T1  Age 2 13    63-year-old

T2  Sex 14 19   woman

T3  History 25 49   no known cardiac history

T4  Sign_symptom 83 90  dyspnea

E1  Sign_symptom:T4 

T5  Therapeutic_procedure 101 111   intubation

E2  Therapeutic_procedure:T5 

T6  Therapeutic_procedure 116 135   ventilatory support

E3  Therapeutic_procedure:T6 

T7  Nonbiological_location 136 151  out of hospital

R1  MODIFY Arg1:T7 Arg2:E3  

T8  Detailed_description 67 79  sudden onset

R2  MODIFY Arg1:T8 Arg2:E1  

T9  Clinical_event 50 59    presented

E4  Clinical_event:T9 

T10 Sign_symptom 192 202    discomfort

E5  Sign_symptom:T10 

A1  POLARITY E5 NEG

T11 Biological_structure 186 191    chest

R3  MODIFY Arg1:T11 Arg2:E5 

T12 Sign_symptom 204 216    palpitations

E6  Sign_symptom:T12 

A2  POLARITY E6 NEG

T13 Sign_symptom 218 225    syncope

E7  Sign_symptom:T13 

A3  POLARITY E7 NEG

T14 Disease_disorder 229 238    infection

E8  Disease_disorder:T14 

A4  POLARITY E8 NEG

T15 Sign_symptom 256 264    afebrile

E9  Sign_symptom:T15 

T16 Sign_symptom 269 281    normotensive

E10 Sign_symptom:T16 

T17 Sign_symptom 296 307    tachycardia

E11 Sign_symptom:T17 

T18 Detailed_description 290 295    sinus

R4  MODIFY Arg1:T18 Arg2:E11    

T19 Lab_value 311 324   140 beats/min

R5  MODIFY Arg1:T19 Arg2:E11    

T20 Diagnostic_procedure 330 359    cardiorespiratory examination

E12 Diagnostic_procedure:T20 

T21 Diagnostic_procedure 391 414    jugular venous pressure

E13 Diagnostic_procedure:T21 

T23 Biological_structure 422 438    angle of the jaw

R7  MODIFY Arg1:T23 Arg2:E13    

T24 Sign_symptom 453 470    third heart sound

E14 Sign_symptom:T24 

T25 Detailed_description 442 452    left-sided

R8  MODIFY Arg1:T25 Arg2:E14    

T26 Sign_symptom 485 493    crackles

E15 Sign_symptom:T26 

T27 Detailed_description 475 484    bibasilar

R9  MODIFY Arg1:T27 Arg2:E15    

T28 Biological_structure 497 506    both lung

R10 MODIFY Arg1:T28 Arg2:E15    

T29 Diagnostic_procedure 519 544    complete blood cell count

E16 Diagnostic_procedure:T29 

T30 Diagnostic_procedure 546 558    electrolytes

E17 Diagnostic_procedure:T30 

T31 Diagnostic_procedure 563 581    cardiac biomarkers

E18 Diagnostic_procedure:T31 

T33 Diagnostic_procedure 620 637    electrocardiogram

E19 Diagnostic_procedure:T33 

T34 Sign_symptom 647 660    ST depression

E20 Sign_symptom:T34 

T35 Diagnostic_procedure 664 678    leads V2 to V6

E21 Diagnostic_procedure:T35 

R14 SUB_PROCEDURE Arg1:E21 Arg2:E19 

R15 MODIFY Arg1:E20 Arg2:E21    

T36 Disease_disorder 694 716    anterolateral ischemia

E22 Disease_disorder:T36 

T37 Diagnostic_procedure 737 747    radiograph

E23 Diagnostic_procedure:T37 

T38 Biological_structure 731 736    chest

R16 MODIFY Arg1:T38 Arg2:E23    

T39 Sign_symptom 771 790    vascular congestion

E24 Sign_symptom:T39 

T40 Biological_structure 761 770    pulmonary

R17 MODIFY Arg1:T40 Arg2:E24    

T41 Disease_disorder 822 837    pulmonary edema

E25 Disease_disorder:T41 

T42 Diagnostic_procedure 853 882    echocardiographic examination

E26 Diagnostic_procedure:T42 

T43 Diagnostic_procedure 899 917    cardiac dimensions

E27 Diagnostic_procedure:T43 

T45 Diagnostic_procedure 926 937    wall motion

E28 Diagnostic_procedure:T45 

T47 Disease_disorder 947 968    diastolic dysfunction

E29 Disease_disorder:T47 

T48 Severity 942 946    mild

R20 MODIFY Arg1:T48 Arg2:E29    

T49 Diagnostic_procedure 977 1028   early diastolic to late diastolic transmitral ratio

E30 Diagnostic_procedure:T49 

T51 Diagnostic_procedure 1055 1072  deceleration time

E31 Diagnostic_procedure:T51 

R22 SUB_PROCEDURE Arg1:E27 Arg2:E26 

R23 SUB_PROCEDURE Arg1:E28 Arg2:E26 

R24 SUB_PROCEDURE Arg1:E30 Arg2:E26 

T52 Lab_value 1074 1080 250 ms

R25 MODIFY Arg1:T52 Arg2:E31    

R27 SUB_PROCEDURE Arg1:E31 Arg2:E26 

T54 Biological_structure 1136 1164  lateral mitral valve annulus

T55 Diagnostic_procedure 1096 1128  early diastolic annular velocity

E32 Diagnostic_procedure:T55 

R29 MODIFY Arg1:T54 Arg2:E32    

R30 SUB_PROCEDURE Arg1:E32 Arg2:E26 

T57 Sign_symptom 1187 1195  diuresis

E33 Sign_symptom:T57 

T58 Therapeutic_procedure 1218 1237 ventilatory support

E34 Therapeutic_procedure:T58 

T59 Therapeutic_procedure 1187 1195 diuresis

E35 Therapeutic_procedure:T59 

#1  AnnotatorNotes E35  Intentional, likely through medication (diuretics)

T60 Lab_value 1176 1186 aggressive

R31 MODIFY Arg1:T60 Arg2:E35    

T61 Lab_value 1210 1217 minimal

R32 MODIFY Arg1:T61 Arg2:E34    

T62 Therapeutic_procedure 1255 1264 extubated

E36 Therapeutic_procedure:T62 

T63 Date 1265 1282  one day following

E37 Date:T63 

T64 Time 1309 1319  Within 1 h

E38 Time:T64 

T65 Disease_disorder 1367 1382  pulmonary edema

E39 Disease_disorder:T65 

T66 Detailed_description 1357 1366  recurrent

R33 MODIFY Arg1:T66 Arg2:E39    

T67 Diagnostic_procedure 1398 1414  radiographically

E40 Diagnostic_procedure:T67 

T68 Therapeutic_procedure 1426 1448 mechanical ventilation

E41 Therapeutic_procedure:T68 

T69 Diagnostic_procedure 1450 1473  Cardiac catheterization

E42 Diagnostic_procedure:T69 

T70 Lab_value 1501 1507 normal

T71 Biological_structure 1508 1525  coronary arteries

R34 MODIFY Arg1:T71 Arg2:T70    

R35 MODIFY Arg1:T70 Arg2:E42    

T72 Date 1527 1535  On day 4

E43 Date:T72 

T73 Clinical_event 1562 1571    admission

E44 Clinical_event:T73 

T74 Nonbiological_location 1543 1561    coronary care unit

R36 MODIFY Arg1:T74 Arg2:E44    

T75 Therapeutic_procedure 1612 1622 extubation

E45 Therapeutic_procedure:T75 

A5  POLARITY E45 NEG

T77 Diagnostic_procedure 1626 1646  computed tomographic

E46 Diagnostic_procedure:T77 

T78 Disease_disorder 1688 1694  goiter

E47 Disease_disorder:T78 

T79 Detailed_description 1675 1687  multinodular

T80 Area 1663 1674  4 cm × 9 cm

R38 MODIFY Arg1:T79 Arg2:E47    

R39 MODIFY Arg1:T80 Arg2:E47    

T81 Biological_structure 1714 1725  mediastinum

R40 MODIFY Arg1:T81 Arg2:E47    

T82 Sign_symptom 1760 1768  stenosis

E48 Sign_symptom:T82 

T83 Biological_structure 1751 1759  tracheal

R41 MODIFY Arg1:T83 Arg2:E48    

R42 CAUSE Arg1:E47 Arg2:E48 

T84 Disease_disorder 1801 1805  NPPE

E49 Disease_disorder:T84 

#2  AnnotatorNotes E49  Negative pressure pulmonary edema

T85 Disease_disorder 1831 1837  goiter

E50 Disease_disorder:T85 

T86 Severity 1822 1830  enlarged

R43 MODIFY Arg1:T86 Arg2:E50    

R44 CAUSE Arg1:E50 Arg2:E49 

T87 Therapeutic_procedure 1861 1882 surgical intervention

E51 Therapeutic_procedure:T87 

T88 Therapeutic_procedure 1889 1902 thyroidectomy

E52 Therapeutic_procedure:T88 

R45 SUB_PROCEDURE Arg1:E52 Arg2:E51 

T89 Diagnostic_procedure 1919 1931  bronchoscopy

E53 Diagnostic_procedure:T89 

T90 Detailed_description 1904 1918  Intraoperative

R46 MODIFY Arg1:T90 Arg2:E53    

T91 Lab_value 1962 1978 greater than 50%

T92 Sign_symptom 1950 1958  stenosis

E54 Sign_symptom:T92 

T93 Biological_structure 1941 1949  tracheal

R47 MODIFY Arg1:T93 Arg2:E54    

R48 MODIFY Arg1:T91 Arg2:E54    

T94 Diagnostic_procedure 1984 2004  postoperative course

E55 Diagnostic_procedure:T94 

T96 Date 2028 2050  three months following

E56 Date:T96 

T97 Clinical_event 2051 2060    discharge

E57 Clinical_event:T97 

T98 Outcome 2074 2082   returned

E58 Outcome:T98 

T99 Detailed_description 2090 2113  previous activity level

R50 MODIFY Arg1:T99 Arg2:E58    

T100    Sign_symptom 2133 2140  dyspnea

E59 Sign_symptom:T100 

A6  POLARITY E59 NEG

R51 AFTER Arg1:E4 Arg2:E1   

*   OVERLAP E1 E2 E3

R52 AFTER Arg1:E3 Arg2:E5   

*   OVERLAP E5 E6 E7 E8

R53 BEFORE Arg1:E8 Arg2:E9  

*   OVERLAP E9 E10 E11 E12 E13 E14 E15 E16 E17 E18 E19 E20 E22 E23 E24 E25 E26 E29

A7  POLARITY E22 UNCERTAIN

R54 BEFORE Arg1:E29 Arg2:E35    

*   OVERLAP E35 E33 E34

R55 BEFORE Arg1:E34 Arg2:E36    

*   OVERLAP E36 E37

R56 BEFORE Arg1:E37 Arg2:E38    

T101    Coreference 1323 1333   extubation

E60 Coreference:T101 

R57 IDENTICAL Arg1:E60 Arg2:E36 

*   OVERLAP E38 E60 E39 E40 E41

R58 BEFORE Arg1:E41 Arg2:E42    

R59 BEFORE Arg1:E42 Arg2:E43    

*   OVERLAP E43 E44 E45 E46 E47 E48 E49 E50

R60 BEFORE Arg1:E50 Arg2:E51    

*   OVERLAP E51 E53 E54

R61 BEFORE Arg1:E54 Arg2:E55    

R62 BEFORE Arg1:E55 Arg2:E56    

R63 AFTER Arg1:E56 Arg2:E57 

R64 BEFORE Arg1:E57 Arg2:E58    

*   OVERLAP E58 E59

T56 Lab_value 1088 1095 reduced

E61 Lab_value:T56 

R18 MODIFY Arg1:E61 Arg2:E32    

T53 Lab_value 1045 1054 prolonged

E62 Lab_value:T53 

R19 MODIFY Arg1:E62 Arg2:E31    

T50 Lab_value 1032 1043 less than 1

E63 Lab_value:T50 

R21 MODIFY Arg1:E63 Arg2:E30    

T46 Lab_value 919 925   normal

E64 Lab_value:T46 

R26 MODIFY Arg1:E64 Arg2:E28    

T44 Lab_value 892 898   normal

E65 Lab_value:T44 

R28 MODIFY Arg1:E65 Arg2:E27    

T76 Clinical_event 1585 1591    failed

E66 Clinical_event:T76 

R37 MODIFY Arg1:E66 Arg2:E45    

T22 Lab_value 382 390   elevated

E67 Lab_value:T22 

R6  MODIFY Arg1:E67 Arg2:E13    

T32 Lab_value 587 607   within normal limits

E68 Lab_value:T32 

R11 MODIFY Arg1:E68 Arg2:E18    

R12 MODIFY Arg1:E68 Arg2:E17    

R13 MODIFY Arg1:E68 Arg2:E16    

T95 Lab_value 2009 2022 uncomplicated

E69 Lab_value:T95 

R49 MODIFY Arg1:E69 Arg2:E55