 R35 MODIFY Arg1:E41 Arg2:E39 R36 MODIFY Arg1:E41 Arg2:E38 R37 MODIFY Arg1:E41 Arg2:E36 T66 Diagnostic_procedure 1900 1917 Androgen receptor E44 Diagnostic_procedure:T66 T67 Lab_value 1927 1936 expressed E45 Lab_value:T67 R38 MODIFY Arg1:E45 Arg2:E44 T69 Disease_disorder 1971 1990 sebaceous carcinoma E47 Disease_disorder:T69 R39 MODIFY Arg1:E47 Arg2:E45 T68 Lab_value 1996 1999 not E46 Lab_value:T68 T70 Disease_disorder 2003 2018 Bowen’s disease E48 Disease_disorder:T70 R40 MODIFY Arg1:E46 Arg2:E44 R41 MODIFY Arg1:E48 Arg2:E46 T71 Disease_disorder 2077 2092 Bowen’s disease E49 Disease_disorder:T71 T72 Sign_symptom 2039 2055 vacuolated cells E50 Sign_symptom:T72 R42 MODIFY Arg1:E49 Arg2:E50 R43 MODIFY Arg1:E49 Arg2:E32 T73 Sign_symptom 1480 1517 cells containing vacuolated cytoplasm E51 Sign_symptom:T73 T74 Disease_disorder 1552 1567 Bowen’s disease E52 Disease_disorder:T74 T75 Disease_disorder 1584 1603 sebaceous carcinoma E53 Disease_disorder:T75 R44 MODIFY Arg1:E52 Arg2:E51 T76 Disease_disorder 1378 1397 Sebaceous carcinoma E54 Disease_disorder:T76 T77 Sign_symptom 1402 1409 invaded E55 Sign_symptom:T77 T78 Biological_structure 1419 1447 superficial reticular dermis R45 MODIFY Arg1:T78 Arg2:E55 R46 CAUSE Arg1:E54 Arg2:E55 T79 Sign_symptom 1268 1305 cells with vacuolated clear cytoplasm E56 Sign_symptom:T79 T80 Sign_symptom 1316 1354 nuclei containing conspicuous nucleoli E57 Sign_symptom:T80 R47 AFTER Arg1:E2 Arg2:E1 * OVERLAP E1 E3 R48 BEFORE Arg1:E3 Arg2:E8 * OVERLAP E8 E9 E11 E10 R49 BEFORE Arg1:E10 Arg2:E13 R50 BEFORE Arg1:E13 Arg2:E15 * OVERLAP E15 E16 E18 E17 E19 E22 E23 E24 E25 E26 E27 E29 E30 E56 E57 E54 E55 E51 E53 E35 E36 E38 E39 E44 E50 E49 E31 E33 E6 E7 E4 E5 R51 MODIFY Arg1:T31 Arg2:E18