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T1 Age 2 13 49-year-old T2 Sex 14 19 woman T3 Clinical_event 24 32 admitted E1 Clinical_event:T3 T4 Nonbiological_location 40 63 Department of Radiology R1 MODIFY Arg1:T4 Arg2:E1 T5 Nonbiological_location 71 120 Second Affiliated Hospital of Zhejiang University R2 MODIFY Arg1:T5 Arg2:T4 T6 Date 124 136 October 2004 E2 Date:T6 T7 Sign_symptom 163 167 pain E3 Sign_symptom:T7 T8 Sign_symptom 172 183 weight loss E4 Sign_symptom:T8 T9 Biological_structure 142 162 right upper quadrant R3 MODIFY Arg1:T9 Arg2:E3 T10 History 195 220 hepatitis B virus carrier T11 Disease_disorder 195 206 hepatitis B E5 Disease_disorder:T11 T12 Diagnostic_procedure 226 239 α-fetoprotein E6 Diagnostic_procedure:T12 T13 Lab_value 250 262 1185.3 ng/mL R4 MODIFY Arg1:T13 Arg2:E6 T14 Diagnostic_procedure 264 279 Ultrasonography E7 Diagnostic_procedure:T14 T15 Diagnostic_procedure 284 303 computed tomography E8 Diagnostic_procedure:T15 T16 Diagnostic_procedure 305 307 CT E9 Diagnostic_procedure:T16 R5 IDENTICAL Arg1:E9 Arg2:E8 T17 Sign_symptom 326 330 mass E10 Sign_symptom:T17 T18 Distance 320 325 10-cm R6 MODIFY Arg1:T18 Arg2:E10 T19 Biological_structure 364 380 right liver lobe T20 Biological_structure 338 356 posterior segments R7 MODIFY Arg1:T20 Arg2:T19 R8 MODIFY Arg1:T19 Arg2:E10 T21 Sign_symptom 391 395 mass E11 Sign_symptom:T21 T22 Biological_structure 418 438 left lateral segment R9 MODIFY Arg1:T22 Arg2:E11 T23 Distance 384 390 1.5-cm R10 MODIFY Arg1:T23 Arg2:E11 T24 Disease_disorder 503 506 HCC E12 Disease_disorder:T24 #1 AnnotatorNotes E12 hepatocellular carcinoma T25 Detailed_description 492 502 inoperable R11 MODIFY Arg1:T25 Arg2:E12 T26 Disease_disorder 530 539 cirrhosis E13 Disease_disorder:T26 T27 Detailed_description 511 529 Child-Pugh class A R12 MODIFY Arg1:T27 Arg2:E13 T28 Therapeutic_procedure 541 545 TACE E14 Therapeutic_procedure:T28 #2 AnnotatorNotes E14 Transcatheter arterial chemoembolization T29 Diagnostic_procedure 574 583 Angiogram E15 Diagnostic_procedure:T29 T30 Sign_symptom 616 636 arterio-venous shunt E16 Sign_symptom:T30 A1 POLARITY E16 NEG T31 Biological_structure 608 615 hepatic R13 MODIFY Arg1:T31 Arg2:E16 T32 Sign_symptom 659 665 masses E17 Sign_symptom:T32 T33 Detailed_description 642 650 multiple T34 Detailed_description 651 658 smaller T35 Biological_structure 669 692 both lobes of the liver R14 MODIFY Arg1:T35 Arg2:E17 R15 MODIFY Arg1:T34 Arg2:E17 R16 MODIFY Arg1:T33 Arg2:E17 T36 Medication 709 720 oxaliplatin E18 Medication:T36 T37 Medication 722 733 pirarubicin E19 Medication:T37 T38 Medication 735 754 hydroxycamptothecin E20 Medication:T38 T39 Medication 759 767 lipiodol E21 Medication:T39 T40 Administration 697 705 emulsion R17 MODIFY Arg1:T40 Arg2:E18 R18 MODIFY Arg1:T40 Arg2:E19 R19 MODIFY Arg1:T40 Arg2:E20 R20 MODIFY Arg1:T40 Arg2:E21 T41 Dosage 783 788 35 mL T42 Dosage 793 797 3 mL T43 Medication 805 812 mixture E22 Medication:T43 R21 MODIFY Arg1:T42 Arg2:E22 R22 MODIFY Arg1:T41 Arg2:E22 R23 SUB_PROCEDURE Arg1:E21 Arg2:E22 R24 SUB_PROCEDURE Arg1:E20 Arg2:E22 R25 SUB_PROCEDURE Arg1:E19 Arg2:E22 R26 SUB_PROCEDURE Arg1:E18 Arg2:E22 #3 AnnotatorNotes E22 this is a tricky situation! T44 Administration 831 847 intra-arterially R27 MODIFY Arg1:T44 Arg2:E22 T45 Biological_structure 855 884 right and left hepatic artery R28 MODIFY Arg1:T45 Arg2:T44 T46 Sign_symptom 945 949 pain E23 Sign_symptom:T46 T47 Biological_structure 924 944 right upper quadrant R29 MODIFY Arg1:T47 Arg2:E23 T48 Diagnostic_procedure 983 991 recovery E24 Diagnostic_procedure:T48 T49 Lab_value 972 982 uneventful R30 MODIFY Arg1:T49 Arg2:E24 T50 Date 993 1008 One month later E25 Date:T50 T51 Therapeutic_procedure 1019 1023 TACE E26 Therapeutic_procedure:T51 T52 Detailed_description 1012 1018 second R31 MODIFY Arg1:T52 Arg2:E26 T53 Biological_structure 1056 1076 right hepatic artery R32 MODIFY Arg1:T53 Arg2:E26 T54 Coreference 1094 1101 mixture E27 Coreference:T54 R33 IDENTICAL Arg1:E27 Arg2:E22 T55 Dosage 1081 1086 40 mL R34 MODIFY Arg1:T55 Arg2:E27 T56 Date 1127 1135 next day E28 Date:T56 T57 Sign_symptom 1166 1174 dyspnoea E29 Sign_symptom:T57 T58 Detailed_description 1160 1165 acute T59 Detailed_description 1153 1159 sudden R35 MODIFY Arg1:T58 Arg2:E29 R36 MODIFY Arg1:T59 Arg2:E29 T60 Diagnostic_procedure 1183 1211 peripheral oxygen saturation E30 Diagnostic_procedure:T60 T61 Lab_value 1212 1221 decreased T62 Lab_value 1225 1228 90% R37 MODIFY Arg1:T61 Arg2:E30 R38 MODIFY Arg1:T62 Arg2:E30 T63 Diagnostic_procedure 1240 1245 X-ray E31 Diagnostic_procedure:T63 T64 Biological_structure 1234 1239 chest R39 MODIFY Arg1:T64 Arg2:E31 T65 Sign_symptom 1278 1285 shadows E32 Sign_symptom:T65 T66 Biological_structure 1293 1302 left lung R40 MODIFY Arg1:T66 Arg2:E32 T67 Detailed_description 1268 1277 reticular T68 Detailed_description 1258 1267 increased R41 MODIFY Arg1:T67 Arg2:E32 R42 MODIFY Arg1:T68 Arg2:E32 T69 Biological_structure 1322 1333 lower zones R43 MODIFY Arg1:T69 Arg2:E32 T70 Diagnostic_procedure 1347 1349 CT E33 Diagnostic_procedure:T70 T71 Biological_structure 1341 1346 chest R44 MODIFY Arg1:T71 Arg2:E33 T72 Sign_symptom 1403 1412 materials E34 Sign_symptom:T72 T73 Detailed_description 1390 1402 high-density T74 Detailed_description 1381 1389 oil-like T75 Detailed_description 1373 1380 iodized T76 Detailed_description 1364 1372 multiple R45 MODIFY Arg1:T73 Arg2:E34 R46 MODIFY Arg1:T74 Arg2:E34 R47 MODIFY Arg1:T75 Arg2:E34 R48 MODIFY Arg1:T76 Arg2:E34 T77 Biological_structure 1416 1438 parenchyma of the lung R49 MODIFY Arg1:T77 Arg2:E34 T78 Medication 1464 1477 dexamethasone E35 Medication:T78 T79 Dosage 1458 1463 10 mg T80 Administration 1478 1482 i.v. R50 MODIFY Arg1:T79 Arg2:E35 R51 MODIFY Arg1:T80 Arg2:E35 T81 Therapeutic_procedure 1493 1513 supportive therapies E36 Therapeutic_procedure:T81 T82 Coreference 1537 1556 respiratory symptom E37 Coreference:T82 R52 IDENTICAL Arg1:E37 Arg2:E29 A2 POLARITY E37 NEG T83 Date 1573 1587 Two days later E38 Date:T83 T84 Sign_symptom 1625 1633 headache E39 Sign_symptom:T84 T85 Severity 1617 1624 serious R53 MODIFY Arg1:T85 Arg2:E39 T86 Sign_symptom 1648 1666 consciousness loss E40 Sign_symptom:T86 T87 Detailed_description 1638 1647 transient R54 MODIFY Arg1:T87 Arg2:E40 T88 Sign_symptom 1681 1687 nausea E41 Sign_symptom:T88 T89 Sign_symptom 1692 1700 vomiting E42 Sign_symptom:T89 T90 Sign_symptom 1713 1722 confusion E43 Sign_symptom:T90 T91 Sign_symptom 1740 1748 weakness E44 Sign_symptom:T91 T92 Biological_structure 1724 1739 lower extremity R55 MODIFY Arg1:T92 Arg2:E44 T93 Diagnostic_procedure 1772 1774 CT E45 Diagnostic_procedure:T93 T94 Detailed_description 1750 1771 Non-contrast enhanced R56 MODIFY Arg1:T94 Arg2:E45 T95 Sign_symptom 1827 1834 lesions E46 Sign_symptom:T95 T96 Detailed_description 1791 1799 multiple T97 Detailed_description 1800 1812 disseminated T98 Detailed_description 1813 1826 hyper-intense R57 MODIFY Arg1:T98 Arg2:E46 R58 MODIFY Arg1:T97 Arg2:E46 R59 MODIFY Arg1:T96 Arg2:E46 T99 Biological_structure 1842 1847 brain R60 MODIFY Arg1:T99 Arg2:E46 T100 Sign_symptom 1865 1875 deposition E47 Sign_symptom:T100 T101 Detailed_description 1879 1890 iodized oil R61 MODIFY Arg1:T101 Arg2:E47 #4 AnnotatorNotes E47 i.e. material where that material shouldn't be. T102 Date 1904 1918 One week later E48 Date:T102 T103 Sign_symptom 1951 1959 symptoms E49 Sign_symptom:T103 A3 POLARITY E49 NEG T104 Biological_structure 1924 1935 respiratory T105 Biological_structure 1940 1950 neurologic R62 MODIFY Arg1:T105 Arg2:E49 R63 MODIFY Arg1:T104 Arg2:E49 T106 Clinical_event 1996 2006 discharged E50 Clinical_event:T106 T107 Therapeutic_procedure 2064 2068 TACE E51 Therapeutic_procedure:T107 T108 Detailed_description 2052 2063 other three R64 MODIFY Arg1:T108 Arg2:E51 T109 Sign_symptom 2105 2113 symptoms E52 Sign_symptom:T109 A4 POLARITY E52 NEG T110 Detailed_description 2097 2104 similar R65 MODIFY Arg1:T110 Arg2:E52 * OVERLAP E1 E2 E3 E4 R66 AFTER Arg1:E4 Arg2:E5 R67 BEFORE Arg1:E5 Arg2:E6 * OVERLAP E6 E7 E8 E10 E11 E12 E13 R68 BEFORE Arg1:E13 Arg2:E14 * OVERLAP E14 E15 E16 E17 R69 BEFORE Arg1:E17 Arg2:E22 R70 BEFORE Arg1:E22 Arg2:E23 * OVERLAP E23 E24 R71 BEFORE Arg1:E24 Arg2:E25 * OVERLAP E25 E26 E27 R72 BEFORE Arg1:E27 Arg2:E28 * OVERLAP E28 E29 E30 E31 E32 E33 E34 R73 BEFORE Arg1:E34 Arg2:E35 * OVERLAP E35 E36 R74 BEFORE Arg1:E36 Arg2:E37 R75 BEFORE Arg1:E37 Arg2:E38 * OVERLAP E38 E39 E40 E41 E42 E43 E44 E45 E46 E47 R76 BEFORE Arg1:E47 Arg2:E48 * OVERLAP E48 E49 E50 R77 BEFORE Arg1:E50 Arg2:E51 * OVERLAP E51 E52