T1  Age 2 13    60-year-old

T2  Sex 14 17   man

T3  Diagnostic_procedure 32 43  colonoscopy

E1  Diagnostic_procedure:T3 

T4  Sign_symptom 69 82  sessile polyp

E2  Sign_symptom:T4 

T5  Distance 64 68  2 cm

R1  MODIFY Arg1:T5 Arg2:E2  

T6  Distance 100 105    10 cm

T7  Biological_structure 115 125    anal verge

R2  MODIFY Arg1:T6 Arg2:T7  

R3  MODIFY Arg1:T7 Arg2:E2  

T8  Therapeutic_procedure 130 150   successfully removed

E3  Therapeutic_procedure:T8 

T9  Disease_disorder 168 189    tubulovillous adenoma

E4  Disease_disorder:T9 

T10 Coreference 156 161 polyp

E5  Coreference:T10 

R4  IDENTICAL Arg1:E5 Arg2:E2   

T11 Sign_symptom 201 221    high-grade dysplasia

E6  Sign_symptom:T11 

T12 Diagnostic_procedure 225 247    flexible sigmoidoscopy

E7  Diagnostic_procedure:T12 

T13 Date 258 276    three months later

E8  Date:T13 

T14 Diagnostic_procedure 298 309    colonoscopy

E9  Diagnostic_procedure:T14 

T15 Date 310 348    one year after the initial colonoscopy

E10 Date:T15 

R6  MODIFY Arg1:E10 Arg2:E9 

T16 Detailed_description 291 297    repeat

R7  MODIFY Arg1:T16 Arg2:E9 

T17 Lab_value 360 368   negative

R8  MODIFY Arg1:T17 Arg2:E9 

R9  MODIFY Arg1:T17 Arg2:E7 

T18 Diagnostic_procedure 387 398    colonoscopy

E11 Diagnostic_procedure:T18 

T19 Date 409 450    three years after the initial colonoscopy

E12 Date:T19 

T20 Sign_symptom 462 475    sessile polyp

E13 Sign_symptom:T20 

T21 Distance 477 481    3 cm

R10 MODIFY Arg1:T21 Arg2:E13    

T22 Distance 494 499    10 cm

T23 Biological_structure 509 519    anal verge

R11 MODIFY Arg1:T22 Arg2:T23    

R12 MODIFY Arg1:T23 Arg2:E13    

T24 Diagnostic_procedure 521 529    Biopsies

E14 Diagnostic_procedure:T24 

T25 Disease_disorder 575 590    villous adenoma

E15 Disease_disorder:T25 

T26 Sign_symptom 596 615    low-grade dysplasia

E16 Sign_symptom:T26 

R13 MODIFY Arg1:E16 Arg2:E15    

R5  MODIFY Arg1:E6 Arg2:E4  

T27 Diagnostic_procedure 762 788    magnetic resonance imaging

E17 Diagnostic_procedure:T27 

T28 Diagnostic_procedure 790 793    MRI

E18 Diagnostic_procedure:T28 

T29 Biological_structure 755 761    pelvic

R14 MODIFY Arg1:T29 Arg2:E17    

R15 IDENTICAL Arg1:E18 Arg2:E17 

T30 Diagnostic_procedure 807 828    endoscopic ultrasound

E19 Diagnostic_procedure:T30 

T31 Diagnostic_procedure 830 833    EUS

E20 Diagnostic_procedure:T31 

R16 IDENTICAL Arg1:E20 Arg2:E19 

T32 Coreference 882 885 MRI

E21 Coreference:T32 

R17 IDENTICAL Arg1:E21 Arg2:E17 

T33 Sign_symptom 914 918    mass

E22 Sign_symptom:T33 

T34 Biological_structure 907 913    rectal

R18 MODIFY Arg1:T34 Arg2:E22    

T35 Biological_structure 933 951    muscularis propria

R19 MODIFY Arg1:T35 Arg2:E22    

T36 Detailed_description 898 906    invasive

R20 MODIFY Arg1:T36 Arg2:E22    

T37 Disease_disorder 1008 1027  T2 rectal carcinoma

E23 Disease_disorder:T37 

T38 Sign_symptom 1050 1065  lymphadenopathy

E24 Sign_symptom:T38 

A1  POLARITY E24 NEG

T39 Biological_structure 1043 1049  pelvic

R21 MODIFY Arg1:T39 Arg2:E24    

T40 Coreference 1084 1087   EUS

E25 Coreference:T40 

R22 IDENTICAL Arg1:E25 Arg2:E20 

T41 Sign_symptom 1106 1110  mass

E26 Sign_symptom:T41 

T42 Biological_structure 1099 1105  rectal

R23 MODIFY Arg1:T42 Arg2:E26    

T43 Biological_structure 1125 1131  mucosa

T44 Biological_structure 1136 1145  submucosa

R24 MODIFY Arg1:T43 Arg2:E26    

R25 MODIFY Arg1:T44 Arg2:E26    

T45 Therapeutic_procedure 1357 1375 surgical resection

E27 Therapeutic_procedure:T45 

T46 Therapeutic_procedure 1401 1423 low anterior resection

E28 Therapeutic_procedure:T46 

R26 SUB_PROCEDURE Arg1:E28 Arg2:E27 

T47 Therapeutic_procedure 1428 1450 end-to-end anastomosis

E29 Therapeutic_procedure:T47 

T48 Therapeutic_procedure 1456 1470 loop ileostomy

E30 Therapeutic_procedure:T48 

T49 Diagnostic_procedure 1472 1488  Pathology review

E31 Diagnostic_procedure:T49 

T50 Biological_structure 1496 1517  resected rectosigmoid

R27 MODIFY Arg1:T50 Arg2:E31    

T51 Disease_disorder 1529 1544  villous adenoma

E32 Disease_disorder:T51 

T52 Sign_symptom 1550 1568  low-grade dyplasia

E33 Sign_symptom:T52 

R28 MODIFY Arg1:E33 Arg2:E32    

T53 Sign_symptom 1595 1622  muscularis propria invasion

E34 Sign_symptom:T53 

A2  POLARITY E34 NEG

T54 Therapeutic_procedure 1739 1757 ileostomy reversal

E35 Therapeutic_procedure:T54 

T55 Date 1758 1775  five months later

E36 Date:T55 

T56 Sign_symptom 1788 1800  asymptomatic

E37 Sign_symptom:T56 

T57 Sign_symptom 1809 1830  recurrence of tumours

E38 Sign_symptom:T57 

A3  POLARITY E38 NEG

T58 Therapeutic_procedure 1690 1697 excised

E39 Therapeutic_procedure:T58 

T59 Biological_structure 1644 1653;1673 1684    pericolic lymph nodes

T60 Biological_structure 1662 1684  mesorectal lymph nodes

R29 MODIFY Arg1:T59 Arg2:E39    

R30 MODIFY Arg1:T60 Arg2:E39    

T61 Lab_value 1639 1643 five

R31 MODIFY Arg1:T61 Arg2:T59    

T62 Lab_value 1658 1661 two

R32 MODIFY Arg1:T62 Arg2:T60    

T63 Sign_symptom 1709 1715  benign

E40 Sign_symptom:T63 

R33 MODIFY Arg1:E40 Arg2:T59    

R34 MODIFY Arg1:E40 Arg2:T60    

*   OVERLAP E1 E2 E3 E4

R35 BEFORE Arg1:E4 Arg2:E7  

*   OVERLAP E7 E8 E9

R36 BEFORE Arg1:E9 Arg2:E11 

*   OVERLAP E11 E12 E13 E14 E15 E17 E19 E22 E23 E24 E26

R37 BEFORE Arg1:E26 Arg2:E27    

*   OVERLAP E27 E29 E30

R38 BEFORE Arg1:E30 Arg2:E31    

*   OVERLAP E31 E32 E34 E39 E40

R39 BEFORE Arg1:E40 Arg2:E35    

*   OVERLAP E35 E36 E37 E38