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T1 Age 3 14 18-year-old T2 Sex 15 19 male T3 Disease_disorder 39 79 attention-deficit hyperactivity disorder E1 Disease_disorder:T3 T4 Disease_disorder 81 85 ADHD E2 Disease_disorder:T4 T5 Date 90 94 2005 E3 Date:T5 T6 Diagnostic_procedure 121 136 body mass index E4 Diagnostic_procedure:T6 T7 Diagnostic_procedure 138 141 BMI E5 Diagnostic_procedure:T7 T8 Lab_value 146 148 40 R2 MODIFY Arg1:T8 Arg2:E4 T9 History 103 113 overweight T10 Sign_symptom 103 113 overweight E6 Sign_symptom:T10 T11 Medication 168 187 quetiapine fumarate E7 Medication:T11 T12 Medication 188 199 (Seroquel®) E8 Medication:T12 T13 Dosage 200 212 900 mg daily T14 Date 216 226 April 2005 E9 Date:T14 T15 Medication 231 246 methylphenidate E10 Medication:T15 T16 Medication 247 258 (Concerta®) E11 Medication:T16 T17 Dosage 259 270 54 mg daily T18 Date 274 288 September 2005 E12 Date:T18 T19 Date 297 321 beginning of August 2006 E13 Date:T19 T20 Clinical_event 329 337 admitted E14 Clinical_event:T20 T21 Nonbiological_location 345 359 local hospital T22 Severity 365 371 severe T23 Sign_symptom 372 380 dyspnoea E15 Sign_symptom:T23 T24 Sign_symptom 382 391 tachypnea E16 Sign_symptom:T24 T25 Sign_symptom 393 404 tachycardia E17 Sign_symptom:T25 T26 Sign_symptom 410 418 cyanosis E18 Sign_symptom:T26 T27 Clinical_event 423 432 admission E19 Clinical_event:T27 T28 Diagnostic_procedure 437 451 blood pressure E20 Diagnostic_procedure:T28 T29 Lab_value 456 467 120/80 mmHg T30 Diagnostic_procedure 477 495 arterial blood gas E21 Diagnostic_procedure:T30 T31 Diagnostic_procedure 507 509 pH E22 Diagnostic_procedure:T31 T32 Lab_value 513 517 7.45 T33 Diagnostic_procedure 519 523 pCO2 E23 Diagnostic_procedure:T33 T34 Diagnostic_procedure 537 541 paO2 E24 Diagnostic_procedure:T34 T35 Diagnostic_procedure 559 561 BE E25 Diagnostic_procedure:T35 T36 Lab_value 527 535 3.55 kPa T37 Lab_value 545 553 7.76 kPa T38 Lab_value 565 576 −5.1 mmol/l R3 MODIFY Arg1:T32 Arg2:E22 R4 MODIFY Arg1:T36 Arg2:E23 R5 MODIFY Arg1:T37 Arg2:E24 R6 MODIFY Arg1:T38 Arg2:E25 R7 SUB_PROCEDURE Arg1:E22 Arg2:E21 R8 SUB_PROCEDURE Arg1:E23 Arg2:E21 R9 SUB_PROCEDURE Arg1:E24 Arg2:E21 R10 SUB_PROCEDURE Arg1:E25 Arg2:E21 T39 Diagnostic_procedure 578 596 C-reactive protein E26 Diagnostic_procedure:T39 T40 Lab_value 601 613 not elevated R11 MODIFY Arg1:T40 Arg2:E26 T41 Biological_structure 619 624 chest T42 Diagnostic_procedure 625 630 X-ray E27 Diagnostic_procedure:T42 R12 MODIFY Arg1:T41 Arg2:E27 T45 Sign_symptom 641 655 enlarged heart E28 Sign_symptom:T45 R13 MODIFY Arg1:E28 Arg2:E27 T43 Sign_symptom 670 680 hemoptysis E29 Sign_symptom:T43 T44 Medication 717 724 heparin E30 Medication:T44 T46 Detailed_description 702 716 unfractionated R14 MODIFY Arg1:T46 Arg2:E30 T47 Biological_structure 741 750 pulmonary T48 Sign_symptom 751 759 embolism E31 Sign_symptom:T48 R15 MODIFY Arg1:T47 Arg2:E31 A1 POLARITY E31 UNCERTAIN T49 Disease_disorder 787 804 cardiogenic shock E32 Disease_disorder:T49 T50 Medication 826 842 vasoactive drugs E33 Medication:T50 T51 Sign_symptom 880 888 oliguric E34 Sign_symptom:T51 T52 Diagnostic_procedure 897 910 liver enzymes E35 Diagnostic_procedure:T52 T53 Lab_value 916 922 rising R16 MODIFY Arg1:T53 Arg2:E35 T54 Clinical_event 931 939 referred E36 Clinical_event:T54 T55 Nonbiological_location 947 955 hospital T56 Clinical_event 982 991 admission E37 Clinical_event:T56 T57 Diagnostic_procedure 996 1010 blood pressure E38 Diagnostic_procedure:T57 T58 Lab_value 1015 1025 90/60 mmHg T59 Medication 1049 1062 noradrenaline E39 Medication:T59 T60 Administration 1035 1043 infusion R17 MODIFY Arg1:T60 Arg2:E39 T61 Diagnostic_procedure 1068 1078 heart rate E40 Diagnostic_procedure:T61 T62 Lab_value 1083 1093 130/minute T63 Diagnostic_procedure 1102 1113 temperature E41 Diagnostic_procedure:T63 T64 Lab_value 1118 1125 38.4 °C T65 Diagnostic_procedure 1138 1162 computed tomography scan E42 Diagnostic_procedure:T65 T66 Biological_structure 1129 1137 thoracic R18 MODIFY Arg1:T66 Arg2:E42 T67 Sign_symptom 1163 1194 did not show pulmonary embolism E43 Sign_symptom:T67 A2 POLARITY E43 NEG R19 MODIFY Arg1:E43 Arg2:E42 T68 Diagnostic_procedure 1196 1212 Echocardiography E44 Diagnostic_procedure:T68 T69 Sign_symptom 1222 1243 biventricular failure E45 Sign_symptom:T69 T70 Distance 1292 1296 7 cm T71 Diagnostic_procedure 1248 1287 left ventricular end diastolic diameter E46 Diagnostic_procedure:T71 R20 MODIFY Arg1:T70 Arg2:E46 T72 Biological_structure 1302 1316 left ventricle T73 Lab_value 1330 1341 hypokinetic R21 MODIFY Arg1:T73 Arg2:T72 T74 Severity 1321 1329 severely R22 MODIFY Arg1:T74 Arg2:T73 T75 Diagnostic_procedure 1350 1367 ejection fraction E47 Diagnostic_procedure:T75 T76 Diagnostic_procedure 1369 1371 EF E48 Diagnostic_procedure:T76 T77 Lab_value 1376 1383 20%–25% T78 Diagnostic_procedure 1389 1428 left ventricular end diastolic pressure E49 Diagnostic_procedure:T78 T79 Lab_value 1442 1450 elevated R23 MODIFY Arg1:T79 Arg2:E49 T80 Sign_symptom 1477 1497 mitral regurgitation E50 Sign_symptom:T80 T81 Lab_value 1468 1476 moderate R24 MODIFY Arg1:T81 Arg2:E50 T82 Therapeutic_procedure 1512 1524 hemodialysis E51 Therapeutic_procedure:T82 T83 Detailed_description 1499 1511 Intermittent R25 MODIFY Arg1:T83 Arg2:E51 T84 Diagnostic_procedure 1544 1558 liver function E52 Diagnostic_procedure:T84 T85 Coreference 1590 1598 dialysis E53 Coreference:T85 R26 IDENTICAL Arg1:E53 Arg2:E51 T86 Diagnostic_procedure 1603 1617 renal function E54 Diagnostic_procedure:T86 T87 Lab_value 1618 1630 deteriorated R27 MODIFY Arg1:T87 Arg2:E54 T88 Lab_value 1559 1567 improved R28 MODIFY Arg1:T88 Arg2:E52 T89 Severity 1568 1576 slightly R29 MODIFY Arg1:T89 Arg2:T88 T90 Diagnostic_procedure 1647 1664 creatinine values E55 Diagnostic_procedure:T90 R30 SUB_PROCEDURE Arg1:E55 Arg2:E54 T91 Lab_value 1636 1646 increasing R31 MODIFY Arg1:T91 Arg2:E55 T92 Date 1666 1682 After three days E56 Date:T92 T93 Diagnostic_procedure 1720 1754 left ventricular systolic function E57 Diagnostic_procedure:T93 T94 Lab_value 1703 1712 worsening R32 MODIFY Arg1:T94 Arg2:E57 T95 Diagnostic_procedure 1763 1780 ejection fraction E58 Diagnostic_procedure:T95 T96 Lab_value 1784 1791 10%–12% R33 MODIFY Arg1:T96 Arg2:E58 T97 Sign_symptom 1803 1825 pulmonary hypertension E59 Sign_symptom:T97 T98 Diagnostic_procedure 1831 1858 systolic pulmonary pressure E60 Diagnostic_procedure:T98 T99 Lab_value 1872 1879 30 mmHg R34 MODIFY Arg1:T99 Arg2:E60 T100 Disease_disorder 1920 1934 cardiomyopathy E61 Disease_disorder:T100 T101 Detailed_description 1912 1919 dilated R35 MODIFY Arg1:T101 Arg2:E61 T102 Sign_symptom 1940 1958 low output failure E62 Sign_symptom:T102 T103 Sign_symptom 1983 1990 failure E63 Sign_symptom:T103 T104 Biological_structure 1977 1982 liver R36 MODIFY Arg1:T104 Arg2:E63 T105 Biological_structure 1967 1972 renal R37 MODIFY Arg1:T105 Arg2:E63 R38 CAUSE Arg1:E62 Arg2:E63 T106 Coreference 2018 2032 cardiomyopathy E64 Coreference:T106 R39 IDENTICAL Arg1:E64 Arg2:E61 T107 Detailed_description 2005 2017 drug-induced R40 MODIFY Arg1:T107 Arg2:E64 T108 Medication 2037 2052 methylphenidate E65 Medication:T108 T109 Medication 2057 2076 quetiapine fumarate E66 Medication:T109 A3 POLARITY E66 NEG A4 POLARITY E65 NEG T110 Diagnostic_procedure 2096 2130 Screening for infectious pathogens E67 Diagnostic_procedure:T110 T111 Diagnostic_procedure 2132 2153 immunological markers E68 Diagnostic_procedure:T111 T112 Diagnostic_procedure 2159 2163 iron E69 Diagnostic_procedure:T112 T113 Diagnostic_procedure 2167 2185 amyloid deposition E70 Diagnostic_procedure:T113 T114 Lab_value 2195 2203 negative R41 MODIFY Arg1:T114 Arg2:E70 R42 MODIFY Arg1:T114 Arg2:E69 R43 MODIFY Arg1:T114 Arg2:E68 R44 MODIFY Arg1:T114 Arg2:E67 T115 Nonbiological_location 2248 2288 National Hospital (Rikshospitalet, Oslo) T116 Medication 2302 2315 noradrenaline E71 Medication:T116 T117 Medication 2320 2330 dobutamine E72 Medication:T117 T118 Administration 2331 2340 infusions R45 MODIFY Arg1:T118 Arg2:E72 R46 MODIFY Arg1:T118 Arg2:E71 T119 Therapeutic_procedure 2369 2393 intraaortic balloon pump E73 Therapeutic_procedure:T119 T120 Therapeutic_procedure 2395 2399 IABP E74 Therapeutic_procedure:T120 T121 Clinical_event 2356 2365 admission E75 Clinical_event:T121 T122 Coreference 2418 2431 noradrenaline E76 Coreference:T122 R47 IDENTICAL Arg1:E76 Arg2:E71 T123 Medication 2448 2461 nitroprusside E77 Medication:T123 T124 Diagnostic_procedure 2463 2483 Coronary angiography E78 Diagnostic_procedure:T124 T125 Lab_value 2488 2494 normal R48 MODIFY Arg1:T125 Arg2:E78 T126 Diagnostic_procedure 2511 2517 biopsy E79 Diagnostic_procedure:T126 T127 Biological_structure 2496 2510 Endomyocardial R49 MODIFY Arg1:T127 Arg2:E79 T128 Biological_structure 2527 2542 right ventricle R50 MODIFY Arg1:T128 Arg2:E79 T129 Disease_disorder 2571 2591 myocardial pathology E80 Disease_disorder:T129 A5 POLARITY E80 MAYBE_NEG R51 MODIFY Arg1:E80 Arg2:E79 T130 Coreference 2611 2615 IABP E81 Coreference:T130 T131 Coreference 2617 2630 nitroprusside E82 Coreference:T131 R52 IDENTICAL Arg1:E81 Arg2:E73 R53 IDENTICAL Arg1:E82 Arg2:E77 T133 Diagnostic_procedure 2696 2710 liver function E84 Diagnostic_procedure:T133 T134 Lab_value 2723 2729 normal R55 MODIFY Arg1:T134 Arg2:E84 T135 Diagnostic_procedure 2650 2668 clinical situation E85 Diagnostic_procedure:T135 T136 Lab_value 2679 2687 improved R56 MODIFY Arg1:T136 Arg2:E85 T137 Diagnostic_procedure 2735 2749 renal function E86 Diagnostic_procedure:T137 T138 Lab_value 2755 2763 improved R57 MODIFY Arg1:T138 Arg2:E86 T139 Sign_symptom 2780 2788 diuresis E87 Sign_symptom:T139 T140 Diagnostic_procedure 2793 2803 creatinine E88 Diagnostic_procedure:T140 T141 Lab_value 2814 2817 798 T142 Lab_value 2821 2830 98 μmol/l A6 TREND E88 DEC R58 MODIFY Arg1:T141 Arg2:E88 R59 MODIFY Arg1:T142 Arg2:E88 T143 Diagnostic_procedure 2836 2838 EF E89 Diagnostic_procedure:T143 T144 Lab_value 2867 2870 15% R60 MODIFY Arg1:T144 Arg2:E89 T145 Lab_value 2858 2865 reduced R61 MODIFY Arg1:T145 Arg2:E89 T146 Sign_symptom 2884 2903 behavioral problems E90 Sign_symptom:T146 T147 Sign_symptom 2908 2923 adipose stature E91 Sign_symptom:T147 T148 Therapeutic_procedure 2941 2957 heart transplant E92 Therapeutic_procedure:T148 A7 POLARITY E92 NEG T149 Clinical_event 2932 2938 denied E93 Clinical_event:T149 R62 CAUSE Arg1:E91 Arg2:E93 R63 CAUSE Arg1:E90 Arg2:E93 R64 MODIFY Arg1:E93 Arg2:E92 T150 Coreference 2979 2983 IABP E94 Coreference:T150 R65 IDENTICAL Arg1:E94 Arg2:E73 T151 Duration 2988 2995 26 days E95 Duration:T151 T152 Duration 3001 3014 after 28 days E96 Duration:T152 T153 Clinical_event 3022 3033 transferred E97 Clinical_event:T153 T154 Nonbiological_location 3042 3054 our hospital T155 Diagnostic_procedure 3073 3098 liver and renal functions E98 Diagnostic_procedure:T155 T156 Lab_value 3104 3110 normal R66 MODIFY Arg1:T156 Arg2:E98 T157 Medication 3135 3180 angiotensin-converting enzyme (ACE)-inhibitor E99 Medication:T157 T158 Medication 3184 3196 beta-blocker E100 Medication:T158 T159 Medication 3202 3211 diuretics E101 Medication:T159 T160 Clinical_event 3297 3307 discharged E102 Clinical_event:T160 T161 Duration 3234 3243 two weeks E103 Duration:T161 T162 Diagnostic_procedure 3248 3263 clinical status E104 Diagnostic_procedure:T162 T163 Lab_value 3264 3272 improved R67 MODIFY Arg1:T163 Arg2:E104 T164 Diagnostic_procedure 3325 3341 echocardiography E105 Diagnostic_procedure:T164 T165 Diagnostic_procedure 3392 3394 EF E106 Diagnostic_procedure:T165 T166 Lab_value 3398 3401 20% R68 MODIFY Arg1:T166 Arg2:E106 T167 Date 3406 3416 March 2007 E107 Date:T167 T168 Biological_structure 3372 3386 left ventricle T169 Lab_value 3364 3371 dilated T170 Diagnostic_procedure 3422 3437 clinical status E108 Diagnostic_procedure:T170 T171 Lab_value 3442 3450 improved R70 MODIFY Arg1:T171 Arg2:E108 T172 Diagnostic_procedure 3465 3479 function class E109 Diagnostic_procedure:T172 T173 Lab_value 3480 3482 II T175 Diagnostic_procedure 3520 3522 EF E111 Diagnostic_procedure:T175 T176 Diagnostic_procedure 3536 3552 echocardiography E112 Diagnostic_procedure:T176 T177 Lab_value 3556 3563 30%–35% R71 MODIFY Arg1:T177 Arg2:E111 R72 MODIFY Arg1:T29 Arg2:E20 R73 MODIFY Arg1:T58 Arg2:E38 R74 MODIFY Arg1:T62 Arg2:E40 R75 MODIFY Arg1:T77 Arg2:E47 R76 IDENTICAL Arg1:E2 Arg2:E1 R77 MODIFY Arg1:T173 Arg2:E109 T174 Detailed_description 3484 3510 New York Heart Association R78 MODIFY Arg1:T174 Arg2:E109 R79 SUB_PROCEDURE Arg1:E112 Arg2:E111 R80 MODIFY Arg1:T154 Arg2:E97 R81 MODIFY Arg1:T169 Arg2:E105 R69 MODIFY Arg1:T168 Arg2:E105 R82 MODIFY Arg1:T55 Arg2:E36 R83 MODIFY Arg1:T21 Arg2:E14 R84 IDENTICAL Arg1:E11 Arg2:E10 R85 IDENTICAL Arg1:E8 Arg2:E7 R86 MODIFY Arg1:T13 Arg2:E7 R87 MODIFY Arg1:T17 Arg2:E10 R88 MODIFY Arg1:T64 Arg2:E41 T178 Clinical_event 2229 2240 transferred E110 Clinical_event:T178 T179 Date 2205 2221 After three days E113 Date:T179 T180 Nonbiological_location 3311 3319 his home R89 MODIFY Arg1:T180 Arg2:E102 * OVERLAP E1 E3 E6 E4 R1 IDENTICAL Arg1:E5 Arg2:E4 R90 BEFORE Arg1:E4 Arg2:E7 * OVERLAP E7 E9 R91 BEFORE Arg1:E9 Arg2:E10 * OVERLAP E10 E12 R92 BEFORE Arg1:E12 Arg2:E13 * OVERLAP E13 E14 E15 E16 E17 E18 E19 E20 E21 E26 E27 E28 R93 MODIFY Arg1:T22 Arg2:E15 R94 BEFORE Arg1:E28 Arg2:E29 * OVERLAP E29 E30 E31 R95 BEFORE Arg1:E31 Arg2:E32 * OVERLAP E32 E33 R96 BEFORE Arg1:E33 Arg2:E34 * OVERLAP E34 E35 R97 BEFORE Arg1:E35 Arg2:E36 * OVERLAP E36 E37 E38 E39 E40 E41 E42 E44 E45 E46 E47 E49 E50 R98 IDENTICAL Arg1:E48 Arg2:E47 R99 BEFORE Arg1:E50 Arg2:E51 R100 BEFORE Arg1:E51 Arg2:E52 * OVERLAP E52 E54 R101 BEFORE Arg1:E54 Arg2:E56 * OVERLAP E56 E57 E58 E59 E60 E61 E62 E63 E65 E66 E67 E68 E69 E70 R102 BEFORE Arg1:E70 Arg2:E113 * OVERLAP E113 E110 E71 E72 E75 R103 MODIFY Arg1:T115 Arg2:E110 R104 BEFORE Arg1:E75 Arg2:E73 R105 IDENTICAL Arg1:E74 Arg2:E73 * OVERLAP E73 E77 E78 R106 BEFORE Arg1:E78 Arg2:E79 * OVERLAP E79 E80 E83 E85 E84 E86 E87 E88 E89 T132 Therapeutic_procedure 2636 2644 dialysis E83 Therapeutic_procedure:T132 R54 BEFORE Arg1:E89 Arg2:E90 * OVERLAP E90 E91 E93 E92 R107 BEFORE Arg1:E92 Arg2:E94 * OVERLAP E94 E95 R108 BEFORE Arg1:E95 Arg2:E96 * OVERLAP E96 E97 E98 E99 E100 E101 R109 BEFORE Arg1:E101 Arg2:E103 * OVERLAP E103 E104 R110 BEFORE Arg1:E104 Arg2:E102 * OVERLAP E102 E105 E106 R111 BEFORE Arg1:E106 Arg2:E107 * OVERLAP E107 E108 E109 E111