--- a
+++ b/processing/MACCROBAT/23897372.ann
@@ -0,0 +1,300 @@
+T1	Age 2 13	60-year-old
+T2	Personal_background 14 23	Caucasian
+T3	Sex 24 29	woman
+T4	History 35 65	no significant medical history
+T5	Sign_symptom 76 96	exercise intolerance
+E1	Sign_symptom:T5 
+T6	Sign_symptom 98 105	fatigue
+E2	Sign_symptom:T6 
+T7	Sign_symptom 110 129	shortness of breath
+E3	Sign_symptom:T7 
+T8	Detailed_description 133 141	exertion
+R1	MODIFY Arg1:T8 Arg2:E3	
+T9	Duration 151 171	several months prior
+E4	Duration:T9 
+T10	Clinical_event 179 191	presentation
+E5	Clinical_event:T10 
+T11	Nonbiological_location 199 216	outpatient clinic
+R2	MODIFY Arg1:T11 Arg2:E5	
+T12	Sign_symptom 272 277	cough
+E6	Sign_symptom:T12 
+T13	Detailed_description 268 271	dry
+R3	MODIFY Arg1:T13 Arg2:E6	
+T14	Sign_symptom 279 288	orthopnea
+E7	Sign_symptom:T14 
+T15	Sign_symptom 311 319	dyspnoea
+E8	Sign_symptom:T15 
+T16	Detailed_description 301 310	nocturnal
+T17	Detailed_description 290 300	paroxysmal
+R4	MODIFY Arg1:T16 Arg2:E8	
+R5	MODIFY Arg1:T17 Arg2:E8	
+T18	Sign_symptom 333 341	weakness
+E9	Sign_symptom:T18 
+T19	Detailed_description 321 332	generalised
+R6	MODIFY Arg1:T19 Arg2:E9	
+T20	Sign_symptom 359 367	numbness
+E10	Sign_symptom:T20 
+T21	Biological_structure 375 380	hands
+T22	Biological_structure 385 389	feet
+R7	MODIFY Arg1:T21 Arg2:E10	
+R8	MODIFY Arg1:T22 Arg2:E10	
+T23	Detailed_description 346 358	intermittent
+R9	MODIFY Arg1:T23 Arg2:E10	
+T24	Activity 423 430	smoking
+E11	Activity:T24 
+A1	POLARITY E11 NEG
+T25	Activity 432 439	alcohol
+E12	Activity:T25 
+A2	POLARITY E12 NEG
+T26	Activity 443 456	illicit drugs
+E13	Activity:T26 
+A3	POLARITY E13 NEG
+T27	Diagnostic_procedure 458 478	Physical examination
+E14	Diagnostic_procedure:T27 
+T28	Lab_value 483 495	unremarkable
+R10	MODIFY Arg1:T28 Arg2:E14	
+T29	Sign_symptom 523 533	distension
+E15	Sign_symptom:T29 
+T30	Outcome 2470 2479	succumbed
+E16	Outcome:T30 
+T31	Disease_disorder 2483 2503	sudden cardiac death
+E17	Disease_disorder:T31 
+T32	Biological_structure 508 522	jugular venous
+R11	MODIFY Arg1:T32 Arg2:E15	
+T33	Sign_symptom 543 559	S1 and S2 sounds
+E18	Sign_symptom:T33 
+T34	Sign_symptom 571 579	crackles
+E19	Sign_symptom:T34 
+T35	Detailed_description 561 570	bilateral
+R12	MODIFY Arg1:T35 Arg2:E19	
+T36	Diagnostic_procedure 583 600	lung auscultation
+E20	Diagnostic_procedure:T36 
+T37	Sign_symptom 623 629	oedema
+E21	Sign_symptom:T37 
+T38	Detailed_description 615 622	pitting
+T39	Detailed_description 605 614	bilateral
+R13	MODIFY Arg1:T39 Arg2:E21	
+R14	MODIFY Arg1:T38 Arg2:E21	
+T40	Diagnostic_procedure 637 642	X-ray
+E22	Diagnostic_procedure:T40 
+T41	Biological_structure 631 636	Chest
+R15	MODIFY Arg1:T41 Arg2:E22	
+T42	Sign_symptom 650 662	cardiomegaly
+E23	Sign_symptom:T42 
+T43	Sign_symptom 664 680	pulmonary oedema
+E24	Sign_symptom:T43 
+T44	Sign_symptom 707 724	pleural effusions
+E25	Sign_symptom:T44 
+T45	Severity 685 696	small-sized
+T46	Detailed_description 697 706	bilateral
+R16	MODIFY Arg1:T46 Arg2:E25	
+R17	MODIFY Arg1:T45 Arg2:E25	
+T47	Diagnostic_procedure 736 739	ECG
+E26	Diagnostic_procedure:T47 
+T48	Detailed_description 728 735	12-lead
+R18	MODIFY Arg1:T48 Arg2:E26	
+T49	Diagnostic_procedure 760 772	sinus rhythm
+E27	Diagnostic_procedure:T49 
+T50	Lab_value 753 759	normal
+R19	MODIFY Arg1:T50 Arg2:E27	
+T51	Sign_symptom 774 795	low-voltage complexes
+E28	Sign_symptom:T51 
+T52	Sign_symptom 808 828	right-axis deviation
+E29	Sign_symptom:T52 
+T53	Severity 800 807	extreme
+R20	MODIFY Arg1:T53 Arg2:E29	
+T54	Diagnostic_procedure 841 869	Transthoracic echocardiogram
+E30	Diagnostic_procedure:T54 
+T55	Diagnostic_procedure 871 874	TTE
+E31	Diagnostic_procedure:T55 
+R21	IDENTICAL Arg1:E31 Arg2:E30	
+R22	CAUSE Arg1:E17 Arg2:E16	
+T56	Sign_symptom 914 925	hypertrophy
+E32	Sign_symptom:T56 
+T57	Biological_structure 900 913	biventricular
+T58	Detailed_description 889 899	asymmetric
+R23	MODIFY Arg1:T57 Arg2:E32	
+R24	MODIFY Arg1:T58 Arg2:E32	
+T59	Diagnostic_procedure 941 958	ejection fraction
+E33	Diagnostic_procedure:T59 
+T60	Lab_value 931 940	preserved
+R25	MODIFY Arg1:T60 Arg2:E33	
+T61	Lab_value 962 965	60%
+R26	MODIFY Arg1:T61 Arg2:E33	
+T62	Diagnostic_procedure 994 1011	systolic pressure
+E34	Diagnostic_procedure:T62 
+T63	Lab_value 967 975	elevated
+T64	Biological_structure 976 993	right-ventricular
+R27	MODIFY Arg1:T64 Arg2:E34	
+R28	MODIFY Arg1:T63 Arg2:E34	
+T65	Lab_value 1015 1023	36 mm Hg
+R29	MODIFY Arg1:T65 Arg2:E34	
+T66	Diagnostic_procedure 1037 1055	myocardial texture
+E35	Diagnostic_procedure:T66 
+T67	Lab_value 1028 1036	abnormal
+R30	MODIFY Arg1:T67 Arg2:E35	
+T68	Texture 1071 1089	granular sparkling
+R31	MODIFY Arg1:T68 Arg2:E35	
+T69	Diagnostic_procedure 1112 1124	CT angiogram
+E36	Diagnostic_procedure:T69 
+T70	Biological_structure 1103 1111	Coronary
+R32	MODIFY Arg1:T70 Arg2:E36	
+T71	Lab_value 1138 1144	normal
+R33	MODIFY Arg1:T71 Arg2:E36	
+T72	Biological_structure 1145 1162	coronary arteries
+R34	MODIFY Arg1:T72 Arg2:T71	
+T73	Diagnostic_procedure 1186 1189	MRI
+E37	Diagnostic_procedure:T73 
+T74	Biological_structure 1178 1185	cardiac
+R35	MODIFY Arg1:T74 Arg2:E37	
+T75	Sign_symptom 1236 1255	delayed enhancement
+E38	Sign_symptom:T75 
+T76	Biological_structure 1221 1235	subendocardial
+T77	Detailed_description 1213 1220	diffuse
+T78	Detailed_description 1203 1208	early
+R36	MODIFY Arg1:T76 Arg2:E38	
+R37	MODIFY Arg1:T77 Arg2:E38	
+R38	MODIFY Arg1:T78 Arg2:E38	
+T79	Disease_disorder 1272 1303	infiltrative myocardial disease
+E39	Disease_disorder:T79 
+A4	POLARITY E39 UNCERTAIN
+T80	Sign_symptom 1334 1345	hypertrophy
+E40	Sign_symptom:T80 
+T81	Detailed_description 1312 1319	diffuse
+T82	Biological_structure 1320 1333	biventricular
+R39	MODIFY Arg1:T82 Arg2:E40	
+R40	MODIFY Arg1:T81 Arg2:E40	
+T83	Diagnostic_procedure 1359 1376	ejection fraction
+E41	Diagnostic_procedure:T83 
+T84	Lab_value 1352 1358	normal
+R41	MODIFY Arg1:T84 Arg2:E41	
+T85	Therapeutic_procedure 1417 1438	heart catheterisation
+E42	Therapeutic_procedure:T85 
+T86	Detailed_description 1411 1416	right
+R42	MODIFY Arg1:T86 Arg2:E42	
+T87	Diagnostic_procedure 1459 1465	biopsy
+E43	Diagnostic_procedure:T87 
+T88	Biological_structure 1444 1458	endomyocardial
+R43	MODIFY Arg1:T88 Arg2:E43	
+T89	Disease_disorder 1485 1496	amyloidosis
+E44	Disease_disorder:T89 
+T90	Detailed_description 1477 1484	diffuse
+R44	MODIFY Arg1:T90 Arg2:E44	
+T91	Sign_symptom 1512 1534	proteinaceous material
+E45	Sign_symptom:T91 
+T92	Detailed_description 1502 1511	amorphous
+R45	MODIFY Arg1:T92 Arg2:E45	
+T93	Biological_structure 1542 1558	cardiac myocytes
+R46	MODIFY Arg1:T93 Arg2:E45	
+T94	Biological_structure 1570 1583	blood vessels
+R47	MODIFY Arg1:T94 Arg2:E45	
+T95	Diagnostic_procedure 1608 1623	Congo red stain
+E46	Diagnostic_procedure:T95 
+T96	Lab_value 1595 1603	positive
+R48	MODIFY Arg1:E45 Arg2:E46	
+R49	MODIFY Arg1:T96 Arg2:E46	
+T97	Diagnostic_procedure 1647 1668	laboratory evaluation
+E47	Diagnostic_procedure:T97 
+T98	Diagnostic_procedure 1690 1709	free λ light chains
+E48	Diagnostic_procedure:T98 
+T99	Lab_value 1680 1688	elevated
+R50	MODIFY Arg1:T99 Arg2:E48	
+T100	Lab_value 1711 1720	86.3 mg/L
+R51	MODIFY Arg1:T100 Arg2:E48	
+T101	Diagnostic_procedure 1759 1778	Bence-Jones protein
+E49	Diagnostic_procedure:T101 
+T102	Lab_value 1750 1758	positive
+R52	MODIFY Arg1:T102 Arg2:E49	
+T103	Detailed_description 1800 1805	urine
+R53	MODIFY Arg1:T103 Arg2:E49	
+T104	Lab_value 1780 1791	0.37 g/24 h
+R54	MODIFY Arg1:T104 Arg2:E49	
+T105	Diagnostic_procedure 1819 1825	biopsy
+E50	Diagnostic_procedure:T105 
+T106	Biological_structure 1807 1818	Bone marrow
+R55	MODIFY Arg1:T106 Arg2:E50	
+T107	Disease_disorder 1971 1973	MM
+E51	Disease_disorder:T107 
+#1	AnnotatorNotes E51	multiple myeloma
+T108	Disease_disorder 2029 2040	amyloidosis
+E52	Disease_disorder:T108 
+T109	Detailed_description 2026 2028	AL
+#2	AnnotatorNotes T109	immunoglobulin light chain amyloidosis
+R56	MODIFY Arg1:T109 Arg2:E52	
+T110	Detailed_description 2017 2025	systemic
+R57	MODIFY Arg1:T110 Arg2:E52	
+T111	Disease_disorder 2075 2086	amyloidosis
+E53	Disease_disorder:T111 
+T112	Biological_structure 2067 2074	cardiac
+T113	Detailed_description 2056 2065	stage III
+T114	Severity 2046 2054	advanced
+R58	MODIFY Arg1:T112 Arg2:E53	
+R59	MODIFY Arg1:T113 Arg2:E53	
+R60	MODIFY Arg1:T114 Arg2:E53	
+T115	Disease_disorder 2105 2107	MM
+E54	Disease_disorder:T115 
+R61	CAUSE Arg1:E54 Arg2:E53	
+T116	Diagnostic_procedure 1852 1864	infiltration
+E55	Diagnostic_procedure:T116 
+T117	Lab_value 1835 1851	greater than 10%
+R62	MODIFY Arg1:T117 Arg2:E55	
+T118	Detailed_description 1868 1899	CD19− CD56+ CD138+ plasma cells
+R63	MODIFY Arg1:T118 Arg2:E55	
+T119	Lab_value 1905 1913	reversal
+T120	Diagnostic_procedure 1917 1933	marrow κ/λ ratio
+E56	Diagnostic_procedure:T120 
+R64	MODIFY Arg1:T119 Arg2:E56	
+T121	Lab_value 1935 1939	<1:2
+R65	MODIFY Arg1:T121 Arg2:E56	
+T122	Disease_disorder 2136 2147	amyloidosis
+E57	Disease_disorder:T122 
+T123	Biological_structure 2128 2135	cardiac
+T124	Severity 2119 2127	advanced
+R66	MODIFY Arg1:T123 Arg2:E57	
+R67	MODIFY Arg1:T124 Arg2:E57	
+T125	Therapeutic_procedure 2193 2229	autologous stem-cell transplantation
+E58	Therapeutic_procedure:T125 
+A5	POLARITY E58 NEG
+T126	Medication 2267 2279	chemotherapy
+E59	Medication:T126 
+T127	Detailed_description 2258 2266	systemic
+R68	MODIFY Arg1:T127 Arg2:E59	
+T128	Medication 2285 2294	melphalan
+E60	Medication:T128 
+T129	Medication 2299 2312	dexamethasone
+E61	Medication:T129 
+R69	SUB_PROCEDURE Arg1:E60 Arg2:E59	
+R70	SUB_PROCEDURE Arg1:E61 Arg2:E59	
+T130	Medication 2377 2386	diuretics
+E62	Medication:T130 
+T131	Medication 2388 2398	β-blockers
+E63	Medication:T131 
+T132	Medication 2403 2417	ACE inhibitors
+E64	Medication:T132 
+T133	Diagnostic_procedure 2432 2441	condition
+E65	Diagnostic_procedure:T133 
+T134	Lab_value 2455 2461	worsen
+R71	MODIFY Arg1:T134 Arg2:E65	
+*	OVERLAP E1 E2 E3 E4
+R72	BEFORE Arg1:E4 Arg2:E5	
+*	OVERLAP E5 E6 E7 E8 E9 E10
+R73	AFTER Arg1:E10 Arg2:E11	
+*	OVERLAP E11 E12 E13
+T135	History 391 456	Social history was negative for smoking, alcohol or illicit drugs
+R74	BEFORE Arg1:E13 Arg2:E14	
+*	OVERLAP E14 E15 E18 E19 E20 E21 E22 E23 E24 E25 E26 E27 E28 E29 E30 E32 E33 E34 E35 E36
+R75	BEFORE Arg1:E36 Arg2:E37	
+*	OVERLAP E37 E38 E39 E40 E41
+R76	BEFORE Arg1:E41 Arg2:E42	
+*	OVERLAP E42 E43 E44 E45 E46
+R77	BEFORE Arg1:E46 Arg2:E47	
+R78	SUB_PROCEDURE Arg1:E48 Arg2:E47	
+R79	SUB_PROCEDURE Arg1:E49 Arg2:E47	
+*	OVERLAP E47 E50 E55 E56 E51
+R80	BEFORE Arg1:E51 Arg2:E52	
+*	OVERLAP E52 E53 E54 E57 E58
+R81	BEFORE Arg1:E58 Arg2:E59	
+R82	BEFORE Arg1:E59 Arg2:E62	
+*	OVERLAP E62 E63 E64
+R83	BEFORE Arg1:E64 Arg2:E65	
+R84	BEFORE Arg1:E65 Arg2:E16