Downloads: 1
| # | Patient Number | Date of Diagnosis | Age at Diagnosis | Menopausal Status | BRAC1 | BRAC2 | T | N | M | Grade at Diagnosis | Histology | ER | PgR | HER | Mulitfocal | Unifocal | Axilla | Pre-chemo US | Pre-Chemo Mammo | Mid Chemo US | Mid Chemo Mammo | Mid Chemo Response | Post Chemo US | Post Chemo Mammo | Post Chemo Response | Chemotherapy regimes | Surgery | Size | Post Surgical Tumour Grade | Nodes Positive | Nodes Total | pT | pN | pM | NPI | RCB | Pathological Response | Change in Cellularity | RT | Endocrine Treatment | Bisphosphonates | Trials | 1st Recurrence Date | Recurrence Site(s) | Current | Date of Death/ Last seen | Further information | Unnamed: 47 | Patient Number.1 | Pathological Response.1 | Demographic ID | Pathological Response.2 |
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| 1 | NE000001 | 2014-01-06 00:00:00 | 76 | Post | unknown | unknown | T4d | N1 | M0 | 3 | NST | 0 | 0.0 | Negative | Y | N | 20mm: US 25mm:Mammo | 70 x 40 x 40 mm, 12mm, 6mm | 70 x 52 x 60 mm | 57 x 33 x 44mm, 8 x 8 x9mm, 6 x 4 x 7mm (Axilla: 13mm) | 48 x 52 x 50mm | Partial Response | 49 x 29 x 38mm (Axilla: 9mm) | 34 x 28 x 44mm | Partial Response | 3 cycles Epi Cyclophosphamide / 1 cycle Paclitaxel | Mastectomy and ANC | 48 x 30 mm. | 3.0 | 1 | 20 | T2 | N1 | MX | 5.96 | nan | Poor Response | <50% | 40.05Gy over 15 fractions | nan | nan | nan | 2015-09-10 00:00:00 | Brain, Contralateral breast, lung, nodes, bone, liver and possible renal | Deceased | 2015-11-06 00:00:00 | nan | nan | NE000001 | Poor Response | NEO1 | Partial Response |
| 2 | NE000002 | 2014-02-05 00:00:00 | 51 | Peri | Negative | Negative | T2 | N0 | M0 | 2 | NST | 7 | nan | Negative | N | Y | nan | 50 x 34 x 27mm | 50 x 48 x 52mm | 26 x 18 x 26mm | No significant change seen | Partial Response | 18mm | Reported as less dense | Partial Response | 3 x FEC / 3 x Docetaxel | WLE & ANS & SNB followed by Mastectomy & ANC. | At least 41 mm (Comment: probably underestimation, following mastectomy extending 13mm beyond surface of WLE cavity. In total 54mm.) | 2.0 | 8 | 18 | T2 | N2 | MX | N/A post neoadjuvant chemotherapy. | nan | Poor Response | nan | 40.05GY to both chest wall and supraclavicular fossa over 15 fractions. | Letrozole 02/09/2014 to 08/12/2014. Then Anastrozole | nan | nan | nan | nan | Alive and Well | 2017-09-21 00:00:00 | nan | nan | NE000002 | Poor Response | NEO2 | Partial Response |
| 3 | NE000003 | 2014-02-24 00:00:00 | 52 | Pre | NOT KNOWN | NOT KNOWN | T2 | N0 | M0 | 3 | NST | 0 | 0.0 | Negative | N | Y | nan | 28 x 19 x 23mm | 24 x 26mm | 11 x 9 x 8mm | 14mm | Partial Response | 7 x 8 x 12mm | 10 x 10 x 13mm | Partial Response | 3 x FEC / 3 x Docetaxel | WLE & SNB | 9mm | 3.0 | 0 | 2 | T1b | N0 | MX | 4.18 | nan | Good Response | 60% reduction | 40.05Gy over 15 fractions | nan | nan | nan | nan | nan | Alive and Well | 2017-05-18 00:00:00 | nan | nan | NE000003 | Good Response | NE03 | Partial Response |
| 4 | NE000004 | 2014-02-26 00:00:00 | 53 | Peri | NOT KNOWN | NOT KNOWN | T2 | N0 | M0 | 2 | NST | 8 | nan | Negative | N | Y | nan | Not reported | 25 x 16 x 25mm | 22 x 14 x 23mm (previously 25 x 16 x 25mm) | No significant change seen | ?Partial Response ? No change | 20 x 37 x 21mm | No significant change | Partial Response | 3 x FEC / 3 x Docetaxel | WLE & SNB | 23 x 15 mm. | 2.0 | 0 | 2 | T2 | N0 | MX | 3.46 | 1.802 (class 2) | Poor Response | ` | 42.72GY over 16 fractions & boost of 10.00Gy over 4 fractions | Tamoxifen | nan | nan | nan | nan | Alive and Well | 2017-09-13 00:00:00 | nan | nan | NE000004 | Poor Response | NEO4 | Poor /Partial Response |
| 5 | NE000005 | 2014-03-12 00:00:00 | 37 | Pre | Negative | Negative | T2 | N1 | M0 | 3 | NST | 6 | nan | Negative | Y | N | MRI:10mm | 39 x 26 x 37mm | 32 x 35 x 27mm | 15 x 19 x 10mm | 20mm | Partial Response | 15 x 10 x 12 | No significant change | Partial Response | 3 x FEC / 3 x Docetaxel | ANS & ANC followed by Mastectomy | Complete Response | nan | 0 | 16 | PCR | PCR | PCR | 5.42 (post neoadjuvant chemotherapy). | nan | Complete Response | 100% reduction | nan | Tamoxifen & Zoladex | Zoledronic Acid | nan | 14/01/2015( confirmation of Parietal lesion). 25/03/2015( diagnosis of local recurrence) | Metastatic parietal lesion present at diagnosis followed by local recurrence in left breast. 04/05/2016 & 12/05/2016: Confirmation on MRI / CT of significant progressive disease in lungs, liver, bones and thoracic nodes | Deceased | 2016-07-01 00:00:00 | nan | nan | NE000005 | Complete Response | NEO5 (left side) | Complete Response |
| 6 | NE000006 | 2014-03-05 00:00:00 | 46 | Pre | NOT KNOWN | NOT KNOWN | T2 | N0 | M0 | 3 | NST | 2 | nan | Negative | N | Y | nan | 27 x 15mm | 26 x 24mm | Complete Response | Significantly reduced | ?Complete response ? Partial response | Complete response | Complete response | Complete response | 3 x FEC / 3 x Docetaxel | WLE & SNB | 6mm & 3mm | 2.0 | 0 | 4 | T1b | N0 | MX | 3.20 (post chemotherapy) | nan | Good Response | 75% reduction | 40.05GY over 15 fractions & boost of 10.00Gy over 4 fractions | nan | nan | nan | nan | nan | Alive and Well | 2017-09-28 00:00:00 | nan | nan | NE000006 | Good Response | NEO6 | Partial Response |
| 7 | NE000007 | 2014-04-10 00:00:00 | 43 | Pre | NOT KNOWN | NOT KNOWN | T2 | N0 | M0 | 3 | Ductal NST with basal phenotype | 0 | 0.0 | Negative | N | Y | nan | 31mm | 38mm | 25 x 20 x 10mm | 24 x 12mm | Partial Response | 14 x 4mm | 11 x 18mm | Partial Response | 3 x FEC / 3 x Docetaxel | WLE & SNB | 3 mm. | 3.0 | 0 | 4 | T1 | N0 | MX | 4.06 | 1.198 (Group 1) | Good Response | >95% reduction | 40.05GY over 15 fractions & boost of 10.00Gy over 4 fractions | nan | nan | nan | nan | nan | Alive and Well | 2017-11-15 00:00:00 | nan | nan | NE000007 | Good Response | NEO7 | Partial Response |
| 8 | NE000008 | 2014-04-10 00:00:00 | 52 | Pre | Negative | Negative | T2 | N1 | M0 | 3 | Ductal NST with basal phenotype | 0 | 0.0 | Negative | N | Y | 27mm | 45 x 25mm | 40 x 35mm | 15 x 13 x 16mm | Tumour less defined | Partial Response | 14 x 9mm (compared to 16 x 13mm) | Tumour less defined from mid-point | Partial Response | 3 x FEC / 3 x Docetaxel | WLE & SNB | 16 mm | 3.0 | 0 | 4 | T1c | N0 | MX | 4.32 (intermediate prognostic group) | nan | Poor Response | nan | 40.05GY to breast and 36.045Gy to nodes over 15 fractions. | nan | nan | nan | 2016-05-24 00:00:00 | Lung and mediastinal nodal metastases. 04/08/2016: Bone mets. 29/08/2016: Progression of lung disease, new liver mets. 01/09/2016: Leptomeningeal mets | Deceased | 2016-09-12 00:00:00 | nan | nan | NE000008 | Poor Response | NEO8 | Partial Response |
| 9 | NE000009 | 2014-04-16 00:00:00 | 56 | Post | NOT KNOWN | NOT KNOWN | T2 | N1 | M0 | 2 | Pleomorphic Lobular | 0 | nan | Positive | Y | N | Nodes identified but not quantified | 37 x 30 x 14mm (satellite 4mm) | 25 x 17 x 20mm | 18 x 12 x 7mm (satellite 4mm) | No significant change seen | Partial Response | 14 x 5mm | No significant change | Partial Response | 3 x FEC / 3 x Docetaxel | WLE & SNB & ANS | nan | nan | 0 | 5 | PCR | PCR | PCR | N/A. | nan | Complete Response | 100% reduction | 40.05Gy over 15 fractions to breast and full lymphatics | nan | nan | nan | nan | nan | Alive and Well | 2017-04-27 00:00:00 | nan | nan | NE000009 | Complete Response | NEO9 | Complete Response |
| 10 | NE000010 | 2014-04-25 00:00:00 | 58 | Post | NOT KNOWN | NOT KNOWN | T2 | N0 | M0 | 3 | NST with basal phenotype | 0 | 0.0 | Negative | N | Y | nan | 22 x 20 x 19mm | 28 x 26 x 28mm | 18 x 16 x 16mm | Tumour reduced in size/ less lucent | Partial Response | 15 x 14 x 12mm | 22 x 13mm | Partial Response | 3 x FEC / 3 x Docetaxel | WLE & SNB | 17 mm. | 3.0 | 0 | 1 | T1c | N0 | MX | 4.34 | nan | Poor Response | No significant change | 40.05Gy over 15 fractions | nan | nan | nan | nan | nan | Alive and Well | 2017-11-01 00:00:00 | nan | nan | NE000010 | Poor Response | NEO10 | Poor/Partial Response |
| 11 | NE000011 | 2014-05-02 00:00:00 | 55 | Post | Negative | Negative | T2 | N0 | M0 | 3 | Ductal NST with basal phenotype | 0 | 0.0 | Negative | N | Y | nan | 17 x 16 x 22mm | 18 x 16 x 15mm | 11 x 6 x 10mm | 10 x 9 x 11mm | Partial Response | 15 x 4 x 11mm | No measureable mass seen | Partial Response | 3 x FEC / 3 x Docetaxel | WLE & SNB | 2 mm viable tumour | 3.0 | 0 | 3 | T1a | N0 | MX | 3.04 | nan | Good Response | >95% reduction | 40.05Gy over 15 fractions | nan | nan | nan | nan | nan | Alive and Well | 2017-08-15 00:00:00 | nan | nan | NE000011 | Good Response | NEO11 | Partial Response |
| 12 | NE000012 | 2014-05-07 00:00:00 | 43 | Pre | NOT KNOWN | NOT KNOWN | T3 | N1 | M0 | 3 | NST | 0 | 0.0 | Positive | N | Y | Nodes identified ?4 nodes seen: 5mm, 2 measuring 9mm in total, 4mm | At least 50mm | Approximately 60mm | 19 x19mm | Reduction in size | Partial Response | 8 x 4mm | Further reduction in size | Partial Response | 4 x Fec / 4 x Docetaxel | WLE & SNB & ANS | nan | nan | 0 | 4 | T0 | N0 | MX | nan | nan | Complete Response (see comment) | 100% reduction | 40.05GY over 15 fractions to the breast and nodes & boost of 10.00Gy over 4 fractions to breast only | nan | nan | nan | nan | nan | Alive and Well | 2017-12-14 00:00:00 | nan | nan | NE000012 | Complete Response (see comment) | NEO12 | Complete Response (see comment) |
| 13 | NE000013 | 2014-04-28 00:00:00 | 56 | Post | NOT KNOWN | NOT KNOWN | T2 | N0 | M0 | 2 | NST | 7 | nan | Positive | Y | N | nan | 40 x 19 x 33mm, 9mm, 8mm, 22mm axillary tail | No Mammo report. | 14 x 17mm | Lesion less lucent | Partial Response | 24 x 9 x 28mm (see comment: measurements of mid-chemo response thought to be an undersestimation | No significant change | Partial Response | 2 x FEC / 4 x Docetaxel | WLE & SNB | Difficult to measure: few scattered foci of invasive disease, largest 6 x 1cm | 2.0 | 0 | 6 | T1 | N0 | MX | N/A post neo-adjuvant therapy. | nan | Good Response | >95% reduction | 40.05Gy over 15 fractions | Letrozole | nan | nan | nan | nan | Alive and Well | 2017-08-10 00:00:00 | nan | nan | NE000013 | Good Response | NEO13 | Partial Response |
| 14 | NE000014 | 2014-04-20 00:00:00 | 58 | Post | NOT KNOWN | NOT KNOWN | T2 | N0 | M0 | 3 | Ductal NST | 4 | nan | Negative | N | Y | nan | 57 x 24x 33mm | 56 x 60 x 33mm | Complete Response | Complete Response | Complete Response | Complete Response | Complete Response | Complete Response | 4 x Fec / 3 x Docetaxel | WLE & SNB & ANS | N/A. | nan | 0 | 2 | T0 | N0 | MX | N/A. | nan | Complete Response | 100% reduction | 40.05Gy over 15 fractions | Letrozole | nan | nan | nan | nan | Alive and Well | 2017-12-06 00:00:00 | nan | nan | NE000014 | Complete Response | NEO14 | Complete Response |
| 15 | NE000015 | 2014-06-05 00:00:00 | 59 | Post | Negative | Negative | T2 | N0 | M0 | 3 | Ductal NST | 0 | nan | Negative | Y | N | nan | 16 x 14mm, 4mm | 28 x 16mm | 10.5 x 8.2mm (previously 11 x 9mm) | 25mm (compared to 23mm) | No change | 10 x 9 x 14mm | 18 x 19 x 19mm | No change | 3 x FEC / 3 x Docetaxel | WLE & SNB | 31 mm. | 2.0 | 0 | 1 | T2 | N0 | MX | 3.62 (post-chemotherapy). | nan | Good Response | >75% reduction | 40.05Gy over 15 fractions | nan | nan | nan | 2015-09-03 00:00:00 | Biopies reveal recurrent disease initially in right breast and right right breast skin dermis. 17/09/2015: CT scan revealing suspicious lung nodules.17/02/2017: Fungating right breast lesion, bilateral breast disease and multiple new pulmonary nodules. Worsening of nodal disease (left axillary, mediastinal, hilar).(CT scan) 02/06/2017: Thoracic disease progression and new pleural effusion. | Deceased | 2017-07-04 00:00:00 | nan | nan | NE000015 | Good Response | NEO15 | Partial Response |
| 16 | NE000016 | 2014-06-24 00:00:00 | 63 | Post | NOT KNOWN | NOT KNOWN | T2 | N0 | M0 | 3 | Ductal NST | 8 | nan | Negative | N | Y | nan | 30 x 22mm | 26 x 22mm | 30 x 20 x 19mm | 26 x 21 x 32mm | Poor/Partial Response | 23 x 14 x 17mm | 20 x 16 x 28mm | Poor/Partial Response | 3 x FEC / 3 x Docetaxel | WLE & SNB | 23 x 17 mm. | 2.0 | 0 | 5 | T2 | N0 | MX | N/A post neoadjuvant chemotherapy. | nan | Poor Response (see comment) | No change | 40.05GY over 15 fractions & boost of 10.00Gy over 4 fractions | Letrozole | nan | nan | nan | nan | Alive and Well | 2017-06-06 00:00:00 | nan | nan | NE000016 | Poor Response (see comment) | NEO16 | Poor/Partial Response (see comment) |
| 17 | NE000017 | 2014-07-08 00:00:00 | 65 | Post | NOT KNOWN | NOT KNOWN | T2 | N1 | M0 | 2 | NST | 7 | nan | Positive | N | Y | 34mm | No measurement for L axilary nodes | No measurement for L axilary nodes | 17mm, 7mm | Reduction in size | Partial Response | 13mm | No report for left axilla | Partial Response | 3 x FEC / 3 x Docetaxel | ANC & Apical Node | nan | nan | 0 | 14 | T0 | N0 | MX | N/A. | nan | Complete Response | 100% reduction | 40.05Gy over 15 fractions | Letrozole 04/02/2015 until 30/10/2015 when switched to Tamoxifen. | nan | nan | nan | nan | Alive and Well | 2017-03-14 00:00:00 | nan | nan | NE000017 | Complete Response | NEO17 | Partial Response |
| 18 | NE000018 | 2014-08-11 00:00:00 | 65 | Post | NOT KNOWN | NOT KNOWN | T2 | N1 | M0 | 3 | Ductal NST | 3 | 5.0 | Negative | N | Y | 35mm | 35 x 20 x 24mm | 43 x 32 | 15 x 10 x 13mm | 16 x 13 x 10mm | Partial Response | 5mm | 5 x 5mm | Partial Response | 3 x FEC / 2 x Docetaxel/ 2 x Paclitaxel | WLE & ANC & Apical Node | Complete Response | nan | 0 | 20 | T0 | N0 | MX | nan | nan | Complete Response | 100% reduction | 40.05Gy over 15 fractions | Letrozole | nan | nan | nan | nan | Alive and Well | 2017-02-21 00:00:00 | nan | nan | NE000018 | Complete Response | NEO18 | Partial Response |
| 19 | NE000019 | 2014-08-12 00:00:00 | 29 | Pre | Negative | Negative | T2 | N0 | M0 | 3 | NST | 0 | 0.0 | Negative | N | Y | nan | 40 x 40 x 50mm | 58 x 47mm | 20 x 19 x 13mm | 18mm | Partial Response | 18 x 17 x 8mm | 24mm(previously 28mm) | Partial Response | 4 x Fec / 4 x Docetaxel | WLE & SNB & ANS | 13mm | 3.0 | 0 | 5 | T1c | N0 | MX | 4.26 | nan | Good Response | >90% reduction | 40.05GY over 15 fractions & boost of 10.00Gy over 4 fractions | nan | nan | nan | nan | nan | Alive and Well | 2017-07-25 00:00:00 | nan | nan | NE000019 | Good Response | NEO19 | Partial Response |
| 20 | NE000020 | 2014-09-03 00:00:00 | 48 | Post | NOT KNOWN | NOT KNOWN | T3 | N0 | M0 | 3 | NST | 7 | 5.0 | Negative | N | Y | nan | 55 x 32 x 41mm | 60 x 48 x 37mm | 20 x 14 x 19mm | 28 x 21 x 23mm | Partial Response | 12mm | 22mm | Partial Response | 3 x FEC / 3 x Docetaxel | WLE & SNB | 23mm | 2.0 | 0 | 3 | T2 | N0 | MX | 3.46 | nan | Poor Response | > 95% reduction | 40.05GY over 15 fractions & boost of 10.00Gy over 4 fractions | Letrozole | nan | nan | nan | nan | Alive and Well | 2017-09-11 00:00:00 | nan | nan | NE000020 | Poor Response | NEO21 | Partial Response |
| 21 | NE000021 | 2014-08-18 00:00:00 | 42 | Pre | Negative | Negative | T2 | N0 | M0 | 3 | NST | 0 | 0.0 | Negative | N | Y | nan | 26 x 16 x 18mm | 19 x 25 x 19mm | 19 x 13 x 17mm | 18 x 11mm (previously 22x22mm) | Partial Response | 7 x 4 x 11mm | Further response | Partial Response | 3 x FEC / 12 x Paclitaxel | WLE & SNB | 16mm. | 3.0 | 0 | 2 | T1c | N0 | MX | 4.32 | nan | Good Response | 30% reduction | 40.05GY over 15 fractions & boost of 10.00Gy over 4 fractions | nan | nan | nan | Lost to follow up | Lost to follow up | Lost to follow up | Lost to follow up | nan | nan | NE000021 | Good Response | NEO20 | Partial Response |
| 22 | NE000022 | 2014-10-31 00:00:00 | 61 | Post | NOT KNOWN | NOT KNOWN | T2 | N1 | M0 | 3 | NST | 0 | 0.0 | Negative | N | Y | Multiple pathological nodes: largest 39 x 24 x 29mm | 39 x 17 x 28mm | 40 x 40 x 25mm | 9 x 8mm (from previous of 38 x 16 x 28mm)Nodes significantly reduced in size | 10 x 8mm (previously 40 x 25mm) | Partial Response | 5 x 4mm | Further response | Partial Response | 3 x FEC / 3 x Docetaxel | WLE & SNB & ANC | Complete Response | nan | 1 | 13 | T0 | N1 | MX | N/A. | nan | Good response. Complete response in breast. SNB positive. | nan | 40.05Gy over 15 fractions | nan | nan | nan | nan | nan | Alive and Well | 2017-06-07 00:00:00 | nan | nan | NE000022 | Good response. Complete response in breast. SNB positive. | NEO22 | Complete response in breast. SNB positive. |
| 23 | NE000023 | 2014-12-11 00:00:00 | 43 | Pre | No clear BRCA1 or 2 mutation but indeterminate BRCA gene sequencing. | BRCA2 genetic variant of uncertain significance | T2 | N1 | M0 | 3 | NST with basal phenotype | 0 | 0.0 | Negative | Y | N | 26 x 17mm | 30 x 10 x12mm | 41mm | Not discernible | Not discernible | Complete Response | Complete Response | Complete Response | Complete Response | 3 x FEC / 1 x Docetaxel/ 4 x Paclitaxel | WLE & SNB | Complete Response | nan | 0 | 5 | T0 | N0 | MX | nan | nan | Complete Response | 100% reduction | 40.05GY over 15 fractions & boost of 10.00Gy over 4 fractions | nan | nan | nan | nan | nan | Alive and Well | 2017-03-27 00:00:00 | nan | nan | NE000023 | Complete Response | NEO23 | Complete Response |
| 24 | NE000024 | 2015-01-15 00:00:00 | 72 | Post | NOT KNOWN | NOT KNOWN | T4d | N3 | M0 | 3 | NST | 0 | 0.0 | Positive | Y | N | Multiple pathological nodes. | 70mm + | 120mm + | 57 x 16mm (previously 70 x 31mm) | 65 x 30mm (previously 76 x 35mm) + 17mm | Partial Response | 50 x 17mm | 59 x 25mm | Partial Response | 16 x Paclitaxel | Mastectomy and ANC | Complete Response | nan | 0 | 6 | T0 | N0 | MX | nan | nan | Complete Response | 100% reduction | 40.05GY to both chest wall and supraclavicular fossa over 15 fractions. | nan | nan | nan | nan | nan | Alive and Well | 2017-03-20 00:00:00 | nan | nan | NE000024 | Complete Response | NEO24 | Complete Response |
| 25 | NE000025 | 2015-01-07 00:00:00 | 53 | Peri | NOT KNOWN | NOT KNOWN | T2 | N0 | M0 | 3 | NST | 3 | nan | Negative | N | Y | nan | 37 x 20 x 33mm | 36 x 33 x30mm | 17 x 8mm (previously 37 x 33 x 19mm) | 17 x 10mm | Partial Response | 8 x 2 x 5mm | No discernible tumour visible | Partial Response | 3 x FEC / 3 x Docetaxel | WLE & SNB | Complete Response | nan | 0 | 2 | T0 | N0 | MX | nan | nan | Complete Response | 100% reduction | 40.05Gy over 15 fractions | nan | nan | nan | nan | nan | Alive and Well | 2017-09-18 00:00:00 | nan | nan | NE000025 | Complete Response | NEO25 | Complete Response |
| 26 | NE000026 | 2015-01-29 00:00:00 | 57 | Post | NOT KNOWN | NOT KNOWN | T2 | N1 | M0 | 3 | NST | 0 | nan | Positive | N | N | At lease 3 abnormal nodes. ( cortex up to 7mm) | 35 x 24 x 24mm | 39mm | 12 x 16 x 12mm | 22 x 20mm | Partial Response | Decreased density/ difficult to measure | 8 x 5mm | Partial Response | 3 x FEC / 4 x Paclitaxel | WLE & ANC | Complete Response | nan | 0 | 17 | Tis | N0 | MX | nan | nan | Complete Response | 100% reduction | 40.05GY to breast and medial supraclavicular fossa over 15 fractions. | nan | nan | nan | nan | nan | Alive and Well | 2017-09-14 00:00:00 | nan | nan | NE000026 | Complete Response | NEO26 | Complete Response |
| 27 | NE000027 | 2015-02-02 00:00:00 | 39 | Pre | Negative | Negative | T2 | N0 | M0 | 2 | NST | 7 | nan | Negative | N | Y | nan | 33 x 28 x 33mm | 31 x 28 x 20mm | 17 x 18 x 21mm(previously 33mm x 27 x 34mm) | 24 x 20 x 17mm | Partial Response | 14 x 14 x 12mm | 19 x 17 x 20mm | Partial Response | 3 x FEC / 3 x Docetaxel | WLE & SNB | 17 mm. | 1.0 | 0 | 3 | T1 | N0 | MX | 2.34 | nan | Poor Response | No change | 40.05GY over 15 fractions & boost of 10.00Gy over 4 fractions | Tamoxifen from 28/08/2015 until 29/10/2016. Stopped due to toxicities | nan | nan | nan | nan | Alive and Well | 2017-05-04 00:00:00 | nan | nan | NE000027 | Poor Response | NEO27 | Partial Response |
| 28 | NE000028 | 2015-01-29 00:00:00 | 62 | Post | NOT KNOWN | NOT KNOWN | T2 | N0 | M0 | 3 | Acinic cell like with salivary like features | 2 | 0.0 | Negative | Y | N | nan | 30 x 22 x30mm & 15 x 8mm(9 o'clock) 6 x 4mm(12 o'clock) | 30 x 30 x 30mm(9 o'clock) | 9mm (9 o'clock) | No significant residual mass | Partial Response | 18 x 21mm (7 o'clock). 14 x 7mm (8 o'clock) | Area 1: decrease in size & density. Other lesions not visible. | Partial Response | 3 x FEC / 3 x Docetaxel | WLE & SNB followed by re-excision and then mastectomy | 71mm | 3.0 | 0 | 2 | T2 | N0 | MX | nan | nan | Poor Response | No change | 40.05Gy over 15 fractions | nan | nan | nan | 2017-02-11 00:00:00 | Peritoneal mets, thickening of gastric pylorus, intra and extra hepatic bilary dilation, right hydronephrosis and right hydroureter | Metastatic disease but doing well on treatment | 2018-01-08 00:00:00 | nan | nan | NE000028 | Poor Response | NEO29 | Partial Response |
| 29 | NE000029 | 2015-02-09 00:00:00 | 52 | Peri | Negative | Negative | T2 | N1 | M0 | 3 | NST | 0 | 0.0 | Negative | Y | N | Node with 6mm cortex | Area 1: 22x24mmx16mm, satellite 8mm. Area 2: 8mm | 27 x 26 x 30mm | Area 1:14.5mm, satellite not visible, Area 2:6 x 2mm | Area 1:23mm, satellite 8mm, Area 2: less dense/ conspicious | Partial Response | Area 1: 10 x 7mm, satellite 6mm, Area 2: not visible | No significant residual mass | Partial Response | 3 x FEC / 3 x Docetaxel | WLE & SNB | Approximately 50 mm. | 1.0 | 15 | 2 | T1b | N1 | MX | N/A. | nan | Poor Response | Similar | 40.05Gy over 15 fractions | Letrozole (03/12/2015 until 06/10/2016) | nan | nan | 2015-11-10 00:00:00 | Brain metastases | Deceased | 2017-03-01 00:00:00 | nan | nan | NE000029 | Poor Response | NEO28 | Partial Response |
| 30 | NE000030 | 2015-03-16 00:00:00 | 54 | Post | NOT KNOWN | NOT KNOWN | T2 | N0 | M0 | 2 | NST | 7 | nan | Negative | N | Y | nan | 26 x 27 x 34mm | 26 x 20 x 29mm | 20 x 22 x 31mm | 28 x 27 x 25mm | Partial Response | 16 x 20 x 22mm(previously 24 x 19 x 31mm) | Further decrease in density. Calcs more conspicious | Partial Response | 3 x FEC / 3 x Docetaxel | WLE & SNB | 25mm | 2.0 | 0 | 4 | T2 | N0 | MX | 3.5 | nan | Poor Response | No change | 40.05Gy over 15 fractions | Tamoxifen 14/09/2015 to 12/12/2015. Letrozole 15/01/2016 to 16/05/2016 | nan | nan | nan | nan | Alive and Well | 2016-08-04 00:00:00 | nan | nan | NE000030 | Poor Response | NEO33 | Partial Response |
| 31 | NE000031 | 2015-03-16 00:00:00 | 53 | Peri | Negative | Negative | T2 | N1 | M0 | 3 | NST | 8 | nan | Negative | N | Y | 13mm (cortex 6mm) | 43 x 19 x 24mm | 53 x 40 x 35mm | 38 x 18mm | Slight reduction in one axis | Partial Response | 32 x 21 x 16mm | Further decrease in general oedema. Calcs: 22 x 32 x 42mm | Partial Response/Stable disease | 3 x FEC / 3 x Docetaxel | WLE & ANC | 37mm | 3.0 | 2 | 17 | T2 | N1 | MX | 5.74 | nan | Poor Response | No change | 40.05Gy over 15 fractions | Letrozole :22/09/2015 to 24/10/2016. Switched to Anastrozole. | nan | nan | nan | nan | Alive and Well | 2017-10-24 00:00:00 | nan | nan | NE000031 | Poor Response | NEO32 | Complete histological response |
| 32 | NE000032 | 2015-03-17 00:00:00 | 42 | Pre | NOT KNOWN | NOT KNOWN | T3 | N1 | M0 | 2 | NST | 0 | 0.0 | Positive | N | Y | Several bulky LN. 26mm (8mm cortex) | Inflammatory disease .No definite focal mass. Area of 50mm suspicious for malignancy | Inflammatory so no definite measurement. Calcs over 19 x 27 x 7mm. Markers indicate c.51 x 24mm | Less oedatous & significantly improved nodes | Calcs unchanged and extend over 55mm | Partial Response | Difficult to see. Breast no longer oedematous. Calcs:13 x 6 x 11mm | No significant change | Partial Response | 3 x FEC / 3 x Docetaxel | Mastectomy & ANC | Complete Response | nan | 0 | 9 | T0 | N0 | MX | nan | nan | Complete Response | 100% reduction | 40.05GY to both chest wall and medial supraclavicular fossa over 15 fractions. | nan | Zoledronic Acid | nan | 2016-11-29 00:00:00 | Bone and mediatinal nodal metastases. 09/11/2017: Progression of thorax. New small volume nodes in left upper lobe of lung. | Metastatic. Alive | 2018-01-03 00:00:00 | nan | nan | NE000032 | Complete Response | NEO31 | No histological evidence of response to chemo |
| 33 | NE000033 | 2015-03-18 00:00:00 | 43 | Pre | NOT KNOWN | NOT KNOWN | T2 | N0 | M0 | 2 | NST | 7 | 6.0 | Negative | Y | N | nan | 37 x 20 x 22mm, 7 x 6mm | 37 x 19 x 18 mm | 32 x 12 x 10mm, 5 x 5mm | Slight reduction in density. Increase in microcalcs | Partial Response | 10 x 9.5 x 13mm, 5mm | 27 x 24 x 25mm | Partial Response | 3 x FEC / 3 x Docetaxel | Mastectomy & ANS & SNB | 12 mm | 2.0 | 0 | 2 | T1 | N0 | MX | 3.24 | nan | Poor Response | No change | nan | Tamoxifen with Zoladex | nan | nan | nan | nan | Alive and Well | 2017-05-25 00:00:00 | nan | nan | NE000033 | Poor Response | NEO30 | Little histological evidence of response to chemo |
| 34 | NE000034 | 2015-03-25 00:00:00 | 30 | Pre | Negative | Negative | T2 | N0 | M0 | 2 | NST | 8 | nan | Negative | N | Y | nan | 35mm | 35mm | 22x 20mm | No significant change seen | Partial Response | 18 x 15 x 12mm | No significant change | Partial Response | 3 x FEC / 3 x Docetaxel | WLE & SNB | 18 mm + satellites (9 mm and 7 mm). | 0.0 | 2 | 2 | T1c | N0 | MX | 3.36 (post-chemotherapy). | nan | Good Response | >90% reduction | 40.05GY over 15 fractions & boost of 10.00Gy over 4 fractions | Tamoxifen (interruption Sept 2017 as wishes to conceive) | nan | nan | nan | nan | Alive and Well | 2017-09-27 00:00:00 | nan | nan | NE000034 | Good Response | NEO34 | Partial Response |
| 35 | NE000035 | 2015-04-27 00:00:00 | 51 | Pre | NOT KNOWN | NOT KNOWN | T2 | N1 | M0 | 2 | NST | 7 | nan | Negative | Y | N | At least 5 abnormal nodes in left axilla (9 & 7mm) | nan | MRI: 66 x 43 x 56mm, 9mm | 41 x 27mm, satellite lesion no longer visible | Distortion less prominent and node smaller | Partial Response | 41 x 19mm | Further decrease in volume. Node similar | Partial Response | 3 x FEC / 3 x Docetaxel | WLE & ANC | 21 mm. | 2.0 | 3 | 12 | T2 | N1 | MX | 4.42 | nan | Good Response | >90% reduction | 40.05GY to breast and medial supraclavicular fossa over 15 fractions & boost to both over 4 fractions | Tamoxifen | nan | nan | nan | nan | Alive and Well | 2017-11-30 00:00:00 | nan | nan | NE000035 | Good Response | NEO35 | Partial Response |
| 36 | NE000036 | 2015-05-19 00:00:00 | 46 | Pre | NOT KNOWN | NOT KNOWN | T3 | N1 | M0 | 3 | NST | 0 | 0.0 | Positive | Y | N | Multiple abnormal nodes | 46 x 15 x 30mm (upper breast) 3 x 5mm foci (total 20mm lower breast) | 72 x 35 x 51mm | Reduction in size /density | Reduction in size /density | Partial Response | 17 x 14 x 9mm, 7mm | Marked decrease in volume | Partial Response | 3 x FEC / 3 x Docetaxel | Mastectomy and ANC | nan | nan | 0 | 18 | TX | N0 | MX | Not calculable post chemotherapy. | nan | Complete Response | 100% reduction although invasive disease remains in vascular/lympatic systems. | 40.05Gy over 15 fractions | nan | nan | Add Aspirin Trial | nan | nan | Alive and Well | 2017-11-30 00:00:00 | nan | nan | NE000036 | Complete Response | NEO36 | Partial Response |
| 37 | NE000037 | 2015-05-18 00:00:00 | 47 | Pre | NOT KNOWN | NOT KNOWN | T2 | N1 | M0 | 2 | Lobular | 7 | nan | Negative | Y | N | Nodal disease identified through biopsy | 60 x 45 x 33mm | 50 x 40 x 43mm | 20 x 50 x 25mm | 47 x 24 x 40mm | Partial Response | 25 x 18mm | 30 x 15 x 20mm | Partial Response | 3 x FEC / 3 x Docetaxel | Mastectomy and ANC | Scattered cells | 2.0 | 5 | 18 | T2 | N2 | MX | 5.94 | 3.009 | Good Response | >90% reduction | 40.05GY to breast & medial supraclavicular fossa over 15 fractions. | Tamoxifen & Zoladex | nan | nan | nan | nan | Alive and Well | 2018-01-03 00:00:00 | nan | nan | NE000037 | Good Response | NEO37 | Partial Response |
| 38 | NE000039 | 2015-05-28 00:00:00 | 52 | Peri | Unknown | Unknown | T3 | N0 | M0 | 2 | Lobular | 6 | nan | Positive | N | Y | nan | c.45mm | nan | 41mm (previously 44mm) | Reduction in density/ size unchanged | Stable Disease | 38mm | Significant reduction | Partial Response | 3 x FEC / 3 x Docetaxel | WLE & SNB | 21 x 14mm | 2.0 | 0 | 3 | T2 | N0 | MX | nan | 1.253 | Good Response | >95% reduction | 40.05GY over 15 fractions & boost of 10.00Gy over 4 fractions | Tamoxifen | nan | nan | nan | nan | Alive and Well | 2017-12-01 00:00:00 | nan | nan | NE000039 | Good Response | NEO39 | Partial Response |
| 39 | NE000040 | 2015-06-02 00:00:00 | 48 | Peri | Negative | Negative | T2 | N1 | M0 | 3 | NST | 0 | 0.0 | Negative | N | Y | Multiple nodes mesuring up to 24mm. | 32 x 20 x 28mm | 34mm | 15 x 8mm(previously 28 x 22mm) | 13 x 9mm (previously 36mm) | Partial Response | 13 x 12 x 10mm | 22mm | Partial Response | 3 x FEC / 3 x Docetaxel | WLE & SNB & ANS | 20 x 12 mm | 3.0 | 0 | 5 | T1c | N0 | MX | 4.4 [post neoadjuvant chemotherapy] | nan | Poor Response | 30% reduction | 40.05GY over 15 fractions to the breast and nodes & boost of 10.00Gy over 4 fractions to breast only | nan | nan | nan | nan | nan | Alive and Well | 2017-11-27 00:00:00 | nan | nan | NE000040 | Poor Response | NEO40 | Partial Response |
| 40 | NE000041 | 2015-06-30 00:00:00 | 58 | Post | Negative | Negative | T2 | N0 | M0 | 3 | NST | 0 | 0.0 | Negative | N | Y | nan | nan | 50 x 38 x 37mm | 24 x 19 x 7mm, 4mm satellite (considerable smaller than original scan) | Stable disease, decrease in tissue density | Partial Response | 6mm | Mammo:Decrease in density. MRI: complete radiological response | Partial Response | 3 x FEC / 3 x Docetaxel | WLE & SNB | N/A. | 0.0 | 0 | 2 | T0 | N0 | MX | N/A. | nan | Complete Response | 100% reduction | 40.05Gy over 15 fractions | nan | nan | nan | nan | nan | Alive and Well | 2018-02-01 00:00:00 | nan | nan | NE000041 | Complete Response | NEO41 | Complete Response |
| 41 | NE000042 | 2015-07-22 00:00:00 | 67 | Post | Negative | Negative | T3 | N0 | M0 | 2 | NST | 7 & 8 | 0.0 | Negative | N | Y | nan | 50mm | 62 x 43 x 50mm. MRI: 70 x 63 x 46mm | 35mm (previously 46mm) | No significant change seen | Partial Response | 31mm | MRI: 27 x 32 x 35mm | Partial Response | 3 x EC, 12 x Paclitaxel | WLE & SNB & ANS followed by Mastectomy | >50mm | 2.0 | 1 | 5 | T3 | N1 | MX | 4.88 (post chemotherapy). | 3.638 | Good Response | 50-60% reduction | 40.05Gy over 15 fractions to breast and peripheral lymphatics | Letrozole | nan | nan | nan | nan | Alive and Well | 2018-01-04 00:00:00 | nan | nan | NE000042 | Good Response | NEO42 | Partial Response |
| 42 | NE000043 | 2015-07-21 00:00:00 | 51 | Pre | NOT KNOWN | NOT KNOWN | T2 | N1 | M0 | 2 | Lobular | 7 | 7.0 | Negative | Y | N | Multiple nodes measuring up to 29mm (US)16mm(MRI) | 46mm | MRI: 38 x 18 x 36mm | 20mm | No significant change seen | Partial Response | 20 x 8 x 32mm | nan | Partial Response | 3 x FEC / 3 x Docetaxel | Mastectomy and ANC | Path CR in breast but postive ANC | 0.0 | 9 | 12 | T0 | N2 | MX | nan | 1.642 | Path CR in breast but poor response in nodes | nan | 40.05GY to breast and supraclavicular nodes over 15 fractions. | Tamoxifen & Zoladex (21/10/2016 to 06/04/2017) | Zoledronic Acid | Plasma Match | 2017-03-30 00:00:00 | Liver, pelvis with ascites, recurrent pleural effusion | Metastatic/palliative | 2018-01-09 00:00:00 | nan | nan | NE000043 | Path CR in breast but poor response in nodes | NEO43 | Partial Response |
| 43 | NE000044 | 2015-07-27 00:00:00 | 48 | Pre | NOT KNOWN | NOT KNOWN | T2 | N0 | M0 | 2 | Lobular | 8 | 8.0 | Negative | N | Y | nan | 49 x 20 x 25mm | 45 x 29 x 43mm | 33 x 11mm | 41 x 27 x 46mm | Partial Response | 27mm | Improvement in architectural distortion | Partial Response | 3 x FEC / 3 x Docetaxel | WLE & SNB | 60 mm tumour bed with foci of malignant cells(see comment) | 2.0 | 0 | 3 | T3 | N0 | MX | N/A post neoadjuvant chemotherapy | nan | Good Response | >95% reduction | 40.05GY over 15 fractions & boost of 10.00Gy over 4 fractions | Tamoxifen | nan | nan | nan | nan | Alive and Well | 2017-12-07 00:00:00 | nan | nan | NE000044 | Good Response | NEO44 | Partial Response |
| 44 | NE000045 | 2015-07-23 00:00:00 | 47 | Pre | NOT KNOWN | NOT KNOWN | T2 | N1 | M0 | 2 | NST | 7 | nan | Negative | N | Y | US:19 x 6mm Mammo: 30 x 14mm | 21 x 20 x 25mm, 12mm | 35 x 34 x 25mm MRI: 28 x 21 x 26mm | 19 x 14 x 16mm | 20 x 17 (previously 30 x 25mm) | Partial Response | 18 x 10 x 11mm | 16 x 24mm (previously 21 x 22mm) | Partial response | 3 x FEC / 3 x Docetaxel | WLE & ANC | 14 X 9mm | 2.0 | 1 | 14 | T1 | N1 | MX | 4.28 | 3.34 | Poor Response | <50% | 40.05GY over 15 fractions & boost of 10.00Gy over 4 fractions | Tamoxifen | nan | nan | nan | nan | Alive and Well | 2017-03-16 00:00:00 | nan | nan | NE000045 | Poor Response | NEO45 | Partial Response |
| 45 | NE000046 | 2015-08-18 00:00:00 | 39 | Pre | YES- DELETION ON 464 ( HETERZYGOUS) | No | T2 | N0 | M0 | 3 | NST | 7 | nan | Negative | N | Y | nan | 15 x 17 x24mm | 24mm | 11 x 9 x 11mm (previously 15 x 17 x 25mm) | 9mm | Partial Response | 7 x 4 x 6mm | 7mm | Partial Response | 3 x FEC, 3 x Docetaxel/ Carboplatin | Mastectomy & ANS & SNB | 12 x 11 mm tumour bed with scattered cells | 2.0 | 0 | 5 | T1 | N0 | MX | 2.24 [post chemo] | 1.083 | Good Response | >95% reduction | nan | Tamoxifen | nan | nan | nan | nan | Alive and Well | 2017-07-10 00:00:00 | nan | nan | NE000046 | Good Response | NEO46 | Partial Response |
| 46 | NE000047 | 2015-08-12 00:00:00 | 52 | nan | Negative | Negative | T2 | N0 | M0 | 2 | Apocrine | 0 | 0.0 | Negative | N | y | nan | 50 x 26mm | 47 x 37 x 53mm | 42 x 21mm(previously 43 x 26mm) | 37 x 33 x 47mm | Partial Response | 37 x 24mm | No significant chnage | Partial Response | 3 x FEC / 3 x Docetaxel | WLE & SNB & ANS | 20mm | 1.0 | 0 | 3 | T1 | N0 | MX | 2.4 [post chemo] | nan | Poor Response | 30% reduction | 40.05Gy over 15 fractions | nan | nan | Add Aspirin Trial | nan | nan | Alive and Well | 2017-12-14 00:00:00 | nan | nan | NE000047 | Poor Response | NEO47 | Partial Response |
| 47 | NE000048 | 2015-08-28 00:00:00 | 47 | Peri | NOT KNOWN | NOT KNOWN | T3 | N1 | M0 | 2 | Pleomorphic Lobular | 7 | nan | Positive | Y | N | 21mm | Multifocal. Largest lesion 18mm | 80 x 75 x 65mm MRI: 72 x 68 x 82mm | Foci all appear smaller. Largest 9x 6mm | Upper area: 7 x 9mm (previously 12 x 12mm) Lower area 6 x 6mm (previously 10 x 7.5mm) | Partial Response | Further reduction in bulk and foci decreased in size | Further decrease in density. | Partial response | 3 x FEC / 3 x Docetaxel | Mastectomy and SNB | 4mm | 2.0 | 0 | 8 | T1 | N0 | MX | 3.32 | 0.81 | Good Response | >95% reduction | 40.05GY to breast, axilla & medial supraclavicular fossa over 15 fractions. | Tamoxifen 25/03/2016 to 22/08/2016. Started Letrozole 17/10/2016 | nan | nan | nan | nan | Alive and Well | 2017-04-24 00:00:00 | nan | nan | NE000048 | Good Response | NEO48 | Partial Response |
| 48 | NE000049 | 2015-09-11 00:00:00 | 50 | Post | Positive. Genetic variant favouring polymorphism | Positive. Genetic variant favouring polymorphism | T2 | N0 | M0 | 3 | NST with basal phenotype | 0 | 0.0 | Negative | N | Y | nan | 35 x 24 x 37mm | 42 x 27mm | 25 x 16mm | 26mm(previously 42mm) | Partial Response | 32 x 19 x29mm(previously 21 x 16 x 21mm) | 26 x 27 x 28mm (previously 20 x 19 x20mm | Disease Progression | 6 x Docetaxel/Cyclo (Reg 229) | WLE & SNB & ANS | 42 x 29 mm. | 3.0 | 0 | 2 | T2 | N0 | MX | 4.84 | 2.276 | Poor Response | No change | 40.05Gy over 15 fractions | nan | nan | MetcfDNA | 2017-01-17 00:00:00 | Originally recurred in lung, then in pleural and thorax. Further progression in the above areas plus new progression with a single brain stem met in August 2017 | Deceased | 2017-09-27 00:00:00 | nan | nan | NE000049 | Poor Response | NEO49 | Progressive Disease |
| 49 | NE000050 | 2015-10-05 00:00:00 | 39 | Pre | NOT KNOWN | NOT KNOWN | T2 | N0 | M0 | 2 | NST | 7 | 8.0 | Negative | N | y | nan | 38 x 12 x 23mm | 36 x40 x 23mm | 32mm (previously 38mm) | No significant change seen | Partial Response | 29mm | 35 x 21mm | Partial Response (minimal) | 3 x FEC / 3 x Docetaxel | Mastectomy & ANS & SNB | 29 x 20 mm. | 1.0 | 0 | 4 | T2 | N0 | MX | 2.58 | 1.626 | Good Response | >80% reduction | 40.05Gy over 15 fractions | Tamoxifen | nan | nan | nan | nan | Alive and Well | 2017-05-09 00:00:00 | nan | nan | NE000050 | Good Response | NEO50 | Partial Response |
| 50 | NE000051 | 2015-10-16 00:00:00 | 62 | Post | NOT KNOWN | NOT KNOWN | T3 | N1 | M0 | 2 | NST | 8 | 7.0 | Negative | N | Y | 2/3 suspicious nodes identified | 44 x 33 x 38mm | Mammo:55 x 46mm MRI:77 x 49 x 60mm,17 x 11mm | 32 x 26 x 33mm | 38 x 30mm | Partial Response | MRI: 38 x 31 x 35mm | nan | Partial Response | 3 x FEC, 1 x Docetaxel | Mastectomy & ANC | 34 x 33mm. | 2.0 | 3 | 15 | T2 | N1 | MX | 4.68 | 3.712 | Poor Response | 40% reduction | 40.05Gy over 15 fractions | Letrozole | Zoledronic Acid | Add Aspirin Trial | nan | nan | Alive and Well | 2017-10-05 00:00:00 | nan | nan | NE000051 | Poor Response | NEO51 | Partial Response |