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T1 Age 2 13 57-year-old T2 Personal_background 14 20 Jewish T3 Sex 21 24 man T4 Disease_disorder 30 45 Crohn's disease E1 Disease_disorder:T4 T5 Disease_disorder 47 49 CD E2 Disease_disorder:T5 R1 IDENTICAL Arg1:E2 Arg2:E1 T6 Biological_structure 58 63 ileum R2 MODIFY Arg1:T6 Arg2:E1 T7 Date 81 96 age of thirteen E3 Date:T7 T8 History 30 45 Crohn's disease T9 Clinical_event 98 107 presented E4 Clinical_event:T9 T10 Disease_disorder 122 146 nonmelanoma skin cancers E5 Disease_disorder:T10 T11 Disease_disorder 148 153 NMSCs E6 Disease_disorder:T11 R3 IDENTICAL Arg1:E6 Arg2:E5 T12 Detailed_description 113 121 multiple R4 MODIFY Arg1:T12 Arg2:E5 T13 Duration 176 198 over the past 16 years E7 Duration:T13 T14 Medication 259 269 thiopurine E8 Medication:T14 T15 Medication 270 286 6-mercaptopurine E9 Medication:T15 R5 SUB_PROCEDURE Arg1:E9 Arg2:E8 T16 Dosage 235 251 prolonged course R6 MODIFY Arg1:T16 Arg2:E8 T17 Medication 288 302 mercaptopurine E10 Medication:T17 R7 IDENTICAL Arg1:E10 Arg2:E9 T18 Disease_disorder 347 351 NMSC E11 Disease_disorder:T18 T19 Lab_value 344 346 84 R8 MODIFY Arg1:T19 Arg2:E11 T20 Nonbiological_location 364 374 our clinic T21 Nonbiological_location 384 397 other clinics T22 Lab_value 353 355 72 T23 Coreference 356 360 NMSC E12 Coreference:T23 T24 Lab_value 376 378 12 R9 IDENTICAL Arg1:E12 Arg2:E11 R10 MODIFY Arg1:T20 Arg2:T22 R11 MODIFY Arg1:T22 Arg2:E12 R12 MODIFY Arg1:T21 Arg2:T24 R13 MODIFY Arg1:T24 Arg2:E12 T25 Diagnostic_procedure 420 426 biopsy E13 Diagnostic_procedure:T25 A1 POLARITY E13 UNCERTAIN T26 Therapeutic_procedure 431 438 removal E14 Therapeutic_procedure:T26 A2 POLARITY E14 UNCERTAIN T27 Disease_disorder 467 469 CD E15 Disease_disorder:T27 T28 Medication 497 510 sulfasalazine E16 Medication:T28 T29 Medication 528 536 steroids E17 Medication:T29 T30 Frequency 515 527 intermittent R14 MODIFY Arg1:T30 Arg2:E17 T31 Duration 563 576 past 20 years E18 Duration:T31 T32 Medication 596 600 6-MP E19 Medication:T32 T33 Medication 304 308 6-MP E20 Medication:T33 R15 IDENTICAL Arg1:E20 Arg2:E9 T34 Frequency 601 606 daily R16 MODIFY Arg1:T34 Arg2:E19 T35 Duration 615 630 first ten years E21 Duration:T35 T36 Medication 647 651 6-MP E22 Medication:T36 T37 Lab_value 665 667 30 T38 Disease_disorder 668 672 NMSC E23 Disease_disorder:T38 R17 MODIFY Arg1:T37 Arg2:E23 T39 Disease_disorder 682 705 squamous cell carcinoma E24 Disease_disorder:T39 T40 Lab_value 674 676 14 R18 MODIFY Arg1:T40 Arg2:E24 T41 Disease_disorder 707 710 SCC E25 Disease_disorder:T41 R19 IDENTICAL Arg1:E25 Arg2:E24 T42 Lab_value 716 718 16 T43 Disease_disorder 724 744 basal cell carcinoma E26 Disease_disorder:T43 T44 Disease_disorder 746 749 BCC E27 Disease_disorder:T44 R20 IDENTICAL Arg1:E27 Arg2:E26 T45 Therapeutic_procedure 773 780 treated E28 Therapeutic_procedure:T45 T46 Nonbiological_location 781 790 elsewhere R21 MODIFY Arg1:T46 Arg2:E28 T47 Duration 799 819 subsequent ten years E29 Duration:T47 T48 Date 826 835 past year E30 Date:T48 T49 Clinical_event 849 857 returned E31 Clinical_event:T49 T50 Nonbiological_location 865 871 clinic R22 MODIFY Arg1:T50 Arg2:E31 T51 Lab_value 882 885 100 T52 Sign_symptom 890 897 lesions E32 Sign_symptom:T52 R23 MODIFY Arg1:T51 Arg2:E32 T53 Lab_value 886 889 new R24 MODIFY Arg1:T53 Arg2:E32 T54 Disease_disorder 912 922 malignancy E33 Disease_disorder:T54 T55 Biological_structure 930 935 torso T56 Biological_structure 940 951 extremities R25 MODIFY Arg1:T55 Arg2:E33 R26 MODIFY Arg1:T56 Arg2:E33 T57 Lab_value 985 987 42 T58 Sign_symptom 1002 1009 lesions E34 Sign_symptom:T58 T59 Disease_disorder 1013 1017 NMCS E35 Disease_disorder:T59 T60 Diagnostic_procedure 988 994 biopsy E36 Diagnostic_procedure:T60 R27 MODIFY Arg1:T57 Arg2:E34 T61 Lab_value 1019 1021 20 T62 Disease_disorder 1027 1030 SCC E37 Disease_disorder:T62 R28 MODIFY Arg1:T61 Arg2:E37 T63 Lab_value 1035 1037 22 T64 Disease_disorder 1043 1046 BCC E38 Disease_disorder:T64 R29 MODIFY Arg1:T63 Arg2:E38 T65 Lab_value 1061 1066 three T66 Disease_disorder 1074 1078 SCCs E39 Disease_disorder:T66 R30 MODIFY Arg1:T65 Arg2:E39 T67 Lab_value 1084 1109 moderately differentiated R31 MODIFY Arg1:T67 Arg2:T65 T68 Lab_value 1114 1117 two T69 Lab_value 1123 1144 poorly differentiated R32 MODIFY Arg1:T69 Arg2:T68 R33 MODIFY Arg1:T68 Arg2:E39 T70 Therapeutic_procedure 1199 1211 Mohs surgery E40 Therapeutic_procedure:T70 T71 Therapeutic_procedure 1216 1228 xenografting E41 Therapeutic_procedure:T71 T72 Disease_disorder 1168 1180 skin cancers E42 Disease_disorder:T72 R34 MODIFY Arg1:E42 Arg2:E40 R35 MODIFY Arg1:E42 Arg2:E41 T73 Sign_symptom 1249 1256 lesions E43 Sign_symptom:T73 T74 Biological_structure 1261 1270 pretibial R36 MODIFY Arg1:T74 Arg2:E43 T75 Area 1284 1292 64x53 mm R37 MODIFY Arg1:T75 Arg2:E43 T76 Lab_value 1234 1241 largest R38 MODIFY Arg1:T76 Arg2:E43 T77 Diagnostic_procedure 1321 1327 biopsy E44 Diagnostic_procedure:T77 A3 POLARITY E44 NEG T78 Sign_symptom 1355 1361 esions E45 Sign_symptom:T78 R39 MODIFY Arg1:E45 Arg2:E44 T79 Diagnostic_procedure 1394 1403 skin type E46 Diagnostic_procedure:T79 T80 Lab_value 1379 1393 Fitzpatrick II R40 MODIFY Arg1:T80 Arg2:E46 T81 Activity 1430 1442 sun exposure E47 Activity:T81 T82 Detailed_description 1420 1429 excessive R41 MODIFY Arg1:T82 Arg2:E47 T83 Duration 1447 1455 25 years E48 Duration:T83 T84 Nonbiological_location 1459 1466 Hawai‘i R42 MODIFY Arg1:T84 Arg2:E47 R43 BEFORE Arg1:E48 Arg2:E47 T85 Medication 1492 1501 sunscreen E49 Medication:T85 A4 POLARITY E49 NEG T86 Date 1468 1476 Early on E50 Date:T86 T87 Activity 1513 1517 sail E51 Activity:T87 T88 Detailed_description 1530 1551 during peak sun hours T89 Detailed_description 1520 1529 catamaran R44 MODIFY Arg1:T89 Arg2:E51 R45 MODIFY Arg1:T88 Arg2:E51 T90 Subject 1579 1585 mother T91 Detailed_description 1590 1620 one skin cancer lesion removed R46 MODIFY Arg1:T91 Arg2:T90 T92 Family_history 1579 1620 mother had one skin cancer lesion removed T93 Activity 1651 1657 smoker E52 Activity:T93 A5 POLARITY E52 NEG T94 History 1625 1657 denied ever having been a smoker T95 History 1420 1455 excessive sun exposure for 25 years T96 History 1480 1501 did not use sunscreen T97 History 1513 1551 sail a catamaran during peak sun hours T98 Date 1670 1679 past year E53 Date:T98 T99 Medication 1696 1700 6-MP E54 Medication:T99 A6 POLARITY E54 NEG T100 Medication 1717 1727 mesalamine E55 Medication:T100 T101 Medication 1729 1736 Pentasa E56 Medication:T101 R47 IDENTICAL Arg1:E56 Arg2:E55 T102 Medication 1748 1758 adalimumab E57 Medication:T102 T103 Medication 1760 1766 Humira E58 Medication:T103 R48 IDENTICAL Arg1:E58 Arg2:E57 T104 Diagnostic_procedure 1843 1853 skin exams E59 Diagnostic_procedure:T104 T105 Frequency 1835 1842 monthly R49 MODIFY Arg1:T105 Arg2:E59 T106 Clinical_event 1871 1883 hospitalized E60 Clinical_event:T106 T107 Lab_value 1884 1892 16 times R50 MODIFY Arg1:T107 Arg2:E60 T108 Disease_disorder 1901 1903 CD E61 Disease_disorder:T108 T109 Therapeutic_procedure 1939 1948 resection E62 Therapeutic_procedure:T109 A7 POLARITY E62 NEG T110 Biological_structure 1928 1938 intestinal R51 MODIFY Arg1:T110 Arg2:E62 T111 Clinical_event 1984 1999 hospitalization E63 Clinical_event:T111 T112 Disease_disorder 2033 2047 adenocarcinoma E64 Disease_disorder:T112 T113 Detailed_description 2022 2032 metastatic R52 MODIFY Arg1:T113 Arg2:E64 T114 Biological_structure 2055 2066 small bowel R53 MODIFY Arg1:T114 Arg2:E64 T115 Outcome 2072 2083 passed away E65 Outcome:T115 T116 Date 2084 2097 shortly after E66 Date:T116 * OVERLAP E1 E3 R54 BEFORE Arg1:E3 Arg2:E4 R55 AFTER Arg1:E4 Arg2:E5 * OVERLAP E5 E7 E8 R56 BEFORE Arg1:E8 Arg2:E11 * OVERLAP E11 E13 E14 E67 T117 Sign_symptom 454 461 lesions E67 Sign_symptom:T117 R57 AFTER Arg1:E67 Arg2:E15 * OVERLAP E15 E16 E17 R58 BEFORE Arg1:E17 Arg2:E18 * OVERLAP E18 E19 R59 AFTER Arg1:E19 Arg2:E21 * OVERLAP E21 E22 E23 E24 E26 R60 MODIFY Arg1:T42 Arg2:E26 R61 BEFORE Arg1:E26 Arg2:E28 * OVERLAP E28 E29 R62 BEFORE Arg1:E29 Arg2:E30 * OVERLAP E30 E31 E32 E33 R63 AFTER Arg1:E33 Arg2:E36 * OVERLAP E36 E34 E35 E37 E38 E39 E42 E40 E41 E43 E44 E45 E46 R64 AFTER Arg1:E46 Arg2:E47 * OVERLAP E47 E50 E49 E51 E52 R65 BEFORE Arg1:E52 Arg2:E53 * OVERLAP E53 E54 E55 R66 BEFORE Arg1:E55 Arg2:E57 * OVERLAP E57 E59 E60 E61 E62 R67 BEFORE Arg1:E62 Arg2:E63 * OVERLAP E63 E64 R68 BEFORE Arg1:E64 Arg2:E65 * OVERLAP E65 E66