Surgery (partial or gross total resection or biopsy) must be performed >= 2 weeks prior to registration; patient must have recovered adequately from the effects of surgeryXx_NEWLINE_xXPatients must not have had major surgery within 6 weeks prior to enrollment on the high risk stratum; patients with history of recent minor surgical procedures (vascular catheter placement, bone marrow evaluation, laparoscopic surgery, liver tumor biopsy) will be eligibleXx_NEWLINE_xXPatients should not be randomized less than 3 weeks post-surgery but will not be acceptable for randomization more than 8 weeks post-surgeryXx_NEWLINE_xXPatients must not have had a previous surgical resection; however, patients may have undergone exploratory thoracotomy, mediastinoscopy, excisional biopsy or similar surgery for the purpose of determining the diagnosis, stage or potential resectability of newly diagnosed lung tumor; at least 28 days must have elapsed since thoracic surgery (excluding mediastinoscopy or other minor surgeries) and patients should have recovered from all associated toxicities at the time of registration; patients must not be planning to undergo a minor surgical procedure while on this studyXx_NEWLINE_xXPrevious radical surgery (prostatectomy) or cryosurgery for prostate cancerXx_NEWLINE_xXBilateral mammogram =< 90 days prior to date of surgery; Note: for patients undergoing more than 1 breast operation, this is the date of the first breast surgery for breast cancer treatmentXx_NEWLINE_xXLumbar CSF must be obtained prior to study enrollment unless medically contraindicated; if a patient undergoes surgery and lumbar CSF cannot be obtained at this time, then it should be performed at least 10 days following surgery before study enrollment; false positive cytology can occur within 10 days of surgery; Note: patients with positive CSF cytology obtained prior to 10 days after surgery may have cytology repeated to determine eligibilityXx_NEWLINE_xXPatient must consent for the appropriate surgeryXx_NEWLINE_xXThe patient must have recovered from surgery with the incision completely healed and no signs of infectionXx_NEWLINE_xXPatients with microscopic positive margins after definitive surgeryXx_NEWLINE_xXPatients with residual macroscopic disease after surgeryXx_NEWLINE_xXPatients may have received prior surgery (for both the primary and stage IV disease); all adverse events associated with prior surgery must have resolved to =< grade 1 prior to registrationXx_NEWLINE_xXRecent major surgery within a minimum of 4 weeks prior to starting study treatment, with the exception of surgical placement for vascular accessXx_NEWLINE_xXMajor surgery within 4 weeks prior to entry into the study, or a surgical incision that is not fully healedXx_NEWLINE_xXPatients who have received any cytotoxic therapy, immunotherapy, antitumor vaccines, monoclonal antibodies or major surgery in the 4 weeks prior to the start of the studyXx_NEWLINE_xXHave surgery planned within 3 months of consent; patients who have previously received surgery are eligibleXx_NEWLINE_xXPatients who are not currently candidates for radical cystectomy (e.g. patient refuses surgery, comorbidities preclude major surgery, etc.)Xx_NEWLINE_xXPatient must have fully recovered from the effects of prior surgery at least 14 days prior to sub-study registrationXx_NEWLINE_xXAt least 4 weeks must have elapsed since the patient underwent any major surgery (eg. MAJOR: laparotomy, laparoscopy, thoracotomy, VATS [video assisted thorascopic surgery]); there is no restriction on MINOR procedures: (eg. central venous catheter placement, ureteral stent placement or exchange, tumor core or fine-needle aspirate [FNA] biopsy)Xx_NEWLINE_xXMajor surgery within 2 weeks prior to randomization: patients must have recovered from any effects of any major surgeryXx_NEWLINE_xXPrior surgery for the IHC; (liver resection is not allowed)Xx_NEWLINE_xXThe patient must have recovered from effects of surgery, postoperative infection, and other complications within 28 days prior to step 2 registrationXx_NEWLINE_xXPatients must be adequately recovered from surgery at the time of randomizationXx_NEWLINE_xXPatients must have discontinued radiation therapy prior to registering to Step 2 of the study and recovered from any adverse events associated with treatment; prior surgery must be >= 2 weeks from registration to Step 2 and patients must be fully recovered from post-surgical complicationsXx_NEWLINE_xXMajor surgery within 4 weeks of first dose of study drugXx_NEWLINE_xXPatients who are less than 4 weeks post-operative (op) after major surgeryXx_NEWLINE_xXNo clinically significant bleeding (i.e. gastrointestinal [GI] bleed, intracranial bleeding) within 6 months or major surgery within 4 weeks; minor surgeries (i.e. port placement, cataract surgery) are allowed within 2 weeksXx_NEWLINE_xXHave had recent major surgery within a minimum of 4 weeks prior to starting study treatment, with the exception of surgical placement for vascular accessXx_NEWLINE_xXPatients, who have had a major surgery or significant traumatic injury within 4 weeks of start of study drug, patients who have not recovered from the side effects of any major surgery (defined as requiring general anesthesia) or patients that may require major surgery during the course of the studyXx_NEWLINE_xXPatients may have received prior surgery; at least 28 days must have elapsed since surgery and patient must have recovered from any adverse effects of surgeryXx_NEWLINE_xXPatients must not have any unresolved wounds from previous surgeryXx_NEWLINE_xXIbrutinib should be held at least 3 to 7 days pre- and post-surgery, depending upon the type of surgery and risk of bleedingXx_NEWLINE_xXAt least 4 weeks since major surgery or radiation therapyXx_NEWLINE_xXInability to safely delay surgery by 8 weeks as per surgeon�s discretionXx_NEWLINE_xXNo prior bariatric surgery or planning to undergo this procedure within the next 2 years after study registrationXx_NEWLINE_xXPRIOR/CONCURRENT THERAPY CRITERIA: Patients must not have had a major surgery within 28 days prior to registration; patients must have recovered from any adverse effects of prior surgery to the satisfaction of the treating physician; biopsies and central IV access placement are not considered major surgeryXx_NEWLINE_xXPatients must be enrolled on ALTE07C1 prior to enrollment on ACNS1422* Patients must be enrolled within 36 days of definitive diagnostic surgery (day 0)** Note: patients must begin treatment within 36 days of definitive surgeryXx_NEWLINE_xXPatients who are not candidates for major abdominal surgery due to known medical comorbiditiesXx_NEWLINE_xXMajor surgery within 4 weeks before randomizationXx_NEWLINE_xXPatients must have recovered from effects of recent surgery, radiotherapy, or chemotherapy; at least 4 weeks must have elapsed since the patient underwent any major surgery (e.g., major: laparotomy, laparoscopy); there is no delay required for minor procedures (e.g., tumor fine-needle aspiration [FNA] or core biopsy, venous access device placement)Xx_NEWLINE_xXPatients must have fully recovered from any adverse effects of major surgery (to =< grade 1) at least 14 days prior to registrationXx_NEWLINE_xXHave had recent major surgery within a minimum of 4 weeks prior to starting study treatment, with the exception of surgical placement for vascular accessXx_NEWLINE_xXMajor surgical procedure (as defined by the investigator) within 28 days prior to the first dose of IP; Note: local surgery of isolated lesions for palliative intent is acceptableXx_NEWLINE_xXPatients must NOT have radiotherapy, or major surgery or active drug therapy for pNET (SSA permitted) within 4 weeks prior to study treatment startXx_NEWLINE_xXPatients who have had major surgery or trauma within 28 days prior to entering the study; patients must have recovered from any effects of any major surgery and surgical wound should have healed prior to starting treatmentXx_NEWLINE_xXStep 1 registration must occur within 180 days of the initial surgery; within this 180 day interval, a second surgery is permitted in order to achieve GTR, but even with a second surgery, step 1 registration must occur within 180 days of the initial resectionXx_NEWLINE_xXMajor surgery must not have occurred within 2 weeks prior to enrollment and patients must have recovered from any effects of any major surgeryXx_NEWLINE_xX