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T1 Age 18 27 34-yr-old T2 Sex 28 31 man T3 Clinical_event 36 45 presented E1 Clinical_event:T3 T4 Sign_symptom 65 70 fever E2 Sign_symptom:T4 T5 Sign_symptom 85 90 cough E3 Sign_symptom:T5 T6 Detailed_description 77 84 chronic R1 MODIFY Arg1:T6 Arg2:E3 T7 History 101 107 smoker T8 History 118 151 history of pulmonary tuberculosis T9 Disease_disorder 139 151 tuberculosis E4 Disease_disorder:T9 T10 Biological_structure 129 138 pulmonary R2 MODIFY Arg1:T10 Arg2:E4 T13 Diagnostic_procedure 187 207 computed tomographic E7 Diagnostic_procedure:T13 T14 Diagnostic_procedure 208 212 (CT) E8 Diagnostic_procedure:T14 T15 Sign_symptom 241 248 nodules E9 Sign_symptom:T15 T16 Detailed_description 236 240 tiny R5 MODIFY Arg1:T16 Arg2:E9 T17 Detailed_description 227 235 multiple R6 MODIFY Arg1:T17 Arg2:E9 T18 Biological_structure 252 262 both lungs R7 MODIFY Arg1:T18 Arg2:E9 T19 Diagnostic_procedure 285 291 biopsy E10 Diagnostic_procedure:T19 T20 Biological_structure 280 284 lung R8 MODIFY Arg1:T20 Arg2:E10 T21 Detailed_description 266 279 thoracoscopic R9 MODIFY Arg1:T21 Arg2:E10 T22 Biological_structure 311 327 right upper lobe R10 MODIFY Arg1:T22 Arg2:E10 T23 Diagnostic_procedure 333 356 microscopic examination E11 Diagnostic_procedure:T23 T24 Sign_symptom 376 379 LCH E12 Sign_symptom:T24 #1 AnnotatorNotes E12 Langerhans cell histiocytosis T25 Coreference 385 396 tumor cells E13 Coreference:T25 R11 IDENTICAL Arg1:E13 Arg2:E12 T26 Biological_structure 423 429 nuclei T27 Texture 415 422 grooved T28 Detailed_description 401 410 vesicular R12 MODIFY Arg1:T27 Arg2:T26 R13 MODIFY Arg1:T28 Arg2:T26 T29 Biological_structure 466 488 around the bronchioles T30 Coreference 502 513 tumor cells E14 Coreference:T30 T31 Diagnostic_procedure 541 554 S-100 protein E15 Diagnostic_procedure:T31 #2 AnnotatorNotes E15 This is a Diagnostic Procedure because a test had to be run to detect presence of this protein. T32 Diagnostic_procedure 556 564 vimentin E16 Diagnostic_procedure:T32 T33 Diagnostic_procedure 566 570 CD68 E17 Diagnostic_procedure:T33 T34 Diagnostic_procedure 575 579 CD1a E18 Diagnostic_procedure:T34 T35 Lab_value 528 536 positive T36 Severity 519 527 strongly R15 MODIFY Arg1:T36 Arg2:T35 T37 Biological_attribute 447 452 small T38 Biological_attribute 453 465 aggregations R16 MODIFY Arg1:T37 Arg2:T38 R17 MODIFY Arg1:T38 Arg2:T29 R18 MODIFY Arg1:E15 Arg2:T35 R19 MODIFY Arg1:E16 Arg2:T35 R20 MODIFY Arg1:E16 Arg2:T35 R21 MODIFY Arg1:E17 Arg2:T35 R22 MODIFY Arg1:E18 Arg2:T35 R23 MODIFY Arg1:E14 Arg2:E15 R24 MODIFY Arg1:E14 Arg2:E16 R25 MODIFY Arg1:E14 Arg2:E17 R26 MODIFY Arg1:E14 Arg2:E18 T39 Biological_structure 609 620 lymphocytes T40 Biological_structure 625 636 eosinophils T41 Coreference 648 659 tumor cells E19 Coreference:T41 T42 Biological_structure 592 605 infiltrations R28 MODIFY Arg1:T42 Arg2:T39 R29 MODIFY Arg1:T42 Arg2:T40 R30 MODIFY Arg1:E19 Arg2:T42 T43 Diagnostic_procedure 688 711 radiologic examinations E20 Diagnostic_procedure:T43 T44 Sign_symptom 713 756 no other organs were thought to be involved E21 Sign_symptom:T44 A1 POLARITY E21 NEG T45 Activity 761 773 quit smoking E22 Activity:T45 #3 AnnotatorNotes E22 Note that this is an activity here though it was history before. A2 POLARITY E22 NEG T46 Sign_symptom 827 831 well E23 Sign_symptom:T46 T47 Duration 832 858 for the following one year E24 Duration:T47 T48 Diagnostic_procedure 884 891 CT scan E25 Diagnostic_procedure:T48 T49 Shape 922 932 4 cm-sized T50 Sign_symptom 933 937 mass E26 Sign_symptom:T50 T51 Biological_structure 945 960 left lower lobe R31 MODIFY Arg1:T49 Arg2:E26 R32 MODIFY Arg1:T51 Arg2:E26 T52 Biological_structure 1006 1016 both lungs T53 Detailed_description 981 989 multiple T54 Detailed_description 990 994 tiny T55 Sign_symptom 995 1002 nodules E27 Sign_symptom:T55 R33 MODIFY Arg1:T52 Arg2:E27 R34 MODIFY Arg1:T54 Arg2:E27 R35 MODIFY Arg1:T53 Arg2:E27 T56 Diagnostic_procedure 1035 1041 biopsy E28 Diagnostic_procedure:T56 T57 Detailed_description 1028 1034 needle R36 MODIFY Arg1:T57 Arg2:E28 T58 Sign_symptom 1064 1088 possibility of a sarcoma E29 Sign_symptom:T58 A3 POLARITY E29 MAYBE_POS T59 Therapeutic_procedure 1103 1112 lobectomy E30 Therapeutic_procedure:T59 T60 Shape 1139 1149 4 cm-sized T61 Detailed_description 1150 1170 poorly-circumscribed T62 Detailed_description 1171 1180 lobulated T63 Color 1181 1191 gray-white T64 Sign_symptom 1192 1196 mass E31 Sign_symptom:T64 T65 Detailed_description 1237 1242 small T66 Detailed_description 1243 1252 satellite T67 Sign_symptom 1253 1260 nodules E32 Sign_symptom:T67 T68 Coreference 1272 1281 main mass E33 Coreference:T68 R37 IDENTICAL Arg1:E33 Arg2:E31 R38 MODIFY Arg1:T66 Arg2:E32 R39 MODIFY Arg1:T65 Arg2:E32 R40 MODIFY Arg1:T63 Arg2:E31 R41 MODIFY Arg1:T62 Arg2:E31 R42 MODIFY Arg1:T61 Arg2:E31 R43 MODIFY Arg1:T60 Arg2:E31 T69 Diagnostic_procedure 1283 1298 Microscopically E34 Diagnostic_procedure:T69 T70 Coreference 1304 1315 tumor cells E35 Coreference:T70 T71 Detailed_description 1321 1347 aggregated in large sheets T72 Biological_structure 1367 1386 infiltrative growth R45 MODIFY Arg1:T71 Arg2:E35 R46 MODIFY Arg1:T72 Arg2:E35 T73 Coreference 1426 1437 tumor cells E36 Coreference:T73 T75 Detailed_description 1443 1481 similar to those seen in a typical LCH T76 Coreference 1497 1508 tumor cells E38 Coreference:T76 T74 Biological_attribute 1392 1410 cytologic features R49 MODIFY Arg1:T74 Arg2:E36 R50 MODIFY Arg1:T75 Arg2:T74 T77 Biological_attribute 1534 1552 cytologic features T78 Detailed_description 1561 1587 pleomorphic/hyperchromatic T79 Biological_structure 1588 1594 nuclei T80 Biological_attribute 1609 1617 nucleoli T81 Detailed_description 1599 1608 prominent R51 MODIFY Arg1:T81 Arg2:T80 R52 MODIFY Arg1:T78 Arg2:T79 T82 Biological_structure 1646 1663 tumor giant cells T83 Detailed_description 1631 1645 multinucleated R53 MODIFY Arg1:T83 Arg2:T82 R54 MODIFY Arg1:T77 Arg2:E38 R55 MODIFY Arg1:T79 Arg2:T77 R56 MODIFY Arg1:T80 Arg2:T77 R57 MODIFY Arg1:T82 Arg2:T77 T84 Lab_value 1730 1763 30 to 60 per 10 high power fields T85 Biological_structure 1701 1716 mitotic figures T86 Detailed_description 1692 1700 numerous R58 MODIFY Arg1:T86 Arg2:T85 R59 MODIFY Arg1:T84 Arg2:T85 T87 Detailed_description 1769 1795 some of them were abnormal R60 MODIFY Arg1:T87 Arg2:T85 T88 Sign_symptom 1811 1822 typical LCH E37 Sign_symptom:T88 T89 Detailed_description 1799 1807 few foci T90 Detailed_description 1832 1858 around the main tumor mass R61 MODIFY Arg1:T90 Arg2:E37 R62 MODIFY Arg1:T89 Arg2:E37 T91 Diagnostic_procedure 1860 1881 Immunohistochemically E39 Diagnostic_procedure:T91 T92 Severity 1904 1912 strongly T93 Lab_value 1913 1921 positive T94 Diagnostic_procedure 1926 1939 S-100 protein E40 Diagnostic_procedure:T94 R63 SUB_PROCEDURE Arg1:E40 Arg2:E39 T95 Diagnostic_procedure 1952 1960 vimentin E41 Diagnostic_procedure:T95 R64 SUB_PROCEDURE Arg1:E41 Arg2:E39 T96 Lab_value 1977 1985 positive T97 Diagnostic_procedure 1990 1994 CD68 E42 Diagnostic_procedure:T97 R65 SUB_PROCEDURE Arg1:E42 Arg2:E39 T98 Lab_value 2032 2040 positive T99 Detailed_description 2024 2031 focally R66 MODIFY Arg1:T99 Arg2:T98 T100 Diagnostic_procedure 2045 2049 CD1a E43 Diagnostic_procedure:T100 R67 SUB_PROCEDURE Arg1:E43 Arg2:E39 T101 Lab_value 2073 2081 negative T102 Diagnostic_procedure 2086 2097 cytokeratin E44 Diagnostic_procedure:T102 T103 Diagnostic_procedure 2099 2126 epithelial membrane antigen E45 Diagnostic_procedure:T103 T104 Diagnostic_procedure 2128 2131 CD3 E46 Diagnostic_procedure:T104 T105 Diagnostic_procedure 2133 2137 CD20 E47 Diagnostic_procedure:T105 T106 Diagnostic_procedure 2142 2147 HMB45 E48 Diagnostic_procedure:T106 R68 SUB_PROCEDURE Arg1:E44 Arg2:E39 R69 SUB_PROCEDURE Arg1:E45 Arg2:E39 R70 SUB_PROCEDURE Arg1:E46 Arg2:E39 R71 SUB_PROCEDURE Arg1:E47 Arg2:E39 R72 SUB_PROCEDURE Arg1:E48 Arg2:E39 R73 MODIFY Arg1:T92 Arg2:T93 R74 MODIFY Arg1:E40 Arg2:T93 R75 MODIFY Arg1:E41 Arg2:T93 R76 MODIFY Arg1:E42 Arg2:T96 R77 MODIFY Arg1:E43 Arg2:T98 R78 MODIFY Arg1:E44 Arg2:T101 R79 MODIFY Arg1:E45 Arg2:T101 R80 MODIFY Arg1:E46 Arg2:T101 R81 MODIFY Arg1:E47 Arg2:T101 R82 MODIFY Arg1:E48 Arg2:T101 T107 Sign_symptom 2178 2220 failed to demonstrate any Birbeck granules E49 Sign_symptom:T107 T108 Diagnostic_procedure 2153 2177 ultrastructural analysis E50 Diagnostic_procedure:T108 R83 MODIFY Arg1:E50 Arg2:E49 T109 Biological_structure 2228 2237 cytoplasm T110 Sign_symptom 2245 2256 tumor cells E51 Sign_symptom:T110 T111 Date 2266 2283 five months after E52 Date:T111 #4 AnnotatorNotes E52 Note that this is a date due to the "after" (not a duration, as those are continuous) T112 Coreference 2284 2293 lobectomy E53 Coreference:T112 R85 IDENTICAL Arg1:E53 Arg2:E30 T113 Outcome 2310 2320 doing well E54 Outcome:T113 T114 Sign_symptom 2326 2374 no significant change in the radiologic findings E55 Sign_symptom:T114 A4 TREND E55 STAY R14 IDENTICAL Arg1:E14 Arg2:E13 R27 IDENTICAL Arg1:E19 Arg2:E14 R44 IDENTICAL Arg1:E35 Arg2:E33 R47 IDENTICAL Arg1:E36 Arg2:E35 R48 IDENTICAL Arg1:E38 Arg2:E36 T11 Lab_value 166 183 treated and cured R3 MODIFY Arg1:T11 Arg2:E4 * OVERLAP E1 E2 E3 R4 AFTER Arg1:E3 Arg2:E4 R84 BEFORE Arg1:E4 Arg2:E7 R86 IDENTICAL Arg1:E8 Arg2:E7 * OVERLAP E7 E9 R87 BEFORE Arg1:E9 Arg2:E10 * OVERLAP E10 E11 E12 E15 E16 E17 E18 R88 BEFORE Arg1:E18 Arg2:E20 * OVERLAP E20 E21 R89 BEFORE Arg1:E21 Arg2:E22 R90 BEFORE Arg1:E22 Arg2:E23 * OVERLAP E23 E24 R91 BEFORE Arg1:E24 Arg2:E25 * OVERLAP E25 E26 E27 R92 BEFORE Arg1:E27 Arg2:E28 * OVERLAP E28 E29 E30 E31 E32 E34 E37 E39 E50 R93 MODIFY Arg1:T109 Arg2:E51 R94 MODIFY Arg1:E51 Arg2:E50 R95 BEFORE Arg1:E50 Arg2:E52 * OVERLAP E52 E54 E55