Completed, Early positive outcome   0

Completed, Positive outcome/primary endpoint(s) met 0

Terminated, Lack of efficacy    1

Completed, Negative outcome/primary endpoint(s) not met 1

Terminated, Safety/adverse effects  2

Terminated, Poor enrollment 3

Completed, Outcome indeterminate    -1

Completed, Outcome unknown  -1

Terminated, Business decision - Drug strategy shift -1

Terminated, Business decision - Other   -1

Terminated, Business decision - Pipeline reprioritization   -1

Terminated, Lack of funding -1

Terminated, Other   -1

Terminated, Planned but never initiated -1

Terminated, Unknown -1