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T1 Age 3 14 81-year-old T2 Sex 15 21 female T3 Sign_symptom 27 39 hypertension E1 Sign_symptom:T3 T4 Disease_disorder 44 48 gout E2 Disease_disorder:T4 T5 History 27 39 hypertension T6 History 44 48 gout T7 Clinical_event 53 61 admitted E3 Clinical_event:T7 T8 Nonbiological_location 65 98 Taichung Veterans General Hospita R1 MODIFY Arg1:T8 Arg2:E3 T9 Sign_symptom 117 121 pain E4 Sign_symptom:T9 T10 Biological_structure 107 116 abdominal R2 MODIFY Arg1:T10 Arg2:E4 T11 Sign_symptom 126 137 hematemesis E5 Sign_symptom:T11 T12 Sign_symptom 177 190 epigastralgia E6 Sign_symptom:T12 T13 Detailed_description 164 176 intermittent R3 MODIFY Arg1:T13 Arg2:E6 T14 Date 191 213 more than 10 years ago E7 Date:T14 T15 Sign_symptom 234 239 tumor E8 Sign_symptom:T15 T16 Distance 221 225 4 cm T17 Biological_structure 226 233 gastric R4 MODIFY Arg1:T17 Arg2:E8 R5 MODIFY Arg1:T16 Arg2:E8 T18 Sign_symptom 265 269 pain E9 Sign_symptom:T18 A1 TREND E9 INC T19 Biological_structure 255 264 abdominal R6 MODIFY Arg1:T19 Arg2:E9 T20 Lab_value 270 279 got worse R7 MODIFY Arg1:T20 Arg2:E9 T21 Date 280 294 2 years before E10 Date:T21 T22 Clinical_event 314 318 went E11 Clinical_event:T22 T23 Nonbiological_location 324 338 local hospital R8 MODIFY Arg1:T23 Arg2:E11 T24 Diagnostic_procedure 355 357 CT E12 Diagnostic_procedure:T24 T25 Biological_structure 345 354 abdominal R9 MODIFY Arg1:T25 Arg2:E12 T26 Sign_symptom 382 387 tumor E13 Sign_symptom:T26 T27 Biological_structure 374 381 gastric R10 MODIFY Arg1:T27 Arg2:E13 T28 Distance 394 398 6 cm R11 MODIFY Arg1:T28 Arg2:E13 T29 Detailed_description 414 446 well-circumscribed calcification R12 MODIFY Arg1:T29 Arg2:E13 T30 Therapeutic_procedure 459 480 Surgical intervention E14 Therapeutic_procedure:T30 A2 POLARITY E14 NEG T31 Date 520 534 10 days before E15 Date:T31 T32 Sign_symptom 546 557 tarry stool E16 Sign_symptom:T32 T33 Sign_symptom 581 595 bloody vomitus E17 Sign_symptom:T33 T34 Date 606 617 1 day later E18 Date:T34 T35 Diagnostic_procedure 619 628 UGI scope E19 Diagnostic_procedure:T35 T36 Sign_symptom 657 662 tumor E20 Sign_symptom:T36 T37 Biological_structure 649 656 gastric T38 Biological_structure 638 648 submucosal R13 MODIFY Arg1:T37 Arg2:E20 R14 MODIFY Arg1:T38 Arg2:E20 T39 Detailed_description 668 686 central ulceration R15 MODIFY Arg1:T39 Arg2:E20 T40 Clinical_event 704 715 transferred E21 Clinical_event:T40 T41 Nonbiological_location 723 731 hospital R16 MODIFY Arg1:T41 Arg2:E21 T42 Diagnostic_procedure 733 753 Physical examination E22 Diagnostic_procedure:T42 T43 Sign_symptom 777 787 tenderness E23 Sign_symptom:T43 T44 Biological_structure 761 776 upper abdominal R17 MODIFY Arg1:T44 Arg2:E23 T45 Sign_symptom 805 813 guarding E24 Sign_symptom:T45 T46 Severity 793 797 mild T47 Biological_structure 798 804 muscle R18 MODIFY Arg1:T47 Arg2:E24 R19 MODIFY Arg1:T46 Arg2:E24 T48 Diagnostic_procedure 825 836 radiography E25 Diagnostic_procedure:T48 T49 Detailed_description 819 824 plain R20 MODIFY Arg1:T49 Arg2:E25 T50 Sign_symptom 863 876 calcification E26 Sign_symptom:T50 T51 Shape 847 862 irregular shape R21 MODIFY Arg1:T51 Arg2:E26 T52 Biological_structure 882 895 upper abdomen R22 MODIFY Arg1:T52 Arg2:E26 T53 Diagnostic_procedure 897 906 UGI scope E27 Diagnostic_procedure:T53 T54 Sign_symptom 929 934 ulcer E28 Sign_symptom:T54 T55 Sign_symptom 940 952 foreign body E29 Sign_symptom:T55 T56 Biological_structure 916 928 deep gastric R23 MODIFY Arg1:T56 Arg2:E28 T57 Diagnostic_procedure 954 956 CT E30 Diagnostic_procedure:T57 T58 Sign_symptom 1007 1013 lesion E31 Sign_symptom:T58 T59 Biological_structure 1030 1037 stomach R24 MODIFY Arg1:T59 Arg2:E31 T60 Detailed_description 991 1006 space-occupying R25 MODIFY Arg1:T60 Arg2:E31 T61 Shape 972 990 irregularly shaped R26 MODIFY Arg1:T61 Arg2:E31 T62 Sign_symptom 1078 1086 free air E32 Sign_symptom:T62 T63 Detailed_description 1068 1077 localized R27 MODIFY Arg1:T63 Arg2:E32 T64 Detailed_description 1043 1063 plate calcifications R28 MODIFY Arg1:T64 Arg2:E31 T65 Diagnostic_procedure 1165 1175 laparotomy E33 Diagnostic_procedure:T65 T66 Sign_symptom 1207 1211 mass E34 Sign_symptom:T66 T67 Detailed_description 1194 1206 infiltrative R29 MODIFY Arg1:T67 Arg2:E34 T68 Biological_structure 1224 1231 stomach T69 Biological_structure 1236 1252 transverse colon R30 MODIFY Arg1:T68 Arg2:E34 R31 MODIFY Arg1:T69 Arg2:E34 T70 Sign_symptom 1310 1325 calcified plate E35 Sign_symptom:T70 T71 Detailed_description 1304 1309 thick T72 Detailed_description 1283 1288 sharp T73 Detailed_description 1290 1299 bone-like R32 MODIFY Arg1:T71 Arg2:E35 R33 MODIFY Arg1:T73 Arg2:E35 R34 MODIFY Arg1:T72 Arg2:E35 T74 Biological_structure 1347 1361 gastric mucosa R35 MODIFY Arg1:T74 Arg2:E35 T75 Biological_structure 1366 1387 pericolic soft tissue R36 MODIFY Arg1:T75 Arg2:E35 T76 Sign_symptom 1415 1420 tumor E36 Sign_symptom:T76 T77 Biological_structure 1404 1414 submucosal R37 MODIFY Arg1:T77 Arg2:E36 T78 Distance 1427 1433 2.3 cm R38 MODIFY Arg1:T78 Arg2:E36 T79 Coreference 1458 1473 calcified plate E37 Coreference:T79 R39 IDENTICAL Arg1:E37 Arg2:E35 R40 MODIFY Arg1:E37 Arg2:E36 T80 Therapeutic_procedure 1525 1536 gastrectomy E38 Therapeutic_procedure:T80 T81 Therapeutic_procedure 1549 1558 colectomy E39 Therapeutic_procedure:T81 T82 Detailed_description 1516 1524 subtotal T83 Detailed_description 1509 1515 Distal R41 MODIFY Arg1:T82 Arg2:E38 R42 MODIFY Arg1:T83 Arg2:E38 T84 Detailed_description 1541 1548 partial R43 MODIFY Arg1:T84 Arg2:E39 T85 Clinical_event 1591 1601 discharged E40 Clinical_event:T85 T86 Date 1602 1615 13 days after E41 Date:T86 T87 Sign_symptom 1672 1683 tumor cells E42 Sign_symptom:T87 T88 Diagnostic_procedure 1640 1655 Microscopically E43 Diagnostic_procedure:T88 T89 Shape 1657 1671 spindle-shaped R44 MODIFY Arg1:T89 Arg2:E42 T90 Diagnostic_procedure 1693 1710 mitotic frequency E44 Diagnostic_procedure:T90 T91 Lab_value 1689 1692 low T92 Lab_value 1712 1720 4/50 HPF R45 MODIFY Arg1:T92 Arg2:E44 R46 MODIFY Arg1:T91 Arg2:E44 R47 MODIFY Arg1:E42 Arg2:E44 T93 Diagnostic_procedure 1734 1762 Immunohistochemical staining E45 Diagnostic_procedure:T93 T94 Coreference 1770 1775 tumor E46 Coreference:T94 R48 IDENTICAL Arg1:E46 Arg2:E42 R49 MODIFY Arg1:E46 Arg2:E45 R50 SUB_PROCEDURE Arg1:E44 Arg2:E43 T95 Diagnostic_procedure 1830 1836 CD 117 E47 Diagnostic_procedure:T95 T96 Diagnostic_procedure 1862 1866 CD34 E48 Diagnostic_procedure:T96 T97 Diagnostic_procedure 1896 1908 S100 protein E49 Diagnostic_procedure:T97 T98 Diagnostic_procedure 1913 1919 desmin E50 Diagnostic_procedure:T98 R51 SUB_PROCEDURE Arg1:E47 Arg2:E45 R52 SUB_PROCEDURE Arg1:E48 Arg2:E45 R53 SUB_PROCEDURE Arg1:E49 Arg2:E45 R54 SUB_PROCEDURE Arg1:E50 Arg2:E45 T99 Lab_value 1789 1814 diffusely strong positive R55 MODIFY Arg1:T99 Arg2:E47 T100 Lab_value 1838 1846 positive R56 MODIFY Arg1:T100 Arg2:E48 T101 Lab_value 1872 1880 negative R57 MODIFY Arg1:T101 Arg2:E49 R58 MODIFY Arg1:T101 Arg2:E50 T102 Disease_disorder 1967 1971 GIST E51 Disease_disorder:T102 T103 Lab_value 2088 2101 very low risk R59 MODIFY Arg1:T103 Arg2:E51 T104 Family_history 2141 2166 no family history of GIST #1 AnnotatorNotes E51 gastrointestinal stromal tumor * OVERLAP E1 E2 R60 BEFORE Arg1:E2 Arg2:E3 * OVERLAP E3 E4 E5 R61 AFTER Arg1:E5 Arg2:E6 * OVERLAP E6 E7 R62 BEFORE Arg1:E7 Arg2:E8 R63 BEFORE Arg1:E8 Arg2:E9 * OVERLAP E9 E10 R64 BEFORE Arg1:E10 Arg2:E11 * OVERLAP E11 E12 E13 R65 BEFORE Arg1:E13 Arg2:E14 R66 BEFORE Arg1:E14 Arg2:E15 * OVERLAP E15 E16 R67 BEFORE Arg1:E16 Arg2:E17 * OVERLAP E17 E18 R68 BEFORE Arg1:E18 Arg2:E19 * OVERLAP E19 E20 R69 BEFORE Arg1:E20 Arg2:E21 * OVERLAP E21 E22 E23 E24 E25 E26 E27 E28 E29 E30 E31 E32 T105 Detailed_description 1156 1164 emergent R70 MODIFY Arg1:T105 Arg2:E33 R71 BEFORE Arg1:E32 Arg2:E33 * OVERLAP E33 E34 E35 E36 E37 E38 E39 R72 BEFORE Arg1:E39 Arg2:E40 * OVERLAP E40 E41 R73 BEFORE Arg1:E41 Arg2:E43 * OVERLAP E43 E42 E45 E51