T1  Age 3 14    84-year-old

T2  Sex 15 19   male

T3  History 46 110  coronary artery disease and right coronary artery (RCA) stenting

T4  Clinical_event 115 123  admitted

E1  Clinical_event:T4 

T5  Nonbiological_location 131 150  university hospital

T6  Date 154 167    February 2012

E2  Date:T6 

T7  Sign_symptom 191 199    dyspnoea

E3  Sign_symptom:T7 

T8  Sign_symptom 214 222    syncopes

E4  Sign_symptom:T8 

T9  Detailed_description 204 213    recurring

T10 Detailed_description 179 190    progressive

R1  MODIFY Arg1:T10 Arg2:E3 

R2  MODIFY Arg1:T9 Arg2:E4  

T11 Diagnostic_procedure 224 245    Cardiological work-up

E5  Diagnostic_procedure:T11 

T12 Disease_disorder 286 301    aortic stenosis

E6  Disease_disorder:T12 

T13 Lab_value 257 266   grade III

R3  MODIFY Arg1:T13 Arg2:E6 

T14 Detailed_description 274 285    symptomatic

T15 Severity 267 273    severe

R4  MODIFY Arg1:T14 Arg2:E6 

R5  MODIFY Arg1:T15 Arg2:E6 

T16 Diagnostic_procedure 334 352    logistic EuroSCORE

E7  Diagnostic_procedure:T16 

T17 Lab_value 356 365   19 points

R6  MODIFY Arg1:T17 Arg2:E7 

T18 Therapeutic_procedure 438 442   TAVI

E8  Therapeutic_procedure:T18 

#1  AnnotatorNotes E8   transcatheter aortic valve implantation

T19 Disease_disorder 386 398    arteriopathy

E9  Disease_disorder:T19 

T20 Severity 371 377    severe

T21 Biological_structure 378 385    femoral

R7  MODIFY Arg1:T21 Arg2:E9 

R8  MODIFY Arg1:T20 Arg2:E9 

T22 Detailed_description 421 437    trans-subclavian

R9  MODIFY Arg1:T22 Arg2:E8 

T23 Detailed_description 479 499    CoreValve prosthesis

T24 Coreference 461 473 implantation

E10 Coreference:T24 

R10 IDENTICAL Arg1:E10 Arg2:E8  

R11 MODIFY Arg1:T23 Arg2:E10    

T25 Detailed_description 501 510    Medtronic

R12 MODIFY Arg1:T25 Arg2:T23    

T26 Detailed_description 590 604    diameter 31 mm

R13 MODIFY Arg1:T26 Arg2:T23    

T27 Clinical_event 618 627  discharge

E11 Clinical_event:T27 

T28 Clinical_event 636 644  referred

E12 Clinical_event:T28 

R14 MODIFY Arg1:T5 Arg2:E1  

T29 Biological_structure 657 665    hospital

R15 MODIFY Arg1:T29 Arg2:E12    

T30 Sign_symptom 677 685    dyspnoea

E13 Sign_symptom:T30 

T31 Disease_disorder 703 720    pleural effusions

E14 Disease_disorder:T31 

R16 CAUSE Arg1:E14 Arg2:E13 

T32 Detailed_description 693 702    bilateral

R17 MODIFY Arg1:T32 Arg2:E14    

T33 Diagnostic_procedure 722 755    Transoesophageal echocardiography

E15 Diagnostic_procedure:T33 

T34 Diagnostic_procedure 757 760    TEE

E16 Diagnostic_procedure:T34 

R18 IDENTICAL Arg1:E16 Arg2:E15 

T35 Sign_symptom 778 798    mitral regurgitation

E17 Sign_symptom:T35 

T36 Severity 771 777    severe

R19 MODIFY Arg1:T36 Arg2:E17    

T37 Therapeutic_procedure 854 873   mitral valve repair

E18 Therapeutic_procedure:T37 

T38 Biological_structure 884 893    MitraClip

R20 MODIFY Arg1:T38 Arg2:E18    

T39 Detailed_description 839 853    interventional

R21 MODIFY Arg1:T39 Arg2:E18    

T40 Sign_symptom 800 802    MR

E19 Sign_symptom:T40 

R22 IDENTICAL Arg1:E19 Arg2:E17 

T41 Detailed_description 895 962    Abbott Vascular, Abbott Laboratories, Abbott Park, Illinois, U.S.A.

T42 Detailed_description 513 587    Medtronic World Headquarters Medtronic Parkway Minneapolis, Minnesota, USA

R23 MODIFY Arg1:T42 Arg2:T25    

R24 MODIFY Arg1:T41 Arg2:T38    

T43 Therapeutic_procedure 991 1025  atrial septal defect (ASD) closure

E20 Therapeutic_procedure:T43 

T44 Detailed_description 1026 1049  AMPLATZER™ PFO Occluder

R25 MODIFY Arg1:T44 Arg2:E20    

T45 Date 1111 1126  Two weeks after

E21 Date:T45 

T46 Clinical_event 1137 1146    discharge

E22 Clinical_event:T46 

T47 Detailed_description 1127 1136  secondary

R26 MODIFY Arg1:T47 Arg2:E22    

T48 Disease_disorder 1182 1195  heart failure

E23 Disease_disorder:T48 

T49 Detailed_description 1170 1181  progressive

R27 MODIFY Arg1:T49 Arg2:E23    

T50 Disease_disorder 1222 1235  renal failure

E24 Disease_disorder:T50 

T51 Detailed_description 1216 1221  acute

R28 MODIFY Arg1:T51 Arg2:E24    

T52 Diagnostic_procedure 1247 1263  echocardiography

E25 Diagnostic_procedure:T52 

T53 Detailed_description 1237 1246  Immediate

R29 MODIFY Arg1:T53 Arg2:E25    

T54 Sign_symptom 1336 1338  MR

E26 Sign_symptom:T54 

T55 Severity 1329 1335  severe

T56 Detailed_description 1319 1328  recurrent

R30 MODIFY Arg1:T55 Arg2:E26    

R31 MODIFY Arg1:T56 Arg2:E26    

T57 Sign_symptom 1294 1314  aortic regurgitation

E27 Sign_symptom:T57 

T58 Severity 1275 1293  moderate-to-severe

R32 MODIFY Arg1:T58 Arg2:E27    

T59 Sign_symptom 1340 1356  Valvular defects

E28 Sign_symptom:T59 

T60 Sign_symptom 1396 1429  aortic valve prosthesis migration

E29 Sign_symptom:T60 

T61 Severity 1373 1395  slight but significant

R33 MODIFY Arg1:T61 Arg2:E29    

T62 Biological_structure 1442 1472  left ventricular outflow tract

R34 MODIFY Arg1:T62 Arg2:E29    

R35 CAUSE Arg1:E29 Arg2:E28 

T63 Sign_symptom 1491 1518  aortic paravalvular leakage

E30 Sign_symptom:T63 

R36 CAUSE Arg1:E29 Arg2:E30 

T64 Sign_symptom 1541 1566  mitral leaflet detachment

E31 Sign_symptom:T64 

T65 Detailed_description 1531 1540  posterior

T66 Detailed_description 1523 1530  partial

R37 MODIFY Arg1:T65 Arg2:E31    

R38 MODIFY Arg1:T66 Arg2:E31    

R39 CAUSE Arg1:E29 Arg2:E31 

T67 Clinical_event 1628 1639    transferred

E32 Clinical_event:T67 

T68 Nonbiological_location 1647 1673    cardiac surgery department

R40 MODIFY Arg1:T68 Arg2:E32    

T69 Diagnostic_procedure 1697 1708  angiography

E33 Diagnostic_procedure:T69 

T70 Biological_structure 1688 1696  coronary

R41 MODIFY Arg1:T70 Arg2:E33    

T71 Disease_disorder 1739 1762  coronary artery disease

E34 Disease_disorder:T71 

A1  TREND E34 INC

T72 Therapeutic_procedure 1838 1855 valve replacement

E35 Therapeutic_procedure:T72 

T73 Biological_structure 1831 1837  mitral

T74 Biological_structure 1820 1826  aortic

T75 Detailed_description 1807 1819  conventional

R42 MODIFY Arg1:T73 Arg2:E35    

R43 MODIFY Arg1:T74 Arg2:E35    

R44 MODIFY Arg1:T75 Arg2:E35    

T76 Therapeutic_procedure 1932 1949 median sternotomy

E36 Therapeutic_procedure:T76 

R45 SUB_PROCEDURE Arg1:E36 Arg2:E37 

T77 Therapeutic_procedure 1868 1898 coronary artery bypass surgery

E37 Therapeutic_procedure:T77 

T78 Clinical_event 3031 3040    follow-up

E38 Clinical_event:T78 

T79 Date 3041 3059  three months after

E39 Date:T79 

T80 Diagnostic_procedure 3119 3128  condition

E40 Diagnostic_procedure:T80 

T81 Therapeutic_procedure 3152 3165 physiotherapy

E41 Therapeutic_procedure:T81 

T82 Date 2878 2891  After a month

E42 Date:T82 

T83 Therapeutic_procedure 2895 2913 postoperative care

E43 Therapeutic_procedure:T83 

T84 Clinical_event 2931 2941    discharged

E44 Clinical_event:T84 

T85 Nonbiological_location 2947 2955    hospital

R46 MODIFY Arg1:T85 Arg2:E44    

T86 Therapeutic_procedure 2959 2973 rehabilitation

E45 Therapeutic_procedure:T86 

T87 Diagnostic_procedure 2984 2993  condition

E46 Diagnostic_procedure:T87 

T88 Lab_value 2979 2983 good

R47 MODIFY Arg1:T88 Arg2:E46    

T89 Lab_value 3096 3118 cardiopulmonary stable

R48 MODIFY Arg1:T89 Arg2:E40    

T90 Sign_symptom 3003 3026  signs for heart failure

E47 Sign_symptom:T90 

A2  POLARITY E47 NEG

T91 Sign_symptom 2751 2760  recovered

E48 Sign_symptom:T91 

T92 Lab_value 2761 2765 well

R49 MODIFY Arg1:T92 Arg2:E48    

T93 Disease_disorder 2831 2844  renal failure

E49 Disease_disorder:T93 

T94 Disease_disorder 2859 2876  pleural effusions

E50 Disease_disorder:T94 

T95 Detailed_description 2849 2858  recurring

T96 Detailed_description 2821 2830  transient

R50 MODIFY Arg1:T96 Arg2:E49    

R51 MODIFY Arg1:T95 Arg2:E50    

T97 Clinical_event 2788 2817    hospitalization was prolonged

E51 Clinical_event:T97 

T98 Diagnostic_procedure 2591 2607  echocardiography

E52 Diagnostic_procedure:T98 

T99 Detailed_description 2576 2590  Intraoperative

R52 MODIFY Arg1:T99 Arg2:E52    

T100    Lab_value 2617 2653 adequate function of both prostheses

R53 MODIFY Arg1:T100 Arg2:E52   

T101    Therapeutic_procedure 2450 2484 atrial septal occluder was removed

E53 Therapeutic_procedure:T101 

T102    Therapeutic_procedure 2501 2508 closure

E54 Therapeutic_procedure:T102 

T103    Detailed_description 2547 2565  single-suture line

R54 MODIFY Arg1:T103 Arg2:E54   

T104    Sign_symptom 2526 2539  septal defect

E55 Sign_symptom:T104 

R55 MODIFY Arg1:E55 Arg2:E54    

T105    Therapeutic_procedure 2420 2429 implanted

E56 Therapeutic_procedure:T105 

T106    Detailed_description 2375 2398  mitral valve prosthesis

T107    Detailed_description 2400 2414  diameter 31 mm

R56 MODIFY Arg1:T107 Arg2:T106  

T108    Detailed_description 2357 2374  Edwards Perimount

R57 MODIFY Arg1:T108 Arg2:T106  

R58 MODIFY Arg1:T106 Arg2:E56   

T109    Therapeutic_procedure 2207 2220 vein-grafting

E57 Therapeutic_procedure:T109 

T110    Biological_structure 2228 2254  circumflex coronary artery

R59 MODIFY Arg1:T110 Arg2:E57   

T111    Therapeutic_procedure 2310 2317 excised

E58 Therapeutic_procedure:T111 

T112    Detailed_description 2327 2340  attached clip

R60 MODIFY Arg1:T112 Arg2:E58   

T113    Biological_structure 2260 2272  mitral valve

R61 MODIFY Arg1:T113 Arg2:E58   

T114    Detailed_description 2277 2305  explored via the left atrium

R62 MODIFY Arg1:T114 Arg2:T113  

T115    Therapeutic_procedure 2087 2094 removal

E59 Therapeutic_procedure:T115 

T116    Detailed_description 2102 2122  CoreValve prosthesis

R63 MODIFY Arg1:T116 Arg2:E59   

T117    Therapeutic_procedure 2190 2199 implanted

E60 Therapeutic_procedure:T117 

T118    Detailed_description 2145 2168  aortic valve prosthesis

T119    Detailed_description 2127 2144  Edwards Perimount

R64 MODIFY Arg1:T119 Arg2:T118  

R65 MODIFY Arg1:T118 Arg2:E60   

T120    Detailed_description 2170 2184  diameter 25 mm

R66 MODIFY Arg1:T120 Arg2:T118  

T121    Therapeutic_procedure 1972 1994 cardiopulmonary bypass

E61 Therapeutic_procedure:T121 

T122    Therapeutic_procedure 2020 2026 opened

E62 Therapeutic_procedure:T122 

T123    Biological_structure 2000 2015  ascending aorta

R67 MODIFY Arg1:T123 Arg2:E62   

T124    Detailed_description 2031 2062  exploration of the aortic valve

R68 MODIFY Arg1:T124 Arg2:E62   

*   OVERLAP E1 E2 E3 E4 E5 E6 E7 E9

R69 BEFORE Arg1:E9 Arg2:E8  

*   OVERLAP E8 E10

R70 BEFORE Arg1:E10 Arg2:E11    

R71 BEFORE Arg1:E11 Arg2:E12    

*   OVERLAP E12 E13 E14

R72 BEFORE Arg1:E14 Arg2:E15    

*   OVERLAP E15 E17

R73 BEFORE Arg1:E17 Arg2:E18    

*   OVERLAP E18 E20

R74 BEFORE Arg1:E20 Arg2:E21    

R75 AFTER Arg1:E21 Arg2:E22 

R76 BEFORE Arg1:E22 Arg2:E23    

*   OVERLAP E23 E24 E25 E27

*   OVERLAP E26 E28 E29 E30 E31

R77 BEFORE Arg1:E31 Arg2:E32    

*   OVERLAP E32 E33 E34

R78 BEFORE Arg1:E34 Arg2:E35    

*   OVERLAP E35 E37 E61 E62 E59 E60 E57 E58 E56 E53 E54 E52

R79 BEFORE Arg1:E52 Arg2:E48    

R80 BEFORE Arg1:E48 Arg2:E51    

*   OVERLAP E51 E49 E50

R81 BEFORE Arg1:E50 Arg2:E42    

*   OVERLAP E42 E43

R82 BEFORE Arg1:E43 Arg2:E44    

*   OVERLAP E44 E45 E46 E47

R83 BEFORE Arg1:E47 Arg2:E38    

*   OVERLAP E38 E39 E40 E41