AST =< 2 x upper limit of normalXx_NEWLINE_xXTREATMENT: Creatinine =< 2 x upper limit of normal for ageXx_NEWLINE_xXCreatinine =< 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXCreatinine =< 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXCreatinine =< twice upper limit institutional normalXx_NEWLINE_xXCreatinine < 1.5 times institutional upper limit of normal, within 21 days prior to study entryXx_NEWLINE_xXAdequate coagulation defined as:* Prothrombin time (PT) =< 1.2 x upper limit of normalXx_NEWLINE_xXCreatinine < 1.5 institutional upper limit of normal ORXx_NEWLINE_xXSerum creatinine of =< 1.5 X the upper limit of normalXx_NEWLINE_xXTREATMENT: AST (SGOT)/ALT (SGPT) =< 3 x institutional upper limit of normalXx_NEWLINE_xXProthrombin time (PT) =< 1.5 x institutional upper limit of normal (ULN)Xx_NEWLINE_xXProthrombin time (PT) < 1.3 x upper limit of normal (ULN)Xx_NEWLINE_xXCreatinine =< 1.5 x upper limit of normal (ULN) within 14 days prior to study registrationXx_NEWLINE_xXSerum creatinine > 2 times the upper limit of normalXx_NEWLINE_xXCreatinine =< institutional upper limit of normal ORXx_NEWLINE_xXCreatinine =< 1.5 x institutional/laboratory upper limit of normal (ULN)Xx_NEWLINE_xXINCLUSION CRITERIA FOR STRATUM C: ALT (SGPT) =< 3 x institutional upper limit of normalXx_NEWLINE_xXAST/ALT =< 3 x upper limit of normal (ULN)Xx_NEWLINE_xXCreatinine (Cr) < 1.5 upper limit of normal (ULN)Xx_NEWLINE_xXCreatinine =< 1.5 x institutional upper limit of normalXx_NEWLINE_xXCreatine phosphokinase =< institutional upper limit of normalXx_NEWLINE_xXAST (SGOT)/ALT(SGPT) (only if elevated liver function tests [LFTs] are due to disease) =< 5.0 x institutional upper limit of normalXx_NEWLINE_xXSerum creatinine =< 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXCreatinine =< 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXSerum creatinine of =< 1.5 x the upper limit of normalXx_NEWLINE_xXCreatinine =< 1.5 x upper limit of normal (ULN)Xx_NEWLINE_xXNote: ULN is institutional or laboratory upper limit of normalXx_NEWLINE_xXCreatinine =< 1.5 x upper limit of normal (ULN) orXx_NEWLINE_xXWithin 14 days prior to registration: Creatinine =< 1.5 x institutional upper limit of normal (ULN)Xx_NEWLINE_xXCreatinine =< 1.5 x upper limit of normal (ULN) orXx_NEWLINE_xXSodium >= the institutional lower limit of normalXx_NEWLINE_xXAST =< 8 x upper limit of normal (ULN)Xx_NEWLINE_xX