T1  Age 2 13    28-year-old

T2  Sex 14 19   woman

T3  Clinical_event 24 32    referred

E1  Clinical_event:T3 

T4  Duration 40 46  4-week

E2  Duration:T4 

T5  Sign_symptom 100 104    pain

E3  Sign_symptom:T5 

T6  Biological_structure 79 99  right upper quadrant

R1  MODIFY Arg1:T6 Arg2:E3  

T7  Detailed_description 58 68  continuous

T8  Severity 70 78  moderate

R2  MODIFY Arg1:T8 Arg2:E3  

R3  MODIFY Arg1:T7 Arg2:E3  

T9  Sign_symptom 121 129    jaundice

E4  Sign_symptom:T9 

T10 Sign_symptom 142 153    weight loss

E5  Sign_symptom:T10 

T11 Lab_value 155 160   10 kg

T12 Duration 166 174    3 months

E6  Duration:T12 

R4  MODIFY Arg1:T11 Arg2:E5 

R5  MODIFY Arg1:E6 Arg2:E5  

T13 Sign_symptom 188 192    mass

E7  Sign_symptom:T13 

T14 Biological_structure 182 187    liver

R6  MODIFY Arg1:T14 Arg2:E7 

T15 Diagnostic_procedure 207 222    ultrasonography

E8  Diagnostic_procedure:T15 

T16 Sign_symptom 274 289    colicky attacks

E9  Sign_symptom:T16 

T17 Therapeutic_procedure 352 367   cholecystectomy

E10 Therapeutic_procedure:T17 

T18 Detailed_description 339 351    laparoscopic

R7  MODIFY Arg1:T18 Arg2:E10    

T19 Date 368 386    7 years previously

E11 Date:T19 

T20 Diagnostic_procedure 391 411    physical examination

E12 Diagnostic_procedure:T20 

T21 Coreference 228 242 pain sensation

E13 Coreference:T21 

R8  IDENTICAL Arg1:E13 Arg2:E3  

T22 Lab_value 250 259   different

R9  MODIFY Arg1:T22 Arg2:E13    

T23 Sign_symptom 421 426    obese

E14 Sign_symptom:T23 

T24 Diagnostic_procedure 428 443    body mass index

E15 Diagnostic_procedure:T24 

T25 Lab_value 444 448   37.8

R10 MODIFY Arg1:T25 Arg2:E15    

T26 Sign_symptom 456 463    icterus

E16 Sign_symptom:T26 

T27 Biological_structure 479 491    conjunctivae

T28 Biological_structure 493 504    oral mucosa

T29 Biological_structure 509 513    skin

R11 MODIFY Arg1:T27 Arg2:E16    

R12 MODIFY Arg1:T28 Arg2:E16    

R13 MODIFY Arg1:T29 Arg2:E16    

T30 Diagnostic_procedure 543 562    computed tomography

E17 Diagnostic_procedure:T30 

T31 Diagnostic_procedure 564 566    CT

E18 Diagnostic_procedure:T31 

R14 IDENTICAL Arg1:E18 Arg2:E17 

T32 Diagnostic_procedure 569 597    positron emission tomography

E19 Diagnostic_procedure:T32 

T33 Diagnostic_procedure 599 602    PET

E20 Diagnostic_procedure:T33 

R15 IDENTICAL Arg1:E20 Arg2:E19 

T34 Diagnostic_procedure 608 643    endoscopic cholangiopancreatography

E21 Diagnostic_procedure:T34 

T35 Diagnostic_procedure 645 649    ERCP

E22 Diagnostic_procedure:T35 

R16 IDENTICAL Arg1:E22 Arg2:E21 

T36 Diagnostic_procedure 694 704    laparotomy

E23 Diagnostic_procedure:T36 

T37 Detailed_description 682 693    exploratory

R17 MODIFY Arg1:T37 Arg2:E23    

T38 Diagnostic_procedure 721 736    ultrasonography

E24 Diagnostic_procedure:T38 

T39 Detailed_description 706 720    Intraoperative

R18 MODIFY Arg1:T39 Arg2:E24    

T40 Sign_symptom 755 761    lesion

E25 Sign_symptom:T40 

T41 Detailed_description 748 754    cystic

R19 MODIFY Arg1:T41 Arg2:E25    

T42 Area 772 782    3.5 2.5 cm

R20 MODIFY Arg1:T42 Arg2:E25    

T43 Biological_structure 794 822    central portion of the liver

T44 Biological_structure 824 853    anterior to the porta hepatis

R21 MODIFY Arg1:T44 Arg2:E25    

R22 MODIFY Arg1:T43 Arg2:E25    

T45 Diagnostic_procedure 870 885    cholangiography

E26 Diagnostic_procedure:T45 

T46 Detailed_description 855 869    Intraoperative

R23 MODIFY Arg1:T46 Arg2:E26    

T47 Sign_symptom 912 921    stricture

E27 Sign_symptom:T47 

T48 Severity 902 911    extensive

R24 MODIFY Arg1:T48 Arg2:E27    

T49 Biological_structure 939 956    left hepatic duct

R25 MODIFY Arg1:T49 Arg2:E27    

T50 Sign_symptom 971 980    occlusion

E28 Sign_symptom:T50 

T51 Severity 963 970    partial

R26 MODIFY Arg1:T51 Arg2:E28    

T52 Biological_structure 988 1006   right hepatic duct

R27 MODIFY Arg1:T52 Arg2:E28    

T53 Therapeutic_procedure 1025 1034 lobectomy

E29 Therapeutic_procedure:T53 

T54 Detailed_description 1020 1024  left

T55 Detailed_description 1011 1019  extended

R28 MODIFY Arg1:T54 Arg2:E29    

R29 MODIFY Arg1:T55 Arg2:E29    

T56 Detailed_description 1044 1079  en bloc with the biliary confluence

R30 MODIFY Arg1:T56 Arg2:E29    

T57 Diagnostic_procedure 1084 1110  frozen-section examination

E30 Diagnostic_procedure:T57 

T58 Diagnostic_procedure 1116 1147  margins of the excised specimen

E31 Diagnostic_procedure:T58 

T59 Lab_value 1153 1176 free of malignant cells

R31 MODIFY Arg1:T59 Arg2:E31    

R32 SUB_PROCEDURE Arg1:E31 Arg2:E30 

T60 Therapeutic_procedure 1178 1192 Reconstruction

E32 Therapeutic_procedure:T60 

T61 Therapeutic_procedure 1224 1244 cholangiojejunostomy

E33 Therapeutic_procedure:T61 

R33 SUB_PROCEDURE Arg1:E33 Arg2:E32 

T62 Detailed_description 1214 1223  Roux-en-Y

R34 MODIFY Arg1:T62 Arg2:E33    

T63 Biological_structure 1248 1275  3 second bile duct radicals

R35 MODIFY Arg1:T63 Arg2:E33    

T64 Detailed_description 1283 1293  right side

R36 MODIFY Arg1:T64 Arg2:T63    

T65 Therapeutic_procedure 1313 1325 radiotherapy

E34 Therapeutic_procedure:T65 

T66 Biological_structure 1345 1361  surgical margins

R37 MODIFY Arg1:T66 Arg2:E34    

T67 Duration 1397 1404  6 weeks

E35 Duration:T67 

T68 Therapeutic_procedure 1435 1444 radiation

E36 Therapeutic_procedure:T68 

T69 Detailed_description 1421 1434  external beam

T70 Detailed_description 1408 1420  image-guided

R38 MODIFY Arg1:T69 Arg2:E36    

R39 MODIFY Arg1:T70 Arg2:E36    

T71 Biological_structure 1460 1475  resection field

R40 MODIFY Arg1:T71 Arg2:E36    

T72 Disease_disorder 1585 1608  squamous cell carcinoma

E37 Disease_disorder:T72 

T73 Disease_disorder 1632 1641  dysplasia

E38 Disease_disorder:T73 

T74 Severity 1625 1631  severe

R41 MODIFY Arg1:T74 Arg2:E38    

T75 Biological_structure 1649 1669  bile-duct epithelium

R42 MODIFY Arg1:T75 Arg2:E38    

T76 Detailed_description 1545 1557  infiltrating

T77 Detailed_description 1570 1584  differentiated

T78 Lab_value 1559 1569 moderately

R43 MODIFY Arg1:T78 Arg2:T77    

R44 MODIFY Arg1:T77 Arg2:E37    

R45 MODIFY Arg1:T76 Arg2:E37    

T79 Sign_symptom 1691 1700  recovered

E39 Sign_symptom:T79 

T80 Sign_symptom 1709 1722  complications

E40 Sign_symptom:T80 

A1  POLARITY E40 NEG

T81 Sign_symptom 1731 1741  doing well

E41 Sign_symptom:T81 

T82 Date 1742 1757  18 months after

E42 Date:T82 

T83 Diagnostic_procedure 1811 1818  CT scan

E43 Diagnostic_procedure:T83 

T84 Lab_value 1798 1810 unremarkable

R46 MODIFY Arg1:T84 Arg2:E43    

R47 AFTER Arg1:E1 Arg2:E2   

*   OVERLAP E2 E3 E4

R48 AFTER Arg1:E4 Arg2:E5   

*   OVERLAP E5 E6

R49 BEFORE Arg1:E6 Arg2:E7  

*   OVERLAP E7 E8 E13

R50 AFTER Arg1:E13 Arg2:E9  

R51 BEFORE Arg1:E9 Arg2:E10 

*   OVERLAP E10 E11

R52 BEFORE Arg1:E11 Arg2:E12    

*   OVERLAP E12 E14 E15 E16 E17 E19 E21 E23 E24 E25 E26 E27 E28

R53 BEFORE Arg1:E28 Arg2:E29    

R54 BEFORE Arg1:E29 Arg2:E30    

R55 BEFORE Arg1:E30 Arg2:E32    

*   OVERLAP E32 E34

R56 BEFORE Arg1:E34 Arg2:E35    

*   OVERLAP E35 E36 E37 E38

R57 BEFORE Arg1:E38 Arg2:E39    

*   OVERLAP E39 E40

R58 BEFORE Arg1:E40 Arg2:E41    

*   OVERLAP E41 E42 E43