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T1 Age 2 13 59-year-old T2 Sex 14 17 man T3 Clinical_event 22 30 referred E1 Clinical_event:T3 T4 Outcome 3680 3684 died E2 Outcome:T4 T5 Date 3685 3699 9 months later E3 Date:T5 T6 Nonbiological_location 72 80 hospital T7 Nonbiological_location 38 64 general surgery department R1 MODIFY Arg1:T7 Arg2:E1 R2 MODIFY Arg1:T6 Arg2:T7 T8 Duration 87 104 one-month history E4 Duration:T8 T9 Sign_symptom 120 129 dysphagia E5 Sign_symptom:T9 A1 TREND E5 INC T10 Detailed_description 108 119 progressive R3 MODIFY Arg1:T10 Arg2:E5 T11 Detailed_description 134 140 solids R4 MODIFY Arg1:T11 Arg2:E5 T12 Disease_disorder 172 184 malnutrition E6 Disease_disorder:T12 A2 POLARITY E6 NEG T13 Sign_symptom 200 211 weight loss E7 Sign_symptom:T13 A3 POLARITY E7 NEG T14 Diagnostic_procedure 248 274 esophagogastroduodenoscopy E8 Diagnostic_procedure:T14 T15 Nonbiological_location 278 294 another hospital R5 MODIFY Arg1:T15 Arg2:E8 T16 Sign_symptom 334 340 lesion E9 Sign_symptom:T16 T17 Biological_structure 368 377 esophagus R6 MODIFY Arg1:T17 Arg2:E9 T18 Diagnostic_procedure 386 392 biopsy E10 Diagnostic_procedure:T18 A4 POLARITY E10 NEG T19 Disease_disorder 447 451 COPD E11 Disease_disorder:T19 T20 Disease_disorder 476 497 myocardial infarction E12 Disease_disorder:T20 T21 History 447 451 COPD T22 History 476 497 myocardial infarction T23 Activity 523 529 smoked E13 Activity:T23 T24 Diagnostic_procedure 585 605 Physical examination E14 Diagnostic_procedure:T24 T25 Lab_value 610 622 unremarkable E15 Lab_value:T25 R7 MODIFY Arg1:E15 Arg2:E14 T26 Diagnostic_procedure 624 643 Computed tomography E16 Diagnostic_procedure:T26 T27 Diagnostic_procedure 645 647 CT E17 Diagnostic_procedure:T27 T28 Biological_structure 656 661 chest T29 Biological_structure 666 673 abdomen T30 Sign_symptom 683 691 stenosis E18 Sign_symptom:T30 R8 MODIFY Arg1:T28 Arg2:E16 R9 MODIFY Arg1:T29 Arg2:E16 R10 IDENTICAL Arg1:E17 Arg2:E16 T31 Distance 704 708 5-cm T32 Detailed_description 709 736 segment of the middle third T33 Biological_structure 744 753 esophagus R11 MODIFY Arg1:T33 Arg2:E18 R12 MODIFY Arg1:T31 Arg2:T32 R13 MODIFY Arg1:T32 Arg2:T33 T34 Sign_symptom 768 775 lesions E19 Sign_symptom:T34 A5 POLARITY E19 NEG T35 Biological_structure 783 811 thoracic or abdominal organs R14 MODIFY Arg1:T35 Arg2:E19 T36 Diagnostic_procedure 813 827 Barium studies E20 Diagnostic_procedure:T36 T37 Sign_symptom 840 848 swelling E21 Sign_symptom:T37 T38 Biological_structure 856 871 esophageal wall R15 MODIFY Arg1:T38 Arg2:E21 T39 Therapeutic_procedure 3559 3570 splenectomy E22 Therapeutic_procedure:T39 T40 Distance 872 876 7 cm T41 Biological_structure 877 893 above the cardia T42 Detailed_description 902 920 ulcerative pattern R16 MODIFY Arg1:T42 Arg2:E21 R17 MODIFY Arg1:T40 Arg2:T41 R18 MODIFY Arg1:T41 Arg2:T38 T43 Diagnostic_procedure 940 948 diameter E23 Diagnostic_procedure:T43 T44 Lab_value 928 935 reduced E24 Lab_value:T44 R19 MODIFY Arg1:E24 Arg2:E23 T45 Biological_structure 956 961 lumen R20 MODIFY Arg1:T45 Arg2:E23 T46 Lab_value 965 969 5 mm E25 Lab_value:T46 R21 MODIFY Arg1:E25 Arg2:E23 T47 Date 465 469 1999 E26 Date:T47 T48 Date 501 505 2002 E27 Date:T48 T49 Detailed_description 313 321 bleeding T50 Detailed_description 323 333 ulcerative R22 MODIFY Arg1:T50 Arg2:E9 R23 MODIFY Arg1:T49 Arg2:E9 T51 Detailed_description 348 360 middle third R24 MODIFY Arg1:T51 Arg2:T17 T52 Diagnostic_procedure 985 991 biopsy E28 Diagnostic_procedure:T52 T53 Detailed_description 974 984 endoscopic R25 MODIFY Arg1:T53 Arg2:E28 T54 Sign_symptom 1011 1015 mass E29 Sign_symptom:T54 T55 Biological_structure 999 1010 oesophageal R26 MODIFY Arg1:T55 Arg2:E29 T56 Disease_disorder 1056 1079 squamous cell carcinoma E30 Disease_disorder:T56 T57 Lab_value 1052 1054 G3 E31 Lab_value:T57 R27 MODIFY Arg1:E31 Arg2:E30 T58 Detailed_description 1029 1050 poorly differentiated R28 MODIFY Arg1:T58 Arg2:E30 T59 Therapeutic_procedure 1092 1105 esophagectomy E32 Therapeutic_procedure:T59 T60 Detailed_description 1081 1091 Mid-distal R29 MODIFY Arg1:T60 Arg2:E32 T61 Therapeutic_procedure 1125 1153 oesophagogastric anastomosis E33 Therapeutic_procedure:T61 R30 SUB_PROCEDURE Arg1:E33 Arg2:E32 T62 Therapeutic_procedure 1171 1185 reconstruction E34 Therapeutic_procedure:T62 T63 Biological_structure 1158 1170 gastric tube R31 MODIFY Arg1:T63 Arg2:E34 R32 SUB_PROCEDURE Arg1:E34 Arg2:E32 T64 Diagnostic_procedure 1187 1211 Pathological examination E35 Diagnostic_procedure:T64 T65 Lab_value 1294 1296 G3 E36 Lab_value:T65 T66 Disease_disorder 1298 1301 SCC E37 Disease_disorder:T66 #1 AnnotatorNotes E37 squamous cell carcinoma T67 Detailed_description 1271 1292 poorly differentiated R33 MODIFY Arg1:E36 Arg2:E37 R34 MODIFY Arg1:T67 Arg2:E37 T68 Diagnostic_procedure 1251 1257 biopsy E38 Diagnostic_procedure:T68 T69 Coreference 1219 1236 surgical specimen E39 Coreference:T69 R35 IDENTICAL Arg1:E39 Arg2:E29 T70 Coreference 1307 1312 tumor E40 Coreference:T70 R36 IDENTICAL Arg1:E40 Arg2:E39 T71 Distance 1329 1343 3 cm of length R37 MODIFY Arg1:T71 Arg2:E40 T72 Sign_symptom 1349 1360 infiltrated E41 Sign_symptom:T72 T73 Biological_structure 1365 1381 oesophageal wall R38 MODIFY Arg1:T73 Arg2:E41 T74 Biological_structure 1402 1420 paraesophageal fat R39 MODIFY Arg1:T74 Arg2:E41 T75 Diagnostic_procedure 1422 1438 Surgical margins E42 Diagnostic_procedure:T75 T76 Lab_value 1444 1454 tumor-free E43 Lab_value:T76 R40 MODIFY Arg1:E43 Arg2:E42 T77 Quantitative_concept 1463 1468 seven T78 Biological_structure 1469 1492 perigastric limph-nodes R41 MODIFY Arg1:T77 Arg2:T78 T79 Diagnostic_procedure 1493 1502 dissected E44 Diagnostic_procedure:T79 R42 MODIFY Arg1:T78 Arg2:E44 T80 Lab_value 1504 1510 pT3 N0 E45 Lab_value:T80 R43 MODIFY Arg1:E45 Arg2:E44 R44 MODIFY Arg1:E43 Arg2:E44 T81 Diagnostic_procedure 1517 1537 postoperative period E46 Diagnostic_procedure:T81 T82 Lab_value 1548 1560 unremarkable E47 Lab_value:T82 R45 MODIFY Arg1:E47 Arg2:E46 T83 Diagnostic_procedure 1586 1591 x-ray E48 Diagnostic_procedure:T83 T84 Detailed_description 1568 1585 contrast enhanced R46 MODIFY Arg1:T84 Arg2:E48 T85 Date 1608 1615 9th POD E49 Date:T85 #2 AnnotatorNotes E49 9th post-operative day T86 Diagnostic_procedure 1630 1660 esophageal and gastric transit E50 Diagnostic_procedure:T86 T87 Lab_value 1623 1629 normal E51 Lab_value:T87 R47 MODIFY Arg1:E51 Arg2:E50 T88 Date 1669 1677 14th POD E52 Date:T88 T89 Clinical_event 1695 1705 discharged E53 Clinical_event:T89 T90 Clinical_event 1723 1731 referral E54 Clinical_event:T90 T91 Nonbiological_location 1714 1722 oncology R48 MODIFY Arg1:T91 Arg2:E54 T92 Clinical_event 1752 1761 follow-up E55 Clinical_event:T92 T93 Date 1763 1780 Nine months after E56 Date:T93 T94 Diagnostic_procedure 1796 1798 CT E57 Diagnostic_procedure:T94 T95 Diagnostic_procedure 1803 1829 esophagogastroduodenoscopy E58 Diagnostic_procedure:T95 T96 Diagnostic_procedure 1849 1862 imaging study E59 Diagnostic_procedure:T96 T97 Sign_symptom 1877 1889 splenomegaly E60 Sign_symptom:T97 T98 Severity 1872 1876 mild R49 MODIFY Arg1:T98 Arg2:E60 T99 Sign_symptom 1916 1923 nodules E61 Sign_symptom:T99 T100 Quantitative_concept 1895 1903 multiple R50 MODIFY Arg1:T100 Arg2:E61 T101 Biological_structure 1935 1940 organ #3 AnnotatorNotes T101 The spleen R51 MODIFY Arg1:T101 Arg2:E61 T102 Sign_symptom 1980 1992 asymptomatic E62 Sign_symptom:T102 T103 Sign_symptom 2041 2051 discomfort E63 Sign_symptom:T103 T104 Severity 2036 2040 mild R52 MODIFY Arg1:T104 Arg2:E63 T105 Biological_structure 2059 2093 left upper quadrant of the abdomen R53 MODIFY Arg1:T105 Arg2:E63 T106 Diagnostic_procedure 2095 2099 FNAC E64 Diagnostic_procedure:T106 T107 Biological_structure 2107 2113 spleen R54 MODIFY Arg1:T107 Arg2:E64 T108 Disease_disorder 3587 3597 metastases E65 Disease_disorder:T108 T109 Biological_structure 3581 3586 liver R55 MODIFY Arg1:T109 Arg2:E65 T110 Quantitative_concept 3572 3580 multiple R56 MODIFY Arg1:T110 Arg2:E65 T111 Disease_disorder 3638 3648 metastases E66 Disease_disorder:T111 T112 Biological_structure 3628 3637 cutaneous R57 MODIFY Arg1:T112 Arg2:E66 T113 Diagnostic_procedure 3615 3617 CT E67 Diagnostic_procedure:T113 T114 Detailed_description 544 565 25 cigarettes per day R58 MODIFY Arg1:T114 Arg2:E13 T115 Diagnostic_procedure 2285 2295 Gram stain E68 Diagnostic_procedure:T115 T116 Lab_value 2296 2304 negative E69 Lab_value:T116 R59 MODIFY Arg1:E69 Arg2:E68 T117 Diagnostic_procedure 2320 2326 biopsy E70 Diagnostic_procedure:T117 T118 Biological_structure 2308 2319 bone-marrow R60 MODIFY Arg1:T118 Arg2:E70 T119 Lab_value 2331 2339 negative E71 Lab_value:T119 T120 Diagnostic_procedure 2344 2366 metastatic involvement E72 Diagnostic_procedure:T120 R61 MODIFY Arg1:E71 Arg2:E72 T121 Disease_disorder 2395 2405 metastases E73 Disease_disorder:T121 T122 Biological_structure 2413 2419 spleen R62 MODIFY Arg1:T122 Arg2:E73 T123 Sign_symptom 2451 2462 alterations E74 Sign_symptom:T123 T124 Detailed_description 2442 2450 necrotic T125 Detailed_description 2425 2437 inflammatory R63 MODIFY Arg1:T124 Arg2:E74 R64 MODIFY Arg1:T125 Arg2:E74 T126 Clinical_event 2480 2488 referred E75 Clinical_event:T126 T127 Nonbiological_location 2496 2502 centre R65 MODIFY Arg1:T127 Arg2:E75 T128 Therapeutic_procedure 2507 2518 splenectomy E76 Therapeutic_procedure:T128 T129 Sign_symptom 2596 2603 rupture E77 Sign_symptom:T129 A6 POLARITY E77 UNCERTAIN T130 Detailed_description 2584 2595 spontaneous R66 MODIFY Arg1:T130 Arg2:E77 T131 Biological_structure 2611 2617 spleen R67 MODIFY Arg1:T131 Arg2:E77 T132 Date 2622 2640 12th December 2007 E78 Date:T132 T133 Therapeutic_procedure 2679 2690 splenectomy E79 Therapeutic_procedure:T133 T134 Detailed_description 2673 2678 total T135 Detailed_description 2658 2672 transabdominal R68 MODIFY Arg1:T134 Arg2:E79 R69 MODIFY Arg1:T135 Arg2:E79 T136 Therapeutic_procedure 2722 2743 lymph node dissection E80 Therapeutic_procedure:T136 T137 Biological_structure 2708 2721 celiac artery T138 Biological_structure 2696 2703 splenic R70 MODIFY Arg1:T137 Arg2:E80 R71 MODIFY Arg1:T138 Arg2:E80 T139 Diagnostic_procedure 2749 2769 postoperative course E81 Diagnostic_procedure:T139 T140 Lab_value 2774 2784 uneventful E82 Lab_value:T140 R72 MODIFY Arg1:E82 Arg2:E81 T141 Sign_symptom 2145 2188 inflammatory cells admixed with large cells E83 Sign_symptom:T141 T142 Diagnostic_procedure 2243 2255 cytokeratins E84 Diagnostic_procedure:T142 T143 Lab_value 2220 2230 positivity E85 Lab_value:T143 R73 MODIFY Arg1:E85 Arg2:E84 T144 Date 2793 2814 7th postoperative day E86 Date:T144 T145 Diagnostic_procedure 2824 2839 ultrasonography E87 Diagnostic_procedure:T145 T146 Detailed_description 2816 2823 Doppler R74 MODIFY Arg1:T146 Arg2:E87 T147 Disease_disorder 2886 2896 thrombosis E88 Disease_disorder:T147 A7 POLARITY E88 NEG T148 Detailed_description 2849 2860 portal-tree T149 Sign_symptom 2861 2868 patency E89 Sign_symptom:T149 R75 MODIFY Arg1:T148 Arg2:E89 T150 Date 2898 2912 Ten days later E90 Date:T150 T151 Clinical_event 2930 2940 discharged E91 Clinical_event:T151 T152 Diagnostic_procedure 2955 2969 platelet count E92 Diagnostic_procedure:T152 T153 Lab_value 2948 2954 stable E93 Lab_value:T153 T154 Lab_value 2971 2982 780,000/mm3 E94 Lab_value:T154 T155 Diagnostic_procedure 2985 2987 Hb E95 Diagnostic_procedure:T155 T156 Lab_value 2988 2997 10.9 g/dL E96 Lab_value:T156 R76 MODIFY Arg1:E96 Arg2:E95 R77 MODIFY Arg1:E94 Arg2:E92 R78 MODIFY Arg1:E93 Arg2:E92 T157 Diagnostic_procedure 3005 3014 WBC count E97 Diagnostic_procedure:T157 T158 Lab_value 3018 3028 16,500/mm3 E98 Lab_value:T158 R79 MODIFY Arg1:E98 Arg2:E97 T159 Diagnostic_procedure 3030 3054 Pathological examination E99 Diagnostic_procedure:T159 T160 Biological_structure 3062 3068 spleen R80 MODIFY Arg1:T160 Arg2:E99 T161 Sign_symptom 3088 3095 nodules E100 Sign_symptom:T161 T162 Quantitative_concept 3079 3087 multiple R81 MODIFY Arg1:T162 Arg2:E100 T163 Detailed_description 3107 3134 medium to large-sized cells T164 Detailed_description 3136 3166 some of which were keratinized R82 MODIFY Arg1:T163 Arg2:E100 R83 MODIFY Arg1:T164 Arg2:E100 T165 Sign_symptom 3172 3179 nodules E101 Sign_symptom:T165 T166 Texture 3185 3197 mostly solid T167 Detailed_description 3203 3228 areas of central necrosis R84 MODIFY Arg1:T167 Arg2:E101 R85 MODIFY Arg1:T166 Arg2:E101 T168 Disease_disorder 3276 3286 metastases E102 Disease_disorder:T168 T169 Disease_disorder 3290 3293 SCC E103 Disease_disorder:T169 #4 AnnotatorNotes E103 squamous cell carcinoma T170 Clinical_event 3323 3331 referred E104 Clinical_event:T170 T171 Nonbiological_location 3339 3358 oncology department T172 Nonbiological_location 3366 3374 hospital R86 MODIFY Arg1:T172 Arg2:T171 R87 MODIFY Arg1:T171 Arg2:E104 T173 Medication 3456 3468 chemotherapy E105 Medication:T173 T174 Detailed_description 3447 3455 systemic R88 MODIFY Arg1:T174 Arg2:E105 T175 Medication 3478 3492 5-fluorouracil E106 Medication:T175 T176 Medication 3513 3522 cisplatin E107 Medication:T176 R89 SUB_PROCEDURE Arg1:E106 Arg2:E105 R90 SUB_PROCEDURE Arg1:E107 Arg2:E105 T177 Dosage 3394 3410 two 3-day cycles R91 MODIFY Arg1:T177 Arg2:E105 T178 Detailed_description 3412 3442 separated by a 3-week interval R92 MODIFY Arg1:T178 Arg2:T177 T179 Dosage 3494 3504 800 mg/day T180 Dosage 3524 3533 20 mg/day T181 Administration 3505 3507 IV R93 MODIFY Arg1:T179 Arg2:E106 R94 MODIFY Arg1:T181 Arg2:E106 R95 MODIFY Arg1:T180 Arg2:E107 T182 Date 3536 3554 Three months after E108 Date:T182 R96 AFTER Arg1:E1 Arg2:E4 * OVERLAP E4 E5 E6 E7 R97 AFTER Arg1:E7 Arg2:E8 * OVERLAP E8 E9 E10 R98 AFTER Arg1:E10 Arg2:E11 * OVERLAP E11 E26 R99 BEFORE Arg1:E26 Arg2:E12 * OVERLAP E12 E27 R100 AFTER Arg1:E27 Arg2:E13 R101 BEFORE Arg1:E13 Arg2:E14 * OVERLAP E14 E16 E18 E19 E20 E21 E23 E28 E29 E30 R102 BEFORE Arg1:E30 Arg2:E32 * OVERLAP E32 E35 E39 R103 AFTER Arg1:E39 Arg2:E38 R104 BEFORE Arg1:E38 Arg2:E37 * OVERLAP E37 E40 E41 E42 E44 R105 BEFORE Arg1:E44 Arg2:E46 R106 BEFORE Arg1:E46 Arg2:E48 * OVERLAP E48 E49 E50 R107 BEFORE Arg1:E50 Arg2:E52 * OVERLAP E52 E53 E54 E55 R108 BEFORE Arg1:E55 Arg2:E56 * OVERLAP E56 E57 E58 E59 E60 E61 E62 E63 E64 E83 E84 E68 E70 E72 R109 BEFORE Arg1:E72 Arg2:E73 * OVERLAP E73 E74 R110 BEFORE Arg1:E74 Arg2:E75 * OVERLAP E75 E76 E77 E78 E79 E80 R111 BEFORE Arg1:E80 Arg2:E81 R112 BEFORE Arg1:E81 Arg2:E86 * OVERLAP E86 E87 E89 E88 R113 BEFORE Arg1:E88 Arg2:E90 * OVERLAP E90 E91 E92 E95 E97 E99 E100 E101 E102 E103 R114 BEFORE Arg1:E103 Arg2:E104 * OVERLAP E104 E105 R115 BEFORE Arg1:E105 Arg2:E108 R116 AFTER Arg1:E108 Arg2:E22 R117 BEFORE Arg1:E22 Arg2:E65 * OVERLAP E65 E67 E66 R118 BEFORE Arg1:E66 Arg2:E2 * OVERLAP E2 E3