Any of the following:* Pregnant women* Nursing women* Men or women of childbearing potential who are unwilling to employ adequate contraceptionXx_NEWLINE_xXWomen of childbearing potential and male participants who are sexually active must agree to use a medically effective means of birth controlXx_NEWLINE_xXThe following categories are ineligible:* Pregnant women* Nursing women* Men or women of childbearing potential who are unwilling to employ adequate contraception or contraceptive method during this study and 6 months following the completion of chemotherapy treatmentsXx_NEWLINE_xXWomen of childbearing potential and male participants must practice adequate contraceptionXx_NEWLINE_xXAny of the following:* Pregnant women* Nursing women* Men or women of childbearing potential who are unwilling to employ adequate contraception for the duration of study participation; men and women should continue to use adequate birth control after the last administration of sorafenib and TH-302 under the guidance of their treating physicianXx_NEWLINE_xXAny of the following* Pregnant women* Nursing women* Men or women of childbearing potential who are unwilling to employ adequate contraceptionXx_NEWLINE_xXAny of the following:* Pregnant women* Nursing women* Women of childbearing potential who are unwilling to employ adequate contraception (as determined by the treating physician)Xx_NEWLINE_xXSexually active women of childbearing potential and sexually active men must practice adequate contraception during therapy and for 12 months after protocol treatment completionXx_NEWLINE_xXAny of the following:* Pregnant women* Nursing women* Men or women of childbearing potential who are unwilling to employ adequate contraceptionXx_NEWLINE_xXWomen of childbearing potential and male participants must agree to practice adequate contraception while on study and for at least 6 months following the last dose of radiation therapy (RT) and for at least 28 days following the last dose of sorafenib (whichever is later)Xx_NEWLINE_xXAny of the following:* Nursing women* Pregnant women* Women of childbearing potential who are unwilling to employ adequate contraception (non-barrier method)Xx_NEWLINE_xXWomen of childbearing potential and male participants who are sexually active must practice adequate contraception during treatment and for 6 weeks following treatmentXx_NEWLINE_xXWomen of childbearing potential and male participants who are sexually active must agree to use a medically effective means of birth controlXx_NEWLINE_xXInability or refusal to practice effective contraception during therapy or the presence of pregnancy or active breastfeeding (men and women of childbearing potential must use an effective method of birth control or abstinence during treatment and for 4 months after completion of treatment)Xx_NEWLINE_xXWomen of childbearing potential and male participants must practice adequate contraceptionXx_NEWLINE_xXWomen of childbearing potential and male participants who are sexually active must agree to use a medically effective means of birth control throughout protocol treatmentXx_NEWLINE_xXNot pregnant and not nursing; for women of childbearing potential only, a negative serum pregnancy test must be obtained within 14 days prior to registration* Women of childbearing potential must use adequate contraception from study start to one month after the last dose of protocol therapy; adequate contraception is defined as hormonal birth control, intrauterine device, double barrier method or total abstinence; men must practice complete abstinence or agree to use an adequate contraception method from study start to one month after the last dose of protocol therapyXx_NEWLINE_xXMen or women of childbearing potential who are unwilling to employ adequate contraception (e.g., hormonal or barrier method of birth control; abstinence) for the duration of study treatment and for 4 months after the last dose of study therapyXx_NEWLINE_xXFemale patients of childbearing potential and men receiving MK-3475 (pembrolizumab) who are sexually active with women of childbearing potential must be willing to use an adequate method of contraception for the course of the study through 120 days after the last dose of MK-3475 (pembrolizumab); note: abstinence is acceptable if this is the usual lifestyle and preferred contraception for the patientXx_NEWLINE_xXWomen of childbearing potential must not be known to be pregnant or lactatingXx_NEWLINE_xX