--- a
+++ b/processing/MACCROBAT/23312850.ann
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+T1	Age 2 13	54 year-old
+T2	History 14 22	diabetic
+T3	Sex 23 28	woman
+T4	Sign_symptom 43 57	blurred vision
+E1	Sign_symptom:T4 
+T5	Biological_structure 65 73	left eye
+R1	MODIFY Arg1:T5 Arg2:E1	
+T6	Duration 78 84	5 days
+E2	Duration:T6 
+T7	Sign_symptom 99 109	tenderness
+E3	Sign_symptom:T7 
+A1	POLARITY E3 NEG
+T8	Biological_structure 93 98	scalp
+R2	MODIFY Arg1:T8 Arg2:E3	
+T9	Sign_symptom 113 121	headache
+E4	Sign_symptom:T9 
+A2	POLARITY E4 NEG
+T10	Diagnostic_procedure 123 136	Visual acuity
+E5	Diagnostic_procedure:T10 
+T11	Diagnostic_procedure 138 140	VA
+E6	Diagnostic_procedure:T11 
+R3	IDENTICAL Arg1:E6 Arg2:E5	
+T12	Lab_value 146 151	20/20
+T13	Lab_value 166 171	20/30
+T14	Biological_structure 152 161	right eye
+T15	Biological_structure 172 180	left eye
+R4	MODIFY Arg1:T14 Arg2:T12	
+R5	MODIFY Arg1:T15 Arg2:T13	
+R6	MODIFY Arg1:T12 Arg2:E5	
+R7	MODIFY Arg1:T13 Arg2:E5	
+T16	Diagnostic_procedure 182 203	Intraocular pressures
+E7	Diagnostic_procedure:T16 
+T17	Lab_value 209 215	normal
+R8	MODIFY Arg1:T17 Arg2:E7	
+T18	Diagnostic_procedure 217 240	Funduscopic examination
+E8	Diagnostic_procedure:T18 
+T19	Sign_symptom 267 272	edema
+E9	Sign_symptom:T19 
+T20	Sign_symptom 297 307	hemorrhage
+E10	Sign_symptom:T20 
+T21	Severity 279 284	small
+T22	Biological_structure 285 296	disc margin
+R9	MODIFY Arg1:T22 Arg2:E10	
+R10	MODIFY Arg1:T21 Arg2:E10	
+T23	Biological_structure 250 266	left optic nerve
+R11	MODIFY Arg1:T23 Arg2:E9	
+T24	Diagnostic_procedure 309 318	WBC count
+E11	Diagnostic_procedure:T24 
+T25	Lab_value 323 329	12,700
+R12	MODIFY Arg1:T25 Arg2:E11	
+T26	Diagnostic_procedure 331 334	ESR
+E12	Diagnostic_procedure:T26 
+T27	Lab_value 339 340	7
+R13	MODIFY Arg1:T27 Arg2:E12	
+T28	Diagnostic_procedure 365 368	CRP
+E13	Diagnostic_procedure:T28 
+T29	Lab_value 373 376	2.4
+R14	MODIFY Arg1:T29 Arg2:E13	
+T30	Date 399 415	Three days later
+E14	Date:T30 
+T31	Sign_symptom 440 444	pain
+E15	Sign_symptom:T31 
+T32	Biological_structure 431 439	left eye
+R15	MODIFY Arg1:T32 Arg2:E15	
+T33	Diagnostic_procedure 453 459	vision
+E16	Diagnostic_procedure:T33 
+T34	Lab_value 472 488	counting fingers
+#1	AnnotatorNotes T34	i.e., she was only able to count fingers in front of her face, but no more
+R16	MODIFY Arg1:T34 Arg2:E16	
+T35	Sign_symptom 503 507	pain
+E17	Sign_symptom:T35 
+A3	POLARITY E17 NEG
+T36	Detailed_description 508 523	on eye movement
+R17	MODIFY Arg1:T36 Arg2:E17	
+T37	Diagnostic_procedure 529 540	right pupil
+E18	Diagnostic_procedure:T37 
+T38	Distance 545 549	4 mm
+T39	Lab_value 554 570	reacted to light
+R18	MODIFY Arg1:T38 Arg2:E18	
+R19	MODIFY Arg1:T39 Arg2:E18	
+T40	Diagnostic_procedure 576 586	left pupil
+E19	Diagnostic_procedure:T40 
+#2	AnnotatorNotes E18	a diagnostic because this is an assessment of the pupil
+T41	Distance 591 595	4 mm
+R20	MODIFY Arg1:T41 Arg2:E19	
+T42	Sign_symptom 646 652	defect
+E20	Sign_symptom:T42 
+T43	Biological_structure 622 645	left afferent pupillary
+T44	Detailed_description 613 621	relative
+R21	MODIFY Arg1:T44 Arg2:E20	
+R22	MODIFY Arg1:T43 Arg2:E20	
+T45	Sign_symptom 679 686	swollen
+E21	Sign_symptom:T45 
+T46	Biological_structure 658 674	left optic nerve
+R23	MODIFY Arg1:T46 Arg2:E21	
+T47	Sign_symptom 730 741	hemorrhages
+E22	Sign_symptom:T47 
+T48	Detailed_description 694 697	few
+R24	MODIFY Arg1:T48 Arg2:E22	
+T49	Biological_structure 698 729	peripapillary nerve fiber layer
+R25	MODIFY Arg1:T49 Arg2:E22	
+T50	Sign_symptom 766 770	spot
+E23	Sign_symptom:T50 
+T51	Color 755 765	cherry red
+R26	MODIFY Arg1:T51 Arg2:E23	
+T52	Sign_symptom 788 793	edema
+E24	Sign_symptom:T52 
+T53	Severity 775 779	mild
+T54	Biological_structure 780 787	macular
+R27	MODIFY Arg1:T54 Arg2:E24	
+R28	MODIFY Arg1:T53 Arg2:E24	
+T55	Disease_disorder 810 842	central retinal artery occlusion
+E25	Disease_disorder:T55 
+T56	Sign_symptom 895 906	hemorrhages
+E26	Sign_symptom:T56 
+A4	POLARITY E26 NEG
+T57	Biological_structure 876 894	peripheral retinal
+T58	Biological_structure 858 872	posterior pole
+R29	MODIFY Arg1:T57 Arg2:E26	
+R30	MODIFY Arg1:T58 Arg2:E26	
+T59	Diagnostic_procedure 908 919	Trace cells
+E27	Diagnostic_procedure:T59 
+T60	Biological_structure 937 953	anterior chamber
+T61	Lab_value 925 929	seen
+T62	Lab_value 959 962	not
+T63	Biological_structure 970 984	vitreous fluid
+R31	MODIFY Arg1:T63 Arg2:T62	
+R32	MODIFY Arg1:T60 Arg2:T61	
+R33	MODIFY Arg1:T61 Arg2:E27	
+R34	MODIFY Arg1:T62 Arg2:E27	
+T64	Diagnostic_procedure 993 996	WBC
+E28	Diagnostic_procedure:T64 
+T65	Diagnostic_procedure 998 1001	ESR
+E29	Diagnostic_procedure:T65 
+T66	Diagnostic_procedure 1006 1009	CRP
+E30	Diagnostic_procedure:T66 
+T67	Lab_value 1015 1021	normal
+R35	MODIFY Arg1:T67 Arg2:E30	
+R36	MODIFY Arg1:T67 Arg2:E29	
+R37	MODIFY Arg1:T67 Arg2:E28	
+T68	Diagnostic_procedure 1049 1059	antibodies
+E31	Diagnostic_procedure:T68 
+T69	Detailed_description 1038 1048	Bartonella
+T70	Detailed_description 1023 1033	Treponemal
+R38	MODIFY Arg1:T69 Arg2:E31	
+R39	MODIFY Arg1:T70 Arg2:E31	
+T71	Diagnostic_procedure 1065 1084	QuantiFERON-TB test
+E32	Diagnostic_procedure:T71 
+T72	Diagnostic_procedure 1086 1100	blood cultures
+E33	Diagnostic_procedure:T72 
+T73	Diagnostic_procedure 1102 1105	EKG
+E34	Diagnostic_procedure:T73 
+T74	Diagnostic_procedure 1126 1136	ultrasound
+E35	Diagnostic_procedure:T74 
+T75	Detailed_description 1118 1125	Doppler
+T76	Biological_structure 1110 1117	carotid
+R40	MODIFY Arg1:T75 Arg2:E35	
+R41	MODIFY Arg1:T76 Arg2:E35	
+T77	Lab_value 1142 1154	unremarkable
+R42	MODIFY Arg1:T77 Arg2:E31	
+R43	MODIFY Arg1:T77 Arg2:E32	
+R44	MODIFY Arg1:T77 Arg2:E33	
+R45	MODIFY Arg1:T77 Arg2:E34	
+R46	MODIFY Arg1:T77 Arg2:E35	
+T78	Diagnostic_procedure 1171 1174	MRI
+E36	Diagnostic_procedure:T78 
+T79	Detailed_description 1162 1170	contrast
+T80	Biological_structure 1156 1161	Brain
+R47	MODIFY Arg1:T79 Arg2:E36	
+R48	MODIFY Arg1:T80 Arg2:E36	
+T82	Biological_structure 1191 1202	optic nerve
+T81	Lab_value 1188 1190	no
+R49	MODIFY Arg1:T81 Arg2:E36	
+R50	MODIFY Arg1:T82 Arg2:T81	
+T83	Date 1216 1233	Twelve days later
+E37	Date:T83 
+T84	Sign_symptom 1244 1248	pain
+E38	Sign_symptom:T84 
+A5	TREND E38 INC
+T85	Biological_structure 1235 1243	left eye
+R51	MODIFY Arg1:T85 Arg2:E38	
+T86	Diagnostic_procedure 1253 1259	vision
+E39	Diagnostic_procedure:T86 
+T87	Lab_value 1260 1268	worsened
+R52	MODIFY Arg1:T87 Arg2:E39	
+R53	MODIFY Arg1:T87 Arg2:E38	
+T88	Sign_symptom 1304 1316	claudication
+E40	Sign_symptom:T88 
+T89	Biological_structure 1300 1303	jaw
+R54	MODIFY Arg1:T89 Arg2:E40	
+T90	Sign_symptom 1327 1331	pain
+E41	Sign_symptom:T90 
+T91	Biological_structure 1321 1326	scalp
+R55	MODIFY Arg1:T91 Arg2:E41	
+T92	Diagnostic_procedure 1333 1335	VA
+E42	Diagnostic_procedure:T92 
+T93	Lab_value 1348 1367	no light perception
+T94	Biological_structure 1375 1383	left eye
+R56	MODIFY Arg1:T94 Arg2:T93	
+R57	MODIFY Arg1:T93 Arg2:E42	
+T95	Diagnostic_procedure 1392 1407	cells and flare
+E43	Diagnostic_procedure:T95 
+T96	Lab_value 1389 1391	1+
+R58	MODIFY Arg1:T96 Arg2:E43	
+T97	Biological_structure 1411 1427	anterior chamber
+R59	MODIFY Arg1:T97 Arg2:E43	
+T98	Diagnostic_procedure 1435 1458	vitreous cells and haze
+E44	Diagnostic_procedure:T98 
+T99	Lab_value 1432 1434	2+
+R60	MODIFY Arg1:T99 Arg2:E44	
+T100	Diagnostic_procedure 1460 1483	Funduscopic examination
+E45	Diagnostic_procedure:T100 
+T101	Sign_symptom 1511 1519	necrosis
+E46	Sign_symptom:T101 
+T102	Sign_symptom 1532 1543	hemorrhages
+E47	Sign_symptom:T102 
+T103	Biological_structure 1503 1510	retinal
+T104	Severity 1493 1502	extensive
+R61	MODIFY Arg1:T104 Arg2:E46	
+R62	MODIFY Arg1:T103 Arg2:E46	
+T105	Detailed_description 1524 1531	diffuse
+R63	MODIFY Arg1:T105 Arg2:E47	
+T107	Sign_symptom 1573 1587	venous beading
+E49	Sign_symptom:T107 
+T106	Detailed_description 1567 1572	focal
+T108	Detailed_description 1549 1563	multiple areas
+R64	MODIFY Arg1:T106 Arg2:E49	
+R65	MODIFY Arg1:T108 Arg2:E49	
+T109	Disease_disorder 1613 1635	acute retinal necrosis
+E48	Disease_disorder:T109 
+T110	Diagnostic_procedure 1668 1671	PCR
+E50	Diagnostic_procedure:T110 
+T111	Biological_structure 1637 1651	Vitreous fluid
+R66	MODIFY Arg1:T111 Arg2:E50	
+T112	Diagnostic_procedure 1688 1691	HSV
+E51	Diagnostic_procedure:T112 
+T113	Diagnostic_procedure 1693 1696	VZV
+E52	Diagnostic_procedure:T113 
+T114	Diagnostic_procedure 1698 1701	CMV
+E53	Diagnostic_procedure:T114 
+T115	Diagnostic_procedure 1706 1716	toxoplasma
+E54	Diagnostic_procedure:T115 
+T116	Diagnostic_procedure 1753 1756	VZV
+E55	Diagnostic_procedure:T116 
+T117	Detailed_description 1757 1760	DNA
+R67	MODIFY Arg1:T117 Arg2:E55	
+T118	Lab_value 1740 1748	positive
+R68	MODIFY Arg1:T118 Arg2:E55	
+R69	SUB_PROCEDURE Arg1:E51 Arg2:E50	
+R70	SUB_PROCEDURE Arg1:E52 Arg2:E50	
+R71	SUB_PROCEDURE Arg1:E53 Arg2:E50	
+R72	SUB_PROCEDURE Arg1:E54 Arg2:E50	
+R73	SUB_PROCEDURE Arg1:E55 Arg2:E50	
+T119	Medication 1820 1831	ganciclovir
+E56	Medication:T119 
+T120	Administration 1794 1816	intravitreal injection
+T121	Frequency 1785 1793	one-time
+R74	MODIFY Arg1:T121 Arg2:E56	
+R75	MODIFY Arg1:T120 Arg2:E56	
+T122	Dosage 1832 1847	2000 mcg/0.5 ml
+R76	MODIFY Arg1:T122 Arg2:E56	
+T123	Biological_structure 1855 1863	left eye
+R77	MODIFY Arg1:T123 Arg2:E56	
+T124	Medication 1870 1879	acyclovir
+E57	Medication:T124 
+T125	Administration 1865 1869	oral
+R78	MODIFY Arg1:T125 Arg2:E57	
+T126	Dosage 1880 1900	800 mg 5 times daily
+R79	MODIFY Arg1:T126 Arg2:E57	
+T127	Medication 1922 1932	prednisone
+E58	Medication:T127 
+T128	Duration 1905 1912	14 days
+E59	Duration:T128 
+T129	Administration 1917 1921	oral
+R80	MODIFY Arg1:T129 Arg2:E58	
+T130	Dosage 1933 1944	60 mg daily
+T131	Duration 1949 1955	7 days
+E60	Duration:T131 
+R81	MODIFY Arg1:T130 Arg2:E58	
+T132	Dosage 1968 1973	20 mg
+R82	MODIFY Arg1:T132 Arg2:E58	
+T133	Duration 1978 1984	7 days
+E61	Duration:T133 
+T134	Date 1986 2003	Eleven days after
+E62	Date:T134 
+T135	Diagnostic_procedure 2123 2129	biopsy
+E63	Diagnostic_procedure:T135 
+T136	Therapeutic_procedure 2123 2129	biopsy
+E64	Therapeutic_procedure:T136 
+#3	AnnotatorNotes E64	in this case, a treatment
+T137	Sign_symptom 2063 2075	claudication
+E65	Sign_symptom:T137 
+T138	Biological_structure 2059 2062	jaw
+R83	MODIFY Arg1:T138 Arg2:E65	
+T139	Sign_symptom 2099 2103	pain
+E66	Sign_symptom:T139 
+T140	Frequency 2080 2092	intermittent
+T141	Biological_structure 2093 2098	scalp
+R84	MODIFY Arg1:T141 Arg2:E66	
+R85	MODIFY Arg1:T140 Arg2:E66	
+T142	Biological_structure 2107 2122	temporal artery
+R86	MODIFY Arg1:T142 Arg2:E64	
+R87	MODIFY Arg1:T142 Arg2:E63	
+T143	Diagnostic_procedure 2145 2169	Histological examination
+E67	Diagnostic_procedure:T143 
+T144	Lab_value 2174 2180	normal
+R88	MODIFY Arg1:T144 Arg2:E67	
+T145	Diagnostic_procedure 2195 2223	immunohistochemical analysis
+E68	Diagnostic_procedure:T145 
+T146	Diagnostic_procedure 2237 2248	VZV antigen
+E69	Diagnostic_procedure:T146 
+T147	Lab_value 2224 2236	demonstrated
+R89	MODIFY Arg1:T147 Arg2:E69	
+R90	SUB_PROCEDURE Arg1:E69 Arg2:E68	
+T148	Biological_structure 2256 2275	arterial adventitia
+R91	MODIFY Arg1:T148 Arg2:E69	
+T149	Diagnostic_procedure 2313 2326	HSV-1 antigen
+E70	Diagnostic_procedure:T149 
+R92	SUB_PROCEDURE Arg1:E70 Arg2:E68	
+T150	Diagnostic_procedure 2331 2354	infiltrating leukocytes
+E71	Diagnostic_procedure:T150 
+R93	SUB_PROCEDURE Arg1:E71 Arg2:E68	
+T151	Lab_value 2377 2385	negative
+R94	MODIFY Arg1:T151 Arg2:E71	
+R95	MODIFY Arg1:T151 Arg2:E70	
+T152	Medication 2440 2449	acyclovir
+E72	Medication:T152 
+T153	Administration 2428 2439	intravenous
+R96	MODIFY Arg1:T153 Arg2:E72	
+T154	Dosage 2451 2469	10 mg/kg every 8 h
+R97	MODIFY Arg1:T154 Arg2:E72	
+T155	Duration 2474 2481	14 days
+E73	Duration:T155 
+T156	Medication 2487 2495	steroids
+E74	Medication:T156 
+A6	POLARITY E74 NEG
+*	OVERLAP E1 E2 E3 E4 E5 E6 E7 E8 E9 E10 E11 E12 E13
+R98	BEFORE Arg1:E13 Arg2:E14	
+*	OVERLAP E14 E15 E16 E17 E18 E19 E20 E21 E22 E23 E24 E25 E26 E27 E28 E29 E30 E31 E32 E33 E34 E35 E36
+R99	BEFORE Arg1:E36 Arg2:E37	
+*	OVERLAP E37 E38 E39 E40 E41 E42 E43 E44 E45 E46 E47 E49 E48 E50
+R100	BEFORE Arg1:E50 Arg2:E56	
+*	OVERLAP E57 E59 E58 E60 E61
+R101	BEFORE Arg1:E61 Arg2:E62	
+*	OVERLAP E62 E65 E66 E63 E64
+R102	BEFORE Arg1:E64 Arg2:E67	
+*	OVERLAP E67 E68
+R103	BEFORE Arg1:E68 Arg2:E72	
+*	OVERLAP E72 E73 E74