Downloads: 1
354 lines (353 with data), 11.7 kB
T1 Age 2 13 74-year-old T2 Sex 14 17 man T3 Clinical_event 22 30 referred E1 Clinical_event:T3 T4 Nonbiological_location 38 46 hospital T5 Date 50 63 November 2000 E2 Date:T5 T6 Sign_symptom 75 92 liver dysfunction E3 Sign_symptom:T6 T7 Disease_disorder 164 182 nephrotic syndrome E4 Disease_disorder:T7 T8 Date 186 190 1995 E5 Date:T8 T9 Clinical_event 111 126 medical checkup E6 Clinical_event:T9 T10 Diagnostic_procedure 192 215 Laboratory examinations E7 Diagnostic_procedure:T10 T11 Diagnostic_procedure 232 259 serum hepatobiliary enzymes E8 Diagnostic_procedure:T11 T12 Lab_value 223 231 elevated R1 MODIFY Arg1:T12 Arg2:E8 T13 Diagnostic_procedure 264 267 IgM E9 Diagnostic_procedure:T13 R2 MODIFY Arg1:T12 Arg2:E9 T14 Diagnostic_procedure 289 317 antimitochondrial antibodies E10 Diagnostic_procedure:T14 T15 Lab_value 277 285 presence R3 MODIFY Arg1:T15 Arg2:E10 T16 Diagnostic_procedure 341 352 Hepatitis B E11 Diagnostic_procedure:T16 T17 Diagnostic_procedure 319 336 Serologic markers E12 Diagnostic_procedure:T17 R4 SUB_PROCEDURE Arg1:E11 Arg2:E12 T18 Diagnostic_procedure 341 350;357 358 Hepatitis C E13 Diagnostic_procedure:T18 R5 SUB_PROCEDURE Arg1:E13 Arg2:E12 T19 Lab_value 372 380 negative R6 MODIFY Arg1:T19 Arg2:E13 R7 MODIFY Arg1:T19 Arg2:E11 T20 Diagnostic_procedure 382 409 Histopathologic examination E14 Diagnostic_procedure:T20 T21 Diagnostic_procedure 421 436 biopsy specimen E15 Diagnostic_procedure:T21 T22 Biological_structure 415 420 liver R8 MODIFY Arg1:T22 Arg2:E15 T23 Therapeutic_procedure 449 460 laparoscopy E16 Therapeutic_procedure:T23 R9 MODIFY Arg1:E16 Arg2:E15 T24 Disease_disorder 498 509 cholangitis E17 Disease_disorder:T24 T25 Detailed_description 470 485 non-suppurative T26 Detailed_description 486 497 destructive T27 Biological_structure 517 528 portal area R10 MODIFY Arg1:T26 Arg2:E17 R11 MODIFY Arg1:T25 Arg2:E17 R12 MODIFY Arg1:T27 Arg2:E17 T28 Disease_disorder 559 562 PBC E18 Disease_disorder:T28 T29 Disease_disorder 564 579 Scheuer stage 3 E19 Disease_disorder:T29 R13 MODIFY Arg1:E19 Arg2:E18 T30 Medication 599 619 ursodeoxycholic acid E20 Medication:T30 T31 Dosage 621 627 900 mg T32 Frequency 628 633 daily T33 Date 651 672 January and June 2002 E21 Date:T33 T35 Therapeutic_procedure 696 724 endoscopic variceal ligation E23 Therapeutic_procedure:T35 T36 Therapeutic_procedure 730 764 endoscopic injection sclerotherapy E24 Therapeutic_procedure:T36 T37 Therapeutic_procedure 776 800 argon plasma coagulation E25 Therapeutic_procedure:T37 T38 Sign_symptom 815 833 esophageal varices E26 Sign_symptom:T38 T39 Severity 805 814 worsening R14 MODIFY Arg1:T39 Arg2:E26 T40 Date 838 852 September 2007 E27 Date:T40 T41 Clinical_event 870 878 admitted E28 Clinical_event:T41 T42 Sign_symptom 910 928 esophageal varices E29 Sign_symptom:T42 T43 Severity 900 909 recurrent R15 MODIFY Arg1:T43 Arg2:E29 T44 Diagnostic_procedure 934 948 platelet count E30 Diagnostic_procedure:T44 T45 Lab_value 968 978 52 × 109/L T46 Lab_value 983 993 69 × 109/L R16 MODIFY Arg1:T45 Arg2:E30 R17 MODIFY Arg1:T46 Arg2:E30 T47 Duration 998 1011 several years E31 Duration:T47 R18 MODIFY Arg1:E31 Arg2:E30 T48 Lab_value 1033 1041 decrease T49 Lab_value 1047 1057 61 × 109/L T50 Date 1061 1070 June 2007 E32 Date:T50 T51 Lab_value 1074 1083 8 × 109/L T52 Date 1084 1105 just before admission E33 Date:T52 T53 Coreference 1017 1019 it E34 Coreference:T53 R19 IDENTICAL Arg1:E34 Arg2:E30 T54 Sign_symptom 1135 1151 thrombocytopenia E35 Sign_symptom:T54 T55 Detailed_description 1118 1131 deterioration R20 MODIFY Arg1:T55 Arg2:E35 T56 Disease_disorder 1172 1191 infectious diseases E36 Disease_disorder:T56 A1 POLARITY E36 NEG T57 Medication 1214 1224 medication E37 Medication:T57 A2 POLARITY E37 NEG T58 Date 1229 1238 admission E38 Date:T58 T59 Sign_symptom 1264 1271 purpura E39 Sign_symptom:T59 A3 POLARITY E39 NEG T60 Sign_symptom 1276 1293 bleeding episodes E40 Sign_symptom:T60 A4 POLARITY E40 NEG T61 Diagnostic_procedure 1347 1376 platelet-associated IgG level E41 Diagnostic_procedure:T61 T62 Lab_value 1390 1394 high T63 Detailed_description 1381 1389 markedly R21 MODIFY Arg1:T63 Arg2:T62 R22 MODIFY Arg1:T62 Arg2:E41 T64 Diagnostic_procedure 1408 1414 biopsy E42 Diagnostic_procedure:T64 T65 Biological_structure 1396 1407 Bone marrow R23 MODIFY Arg1:T65 Arg2:E42 T66 Sign_symptom 1424 1444 normocellular marrow E43 Sign_symptom:T66 T67 Sign_symptom 1453 1468 cellular atypia E44 Sign_symptom:T67 A5 POLARITY E44 NEG T68 Diagnostic_procedure 1470 1485 Ultrasonography E45 Diagnostic_procedure:T68 T69 Diagnostic_procedure 1490 1516 magnetic resonance imaging E46 Diagnostic_procedure:T69 T70 Sign_symptom 1528 1537 cirrhotic E47 Sign_symptom:T70 T71 Biological_structure 1538 1543 liver R24 MODIFY Arg1:T71 Arg2:E47 T72 Sign_symptom 1549 1561 splenomegaly E48 Sign_symptom:T72 T73 Sign_symptom 1563 1570 ascites E49 Sign_symptom:T73 T74 Sign_symptom 1576 1586 gallstones E50 Sign_symptom:T74 T75 Diagnostic_procedure 1592 1603 spleen size E51 Diagnostic_procedure:T75 T76 Lab_value 1617 1626 unchanged R25 MODIFY Arg1:T76 Arg2:E51 T77 Detailed_description 1632 1640 previous T78 Diagnostic_procedure 1641 1661 imaging examinations E52 Diagnostic_procedure:T78 R26 MODIFY Arg1:T77 Arg2:E52 R27 MODIFY Arg1:E52 Arg2:T76 T79 Disease_disorder 1707 1710 PBC E53 Disease_disorder:T79 T80 Disease_disorder 1712 1741 decompensated liver cirrhosis E54 Disease_disorder:T80 T81 Disease_disorder 1748 1751 ITP E55 Disease_disorder:T81 T82 Diagnostic_procedure 1767 1807 Human leukocyte antigen (HLA) genotyping E56 Diagnostic_procedure:T82 T83 Diagnostic_procedure 1822 1871 polymerase chain reaction-sequencing-based typing E57 Diagnostic_procedure:T83 T84 Diagnostic_procedure 1875 1926 polymerase chain reaction-sequence specific primers E58 Diagnostic_procedure:T84 R28 SUB_PROCEDURE Arg1:E57 Arg2:E56 R29 SUB_PROCEDURE Arg1:E58 Arg2:E56 T85 Sign_symptom 1962 1972 A*02010101 E59 Sign_symptom:T85 T86 Sign_symptom 1974 1982 B*400201 E60 Sign_symptom:T86 T87 Sign_symptom 1984 1992 C*030401 E61 Sign_symptom:T87 T88 Sign_symptom 1994 2004 C*07020101 E62 Sign_symptom:T88 T89 Sign_symptom 2006 2015 DPB1*0501 E63 Sign_symptom:T89 T90 Sign_symptom 2017 2026 DQA1*0103 E64 Sign_symptom:T90 T91 Sign_symptom 2028 2039 DQA1*030101 E65 Sign_symptom:T91 T92 Sign_symptom 2041 2052 DQB1*030201 E66 Sign_symptom:T92 T93 Sign_symptom 2054 2065 DQB1*060101 E67 Sign_symptom:T93 T94 Sign_symptom 2067 2078 DRB1*080201 E68 Sign_symptom:T94 T95 Sign_symptom 2084 2095 DRB1*080302 E69 Sign_symptom:T95 T96 Diagnostic_procedure 2101 2121 13C urea breath test E70 Diagnostic_procedure:T96 T97 Diagnostic_procedure 2126 2144 H pylori infection E71 Diagnostic_procedure:T97 R30 SUB_PROCEDURE Arg1:E70 Arg2:E71 T98 Lab_value 2149 2157 negative R31 MODIFY Arg1:T98 Arg2:E71 T99 Medication 2201 2213 prednisolone E72 Medication:T99 T100 Administration 2196 2200 Oral R32 MODIFY Arg1:T100 Arg2:E72 T101 Dosage 2215 2220 30 mg T102 Frequency 2221 2226 daily T103 Coreference 2232 2235 ITP E73 Coreference:T103 R33 IDENTICAL Arg1:E73 Arg2:E55 T104 Date 2251 2257 day 11 E74 Date:T104 T105 Medication 2263 2279 diuretic therapy E75 Medication:T105 T106 Medication 2294 2310 albumin infusion E76 Medication:T106 R34 CAUSE Arg1:E73 Arg2:E72 T107 Sign_symptom 2315 2322 ascites E77 Sign_symptom:T107 R35 CAUSE Arg1:E77 Arg2:E76 R36 CAUSE Arg1:E77 Arg2:E75 T108 Diagnostic_procedure 2345 2359 platelet count E78 Diagnostic_procedure:T108 T109 Lab_value 2360 2384 did not increase notably R37 MODIFY Arg1:T109 Arg2:E78 T110 Medication 2386 2399 pulse therapy E79 Medication:T110 T111 Administration 2405 2416 intravenous T112 Medication 2417 2435 methylprednisolone E80 Medication:T112 R38 MODIFY Arg1:T111 Arg2:E80 T113 Dosage 2437 2440 1 g T114 Frequency 2441 2446 daily T115 Duration 2461 2471 d 22 to 24 E81 Duration:T115 T116 Coreference 2486 2494 response E82 Coreference:T116 R40 IDENTICAL Arg1:E82 Arg2:E78 T117 Lab_value 2499 2503 weak R41 MODIFY Arg1:T117 Arg2:E82 T118 Detailed_description 2508 2517 temporary R42 MODIFY Arg1:T118 Arg2:E82 T119 Date 2522 2526 d 31 E83 Date:T119 T120 Sign_symptom 2533 2539 melena E84 Sign_symptom:T120 T121 Severity 2528 2532 mild R43 MODIFY Arg1:T121 Arg2:E84 T122 Medication 2601 2630 immune gamma globulin therapy E85 Medication:T122 T123 Administration 2589 2600 intravenous R44 MODIFY Arg1:T123 Arg2:E85 T124 Detailed_description 2580 2585 trial R45 MODIFY Arg1:T124 Arg2:E85 T125 Dosage 2632 2636 25 g T126 Frequency 2637 2642 daily R46 MODIFY Arg1:T126 Arg2:E85 T127 Duration 2647 2657 d 32 to 36 E86 Duration:T127 T128 Medication 2703 2735 methylprednisolone pulse therapy E87 Medication:T128 T129 Administration 2691 2702 intravenous T130 Detailed_description 2675 2687 second round R47 MODIFY Arg1:T130 Arg2:E87 R48 MODIFY Arg1:T129 Arg2:E87 T131 Duration 2739 2749 d 32 to 34 E88 Duration:T131 T132 Coreference 2770 2778 response E89 Coreference:T132 T133 Diagnostic_procedure 2829 2843 platelet count E90 Diagnostic_procedure:T133 R49 IDENTICAL Arg1:E89 Arg2:E78 T134 Lab_value 2761 2769 moderate R50 MODIFY Arg1:T134 Arg2:E89 T135 Medication 2793 2805 prednisolone E91 Medication:T135 T136 Clinical_event 2810 2819 continued E92 Clinical_event:T136 R51 MODIFY Arg1:E92 Arg2:E91 T137 Lab_value 2844 2860 increased slowly R52 MODIFY Arg1:T137 Arg2:E90 T138 Sign_symptom 2866 2904 ascites was relatively well controlled E93 Sign_symptom:T138 T139 Medication 2910 2919 diuretics E94 Medication:T139 R53 CAUSE Arg1:E94 Arg2:E93 T140 Clinical_event 2923 2932 discharge E95 Clinical_event:T140 T141 Disease_disorder 2950 2979 decompensated liver cirrhosis E96 Disease_disorder:T141 T142 Diagnostic_procedure 2988 3002 platelet count E97 Diagnostic_procedure:T142 T143 Clinical_event 3047 3056 follow-up E98 Clinical_event:T143 T144 Sign_symptom 3060 3078 esophageal varices E99 Sign_symptom:T144 T145 Therapeutic_procedure 3087 3118 prophylactic endoscopic therapy E100 Therapeutic_procedure:T145 A6 POLARITY E100 NEG R54 MODIFY Arg1:T4 Arg2:E1 * OVERLAP E1 E2 E3 R55 AFTER Arg1:E3 Arg2:E6 R56 AFTER Arg1:E6 Arg2:E4 * OVERLAP E4 E5 R57 BEFORE Arg1:E5 Arg2:E7 * OVERLAP E7 E8 E9 E10 E12 E14 E15 E17 E18 R58 MODIFY Arg1:T31 Arg2:E20 R59 MODIFY Arg1:T32 Arg2:E20 R60 BEFORE Arg1:E18 Arg2:E20 R61 BEFORE Arg1:E20 Arg2:E21 R63 BEFORE Arg1:E26 Arg2:E27 * OVERLAP E27 E28 E29 R64 AFTER Arg1:E29 Arg2:E30 R65 BEFORE Arg1:E30 Arg2:E34 R66 MODIFY Arg1:T48 Arg2:E34 R67 MODIFY Arg1:T49 Arg2:E34 R68 MODIFY Arg1:E32 Arg2:T49 R69 MODIFY Arg1:T51 Arg2:E34 R70 MODIFY Arg1:E33 Arg2:T51 R71 BEFORE Arg1:E34 Arg2:E32 R72 BEFORE Arg1:E32 Arg2:E33 * OVERLAP E33 E35 R73 AFTER Arg1:E35 Arg2:E36 * OVERLAP E36 E37 R74 BEFORE Arg1:E37 Arg2:E38 * OVERLAP E38 E39 E40 E41 E42 E43 E44 E45 E46 E47 E48 E49 E50 E51 R75 BEFORE Arg1:E51 Arg2:E53 R76 IDENTICAL Arg1:E53 Arg2:E54 * OVERLAP E53 E55 E56 E59 E60 E61 E62 E63 E64 E65 E66 E67 E68 E69 E70 R77 BEFORE Arg1:E70 Arg2:E72 R78 MODIFY Arg1:T101 Arg2:E72 R79 MODIFY Arg1:T102 Arg2:E72 * OVERLAP E72 E74 E75 E76 R80 BEFORE Arg1:E76 Arg2:E78 * OVERLAP E78 E79 E80 E81 R39 MODIFY Arg1:T113 Arg2:E80 R81 MODIFY Arg1:T114 Arg2:E80 R82 BEFORE Arg1:E81 Arg2:E82 R83 BEFORE Arg1:E82 Arg2:E83 R84 MODIFY Arg1:T125 Arg2:E85 * OVERLAP E83 E84 R85 BEFORE Arg1:E84 Arg2:E85 * OVERLAP E85 E86 E87 E88 R86 BEFORE Arg1:E88 Arg2:E89 * OVERLAP E89 E91 E90 R87 BEFORE Arg1:E90 Arg2:E93 * OVERLAP E93 E95 E96 E97 R88 MODIFY Arg1:E99 Arg2:E98 R89 BEFORE Arg1:E97 Arg2:E98 * OVERLAP E98 E100 * OVERLAP E21 E23 E24 E25 E26