a b/processing/MACCROBAT/18416479.ann
1
T1  Age 2 13    74-year-old
2
T2  Sex 14 17   man
3
T3  Clinical_event 22 30    referred
4
E1  Clinical_event:T3 
5
T4  Nonbiological_location 38 46    hospital
6
T5  Date 50 63  November 2000
7
E2  Date:T5 
8
T6  Sign_symptom 75 92  liver dysfunction
9
E3  Sign_symptom:T6 
10
T7  Disease_disorder 164 182    nephrotic syndrome
11
E4  Disease_disorder:T7 
12
T8  Date 186 190    1995
13
E5  Date:T8 
14
T9  Clinical_event 111 126  medical checkup
15
E6  Clinical_event:T9 
16
T10 Diagnostic_procedure 192 215    Laboratory examinations
17
E7  Diagnostic_procedure:T10 
18
T11 Diagnostic_procedure 232 259    serum hepatobiliary enzymes
19
E8  Diagnostic_procedure:T11 
20
T12 Lab_value 223 231   elevated
21
R1  MODIFY Arg1:T12 Arg2:E8 
22
T13 Diagnostic_procedure 264 267    IgM
23
E9  Diagnostic_procedure:T13 
24
R2  MODIFY Arg1:T12 Arg2:E9 
25
T14 Diagnostic_procedure 289 317    antimitochondrial antibodies
26
E10 Diagnostic_procedure:T14 
27
T15 Lab_value 277 285   presence
28
R3  MODIFY Arg1:T15 Arg2:E10    
29
T16 Diagnostic_procedure 341 352    Hepatitis B
30
E11 Diagnostic_procedure:T16 
31
T17 Diagnostic_procedure 319 336    Serologic markers
32
E12 Diagnostic_procedure:T17 
33
R4  SUB_PROCEDURE Arg1:E11 Arg2:E12 
34
T18 Diagnostic_procedure 341 350;357 358    Hepatitis C
35
E13 Diagnostic_procedure:T18 
36
R5  SUB_PROCEDURE Arg1:E13 Arg2:E12 
37
T19 Lab_value 372 380   negative
38
R6  MODIFY Arg1:T19 Arg2:E13    
39
R7  MODIFY Arg1:T19 Arg2:E11    
40
T20 Diagnostic_procedure 382 409    Histopathologic examination
41
E14 Diagnostic_procedure:T20 
42
T21 Diagnostic_procedure 421 436    biopsy specimen
43
E15 Diagnostic_procedure:T21 
44
T22 Biological_structure 415 420    liver
45
R8  MODIFY Arg1:T22 Arg2:E15    
46
T23 Therapeutic_procedure 449 460   laparoscopy
47
E16 Therapeutic_procedure:T23 
48
R9  MODIFY Arg1:E16 Arg2:E15    
49
T24 Disease_disorder 498 509    cholangitis
50
E17 Disease_disorder:T24 
51
T25 Detailed_description 470 485    non-suppurative
52
T26 Detailed_description 486 497    destructive
53
T27 Biological_structure 517 528    portal area
54
R10 MODIFY Arg1:T26 Arg2:E17    
55
R11 MODIFY Arg1:T25 Arg2:E17    
56
R12 MODIFY Arg1:T27 Arg2:E17    
57
T28 Disease_disorder 559 562    PBC
58
E18 Disease_disorder:T28 
59
T29 Disease_disorder 564 579    Scheuer stage 3
60
E19 Disease_disorder:T29 
61
R13 MODIFY Arg1:E19 Arg2:E18    
62
T30 Medication 599 619  ursodeoxycholic acid
63
E20 Medication:T30 
64
T31 Dosage 621 627  900 mg
65
T32 Frequency 628 633   daily
66
T33 Date 651 672    January and June 2002
67
E21 Date:T33 
68
T35 Therapeutic_procedure 696 724   endoscopic variceal ligation
69
E23 Therapeutic_procedure:T35 
70
T36 Therapeutic_procedure 730 764   endoscopic injection sclerotherapy
71
E24 Therapeutic_procedure:T36 
72
T37 Therapeutic_procedure 776 800   argon plasma coagulation
73
E25 Therapeutic_procedure:T37 
74
T38 Sign_symptom 815 833    esophageal varices
75
E26 Sign_symptom:T38 
76
T39 Severity 805 814    worsening
77
R14 MODIFY Arg1:T39 Arg2:E26    
78
T40 Date 838 852    September 2007
79
E27 Date:T40 
80
T41 Clinical_event 870 878  admitted
81
E28 Clinical_event:T41 
82
T42 Sign_symptom 910 928    esophageal varices
83
E29 Sign_symptom:T42 
84
T43 Severity 900 909    recurrent
85
R15 MODIFY Arg1:T43 Arg2:E29    
86
T44 Diagnostic_procedure 934 948    platelet count
87
E30 Diagnostic_procedure:T44 
88
T45 Lab_value 968 978   52 × 109/L
89
T46 Lab_value 983 993   69 × 109/L
90
R16 MODIFY Arg1:T45 Arg2:E30    
91
R17 MODIFY Arg1:T46 Arg2:E30    
92
T47 Duration 998 1011   several years
93
E31 Duration:T47 
94
R18 MODIFY Arg1:E31 Arg2:E30    
95
T48 Lab_value 1033 1041 decrease
96
T49 Lab_value 1047 1057 61 × 109/L
97
T50 Date 1061 1070  June 2007
98
E32 Date:T50 
99
T51 Lab_value 1074 1083 8 × 109/L
100
T52 Date 1084 1105  just before admission
101
E33 Date:T52 
102
T53 Coreference 1017 1019   it
103
E34 Coreference:T53 
104
R19 IDENTICAL Arg1:E34 Arg2:E30 
105
T54 Sign_symptom 1135 1151  thrombocytopenia
106
E35 Sign_symptom:T54 
107
T55 Detailed_description 1118 1131  deterioration
108
R20 MODIFY Arg1:T55 Arg2:E35    
109
T56 Disease_disorder 1172 1191  infectious diseases
110
E36 Disease_disorder:T56 
111
A1  POLARITY E36 NEG
112
T57 Medication 1214 1224    medication
113
E37 Medication:T57 
114
A2  POLARITY E37 NEG
115
T58 Date 1229 1238  admission
116
E38 Date:T58 
117
T59 Sign_symptom 1264 1271  purpura
118
E39 Sign_symptom:T59 
119
A3  POLARITY E39 NEG
120
T60 Sign_symptom 1276 1293  bleeding episodes
121
E40 Sign_symptom:T60 
122
A4  POLARITY E40 NEG
123
T61 Diagnostic_procedure 1347 1376  platelet-associated IgG level
124
E41 Diagnostic_procedure:T61 
125
T62 Lab_value 1390 1394 high
126
T63 Detailed_description 1381 1389  markedly
127
R21 MODIFY Arg1:T63 Arg2:T62    
128
R22 MODIFY Arg1:T62 Arg2:E41    
129
T64 Diagnostic_procedure 1408 1414  biopsy
130
E42 Diagnostic_procedure:T64 
131
T65 Biological_structure 1396 1407  Bone marrow
132
R23 MODIFY Arg1:T65 Arg2:E42    
133
T66 Sign_symptom 1424 1444  normocellular marrow
134
E43 Sign_symptom:T66 
135
T67 Sign_symptom 1453 1468  cellular atypia
136
E44 Sign_symptom:T67 
137
A5  POLARITY E44 NEG
138
T68 Diagnostic_procedure 1470 1485  Ultrasonography
139
E45 Diagnostic_procedure:T68 
140
T69 Diagnostic_procedure 1490 1516  magnetic resonance imaging
141
E46 Diagnostic_procedure:T69 
142
T70 Sign_symptom 1528 1537  cirrhotic
143
E47 Sign_symptom:T70 
144
T71 Biological_structure 1538 1543  liver
145
R24 MODIFY Arg1:T71 Arg2:E47    
146
T72 Sign_symptom 1549 1561  splenomegaly
147
E48 Sign_symptom:T72 
148
T73 Sign_symptom 1563 1570  ascites
149
E49 Sign_symptom:T73 
150
T74 Sign_symptom 1576 1586  gallstones
151
E50 Sign_symptom:T74 
152
T75 Diagnostic_procedure 1592 1603  spleen size
153
E51 Diagnostic_procedure:T75 
154
T76 Lab_value 1617 1626 unchanged
155
R25 MODIFY Arg1:T76 Arg2:E51    
156
T77 Detailed_description 1632 1640  previous
157
T78 Diagnostic_procedure 1641 1661  imaging examinations
158
E52 Diagnostic_procedure:T78 
159
R26 MODIFY Arg1:T77 Arg2:E52    
160
R27 MODIFY Arg1:E52 Arg2:T76    
161
T79 Disease_disorder 1707 1710  PBC
162
E53 Disease_disorder:T79 
163
T80 Disease_disorder 1712 1741  decompensated liver cirrhosis
164
E54 Disease_disorder:T80 
165
T81 Disease_disorder 1748 1751  ITP
166
E55 Disease_disorder:T81 
167
T82 Diagnostic_procedure 1767 1807  Human leukocyte antigen (HLA) genotyping
168
E56 Diagnostic_procedure:T82 
169
T83 Diagnostic_procedure 1822 1871  polymerase chain reaction-sequencing-based typing
170
E57 Diagnostic_procedure:T83 
171
T84 Diagnostic_procedure 1875 1926  polymerase chain reaction-sequence specific primers
172
E58 Diagnostic_procedure:T84 
173
R28 SUB_PROCEDURE Arg1:E57 Arg2:E56 
174
R29 SUB_PROCEDURE Arg1:E58 Arg2:E56 
175
T85 Sign_symptom 1962 1972  A*02010101
176
E59 Sign_symptom:T85 
177
T86 Sign_symptom 1974 1982  B*400201
178
E60 Sign_symptom:T86 
179
T87 Sign_symptom 1984 1992  C*030401
180
E61 Sign_symptom:T87 
181
T88 Sign_symptom 1994 2004  C*07020101
182
E62 Sign_symptom:T88 
183
T89 Sign_symptom 2006 2015  DPB1*0501
184
E63 Sign_symptom:T89 
185
T90 Sign_symptom 2017 2026  DQA1*0103
186
E64 Sign_symptom:T90 
187
T91 Sign_symptom 2028 2039  DQA1*030101
188
E65 Sign_symptom:T91 
189
T92 Sign_symptom 2041 2052  DQB1*030201
190
E66 Sign_symptom:T92 
191
T93 Sign_symptom 2054 2065  DQB1*060101
192
E67 Sign_symptom:T93 
193
T94 Sign_symptom 2067 2078  DRB1*080201
194
E68 Sign_symptom:T94 
195
T95 Sign_symptom 2084 2095  DRB1*080302
196
E69 Sign_symptom:T95 
197
T96 Diagnostic_procedure 2101 2121  13C urea breath test
198
E70 Diagnostic_procedure:T96 
199
T97 Diagnostic_procedure 2126 2144  H pylori infection
200
E71 Diagnostic_procedure:T97 
201
R30 SUB_PROCEDURE Arg1:E70 Arg2:E71 
202
T98 Lab_value 2149 2157 negative
203
R31 MODIFY Arg1:T98 Arg2:E71    
204
T99 Medication 2201 2213    prednisolone
205
E72 Medication:T99 
206
T100    Administration 2196 2200    Oral
207
R32 MODIFY Arg1:T100 Arg2:E72   
208
T101    Dosage 2215 2220    30 mg
209
T102    Frequency 2221 2226 daily
210
T103    Coreference 2232 2235   ITP
211
E73 Coreference:T103 
212
R33 IDENTICAL Arg1:E73 Arg2:E55 
213
T104    Date 2251 2257  day 11
214
E74 Date:T104 
215
T105    Medication 2263 2279    diuretic therapy
216
E75 Medication:T105 
217
T106    Medication 2294 2310    albumin infusion
218
E76 Medication:T106 
219
R34 CAUSE Arg1:E73 Arg2:E72 
220
T107    Sign_symptom 2315 2322  ascites
221
E77 Sign_symptom:T107 
222
R35 CAUSE Arg1:E77 Arg2:E76 
223
R36 CAUSE Arg1:E77 Arg2:E75 
224
T108    Diagnostic_procedure 2345 2359  platelet count
225
E78 Diagnostic_procedure:T108 
226
T109    Lab_value 2360 2384 did not increase notably
227
R37 MODIFY Arg1:T109 Arg2:E78   
228
T110    Medication 2386 2399    pulse therapy
229
E79 Medication:T110 
230
T111    Administration 2405 2416    intravenous
231
T112    Medication 2417 2435    methylprednisolone
232
E80 Medication:T112 
233
R38 MODIFY Arg1:T111 Arg2:E80   
234
T113    Dosage 2437 2440    1 g
235
T114    Frequency 2441 2446 daily
236
T115    Duration 2461 2471  d 22 to 24
237
E81 Duration:T115 
238
T116    Coreference 2486 2494   response
239
E82 Coreference:T116 
240
R40 IDENTICAL Arg1:E82 Arg2:E78 
241
T117    Lab_value 2499 2503 weak
242
R41 MODIFY Arg1:T117 Arg2:E82   
243
T118    Detailed_description 2508 2517  temporary
244
R42 MODIFY Arg1:T118 Arg2:E82   
245
T119    Date 2522 2526  d 31
246
E83 Date:T119 
247
T120    Sign_symptom 2533 2539  melena
248
E84 Sign_symptom:T120 
249
T121    Severity 2528 2532  mild
250
R43 MODIFY Arg1:T121 Arg2:E84   
251
T122    Medication 2601 2630    immune gamma globulin therapy
252
E85 Medication:T122 
253
T123    Administration 2589 2600    intravenous
254
R44 MODIFY Arg1:T123 Arg2:E85   
255
T124    Detailed_description 2580 2585  trial
256
R45 MODIFY Arg1:T124 Arg2:E85   
257
T125    Dosage 2632 2636    25 g
258
T126    Frequency 2637 2642 daily
259
R46 MODIFY Arg1:T126 Arg2:E85   
260
T127    Duration 2647 2657  d 32 to 36
261
E86 Duration:T127 
262
T128    Medication 2703 2735    methylprednisolone pulse therapy
263
E87 Medication:T128 
264
T129    Administration 2691 2702    intravenous
265
T130    Detailed_description 2675 2687  second round
266
R47 MODIFY Arg1:T130 Arg2:E87   
267
R48 MODIFY Arg1:T129 Arg2:E87   
268
T131    Duration 2739 2749  d 32 to 34
269
E88 Duration:T131 
270
T132    Coreference 2770 2778   response
271
E89 Coreference:T132 
272
T133    Diagnostic_procedure 2829 2843  platelet count
273
E90 Diagnostic_procedure:T133 
274
R49 IDENTICAL Arg1:E89 Arg2:E78 
275
T134    Lab_value 2761 2769 moderate
276
R50 MODIFY Arg1:T134 Arg2:E89   
277
T135    Medication 2793 2805    prednisolone
278
E91 Medication:T135 
279
T136    Clinical_event 2810 2819    continued
280
E92 Clinical_event:T136 
281
R51 MODIFY Arg1:E92 Arg2:E91    
282
T137    Lab_value 2844 2860 increased slowly
283
R52 MODIFY Arg1:T137 Arg2:E90   
284
T138    Sign_symptom 2866 2904  ascites was relatively well controlled
285
E93 Sign_symptom:T138 
286
T139    Medication 2910 2919    diuretics
287
E94 Medication:T139 
288
R53 CAUSE Arg1:E94 Arg2:E93 
289
T140    Clinical_event 2923 2932    discharge
290
E95 Clinical_event:T140 
291
T141    Disease_disorder 2950 2979  decompensated liver cirrhosis
292
E96 Disease_disorder:T141 
293
T142    Diagnostic_procedure 2988 3002  platelet count
294
E97 Diagnostic_procedure:T142 
295
T143    Clinical_event 3047 3056    follow-up
296
E98 Clinical_event:T143 
297
T144    Sign_symptom 3060 3078  esophageal varices
298
E99 Sign_symptom:T144 
299
T145    Therapeutic_procedure 3087 3118 prophylactic endoscopic therapy
300
E100    Therapeutic_procedure:T145 
301
A6  POLARITY E100 NEG
302
R54 MODIFY Arg1:T4 Arg2:E1  
303
*   OVERLAP E1 E2 E3
304
R55 AFTER Arg1:E3 Arg2:E6   
305
R56 AFTER Arg1:E6 Arg2:E4   
306
*   OVERLAP E4 E5
307
R57 BEFORE Arg1:E5 Arg2:E7  
308
*   OVERLAP E7 E8 E9 E10 E12 E14 E15 E17 E18
309
R58 MODIFY Arg1:T31 Arg2:E20    
310
R59 MODIFY Arg1:T32 Arg2:E20    
311
R60 BEFORE Arg1:E18 Arg2:E20    
312
R61 BEFORE Arg1:E20 Arg2:E21    
313
R63 BEFORE Arg1:E26 Arg2:E27    
314
*   OVERLAP E27 E28 E29
315
R64 AFTER Arg1:E29 Arg2:E30 
316
R65 BEFORE Arg1:E30 Arg2:E34    
317
R66 MODIFY Arg1:T48 Arg2:E34    
318
R67 MODIFY Arg1:T49 Arg2:E34    
319
R68 MODIFY Arg1:E32 Arg2:T49    
320
R69 MODIFY Arg1:T51 Arg2:E34    
321
R70 MODIFY Arg1:E33 Arg2:T51    
322
R71 BEFORE Arg1:E34 Arg2:E32    
323
R72 BEFORE Arg1:E32 Arg2:E33    
324
*   OVERLAP E33 E35
325
R73 AFTER Arg1:E35 Arg2:E36 
326
*   OVERLAP E36 E37
327
R74 BEFORE Arg1:E37 Arg2:E38    
328
*   OVERLAP E38 E39 E40 E41 E42 E43 E44 E45 E46 E47 E48 E49 E50 E51
329
R75 BEFORE Arg1:E51 Arg2:E53    
330
R76 IDENTICAL Arg1:E53 Arg2:E54 
331
*   OVERLAP E53 E55 E56 E59 E60 E61 E62 E63 E64 E65 E66 E67 E68 E69 E70
332
R77 BEFORE Arg1:E70 Arg2:E72    
333
R78 MODIFY Arg1:T101 Arg2:E72   
334
R79 MODIFY Arg1:T102 Arg2:E72   
335
*   OVERLAP E72 E74 E75 E76
336
R80 BEFORE Arg1:E76 Arg2:E78    
337
*   OVERLAP E78 E79 E80 E81
338
R39 MODIFY Arg1:T113 Arg2:E80   
339
R81 MODIFY Arg1:T114 Arg2:E80   
340
R82 BEFORE Arg1:E81 Arg2:E82    
341
R83 BEFORE Arg1:E82 Arg2:E83    
342
R84 MODIFY Arg1:T125 Arg2:E85   
343
*   OVERLAP E83 E84
344
R85 BEFORE Arg1:E84 Arg2:E85    
345
*   OVERLAP E85 E86 E87 E88
346
R86 BEFORE Arg1:E88 Arg2:E89    
347
*   OVERLAP E89 E91 E90
348
R87 BEFORE Arg1:E90 Arg2:E93    
349
*   OVERLAP E93 E95 E96 E97
350
R88 MODIFY Arg1:E99 Arg2:E98    
351
R89 BEFORE Arg1:E97 Arg2:E98    
352
*   OVERLAP E98 E100
353
*   OVERLAP E21 E23 E24 E25 E26