--- a
+++ b/processing/MACCROBAT/21923918.ann
@@ -0,0 +1,436 @@
+T1	Age 2 13	59-year-old
+T2	Sex 14 17	man
+T3	Clinical_event 22 30	referred
+E1	Clinical_event:T3 
+T4	Outcome 3680 3684	died
+E2	Outcome:T4 
+T5	Date 3685 3699	9 months later
+E3	Date:T5 
+T6	Nonbiological_location 72 80	hospital
+T7	Nonbiological_location 38 64	general surgery department
+R1	MODIFY Arg1:T7 Arg2:E1	
+R2	MODIFY Arg1:T6 Arg2:T7	
+T8	Duration 87 104	one-month history
+E4	Duration:T8 
+T9	Sign_symptom 120 129	dysphagia
+E5	Sign_symptom:T9 
+A1	TREND E5 INC
+T10	Detailed_description 108 119	progressive
+R3	MODIFY Arg1:T10 Arg2:E5	
+T11	Detailed_description 134 140	solids
+R4	MODIFY Arg1:T11 Arg2:E5	
+T12	Disease_disorder 172 184	malnutrition
+E6	Disease_disorder:T12 
+A2	POLARITY E6 NEG
+T13	Sign_symptom 200 211	weight loss
+E7	Sign_symptom:T13 
+A3	POLARITY E7 NEG
+T14	Diagnostic_procedure 248 274	esophagogastroduodenoscopy
+E8	Diagnostic_procedure:T14 
+T15	Nonbiological_location 278 294	another hospital
+R5	MODIFY Arg1:T15 Arg2:E8	
+T16	Sign_symptom 334 340	lesion
+E9	Sign_symptom:T16 
+T17	Biological_structure 368 377	esophagus
+R6	MODIFY Arg1:T17 Arg2:E9	
+T18	Diagnostic_procedure 386 392	biopsy
+E10	Diagnostic_procedure:T18 
+A4	POLARITY E10 NEG
+T19	Disease_disorder 447 451	COPD
+E11	Disease_disorder:T19 
+T20	Disease_disorder 476 497	myocardial infarction
+E12	Disease_disorder:T20 
+T21	History 447 451	COPD
+T22	History 476 497	myocardial infarction
+T23	Activity 523 529	smoked
+E13	Activity:T23 
+T24	Diagnostic_procedure 585 605	Physical examination
+E14	Diagnostic_procedure:T24 
+T25	Lab_value 610 622	unremarkable
+E15	Lab_value:T25 
+R7	MODIFY Arg1:E15 Arg2:E14	
+T26	Diagnostic_procedure 624 643	Computed tomography
+E16	Diagnostic_procedure:T26 
+T27	Diagnostic_procedure 645 647	CT
+E17	Diagnostic_procedure:T27 
+T28	Biological_structure 656 661	chest
+T29	Biological_structure 666 673	abdomen
+T30	Sign_symptom 683 691	stenosis
+E18	Sign_symptom:T30 
+R8	MODIFY Arg1:T28 Arg2:E16	
+R9	MODIFY Arg1:T29 Arg2:E16	
+R10	IDENTICAL Arg1:E17 Arg2:E16	
+T31	Distance 704 708	5-cm
+T32	Detailed_description 709 736	segment of the middle third
+T33	Biological_structure 744 753	esophagus
+R11	MODIFY Arg1:T33 Arg2:E18	
+R12	MODIFY Arg1:T31 Arg2:T32	
+R13	MODIFY Arg1:T32 Arg2:T33	
+T34	Sign_symptom 768 775	lesions
+E19	Sign_symptom:T34 
+A5	POLARITY E19 NEG
+T35	Biological_structure 783 811	thoracic or abdominal organs
+R14	MODIFY Arg1:T35 Arg2:E19	
+T36	Diagnostic_procedure 813 827	Barium studies
+E20	Diagnostic_procedure:T36 
+T37	Sign_symptom 840 848	swelling
+E21	Sign_symptom:T37 
+T38	Biological_structure 856 871	esophageal wall
+R15	MODIFY Arg1:T38 Arg2:E21	
+T39	Therapeutic_procedure 3559 3570	splenectomy
+E22	Therapeutic_procedure:T39 
+T40	Distance 872 876	7 cm
+T41	Biological_structure 877 893	above the cardia
+T42	Detailed_description 902 920	ulcerative pattern
+R16	MODIFY Arg1:T42 Arg2:E21	
+R17	MODIFY Arg1:T40 Arg2:T41	
+R18	MODIFY Arg1:T41 Arg2:T38	
+T43	Diagnostic_procedure 940 948	diameter
+E23	Diagnostic_procedure:T43 
+T44	Lab_value 928 935	reduced
+E24	Lab_value:T44 
+R19	MODIFY Arg1:E24 Arg2:E23	
+T45	Biological_structure 956 961	lumen
+R20	MODIFY Arg1:T45 Arg2:E23	
+T46	Lab_value 965 969	5 mm
+E25	Lab_value:T46 
+R21	MODIFY Arg1:E25 Arg2:E23	
+T47	Date 465 469	1999
+E26	Date:T47 
+T48	Date 501 505	2002
+E27	Date:T48 
+T49	Detailed_description 313 321	bleeding
+T50	Detailed_description 323 333	ulcerative
+R22	MODIFY Arg1:T50 Arg2:E9	
+R23	MODIFY Arg1:T49 Arg2:E9	
+T51	Detailed_description 348 360	middle third
+R24	MODIFY Arg1:T51 Arg2:T17	
+T52	Diagnostic_procedure 985 991	biopsy
+E28	Diagnostic_procedure:T52 
+T53	Detailed_description 974 984	endoscopic
+R25	MODIFY Arg1:T53 Arg2:E28	
+T54	Sign_symptom 1011 1015	mass
+E29	Sign_symptom:T54 
+T55	Biological_structure 999 1010	oesophageal
+R26	MODIFY Arg1:T55 Arg2:E29	
+T56	Disease_disorder 1056 1079	squamous cell carcinoma
+E30	Disease_disorder:T56 
+T57	Lab_value 1052 1054	G3
+E31	Lab_value:T57 
+R27	MODIFY Arg1:E31 Arg2:E30	
+T58	Detailed_description 1029 1050	poorly differentiated
+R28	MODIFY Arg1:T58 Arg2:E30	
+T59	Therapeutic_procedure 1092 1105	esophagectomy
+E32	Therapeutic_procedure:T59 
+T60	Detailed_description 1081 1091	Mid-distal
+R29	MODIFY Arg1:T60 Arg2:E32	
+T61	Therapeutic_procedure 1125 1153	oesophagogastric anastomosis
+E33	Therapeutic_procedure:T61 
+R30	SUB_PROCEDURE Arg1:E33 Arg2:E32	
+T62	Therapeutic_procedure 1171 1185	reconstruction
+E34	Therapeutic_procedure:T62 
+T63	Biological_structure 1158 1170	gastric tube
+R31	MODIFY Arg1:T63 Arg2:E34	
+R32	SUB_PROCEDURE Arg1:E34 Arg2:E32	
+T64	Diagnostic_procedure 1187 1211	Pathological examination
+E35	Diagnostic_procedure:T64 
+T65	Lab_value 1294 1296	G3
+E36	Lab_value:T65 
+T66	Disease_disorder 1298 1301	SCC
+E37	Disease_disorder:T66 
+#1	AnnotatorNotes E37	squamous cell carcinoma
+T67	Detailed_description 1271 1292	poorly differentiated
+R33	MODIFY Arg1:E36 Arg2:E37	
+R34	MODIFY Arg1:T67 Arg2:E37	
+T68	Diagnostic_procedure 1251 1257	biopsy
+E38	Diagnostic_procedure:T68 
+T69	Coreference 1219 1236	surgical specimen
+E39	Coreference:T69 
+R35	IDENTICAL Arg1:E39 Arg2:E29	
+T70	Coreference 1307 1312	tumor
+E40	Coreference:T70 
+R36	IDENTICAL Arg1:E40 Arg2:E39	
+T71	Distance 1329 1343	3 cm of length
+R37	MODIFY Arg1:T71 Arg2:E40	
+T72	Sign_symptom 1349 1360	infiltrated
+E41	Sign_symptom:T72 
+T73	Biological_structure 1365 1381	oesophageal wall
+R38	MODIFY Arg1:T73 Arg2:E41	
+T74	Biological_structure 1402 1420	paraesophageal fat
+R39	MODIFY Arg1:T74 Arg2:E41	
+T75	Diagnostic_procedure 1422 1438	Surgical margins
+E42	Diagnostic_procedure:T75 
+T76	Lab_value 1444 1454	tumor-free
+E43	Lab_value:T76 
+R40	MODIFY Arg1:E43 Arg2:E42	
+T77	Quantitative_concept 1463 1468	seven
+T78	Biological_structure 1469 1492	perigastric limph-nodes
+R41	MODIFY Arg1:T77 Arg2:T78	
+T79	Diagnostic_procedure 1493 1502	dissected
+E44	Diagnostic_procedure:T79 
+R42	MODIFY Arg1:T78 Arg2:E44	
+T80	Lab_value 1504 1510	pT3 N0
+E45	Lab_value:T80 
+R43	MODIFY Arg1:E45 Arg2:E44	
+R44	MODIFY Arg1:E43 Arg2:E44	
+T81	Diagnostic_procedure 1517 1537	postoperative period
+E46	Diagnostic_procedure:T81 
+T82	Lab_value 1548 1560	unremarkable
+E47	Lab_value:T82 
+R45	MODIFY Arg1:E47 Arg2:E46	
+T83	Diagnostic_procedure 1586 1591	x-ray
+E48	Diagnostic_procedure:T83 
+T84	Detailed_description 1568 1585	contrast enhanced
+R46	MODIFY Arg1:T84 Arg2:E48	
+T85	Date 1608 1615	9th POD
+E49	Date:T85 
+#2	AnnotatorNotes E49	9th post-operative day
+T86	Diagnostic_procedure 1630 1660	esophageal and gastric transit
+E50	Diagnostic_procedure:T86 
+T87	Lab_value 1623 1629	normal
+E51	Lab_value:T87 
+R47	MODIFY Arg1:E51 Arg2:E50	
+T88	Date 1669 1677	14th POD
+E52	Date:T88 
+T89	Clinical_event 1695 1705	discharged
+E53	Clinical_event:T89 
+T90	Clinical_event 1723 1731	referral
+E54	Clinical_event:T90 
+T91	Nonbiological_location 1714 1722	oncology
+R48	MODIFY Arg1:T91 Arg2:E54	
+T92	Clinical_event 1752 1761	follow-up
+E55	Clinical_event:T92 
+T93	Date 1763 1780	Nine months after
+E56	Date:T93 
+T94	Diagnostic_procedure 1796 1798	CT
+E57	Diagnostic_procedure:T94 
+T95	Diagnostic_procedure 1803 1829	esophagogastroduodenoscopy
+E58	Diagnostic_procedure:T95 
+T96	Diagnostic_procedure 1849 1862	imaging study
+E59	Diagnostic_procedure:T96 
+T97	Sign_symptom 1877 1889	splenomegaly
+E60	Sign_symptom:T97 
+T98	Severity 1872 1876	mild
+R49	MODIFY Arg1:T98 Arg2:E60	
+T99	Sign_symptom 1916 1923	nodules
+E61	Sign_symptom:T99 
+T100	Quantitative_concept 1895 1903	multiple
+R50	MODIFY Arg1:T100 Arg2:E61	
+T101	Biological_structure 1935 1940	organ
+#3	AnnotatorNotes T101	The spleen
+R51	MODIFY Arg1:T101 Arg2:E61	
+T102	Sign_symptom 1980 1992	asymptomatic
+E62	Sign_symptom:T102 
+T103	Sign_symptom 2041 2051	discomfort
+E63	Sign_symptom:T103 
+T104	Severity 2036 2040	mild
+R52	MODIFY Arg1:T104 Arg2:E63	
+T105	Biological_structure 2059 2093	left upper quadrant of the abdomen
+R53	MODIFY Arg1:T105 Arg2:E63	
+T106	Diagnostic_procedure 2095 2099	FNAC
+E64	Diagnostic_procedure:T106 
+T107	Biological_structure 2107 2113	spleen
+R54	MODIFY Arg1:T107 Arg2:E64	
+T108	Disease_disorder 3587 3597	metastases
+E65	Disease_disorder:T108 
+T109	Biological_structure 3581 3586	liver
+R55	MODIFY Arg1:T109 Arg2:E65	
+T110	Quantitative_concept 3572 3580	multiple
+R56	MODIFY Arg1:T110 Arg2:E65	
+T111	Disease_disorder 3638 3648	metastases
+E66	Disease_disorder:T111 
+T112	Biological_structure 3628 3637	cutaneous
+R57	MODIFY Arg1:T112 Arg2:E66	
+T113	Diagnostic_procedure 3615 3617	CT
+E67	Diagnostic_procedure:T113 
+T114	Detailed_description 544 565	25 cigarettes per day
+R58	MODIFY Arg1:T114 Arg2:E13	
+T115	Diagnostic_procedure 2285 2295	Gram stain
+E68	Diagnostic_procedure:T115 
+T116	Lab_value 2296 2304	negative
+E69	Lab_value:T116 
+R59	MODIFY Arg1:E69 Arg2:E68	
+T117	Diagnostic_procedure 2320 2326	biopsy
+E70	Diagnostic_procedure:T117 
+T118	Biological_structure 2308 2319	bone-marrow
+R60	MODIFY Arg1:T118 Arg2:E70	
+T119	Lab_value 2331 2339	negative
+E71	Lab_value:T119 
+T120	Diagnostic_procedure 2344 2366	metastatic involvement
+E72	Diagnostic_procedure:T120 
+R61	MODIFY Arg1:E71 Arg2:E72	
+T121	Disease_disorder 2395 2405	metastases
+E73	Disease_disorder:T121 
+T122	Biological_structure 2413 2419	spleen
+R62	MODIFY Arg1:T122 Arg2:E73	
+T123	Sign_symptom 2451 2462	alterations
+E74	Sign_symptom:T123 
+T124	Detailed_description 2442 2450	necrotic
+T125	Detailed_description 2425 2437	inflammatory
+R63	MODIFY Arg1:T124 Arg2:E74	
+R64	MODIFY Arg1:T125 Arg2:E74	
+T126	Clinical_event 2480 2488	referred
+E75	Clinical_event:T126 
+T127	Nonbiological_location 2496 2502	centre
+R65	MODIFY Arg1:T127 Arg2:E75	
+T128	Therapeutic_procedure 2507 2518	splenectomy
+E76	Therapeutic_procedure:T128 
+T129	Sign_symptom 2596 2603	rupture
+E77	Sign_symptom:T129 
+A6	POLARITY E77 UNCERTAIN
+T130	Detailed_description 2584 2595	spontaneous
+R66	MODIFY Arg1:T130 Arg2:E77	
+T131	Biological_structure 2611 2617	spleen
+R67	MODIFY Arg1:T131 Arg2:E77	
+T132	Date 2622 2640	12th December 2007
+E78	Date:T132 
+T133	Therapeutic_procedure 2679 2690	splenectomy
+E79	Therapeutic_procedure:T133 
+T134	Detailed_description 2673 2678	total
+T135	Detailed_description 2658 2672	transabdominal
+R68	MODIFY Arg1:T134 Arg2:E79	
+R69	MODIFY Arg1:T135 Arg2:E79	
+T136	Therapeutic_procedure 2722 2743	lymph node dissection
+E80	Therapeutic_procedure:T136 
+T137	Biological_structure 2708 2721	celiac artery
+T138	Biological_structure 2696 2703	splenic
+R70	MODIFY Arg1:T137 Arg2:E80	
+R71	MODIFY Arg1:T138 Arg2:E80	
+T139	Diagnostic_procedure 2749 2769	postoperative course
+E81	Diagnostic_procedure:T139 
+T140	Lab_value 2774 2784	uneventful
+E82	Lab_value:T140 
+R72	MODIFY Arg1:E82 Arg2:E81	
+T141	Sign_symptom 2145 2188	inflammatory cells admixed with large cells
+E83	Sign_symptom:T141 
+T142	Diagnostic_procedure 2243 2255	cytokeratins
+E84	Diagnostic_procedure:T142 
+T143	Lab_value 2220 2230	positivity
+E85	Lab_value:T143 
+R73	MODIFY Arg1:E85 Arg2:E84	
+T144	Date 2793 2814	7th postoperative day
+E86	Date:T144 
+T145	Diagnostic_procedure 2824 2839	ultrasonography
+E87	Diagnostic_procedure:T145 
+T146	Detailed_description 2816 2823	Doppler
+R74	MODIFY Arg1:T146 Arg2:E87	
+T147	Disease_disorder 2886 2896	thrombosis
+E88	Disease_disorder:T147 
+A7	POLARITY E88 NEG
+T148	Detailed_description 2849 2860	portal-tree
+T149	Sign_symptom 2861 2868	patency
+E89	Sign_symptom:T149 
+R75	MODIFY Arg1:T148 Arg2:E89	
+T150	Date 2898 2912	Ten days later
+E90	Date:T150 
+T151	Clinical_event 2930 2940	discharged
+E91	Clinical_event:T151 
+T152	Diagnostic_procedure 2955 2969	platelet count
+E92	Diagnostic_procedure:T152 
+T153	Lab_value 2948 2954	stable
+E93	Lab_value:T153 
+T154	Lab_value 2971 2982	780,000/mm3
+E94	Lab_value:T154 
+T155	Diagnostic_procedure 2985 2987	Hb
+E95	Diagnostic_procedure:T155 
+T156	Lab_value 2988 2997	10.9 g/dL
+E96	Lab_value:T156 
+R76	MODIFY Arg1:E96 Arg2:E95	
+R77	MODIFY Arg1:E94 Arg2:E92	
+R78	MODIFY Arg1:E93 Arg2:E92	
+T157	Diagnostic_procedure 3005 3014	WBC count
+E97	Diagnostic_procedure:T157 
+T158	Lab_value 3018 3028	16,500/mm3
+E98	Lab_value:T158 
+R79	MODIFY Arg1:E98 Arg2:E97	
+T159	Diagnostic_procedure 3030 3054	Pathological examination
+E99	Diagnostic_procedure:T159 
+T160	Biological_structure 3062 3068	spleen
+R80	MODIFY Arg1:T160 Arg2:E99	
+T161	Sign_symptom 3088 3095	nodules
+E100	Sign_symptom:T161 
+T162	Quantitative_concept 3079 3087	multiple
+R81	MODIFY Arg1:T162 Arg2:E100	
+T163	Detailed_description 3107 3134	medium to large-sized cells
+T164	Detailed_description 3136 3166	some of which were keratinized
+R82	MODIFY Arg1:T163 Arg2:E100	
+R83	MODIFY Arg1:T164 Arg2:E100	
+T165	Sign_symptom 3172 3179	nodules
+E101	Sign_symptom:T165 
+T166	Texture 3185 3197	mostly solid
+T167	Detailed_description 3203 3228	areas of central necrosis
+R84	MODIFY Arg1:T167 Arg2:E101	
+R85	MODIFY Arg1:T166 Arg2:E101	
+T168	Disease_disorder 3276 3286	metastases
+E102	Disease_disorder:T168 
+T169	Disease_disorder 3290 3293	SCC
+E103	Disease_disorder:T169 
+#4	AnnotatorNotes E103	squamous cell carcinoma
+T170	Clinical_event 3323 3331	referred
+E104	Clinical_event:T170 
+T171	Nonbiological_location 3339 3358	oncology department
+T172	Nonbiological_location 3366 3374	hospital
+R86	MODIFY Arg1:T172 Arg2:T171	
+R87	MODIFY Arg1:T171 Arg2:E104	
+T173	Medication 3456 3468	chemotherapy
+E105	Medication:T173 
+T174	Detailed_description 3447 3455	systemic
+R88	MODIFY Arg1:T174 Arg2:E105	
+T175	Medication 3478 3492	5-fluorouracil
+E106	Medication:T175 
+T176	Medication 3513 3522	cisplatin
+E107	Medication:T176 
+R89	SUB_PROCEDURE Arg1:E106 Arg2:E105	
+R90	SUB_PROCEDURE Arg1:E107 Arg2:E105	
+T177	Dosage 3394 3410	two 3-day cycles
+R91	MODIFY Arg1:T177 Arg2:E105	
+T178	Detailed_description 3412 3442	separated by a 3-week interval
+R92	MODIFY Arg1:T178 Arg2:T177	
+T179	Dosage 3494 3504	800 mg/day
+T180	Dosage 3524 3533	20 mg/day
+T181	Administration 3505 3507	IV
+R93	MODIFY Arg1:T179 Arg2:E106	
+R94	MODIFY Arg1:T181 Arg2:E106	
+R95	MODIFY Arg1:T180 Arg2:E107	
+T182	Date 3536 3554	Three months after
+E108	Date:T182 
+R96	AFTER Arg1:E1 Arg2:E4	
+*	OVERLAP E4 E5 E6 E7
+R97	AFTER Arg1:E7 Arg2:E8	
+*	OVERLAP E8 E9 E10
+R98	AFTER Arg1:E10 Arg2:E11	
+*	OVERLAP E11 E26
+R99	BEFORE Arg1:E26 Arg2:E12	
+*	OVERLAP E12 E27
+R100	AFTER Arg1:E27 Arg2:E13	
+R101	BEFORE Arg1:E13 Arg2:E14	
+*	OVERLAP E14 E16 E18 E19 E20 E21 E23 E28 E29 E30
+R102	BEFORE Arg1:E30 Arg2:E32	
+*	OVERLAP E32 E35 E39
+R103	AFTER Arg1:E39 Arg2:E38	
+R104	BEFORE Arg1:E38 Arg2:E37	
+*	OVERLAP E37 E40 E41 E42 E44
+R105	BEFORE Arg1:E44 Arg2:E46	
+R106	BEFORE Arg1:E46 Arg2:E48	
+*	OVERLAP E48 E49 E50
+R107	BEFORE Arg1:E50 Arg2:E52	
+*	OVERLAP E52 E53 E54 E55
+R108	BEFORE Arg1:E55 Arg2:E56	
+*	OVERLAP E56 E57 E58 E59 E60 E61 E62 E63 E64 E83 E84 E68 E70 E72
+R109	BEFORE Arg1:E72 Arg2:E73	
+*	OVERLAP E73 E74
+R110	BEFORE Arg1:E74 Arg2:E75	
+*	OVERLAP E75 E76 E77 E78 E79 E80
+R111	BEFORE Arg1:E80 Arg2:E81	
+R112	BEFORE Arg1:E81 Arg2:E86	
+*	OVERLAP E86 E87 E89 E88
+R113	BEFORE Arg1:E88 Arg2:E90	
+*	OVERLAP E90 E91 E92 E95 E97 E99 E100 E101 E102 E103
+R114	BEFORE Arg1:E103 Arg2:E104	
+*	OVERLAP E104 E105
+R115	BEFORE Arg1:E105 Arg2:E108	
+R116	AFTER Arg1:E108 Arg2:E22	
+R117	BEFORE Arg1:E22 Arg2:E65	
+*	OVERLAP E65 E67 E66
+R118	BEFORE Arg1:E66 Arg2:E2	
+*	OVERLAP E2 E3