253 lines (252 with data), 8.9 kB

T1	Age 2 13	26-year-old
T2	Sex 14 17	man
T3	Personal_background 21 39	Portuguese descent
T4	History 45 80	no significant past medical history
T5	Sign_symptom 125 136	hemiparesis
E1	Sign_symptom:T5 
T6	Disease_disorder 141 148	aphasia
E2	Disease_disorder:T6 
T7	Disease_disorder 173 180	aphasia
E3	Disease_disorder:T7 
T8	Sign_symptom 216 234	paraphrasic errors
E4	Sign_symptom:T8 
T9	Frequency 211 215	rare
R1	MODIFY Arg1:T9 Arg2:E4	
T10	Detailed_description 113 124	right-sided
R2	MODIFY Arg1:T10 Arg2:E1	
T11	Severity 155 161	marked
T12	Detailed_description 162 172	expressive
R3	MODIFY Arg1:T11 Arg2:E3	
R4	MODIFY Arg1:T12 Arg2:E3	
T13	Sign_symptom 182 205	word-finding difficulty
E5	Sign_symptom:T13 
T14	Diagnostic_procedure 236 247	Examination
E6	Diagnostic_procedure:T14 
T15	Sign_symptom 282 290	weakness
E7	Sign_symptom:T15 
T16	Biological_structure 261 281	right central facial
R5	MODIFY Arg1:T16 Arg2:E7	
T17	Diagnostic_procedure 298 306	strength
E8	Diagnostic_procedure:T17 
T18	Lab_value 292 297	2–3/5
R6	MODIFY Arg1:T18 Arg2:E8	
T19	Biological_structure 320 323	arm
T20	Biological_structure 328 331	leg
T21	Detailed_description 314 319	right
R7	MODIFY Arg1:T21 Arg2:T19	
R8	MODIFY Arg1:T21 Arg2:T20	
R9	MODIFY Arg1:T19 Arg2:E8	
R10	MODIFY Arg1:T20 Arg2:E8	
T22	Sign_symptom 337 346	dysmetria
E9	Sign_symptom:T22 
T23	Biological_structure 376 387	extremities
T24	Detailed_description 354 359	right
T25	Detailed_description 360 365	upper
T26	Detailed_description 370 375	lower
R11	MODIFY Arg1:T26 Arg2:T23	
R12	MODIFY Arg1:T25 Arg2:T23	
R13	MODIFY Arg1:T24 Arg2:T23	
R14	MODIFY Arg1:T23 Arg2:E9	
T27	Diagnostic_procedure 389 397	Reflexes
E10	Diagnostic_procedure:T27 
T28	Lab_value 403 414	hyperactive
T29	Detailed_description 422 427	right
R15	MODIFY Arg1:T29 Arg2:T28	
T30	Diagnostic_procedure 447 464	Babinski response
E11	Diagnostic_procedure:T30 
T31	Lab_value 435 446	right-sided
R16	MODIFY Arg1:T31 Arg2:E11	
R17	SUB_PROCEDURE Arg1:E11 Arg2:E10	
R18	MODIFY Arg1:T28 Arg2:E10	
T32	Diagnostic_procedure 466 469	MRI
E12	Diagnostic_procedure:T32 
T33	Biological_structure 477 482	brain
R19	MODIFY Arg1:T33 Arg2:E12	
T34	Sign_symptom 530 540	structures
E13	Sign_symptom:T34 
T35	Shape 520 529	ring-like
T36	Detailed_description 509 519	concentric
T37	Detailed_description 499 508	bilateral
T38	Detailed_description 490 498	multiple
R20	MODIFY Arg1:T35 Arg2:E13	
R21	MODIFY Arg1:T36 Arg2:E13	
R22	MODIFY Arg1:T37 Arg2:E13	
R23	MODIFY Arg1:T38 Arg2:E13	
T39	Biological_structure 548 565	centrum semiovale
T40	Biological_structure 574 588	corona radiata
R24	MODIFY Arg1:T39 Arg2:E13	
R25	MODIFY Arg1:T40 Arg2:E13	
T41	Diagnostic_procedure 592 602	T2 imaging
E14	Diagnostic_procedure:T41 
R26	SUB_PROCEDURE Arg1:E14 Arg2:E12	
T42	Disease_disorder 646 671	Balo concentric sclerosis
E15	Disease_disorder:T42 
T43	Sign_symptom 720 727	lesions
E16	Sign_symptom:T43 
T44	Sign_symptom 765 771	lesion
E17	Sign_symptom:T44 
T45	Detailed_description 683 714	associated restricted diffusion
T46	Lab_value 718 719	3
R27	MODIFY Arg1:T46 Arg2:E16	
R28	MODIFY Arg1:T45 Arg2:E16	
T47	Detailed_description 732 759	incomplete ring enhancement
T48	Lab_value 763 764	1
R29	MODIFY Arg1:T48 Arg2:E17	
R30	MODIFY Arg1:T47 Arg2:E17	
T49	Diagnostic_procedure 773 785	CSF analysis
E18	Diagnostic_procedure:T49 
T50	Diagnostic_procedure 796 806	leukocytes
E19	Diagnostic_procedure:T50 
T51	Diagnostic_procedure 812 823	lymphocytes
E20	Diagnostic_procedure:T51 
T52	Diagnostic_procedure 828 837	monocytes
E21	Diagnostic_procedure:T52 
T53	Diagnostic_procedure 840 851	erythrocyte
E22	Diagnostic_procedure:T53 
T54	Diagnostic_procedure 871 888	oligoclonal bands
E23	Diagnostic_procedure:T54 
R31	SUB_PROCEDURE Arg1:E19 Arg2:E18	
T55	Lab_value 793 795	30
R32	MODIFY Arg1:T55 Arg2:E19	
R33	SUB_PROCEDURE Arg1:E20 Arg2:E19	
R34	SUB_PROCEDURE Arg1:E21 Arg2:E19	
T56	Lab_value 808 811	79%
R35	MODIFY Arg1:T56 Arg2:E20	
T57	Lab_value 825 827	4%
R36	MODIFY Arg1:T57 Arg2:E21	
R37	SUB_PROCEDURE Arg1:E22 Arg2:E18	
T58	Lab_value 862 865	850
R38	MODIFY Arg1:T58 Arg2:E22	
T59	Lab_value 894 900	absent
R39	MODIFY Arg1:T59 Arg2:E23	
R40	SUB_PROCEDURE Arg1:E23 Arg2:E18	
T60	Medication 932 950	methylprednisolone
E24	Medication:T60 
T61	Dosage 922 925	1 g
T62	Dosage 951 956	daily
T63	Administration 929 931	IV
R41	MODIFY Arg1:T63 Arg2:E24	
R42	MODIFY Arg1:T61 Arg2:E24	
R43	MODIFY Arg1:T62 Arg2:E24	
T64	Duration 961 967	5 days
E25	Duration:T64 
T67	Therapeutic_procedure 1014 1038	plasmapheresis exchanges
E27	Therapeutic_procedure:T67 
T68	Lab_value 1012 1013	5
R45	MODIFY Arg1:T68 Arg2:E27	
T65	Diagnostic_procedure 1072 1077	motor
E26	Diagnostic_procedure:T65 
T66	Diagnostic_procedure 1079 1086	sensory
E28	Diagnostic_procedure:T66 
T69	Diagnostic_procedure 1109 1113	gait
E29	Diagnostic_procedure:T69 
T70	Lab_value 1045 1068	significant improvement
R44	MODIFY Arg1:T70 Arg2:E26	
R46	MODIFY Arg1:T70 Arg2:E28	
R47	MODIFY Arg1:T70 Arg2:E29	
T71	Disease_disorder 1088 1103	speech deficits
E30	Disease_disorder:T71 
A1	TREND E30 DEC
T72	Date 1115 1136	Forty-five days after
E31	Date:T72 
T73	Clinical_event 1137 1146	discharge
E32	Clinical_event:T73 
T74	Diagnostic_procedure 1152 1163	examination
E33	Diagnostic_procedure:T74 
T75	Diagnostic_procedure 1176 1184	strength
E34	Diagnostic_procedure:T75 
T76	Lab_value 1171 1175	4+/5
R48	MODIFY Arg1:T76 Arg2:E34	
T77	Biological_structure 1192 1227	right intrinsic muscles of the hand
R49	MODIFY Arg1:T77 Arg2:E34	
T78	Sign_symptom 1246 1263	positional tremor
E35	Sign_symptom:T78 
T79	Detailed_description 1234 1245	right-sided
R50	MODIFY Arg1:T79 Arg2:E35	
T80	Diagnostic_procedure 1265 1269	Gait
E36	Diagnostic_procedure:T80 
T81	Diagnostic_procedure 1281 1285	gait
E37	Diagnostic_procedure:T81 
T82	Detailed_description 1274 1280	tandem
R51	MODIFY Arg1:T82 Arg2:E37	
T83	Lab_value 1291 1297	normal
R52	MODIFY Arg1:T83 Arg2:E37	
R53	MODIFY Arg1:T83 Arg2:E36	
T84	Medication 1316 1331	β-interferon-1a
E38	Medication:T84 
T85	Dosage 1332 1337	44 μg
T86	Dosage 1353 1367	3 times a week
T87	Administration 1338 1352	subcutaneously
R54	MODIFY Arg1:T85 Arg2:E38	
R55	MODIFY Arg1:T86 Arg2:E38	
R56	MODIFY Arg1:T87 Arg2:E38	
T88	Disease_disorder 1395 1423	clinically isolated syndrome
E39	Disease_disorder:T88 
T89	Diagnostic_procedure 1435 1443	response
E40	Diagnostic_procedure:T89 
T90	Lab_value 1430 1434	good
R57	MODIFY Arg1:T90 Arg2:E40	
T91	Date 1445 1459	One year later
E41	Date:T91 
T92	Diagnostic_procedure 1465 1487	neurologic examination
E42	Diagnostic_procedure:T92 
T93	Lab_value 1492 1510	essentially normal
R58	MODIFY Arg1:T93 Arg2:E42	
T94	Family_history 1522 1580	no family history of demyelinating or autoimmune disorders
T95	Subject 1586 1592	mother
T96	Family_history 1622 1631	headaches
T97	Family_history 1636 1655	early-onset strokes
R59	MODIFY Arg1:T95 Arg2:T96	
R60	MODIFY Arg1:T95 Arg2:T97	
T98	Family_history 1679 1709	carrier of the Notch3 mutation
T99	Family_history 1726 1816	cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
T100	Family_history 1818 1825	CADASIL
R61	IDENTICAL Arg1:T100 Arg2:T99	
R62	MODIFY Arg1:T95 Arg2:T98	
R63	MODIFY Arg1:T95 Arg2:T99	
T101	Subject 1832 1838	sister
T102	Family_history 1845 1862	stroke in her 30s
T103	Family_history 1881 1899	migraine headaches
T104	Family_history 1909 1941	not undergone medical evaluation
R64	MODIFY Arg1:T101 Arg2:T102	
R65	MODIFY Arg1:T101 Arg2:T103	
R66	MODIFY Arg1:T101 Arg2:T104	
T105	Diagnostic_procedure 1943 1962	Testing for CADASIL
E43	Diagnostic_procedure:T105 
T106	Diagnostic_procedure 1989 2004	Notch3 mutation
E44	Diagnostic_procedure:T106 
T107	Lab_value 1978 1984	showed
R67	MODIFY Arg1:T107 Arg2:E44	
R68	SUB_PROCEDURE Arg1:E44 Arg2:E43	
T108	Detailed_description 2005 2028	associated with CADASIL
T109	Detailed_description 2030 2081	transition C>T, nucleotide position 1750, codon 558
R69	MODIFY Arg1:T108 Arg2:E44	
R70	MODIFY Arg1:T109 Arg2:E44	
T110	Diagnostic_procedure 2089 2095	biopsy
E45	Diagnostic_procedure:T110 
T111	Biological_structure 2084 2088	Skin
R71	MODIFY Arg1:T111 Arg2:E45	
T112	Sign_symptom 2132 2140	material
E46	Sign_symptom:T112 
T113	Detailed_description 2118 2131	extracellular
T114	Detailed_description 2103 2117	electron-dense
R72	MODIFY Arg1:T113 Arg2:E46	
R73	MODIFY Arg1:T114 Arg2:E46	
T115	Biological_structure 2168 2203	smooth muscle of the vascular media
R74	MODIFY Arg1:T115 Arg2:E46	
T116	Clinical_event 81 89	presents
E47	Clinical_event:T116 
*	OVERLAP E47 E1 E2 E3 E5 E4 E6 E7 E8 E9 E10 E12 E13 E15 E16 E17 E18
R75	BEFORE Arg1:E18 Arg2:E24	
*	OVERLAP E24 E25
R76	BEFORE Arg1:E25 Arg2:E27	
*	OVERLAP E27 E26 E28 E30 E29
R77	BEFORE Arg1:E29 Arg2:E31	
R78	AFTER Arg1:E31 Arg2:E32	
R79	BEFORE Arg1:E32 Arg2:E33	
*	OVERLAP E33 E34 E35 E36 E37
R80	BEFORE Arg1:E37 Arg2:E38	
*	OVERLAP E38 E39
R81	BEFORE Arg1:E39 Arg2:E40	
R82	BEFORE Arg1:E40 Arg2:E41	
*	OVERLAP E41 E42 E43 E45 E46